JP2000044467A - Agent for stimulating blood flow - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject agent having an excellent blood flow-stimulating effect, hardly having the problems of smell, irritation, etc., on employment, giving a high refreshing feeling, having a good touch, and useful as an ingredient for compositions for oral cavities, medicines, cosmetics, etc., by adding citral as an active ingredient. SOLUTION: This agent for stimulating the flow of blood contains as an active ingredient citral which is obtained from a plant such as lemon grass as a fractionated product or an isolated product or obtained as a synthesized product. The agent can be added to hair tonics, bathing agents, preparations for external uses, etc., preferably in an amount of 0.1-5% based on the total amount of the preparation to which the citral is added. The agent is useful for periodontal diseases, the improvement of skin drabness and alopecia, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a blood flow promoting agent which has an excellent blood flow promoting effect and can be suitably blended and used in oral compositions, pharmaceuticals, cosmetics and the like.

[0002]

2. Description of the Related Art It is generally said that the blood flow is proportional to the fourth power of the inner diameter of a blood vessel, and narrowing of the inner diameter of an artery, particularly an arteriole, leads to a long-term inadequate supply of arterial blood in the governing region. This inadequate arterial blood supply causes metabolic disorders (atrophy, degeneration, necrosis) in local tissues, and appears as disorders such as periodontal disease in the oral cavity, "dullness" in the skin, hair loss in the hair, stiff shoulders, and muscle pain.

[0003] Therefore, various preparations have been developed to improve these blood flow promoting disorders. Specifically, dentifrices containing vitamin E (tocopherol) and caropeptides to improve blood flow (Japanese Patent Publication No.
No. 23636), a composition for oral cavity using a solvent extract of a plant such as hinoki, western horse chestnut, arnica and the like in combination with a caropeptide for the prevention and treatment of periodontal disease (Japanese Patent Application Laid-Open No. Sho 57)
-82307) has been proposed. In addition, cinnamoyl-type compounds such as cinnamaldehyde (JP-A-7-258074), and eugenol derivatives such as acetyleugenol (JP-A-9-209) are used as blood flow enhancers for plant essential oil components.
-241116) has also been proposed.

[0004]

However, it is hard to say that tocopherol and caropeptide have a satisfactory blood flow promoting effect, and cinnamoyl-type compounds and eugenol derivatives have a good effect but a refreshing feeling. Not a scent. Furthermore, although capsaicin is also known to have a blood flow promoting effect, it has a drawback that a refreshing feeling cannot be obtained. Therefore, it is desired to develop a high-quality blood flow promoting agent that has a strong cooling sensation and can exhibit a higher blood flow promoting effect.

The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a blood flow promoting agent having an excellent blood flow promoting effect, a high refreshing feeling, and a good feeling in use.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, citral, which is known as a fragrance, has been surprisingly localized due to a decrease in peripheral blood flow. Improves tissue metabolic disorders and exerts a high blood circulation promoting effect. Therefore, by using citral as an active ingredient for promoting blood circulation, it has an excellent blood flow promoting effect and is suitable for use such as fragrance and irritation. There are few problems, refreshing feeling is high, feeling of use is good, oral compositions, pharmaceuticals,
The present inventors have found that a blood flow promoter which can be blended and used in cosmetics and the like can be obtained, and have accomplished the present invention.

Citral is used not only as a flavor component as described above, but also has an excellent effect of removing tarnish from tobacco, and an oral composition containing the same has been proposed (Japanese Patent Application Laid-Open No. Sho 62-181212). No.). However, it has not yet been known that citral has such an excellent blood flow promoting effect as described above, and this was first discovered by the present inventors.

Accordingly, the present invention provides a blood flow enhancer containing citral as an active ingredient.

The present invention will be described in more detail below. Citral, which is an active ingredient of the blood flow enhancer of the present invention, can be obtained as a fraction or an isolated product from a plant containing the same or as a synthetic product. Can be. In this case, when citral is obtained as a fraction or an isolated product from a plant, for example, a plant containing citral is fractionated by a known method to obtain an extract or an essential oil, or further fractionated by a known method. An isolate can be obtained. Specific examples of plants containing citral include the following plants. Cymbopog of the genus Ogarukaya, especially lemongrass
on citratus (DC) Stap. (Symbopogon Citratus), C.I. flexuosus
(DC) Stapf. (Flex male), C.I. p
endulus Stapf. (Pendulus) and so on.
Lilium spp., Especially Lemon Verbena (L
ipia citriodora H .; B. et K
it. )Such. Lamiaceae Lamiaceae, especially lemon perilla (P
erilla flutescens Brit. )Such. Citrus citrus, especially Citrus auran
tifolia Swing. (Citrus aurantifolia), C.I. aurantium L. (Aurantium), C.I. histrix D. C. (History), C.I. lemon (L.) Burm. f. (Lemon), C.I. limetta Russo (Limetta), C.I. maxima (Burn.f.) Merr.
(Maxima), C.I. medica L. (Medica),
C. paradisi Macfayden (Paradisi), C.I. C. reticulata Blanco (Reticulata), C.I. sinensis Osbeck
(Sinensis). And their subspecies, variants, etc.

In the present invention, citral or a plant extract containing the same can be used as an active ingredient in combination with other existing blood flow-promoting components, and thus other blood flow-promoting components can be used in combination. Thereby, a stronger blood flow promoting effect having a refreshing feeling can be exerted.

Here, the other blood flow promoting components include, for example, cinnamaldehyde, eugenol, carvacrol,
Examples include thymol, capsaicin, gingerol, assembly extract, carrot extract, garlic extract, and tocopherol.

The blood flow enhancer of the present invention can be used, for example, by blending it in oral compositions, cosmetics, pharmaceuticals, hair restorers, bath agents, external preparations and the like.

In this case, the amount of the citral-containing blood flow promoting agent of the present invention is 0.01 to 10% (% by weight, hereinafter the same) of the whole preparation to which the citral component is added.
In particular, the range of 0.1 to 5% is preferable, and the blending amount is 0.1%.
If it is less than 01%, a satisfactory blood flow promoting effect may not be exhibited, and if it exceeds 10%, the stability and flavor of the formulation may be impaired.

When the blood flow enhancer of the present invention is blended with an oral composition, a pharmaceutical, a cosmetic, a hair restorer, a bath preparation, an external preparation, etc., the components usually used in the preparation are used. These components can be added in usual amounts as long as the effects of the present invention are not impaired.

[0015]

Industrial Applicability The blood flow enhancer of the present invention improves metabolic disorders in local tissues due to a decrease in peripheral blood flow, exhibits an excellent blood flow promoting effect, and has few problems in use such as fragrance and irritation. It has a high refreshing sensation and excellent feeling in use.It is blended in oral compositions, pharmaceuticals, cosmetics, hair restorers, bath preparations, external preparations, etc. to provide periodontal disease, dull skin, hair loss, Stiff shoulder,
It can be used to improve muscle pain.

[0016]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In addition, in the following examples, all% are weight%.

[0017] Examples and Comparative Examples bloodstream promoting evaluation laser Doppler blood flow measuring device (Periflux
Using PF1b (manufactured by Perimed, Sweden), the samples shown in Table 1 were dissolved at 5% in ethanol, and 10 μl of the sample was dropped into a probe holder attached to the skin inside the forearm. The measured value was AD-converted, taken into a computer, and the average value per minute was plotted. Table 1 shows the value obtained by dividing the highest value of the blood flow rate by the base value from this graph as the blood flow promotion magnification.

Evaluation of Refreshing Sensitivity A solution for measuring blood flow (a 5% ethanol solution of a sample) was immersed in filter paper and subjected to sensory evaluation according to the following criteria. Table 1 shows the results. ++ Very refreshing ++ Very refreshing + Slightly refreshing-No refreshing

[0019]

[Table 1]

In the following, prescription examples are shown. [Formulation Example 1] Toothpaste Precipitated silica 25.00% Glycerin 25.00 Sorbit 15.00 Xylitol 10.00 Lauroyldecaglycerin ester 1.00 Myristic acid diethanolamide 2.00 Fragrance 1.00 Saccharin sodium 0.20 Lemon Glass oil 1.00 water balance 100.00%

[Formulation Example 2] Liquid dentifrice Precipitable silica 20.00% Glycerin 25.00 Sorbit 35.00 Xanthan gum (compliant with pharmaceutical standards) 0.20 Propylene glycol 2.00 Sodium lauryl sulfate 1.50 Decaglyceryl monolaurate 2.00 Fragrance 0.50 Saccharin sodium 0.10 Thymol 0.50 Citral 0.50 Water Balance 100.00%

[Formulation Example 3] Oral ointment Liquid paraffin 15.00% Cetanol 10.00 Glycerin 20.00 Polyoxyethylene sorbitan fatty acid ester 5.00 Fragrance 0.50 Saccharin sodium 0.10 Verbena oil 1.50 Water Balance 100.00%

[Formulation Example 4] Mouthwash Ethanol 20.00% Fragrance 1.00 Polyoxyethylene hydrogenated castor oil (EO = 60) 0.30 Sodium monofluorophosphate 0.10 Saccharin sodium 0.05 Lemon perilla oil 1.50 water balance 100.00%

[Formulation Example 5] Candy sugar 50.00% water candy 33.00 Organic acid 2.00 Flavor 0.20 Carvacrol 0.50 Lemongrass n-hexane extract 0.50 Water balance 100.00%

[Formulation Example 6] Chewing gum sugar 53.00% Gum base 20.00 Glucose 10.00 Water candy 16.00 Flavor 0.50 Lemon oil 1.50 Total 101.00%

[Formulation Example 7] Cosmetic cream stearic acid 2.00% stearyl alcohol 7.00 polyoxyethylene cetyl ether (EO = 25) 4.00 propylene glycol 8.00 hydrogenated lanolin 2.00 2-octyldodecyl Alcohol 6.00 Glycerin monostearate 2.00 Squalane 5.00 Fragrance 0.50 Citron leaf oil 1.00 Water Balance 100.00%

[Formulation Example 8] Hair restorer ethanol 60.00% glycerin 0.50 flavoring agent 0.50 polyoxyethylene hydrogenated castor oil (EO = 60) 0.50 tocopherol acetate 0.10 citral 0.50 lemon oil 1 0.00 water balance 100.00%

[Formulation Example 9] Bath agent Sodium sulfate 46.00% Sodium hydrogen carbonate 13.00 Sodium carbonate 13.00 Malic acid 26.00 Polyethylene glycol 400 1.00 Fragrance 0.50 Lemongrass oil 0.50 Total 100.00%

[Formulation Example 10] Antiphlogistic analgesic liniment agent Ethanol 45.00% Indomethacin 1.00 Polyoxyethylene lauryl ether (EO = 21) 1.00 Isopropyl adipate 5.00 1,3-Butanediol 10.00 Verbena oil 1.00 water balance 100.00%

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/50 A61K 7/50 // A23L 1/30 A23L 1/30 BF Term (Reference) 4B018 LB01 LE05 MS03 4C083 AA122 AB172 AB312 AB352 AB472 AC022 AC072 AC092 AC102 AC122 AC132 AC182 AC211 AC212 AC242 AC302 AC352 AC402 AC422 AC432 AC472 AC542 AC782 AC852 AC862 AD042 AD352 AD512 AD662 CC03 CC05 CC25 CC37 CC41 DD22 DD23 DD27 DD31 EE11 AE18 EE11 AE22 MA04 NA14 ZA36

Claims (1)

[Claims] 1. A blood flow promoter comprising citral as an active ingredient.