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ITMI931306A1 - MICROBIAL PROCEDURE FOR THE PREPARATION OF MEVINOLINA - Google Patents

MICROBIAL PROCEDURE FOR THE PREPARATION OF MEVINOLINA

Info

Publication number
ITMI931306A1
ITMI931306A1 IT001306A ITMI931306A ITMI931306A1 IT MI931306 A1 ITMI931306 A1 IT MI931306A1 IT 001306 A IT001306 A IT 001306A IT MI931306 A ITMI931306 A IT MI931306A IT MI931306 A1 ITMI931306 A1 IT MI931306A1
Authority
IT
Italy
Prior art keywords
mevinolina
preparation
microbial
procedure
microbial procedure
Prior art date
Application number
IT001306A
Other languages
Italian (it)
Inventor
Gabor Ambrus
Attilia Andor
Laszlo Cseke
Janos Erdei
Edit Halasz
Eva Ilkoy
Antonia Nata Bokany Jekkel
Mihaly Kaszas
Andras Kiss
Lajos Kiss
Istvan Magyi
Imre Moravcsik
Karoly Nagy
Kalman Polya
Gyorgy Santha
Istavan Mihaly Szabo
Istvan Szabo
Ilona Nata Bosinger Varga
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of ITMI931306A0 publication Critical patent/ITMI931306A0/en
Publication of ITMI931306A1 publication Critical patent/ITMI931306A1/en
Application granted granted Critical
Publication of IT1264629B1 publication Critical patent/IT1264629B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT93MI001306A 1992-06-17 1993-06-17 MICROBIAL PROCEDURE FOR THE PREPARATION OF MEVINOLINA IT1264629B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9202020A HU208997B (en) 1992-06-17 1992-06-17 Microbiological method for producing mevinoline

Publications (3)

Publication Number Publication Date
ITMI931306A0 ITMI931306A0 (en) 1993-06-17
ITMI931306A1 true ITMI931306A1 (en) 1994-12-17
IT1264629B1 IT1264629B1 (en) 1996-10-04

Family

ID=10982069

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001306A IT1264629B1 (en) 1992-06-17 1993-06-17 MICROBIAL PROCEDURE FOR THE PREPARATION OF MEVINOLINA

Country Status (9)

Country Link
US (1) US5403728A (en)
AT (1) AT399722B (en)
CA (1) CA2098698C (en)
DE (1) DE4320023A1 (en)
ES (1) ES2064282B1 (en)
GR (1) GR1002573B (en)
HU (1) HU208997B (en)
IT (1) IT1264629B1 (en)
JO (1) JO1764B1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US20060223150A1 (en) * 1993-09-08 2006-10-05 Vilmos Keri Process for the isolation and purification of mevinolin
SI9500238A (en) * 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
KR100234976B1 (en) * 1997-08-01 1999-12-15 김충환 Aspergillus genus showing resistance to cerulenin and l-methionine and analogue and a process for preparing mevinolinic acid therefrom
CA2289553C (en) * 1998-03-20 2004-05-18 Biogal Gyogyszergyar Rt. Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process
KR100342789B1 (en) * 1999-10-29 2002-07-04 김용규 Nystatin-Resistant Aspergillus sp. and Process for Preparing Triol Heptanoic Acid Employing the Same
KR20030013373A (en) 2000-02-24 2003-02-14 비오갈 기오기스제르갸르 알티. Method of purifying a fermentation broth
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
EP1176208A1 (en) * 2000-07-28 2002-01-30 Société des Produits Nestlé S.A. Koji molds and use thereof for preparing cholesterol-lowering products
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
US20070020554A1 (en) * 2005-07-25 2007-01-25 Xerox Corporation Toner process
TWI415619B (en) * 2011-08-02 2013-11-21 Sunway Biotech Co Ltd Composition for lowering blood lipid and elevating high-density lipoprotein and a method for manufacturing the same
CN112481139B (en) * 2020-12-22 2022-08-05 华东理工大学 Culture medium for producing emodin by using marine fungus aspergillus flavus HN4-13 and preparation method thereof
CN115232096B (en) * 2022-06-15 2023-05-05 福建卫生职业技术学院 Lactone compound from aspergillus flavus, preparation method thereof and application thereof in anti-human liver cancer drugs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
DE3682557D1 (en) * 1985-09-13 1992-01-02 Sankyo Co HYDROXY-ML-236B DERIVATIVES, THEIR PRODUCTION AND USE.
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
CA2009043A1 (en) * 1989-02-01 1990-08-01 Michael J. Ferris Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

Also Published As

Publication number Publication date
GR930100259A (en) 1994-02-28
AT399722B (en) 1995-07-25
CA2098698C (en) 1998-05-19
DE4320023A1 (en) 1993-12-23
HU9202020D0 (en) 1992-10-28
HU208997B (en) 1994-02-28
ES2064282A1 (en) 1995-01-16
US5403728A (en) 1995-04-04
JO1764B1 (en) 1994-05-15
GR1002573B (en) 1997-02-06
ATA118993A (en) 1994-11-15
IT1264629B1 (en) 1996-10-04
ITMI931306A0 (en) 1993-06-17
CA2098698A1 (en) 1993-12-18
ES2064282B1 (en) 1995-08-01

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970627