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ITMI20130706A1 - Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi - Google Patents

Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi

Info

Publication number
ITMI20130706A1
ITMI20130706A1 IT000706A ITMI20130706A ITMI20130706A1 IT MI20130706 A1 ITMI20130706 A1 IT MI20130706A1 IT 000706 A IT000706 A IT 000706A IT MI20130706 A ITMI20130706 A IT MI20130706A IT MI20130706 A1 ITMI20130706 A1 IT MI20130706A1
Authority
IT
Italy
Prior art keywords
proteasis
viral
inhibitor
procedure
preparation
Prior art date
Application number
IT000706A
Other languages
English (en)
Inventor
Emanuele Attolino
Anna Iuliano
Varsha Ravindra Jumde
Maurizio Taddei
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Priority to IT000706A priority Critical patent/ITMI20130706A1/it
Priority to EP20140162529 priority patent/EP2801566A1/en
Priority to US14/257,106 priority patent/US20140323689A1/en
Publication of ITMI20130706A1 publication Critical patent/ITMI20130706A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT000706A 2013-04-30 2013-04-30 Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi ITMI20130706A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT000706A ITMI20130706A1 (it) 2013-04-30 2013-04-30 Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi
EP20140162529 EP2801566A1 (en) 2013-04-30 2014-03-31 Process for the preparation of a viral protease inhibitor and its intermediates
US14/257,106 US20140323689A1 (en) 2013-04-30 2014-04-21 Process for the preparation of a viral protease inhibitor and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000706A ITMI20130706A1 (it) 2013-04-30 2013-04-30 Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi

Publications (1)

Publication Number Publication Date
ITMI20130706A1 true ITMI20130706A1 (it) 2014-10-31

Family

ID=48628791

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000706A ITMI20130706A1 (it) 2013-04-30 2013-04-30 Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi

Country Status (3)

Country Link
US (1) US20140323689A1 (it)
EP (1) EP2801566A1 (it)
IT (1) ITMI20130706A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646329A (zh) * 2014-11-28 2016-06-08 重庆圣华曦药业股份有限公司 一种制备特拉匹韦中间体的方法
CN105111129A (zh) * 2015-08-24 2015-12-02 上海合全药业股份有限公司 (1S,3aR,6aS)-八氢环戊烯并[C]吡咯-1-羧酸叔丁酯草酸盐的制备方法
CN107674016B (zh) * 2016-12-21 2020-06-16 联化科技股份有限公司 特拉匹韦中间体的制备方法及其中间体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070087973A1 (en) * 2005-08-19 2007-04-19 Tanoury Gerald J Processes and intermediates
WO2009004584A1 (en) * 2007-07-03 2009-01-08 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.3.0]octane compounds
WO2010008828A2 (en) * 2008-06-24 2010-01-21 Codexis, Inc. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070087973A1 (en) * 2005-08-19 2007-04-19 Tanoury Gerald J Processes and intermediates
WO2009004584A1 (en) * 2007-07-03 2009-01-08 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.3.0]octane compounds
WO2010008828A2 (en) * 2008-06-24 2010-01-21 Codexis, Inc. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

Also Published As

Publication number Publication date
EP2801566A1 (en) 2014-11-12
US20140323689A1 (en) 2014-10-30

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