JO3668B1 - مركبات بلاديينوليد البيريدين وطرق استعمالها - Google Patents
مركبات بلاديينوليد البيريدين وطرق استعمالهاInfo
- Publication number
- JO3668B1 JO3668B1 JOP/2015/0113A JOP20150113A JO3668B1 JO 3668 B1 JO3668 B1 JO 3668B1 JO P20150113 A JOP20150113 A JO P20150113A JO 3668 B1 JO3668 B1 JO 3668B1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- methods
- pyridine
- pallidinolides
- useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 210000001324 spliceosome Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
يقدم الاختراع الحالي مركبات بلاديينوليد البيريدين الجديدة وتركيبات دوائية تحتوي على المركبات المذكورة وطرق استخدام المركبات كعوامل علاجية. ويمكن استخدام هذه المركبات في علاج السرطان، وبالتحديد السرطانات بحيث العوامل التي تستهدف جسيم التضفير وطفراتها هي معروفة أنها مفيدة.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993423P | 2014-05-15 | 2014-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3668B1 true JO3668B1 (ar) | 2020-08-27 |
Family
ID=53284528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2015/0113A JO3668B1 (ar) | 2014-05-15 | 2015-05-13 | مركبات بلاديينوليد البيريدين وطرق استعمالها |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US9481669B2 (ar) |
| EP (2) | EP3514154B1 (ar) |
| JP (1) | JP6067943B1 (ar) |
| KR (2) | KR102146726B1 (ar) |
| CN (1) | CN107074827B (ar) |
| AR (1) | AR100431A1 (ar) |
| AU (1) | AU2015259237B2 (ar) |
| BR (1) | BR112016026638B1 (ar) |
| CA (1) | CA2947754C (ar) |
| CL (1) | CL2016002835A1 (ar) |
| CY (1) | CY1121550T1 (ar) |
| DK (1) | DK3143016T3 (ar) |
| ES (1) | ES2712401T3 (ar) |
| HR (1) | HRP20190432T1 (ar) |
| HU (1) | HUE041838T2 (ar) |
| IL (1) | IL248529B (ar) |
| JO (1) | JO3668B1 (ar) |
| LT (1) | LT3143016T (ar) |
| MA (1) | MA39915B1 (ar) |
| ME (1) | ME03417B (ar) |
| MX (2) | MX2020004476A (ar) |
| MY (1) | MY195081A (ar) |
| PE (1) | PE20170384A1 (ar) |
| PH (1) | PH12016502249B1 (ar) |
| PL (1) | PL3143016T3 (ar) |
| PT (1) | PT3143016T (ar) |
| RS (1) | RS58400B1 (ar) |
| RU (1) | RU2707730C2 (ar) |
| SG (1) | SG11201609693XA (ar) |
| SI (1) | SI3143016T1 (ar) |
| SM (1) | SMT201900158T1 (ar) |
| TR (1) | TR201902328T4 (ar) |
| TW (1) | TWI634115B (ar) |
| UA (1) | UA119458C2 (ar) |
| WO (1) | WO2015175594A1 (ar) |
| ZA (1) | ZA201607354B (ar) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2887201T3 (es) | 2015-09-01 | 2021-12-22 | Eisai R&D Man Co Ltd | Variantes de empalme asociadas con mutantes neomórficos de SF3B1 |
| RU2743349C2 (ru) * | 2015-11-18 | 2021-02-17 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Твердые формы пладиенолидпиридиновых соединений и способы их применения |
| RU2019132208A (ru) * | 2017-03-15 | 2021-04-15 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Мутации сплайсингосомы и их применения |
| MX2020004179A (es) * | 2017-10-31 | 2020-08-03 | Eisai R&D Man Co Ltd | Combinacion que comprende al menos un modulador de espliceosomas y al menos un inhibidor elegido de inhibidores de bcl2, bcl2/bclxl y bclxl, y metodos de uso. |
| EP3774759A2 (en) * | 2018-04-09 | 2021-02-17 | Eisai R&D Management Co., Ltd. | Pladienolide compounds and their use |
| SG11202009907XA (en) | 2018-04-12 | 2020-11-27 | Eisai R&D Man Co Ltd | Pladienolide derivatives as spliceosome targeting agents for treating cancer |
| WO2019232433A2 (en) * | 2018-06-01 | 2019-12-05 | Eisai R&D Management Co., Ltd. | Methods of using splicing modulators |
| IL262658A (en) * | 2018-10-28 | 2020-04-30 | Memorial Sloan Kettering Cancer Center | Prevention of age related clonal hematopoiesis and diseases associated therewith |
| EP4161966A1 (en) * | 2020-06-05 | 2023-04-12 | Eisai R&D Management Co., Ltd. | Anti-bcma antibody-drug conjugates and methods of use |
| EP4240360A1 (en) | 2020-11-04 | 2023-09-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| EP4361136A1 (en) * | 2021-06-18 | 2024-05-01 | Universidad De Córdoba | Compound for the treatment of glioblastoma |
| CN113876771B (zh) * | 2021-11-12 | 2022-09-23 | 中国医学科学院基础医学研究所 | 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI312681B (en) | 2001-02-01 | 2009-08-01 | Novel physiologically active substance | |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| US7256178B2 (en) | 2002-07-31 | 2007-08-14 | Eisai Co., Ltd. | Physiologically active substances |
| WO2004011459A1 (ja) | 2002-07-31 | 2004-02-05 | Mercian Corporation | 新規生理活性物質 |
| WO2004037212A2 (en) | 2002-10-24 | 2004-05-06 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| JP4439401B2 (ja) | 2002-11-29 | 2010-03-24 | メルシャン株式会社 | マクロライド系化合物の製造方法 |
| WO2005052152A1 (ja) | 2003-11-27 | 2005-06-09 | Mercian Corporation | マクロライド系化合物の水酸化に関与するｄｎａ |
| US20080112956A1 (en) | 2003-11-28 | 2008-05-15 | Kanagawa Academy Of Science And Technology | Method of Detecting Liver Cancer, Diagnostic for Liver Cancer and Remedy for Cancer |
| US20070199741A1 (en) | 2004-07-02 | 2007-08-30 | Kenji Noumi | Combined Weighing Apparatus |
| CN1977046A (zh) | 2004-07-20 | 2007-06-06 | 卫材R&D管理有限公司 | 编码参与普拉地内酯生物合成的多肽的dna |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| CN101282967B (zh) | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
| JPWO2008111464A1 (ja) * | 2007-03-05 | 2010-06-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スプライシング異常を指標とする抗ガン剤の作用検定方法 |
| US20080312317A1 (en) | 2007-04-12 | 2008-12-18 | Eisai R&D Management Co., Ltd. | 12 membered-ring macrolactam derivatives |
-
2015
- 2015-05-13 EP EP18210019.8A patent/EP3514154B1/en active Active
- 2015-05-13 KR KR1020177004442A patent/KR102146726B1/ko active IP Right Grant
- 2015-05-13 PE PE2016002233A patent/PE20170384A1/es unknown
- 2015-05-13 EP EP15727125.5A patent/EP3143016B1/en active Active
- 2015-05-13 RU RU2016148887A patent/RU2707730C2/ru active
- 2015-05-13 JO JOP/2015/0113A patent/JO3668B1/ar active
- 2015-05-13 AU AU2015259237A patent/AU2015259237B2/en active Active
- 2015-05-13 SI SI201530641T patent/SI3143016T1/sl unknown
- 2015-05-13 UA UAA201612731A patent/UA119458C2/uk unknown
- 2015-05-13 MX MX2020004476A patent/MX2020004476A/es unknown
- 2015-05-13 PT PT15727125T patent/PT3143016T/pt unknown
- 2015-05-13 BR BR112016026638-2A patent/BR112016026638B1/pt active IP Right Grant
- 2015-05-13 ME MEP-2019-81A patent/ME03417B/me unknown
- 2015-05-13 PH PH1/2016/502249A patent/PH12016502249B1/en unknown
- 2015-05-13 ES ES15727125T patent/ES2712401T3/es active Active
- 2015-05-13 WO PCT/US2015/030464 patent/WO2015175594A1/en active Application Filing
- 2015-05-13 MA MA39915A patent/MA39915B1/fr unknown
- 2015-05-13 TW TW104115293A patent/TWI634115B/zh active
- 2015-05-13 MX MX2016014997A patent/MX2016014997A/es active IP Right Grant
- 2015-05-13 LT LTEP15727125.5T patent/LT3143016T/lt unknown
- 2015-05-13 SG SG11201609693XA patent/SG11201609693XA/en unknown
- 2015-05-13 MY MYPI2016001944A patent/MY195081A/en unknown
- 2015-05-13 JP JP2016526218A patent/JP6067943B1/ja active Active
- 2015-05-13 CA CA2947754A patent/CA2947754C/en active Active
- 2015-05-13 HU HUE15727125A patent/HUE041838T2/hu unknown
- 2015-05-13 US US14/710,687 patent/US9481669B2/en active Active
- 2015-05-13 CN CN201580025344.0A patent/CN107074827B/zh active Active
- 2015-05-13 AR ARP150101485A patent/AR100431A1/es active IP Right Grant
- 2015-05-13 SM SM20190158T patent/SMT201900158T1/it unknown
- 2015-05-13 DK DK15727125.5T patent/DK3143016T3/en active
- 2015-05-13 RS RS20190233A patent/RS58400B1/sr unknown
- 2015-05-13 PL PL15727125T patent/PL3143016T3/pl unknown
- 2015-05-13 TR TR2019/02328T patent/TR201902328T4/tr unknown
- 2015-05-13 KR KR1020167016648A patent/KR101710318B1/ko active IP Right Grant
-
2016
- 2016-10-25 ZA ZA2016/07354A patent/ZA201607354B/en unknown
- 2016-10-26 IL IL24852916A patent/IL248529B/en active IP Right Grant
- 2016-11-08 CL CL2016002835A patent/CL2016002835A1/es unknown
-
2019
- 2019-02-22 CY CY20191100228T patent/CY1121550T1/el unknown
- 2019-03-04 HR HRP20190432TT patent/HRP20190432T1/hr unknown
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