ITPD20120155A1 - BREAST PROSTHESIS - Google Patents
BREAST PROSTHESIS Download PDFInfo
- Publication number
- ITPD20120155A1 ITPD20120155A1 IT000155A ITPD20120155A ITPD20120155A1 IT PD20120155 A1 ITPD20120155 A1 IT PD20120155A1 IT 000155 A IT000155 A IT 000155A IT PD20120155 A ITPD20120155 A IT PD20120155A IT PD20120155 A1 ITPD20120155 A1 IT PD20120155A1
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- Italy
- Prior art keywords
- per
- prosthesis
- breast prosthesis
- biological
- cavities
- Prior art date
Links
- 210000000481 breast Anatomy 0.000 title claims description 21
- 239000000126 substance Substances 0.000 claims description 10
- 230000017423 tissue regeneration Effects 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 241000277331 Salmonidae Species 0.000 claims description 2
- 210000001789 adipocyte Anatomy 0.000 claims description 2
- 210000002149 gonad Anatomy 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 239000000945 filler Substances 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000000560 biocompatible material Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000005240 physical vapour deposition Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0091—Additional features; Implant or prostheses properties not otherwise provided for transparent or translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/303—Carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Description
PROTESI MAMMARIA BREAST PROSTHESIS
DESCRIZIONE DESCRIPTION
II presente brevetto è attinente alle protesi mammarie impiantabili ed in particolare concerne un nuovo tipo di protesi mammaria impiantabile in materiali biocompatibili e conformata per migliorare la rigenerazione tissutale. The present patent relates to implantable breast prostheses and in particular it concerns a new type of implantable breast prosthesis made of biocompatible materials and shaped to improve tissue regeneration.
Sono note le protesi mammarie impiantabili, utilizzate nella sostituzione della mammella nella chirurgia plastica ricostruttiva o per l’aumento del volume della mammella nella chirurgia plastica additiva. Implantable breast implants are known, used in breast replacement in reconstructive plastic surgery or for breast augmentation in additive plastic surgery.
Le protesi mammarie del tipo noto comprendono un involucro impermeabile in elastomeri siliconici, con riempimento in gel siliconico. Breast implants of the known type comprise a waterproof casing made of silicone elastomers, filled with silicone gel.
Detto involucro deve essere impermeabile, per evitare il trasudamento del riempitivo, che comporterebbe infiammazione e, in generale, reazioni da corpo estraneo. Per evitare la dispersione del riempitivo in caso di rottura dell’ involucro, il gel siliconico è ad alta coesività tale da formare un corpo unito. Said envelope must be waterproof, to avoid the oozing of the filler, which would lead to inflammation and, in general, reactions from a foreign body. To avoid the dispersion of the filler in case of breakage of the casing, the silicone gel is highly cohesive to form a united body.
La superficie esterna della protesi può essere liscia, con il vantaggio di facilitarne Γ inserimento nella sede chirurgica, oppure testurizzata, ossia resa sostanzialmente rugosa o porosa per aumentare la superficie di contatto tra protesi e tessuti organici. The external surface of the prosthesis can be smooth, with the advantage of facilitating its insertion into the surgical site, or textured, ie made substantially rough or porous to increase the contact surface between the prosthesis and organic tissues.
Tra la protesi impiantata e i tessuti biologici con cui la protesi entra in contatto avvengono fenomeni di interazione che possono portare a diverse conseguenze. Interaction phenomena occur between the implanted prosthesis and the biological tissues with which the prosthesis comes into contact, which can lead to various consequences.
La protesi impiantata viene inizialmente percepita dall’organismo come un corpo estraneo, inducendo una serie di reazioni biologiche (infiammazione, formazione di capsula periprotetica di tessuto fibroso, ecc.) che, in casi gravi, può rendere necessaria la rimozione della protesi stessa e della capsula fibrotica . The implanted prosthesis is initially perceived by the body as a foreign body, inducing a series of biological reactions (inflammation, formation of a periprosthetic capsule of fibrous tissue, etc.) which, in severe cases, may make it necessary to remove the prosthesis itself and the fibrotic capsule.
Affinché la protesi risulti stabile, la crescita del tessuto a contatto deve avvenire in modo fisiologico, con una ricostruzione cellulare corretta. In order for the prosthesis to be stable, the growth of the tissue in contact must occur in a physiological way, with a correct cell reconstruction.
Le protesi mammarie, così come strutturate da tecnica nota, anche quando vengono impiantate correttamente e non danno luogo a reazioni anomale, vengono comunque percepite dal paziente come un corpo estraneo, sia al tatto, sia alla vista. Breast implants, as structured by the known technique, even when they are implanted correctly and do not give rise to abnormal reactions, are however perceived by the patient as a foreign body, both to the touch and to the sight.
Le protesi possono essere rivestite con sottili strati di materiali biocompatibili, tra i quali è noto l'utilizzo di carbonio turbostratico, materiale particolarmente adatto per la realizzazione di dispositivi impiantabili, grazie alle sue caratteristiche di inerzia chimica ed elevata biocompatibilità, congiunte ad un complesso di caratteristiche chimicofisiche particolarmente indicato per queste applicazioni. The prostheses can be coated with thin layers of biocompatible materials, among which the use of turbostratic carbon is known, a material particularly suitable for the realization of implantable devices, thanks to its characteristics of chemical inertness and high biocompatibility, combined with a complex of chemical-physical characteristics particularly suitable for these applications.
Un inconveniente derivante dall'utilizzo del carbonio consiste nel fatto che la protesi assume un colore scuro, dovuto al colore nero del carbonio turbostratico nella forma attualmente disponibile. A drawback deriving from the use of carbon consists in the fact that the prosthesis takes on a dark color, due to the black color of the turbostratic carbon in the form currently available.
Una volta impiantata la protesi, tale colore scuro può trasparire attraverso la cute del paziente, rendendo l'aspetto generale innaturale, con conseguente disagio del paziente. Once the prosthesis is implanted, this dark color can show through the patient's skin, making the general appearance unnatural, resulting in patient discomfort.
Per ovviare ai suddetti inconvenienti si è studiato e realizzato un nuovo tipo di protesi mammaria impiantabile, in materiali biocompatibili e con superficie conformata per favorire la rigenerazione tissutale. To obviate the aforementioned drawbacks, a new type of implantable breast prosthesis has been studied and manufactured, in biocompatible materials and with a surface shaped to favor tissue regeneration.
Compito principale del presente trovato è quello di migliorare la rigenerazione del tessuti biologici a contatto con la protesi impiantata, inducendo un’attività fisiologica di rigenerazione dei tessuti a contatto. Altro scopo del presente trovato è quello di minimizzare il rischio di infiammazioni, accelerando i tempi di guarigione. The main aim of the present invention is to improve the regeneration of biological tissues in contact with the implanted prosthesis, inducing a physiological regeneration of the tissues in contact. Another object of the present invention is to minimize the risk of inflammation by accelerating healing times.
Altro scopo del presente trovato è migliorare la sensazione visiva della mammella con protesi impiantata. Another object of the present invention is to improve the visual sensation of the breast with an implanted prosthesis.
Questi ed altri scopi, diretti e complementari, sono raggiunti dalla nuova protesi mammaria comprendente nelle sue parti principali un involucro impermeabile con adeguato riempitivo. These and other direct and complementary purposes are achieved by the new breast prosthesis comprising in its main parts a waterproof casing with suitable filler.
Ad esempio, detto involucro è realizzato in elastomeri siliconici ed è impermeabile per limitare il trasudamento del riempitivo. For example, said casing is made of silicone elastomers and is waterproof to limit the exudation of the filler.
Detto riempitivo di detto involucro è preferibilmente realizzato in gel siliconico. Said filler of said casing is preferably made of silicone gel.
In una possibile soluzione realizzativa, detto involucro comprende un rivestimento esterno (coating di un film sottile adeso alla superficie esterna) di interfaccia con i tessuti dell'organismo del paziente, dove detto rivestimento esterno è in carbonio non nero, incolore, trasparente o semitrasparente, oppure di colore simile al colore naturale della pelle. In a possible embodiment, said envelope comprises an external coating (coating of a thin film adhered to the external surface) interfacing with the tissues of the patient's organism, where said external coating is in non-black, colorless, transparent or semitransparent carbon, or similar in color to the natural color of the skin.
Detto rivestimento esterno è ad esempio applicato utilizzando una tecnica di deposizione fisica da vapore o "Physical Vapor Deposition" o PVD. Said external coating is for example applied using a physical vapor deposition technique or "Physical Vapor Deposition" or PVD.
Detto involucro, con o senza detto rivestimento di cui sopra, ha preferibilmente superficie esterna comprendente una pluralità di recessi, cavità o microcavità non passanti, distribuite su tutta la superficie stessa, atte ad aumentare la superficie attiva di interazione tra la superficie della protesi e i tessuti. Said envelope, with or without said above coating, preferably has an external surface comprising a plurality of recesses, cavities or non-passing microcavities, distributed over the entire surface itself, suitable for increasing the active interaction surface between the surface of the prosthesis and the tissues. .
Nel caso in cui detto involucro comprenda anche detto rivestimento o coating esterno, quest'ultimo è distribuito parzialmente o totalmente anche all'intemo di dette cavità o recessi. If said envelope also includes said external coating or coating, the latter is partially or totally distributed also within said cavities or recesses.
Si prevede inoltre che tutte o parte di dette cavità possano essere riempite di prodotti o sostanze medicali o biologiche o sintetiche, atte ad indurre la rigenerazione tissutale sull’ interfaccia tra la protesi e i tessuti biologici a contatto. It is also expected that all or part of these cavities can be filled with medical or biological or synthetic products or substances, capable of inducing tissue regeneration on the interface between the prosthesis and the biological tissues in contact.
Ad esempio, detti prodotti o sostanze medicali o biologiche o sintetiche comprendono cellule staminali o microfrazioni di DNA per la rigenerazione tissutale. For example, said medical or biological or synthetic products or substances comprise stem cells or DNA microfractions for tissue regeneration.
Dette microfrazioni di DNA possono ad esempio essere ottenute dalle gonadi di pesci, quali preferibilmente di salmonidi e/o acipenseridi, di cui è stata riscontrata una elevata capacità di differenziazione, inducendo la corretta ricostruzione delle cellule e quindi la rigenerazione tissutale di tipo fisiologico. Said DNA microfractions can for example be obtained from the gonads of fish, such as preferably of salmonids and / or acipenserides, of which a high differentiation capacity has been found, inducing the correct reconstruction of the cells and therefore the physiological tissue regeneration.
Dette sostanze biologiche comprendono anche cellule adipose, preferibilmente estratte dal corpo del paziente stesso cui viene impiantata la protesi. Said biological substances also include fat cells, preferably extracted from the patient's body to whom the prosthesis is implanted.
Le caratteristiche della nuova protesi saranno meglio chiarite dalla seguente descrizione con riferimento alla tavola di disegno, allegata a titolo di esempio non limitativo. The characteristics of the new prosthesis will be better clarified by the following description with reference to the drawing table, attached as a non-limiting example.
In figura 1 è schematizzata la nuova protesi (P), mentre in figura 2 è rappresentato un dettaglio ingrandito del solo involucro (1) esterno. Figure 1 schematizes the new prosthesis (P), while Figure 2 shows an enlarged detail of the outer casing (1) only.
La nuova protesi (P) comprende un involucro (1) con riempitivo (11). The new prosthesis (P) comprises a housing (1) with filler (11).
Detto involucro (1), rappresentato in un dettaglio in figura 2, comprende una pluralità di recessi o cavità non passanti (12) sulla sua superficie esterna. Detta superficie esterna può essere rivestita da un “coating” (2) visibile in figura, distribuito parzialmente o totalmente anche all'interno di dette cavità (12). Said casing (1), shown in detail in Figure 2, comprises a plurality of non-passing recesses or cavities (12) on its external surface. Said external surface can be coated with a coating (2) visible in the figure, partially or totally distributed also inside said cavities (12).
Dette cavità (12) possono essere riempite con sostanze medicali o biologiche o sintetiche. Said cavities (12) can be filled with medical or biological or synthetic substances.
Queste sono le modalità schematiche sufficienti alla persona esperta per realizzare il trovato, di conseguenza, in concreta applicazione potranno esservi delle varianti senza pregiudizio alla sostanza del concetto innovativo. These are the schematic modalities sufficient for the skilled person to realize the invention, consequently, in concrete application there may be variations without prejudice to the substance of the innovative concept.
Pertanto con riferimento alla descrizione che precede e alla tavola acclusa si esprimono le seguenti rivendicazioni. Therefore, with reference to the preceding description and to the attached table, the following claims are expressed.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000155A ITPD20120155A1 (en) | 2012-05-15 | 2012-05-15 | BREAST PROSTHESIS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000155A ITPD20120155A1 (en) | 2012-05-15 | 2012-05-15 | BREAST PROSTHESIS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITPD20120155A1 true ITPD20120155A1 (en) | 2013-11-16 |
Family
ID=46321309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000155A ITPD20120155A1 (en) | 2012-05-15 | 2012-05-15 | BREAST PROSTHESIS |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | ITPD20120155A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3366975A (en) * | 1965-06-04 | 1968-02-06 | William J. Pangman | Compound prosthesis |
| US5376117A (en) * | 1991-10-25 | 1994-12-27 | Corvita Corporation | Breast prostheses |
| WO2009016503A2 (en) * | 2007-08-01 | 2009-02-05 | Tecnologie Biomediche Srl | Development of improved smooth and textured mammary prostheses coated with highly biocompatible materials |
| US20110009960A1 (en) * | 2001-11-16 | 2011-01-13 | Allergan, Inc. | Prosthetic fabric structure |
| WO2011160875A1 (en) * | 2010-06-25 | 2011-12-29 | Antonio Sambusseti | Orthotopic artificial bladder prosthesis |
-
2012
- 2012-05-15 IT IT000155A patent/ITPD20120155A1/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3366975A (en) * | 1965-06-04 | 1968-02-06 | William J. Pangman | Compound prosthesis |
| US5376117A (en) * | 1991-10-25 | 1994-12-27 | Corvita Corporation | Breast prostheses |
| US20110009960A1 (en) * | 2001-11-16 | 2011-01-13 | Allergan, Inc. | Prosthetic fabric structure |
| WO2009016503A2 (en) * | 2007-08-01 | 2009-02-05 | Tecnologie Biomediche Srl | Development of improved smooth and textured mammary prostheses coated with highly biocompatible materials |
| WO2011160875A1 (en) * | 2010-06-25 | 2011-12-29 | Antonio Sambusseti | Orthotopic artificial bladder prosthesis |
Non-Patent Citations (1)
| Title |
|---|
| BOSETTI MICHELA ET AL: "Histochemical and morphometric observations on the new tissue formed around mammary expanders coated with pyrolytic carbon", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, WILEY, NEW YORK, NY, US, vol. 40, no. 2, 1 May 1998 (1998-05-01), pages 307 - 313, XP002510934, ISSN: 0021-9304, DOI: 10.1002/(SICI)1097-4636(199805)40:2<307::AID-JBM16>3.0.CO;2-I * |
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