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IT8247881A0 - Antinfiammatoria amidi pirrolacetiche ad attivita' - Google Patents

Antinfiammatoria amidi pirrolacetiche ad attivita'

Info

Publication number
IT8247881A0
IT8247881A0 IT8247881A IT4788182A IT8247881A0 IT 8247881 A0 IT8247881 A0 IT 8247881A0 IT 8247881 A IT8247881 A IT 8247881A IT 4788182 A IT4788182 A IT 4788182A IT 8247881 A0 IT8247881 A0 IT 8247881A0
Authority
IT
Italy
Prior art keywords
pyrrolacetic
starches
inflammatory
activity
pyrrolacetic starches
Prior art date
Application number
IT8247881A
Other languages
English (en)
Other versions
IT1210673B (it
Inventor
Baglioni Claudio
Original Assignee
Medosan Ind Biochimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medosan Ind Biochimi filed Critical Medosan Ind Biochimi
Publication of IT8247881A0 publication Critical patent/IT8247881A0/it
Priority to IT8247881A priority Critical patent/IT1210673B/it
Priority to IE310/83A priority patent/IE54896B1/en
Priority to IL8367929A priority patent/IL67929A/xx
Priority to DK070083A priority patent/DK155792C/da
Priority to CA000421878A priority patent/CA1207769A/en
Priority to FI830556A priority patent/FI77227C/fi
Priority to ZA831110A priority patent/ZA831110B/xx
Priority to DE19833306006 priority patent/DE3306006A1/de
Priority to SE8301008A priority patent/SE453388B/sv
Priority to GB08304996A priority patent/GB2115417B/en
Priority to GR70582A priority patent/GR77920B/el
Priority to LU84660A priority patent/LU84660A1/fr
Priority to BE0/210207A priority patent/BE896018A/fr
Priority to NL8300693A priority patent/NL193217C/nl
Priority to AT0067383A priority patent/AT376204B/de
Priority to ES520112A priority patent/ES8403453A1/es
Priority to CH1062/83A priority patent/CH658650A5/it
Priority to JP58031721A priority patent/JPS58159458A/ja
Priority to MX83196365A priority patent/MX161088A/es
Priority to KR1019830000794A priority patent/KR890004127B1/ko
Priority to FR8303275A priority patent/FR2522324B1/fr
Priority to US06/700,059 priority patent/US4882349A/en
Priority to US06/728,758 priority patent/US4578481A/en
Application granted granted Critical
Publication of IT1210673B publication Critical patent/IT1210673B/it
Priority to JP3033082A priority patent/JPH0662562B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8247881A 1982-02-26 1982-02-26 Antinfiammatoria amidi pirrolacetiche ad attivita' IT1210673B (it)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IT8247881A IT1210673B (it) 1982-02-26 1982-02-26 Antinfiammatoria amidi pirrolacetiche ad attivita'
IE310/83A IE54896B1 (en) 1982-02-26 1983-02-15 Pyrrolacetic amides having antiinflammatory activity
IL8367929A IL67929A (en) 1982-02-26 1983-02-16 1-methyl-5-p-toluoylpyrrole-2-acetic acid amides,their preparation and pharmaceutical compositions comprising them
DK070083A DK155792C (da) 1982-02-26 1983-02-17 Analogifremgangsmaade til fremstilling af pyrrol-eddikesyreamider eller salte deraf
CA000421878A CA1207769A (en) 1982-02-26 1983-02-17 Pyrrolacetic amides having antiinflammatory activity
FI830556A FI77227C (fi) 1982-02-26 1983-02-18 Foerfarande foer framstaellning farmakologiskt aktiva 1-metyl-5-p-toluoylpyrrol-2-aettiksyra amider.
ZA831110A ZA831110B (en) 1982-02-26 1983-02-18 Pyrrolacetic amides having antiinflammatory activity
DE19833306006 DE3306006A1 (de) 1982-02-26 1983-02-22 Pyrrolessigsaeureamide mit antiinflammatorischer aktivitaet, verfahren zu deren herstellung und arzneimittel, die dieselben enthalten
SE8301008A SE453388B (sv) 1982-02-26 1983-02-23 Pyrrolacetamider och en farmaceutisk komposition med antiinflammatorisk, smertstillande, febernedsettande och antisekretorisk verkan
GB08304996A GB2115417B (en) 1982-02-26 1983-02-23 Pyrrolacetic amides having antiinflammatory activity
GR70582A GR77920B (it) 1982-02-26 1983-02-23
BE0/210207A BE896018A (fr) 1982-02-26 1983-02-24 Amides pyrrolacetiques, leur preparation et leur utilisation
LU84660A LU84660A1 (fr) 1982-02-26 1983-02-24 Nouvelle classe d'amides de l'acide 1-methyl-5-p-toluoylpyrrole,2-acetique
NL8300693A NL193217C (nl) 1982-02-26 1983-02-24 1-Methyl-5-p-toluoyl-2-pyrroolaceetamiderivaat met ontstekingsremmende en analgetische eigenschappen en farmaceutisch preparaat dat het bevat.
MX83196365A MX161088A (es) 1982-02-26 1983-02-25 Procedimiento para preparar derivados de 1-metil-5-p-tolilpirrol-2-acetamida
ES520112A ES8403453A1 (es) 1982-02-26 1983-02-25 Un procedimiento para preparar amidas del acido 1-metil-5-p-toluoilpirrol-2-acetico.
CH1062/83A CH658650A5 (it) 1982-02-26 1983-02-25 Ammidi pirrolacetiche aventi attivita antiinfiammatoria.
JP58031721A JPS58159458A (ja) 1982-02-26 1983-02-25 ピロール酢酸アミドを有効成分とする医薬
AT0067383A AT376204B (de) 1982-02-26 1983-02-25 Verfahren zur herstellung von neuen amiden der 1-methyl-5-p-toluoylpyrrol-2-essigsaeure
KR1019830000794A KR890004127B1 (ko) 1982-02-26 1983-02-26 항염 작용을 갖는 피롤아세트 아미드의 제조방법
FR8303275A FR2522324B1 (fr) 1982-02-26 1983-02-28 Pyrrole-acetamides, leur procede de preparation et composition therapeutique les contenant
US06/700,059 US4882349A (en) 1982-02-26 1985-02-11 Pyrrolacetic amides having antiinflammatory activity
US06/728,758 US4578481A (en) 1982-02-26 1985-04-30 Pyrrolacetic amides having antiinflammatory activity
JP3033082A JPH0662562B2 (ja) 1982-02-26 1991-02-27 ピロール酢酸アミド

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8247881A IT1210673B (it) 1982-02-26 1982-02-26 Antinfiammatoria amidi pirrolacetiche ad attivita'

Publications (2)

Publication Number Publication Date
IT8247881A0 true IT8247881A0 (it) 1982-02-26
IT1210673B IT1210673B (it) 1989-09-20

Family

ID=11263094

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8247881A IT1210673B (it) 1982-02-26 1982-02-26 Antinfiammatoria amidi pirrolacetiche ad attivita'

Country Status (22)

Country Link
US (2) US4882349A (it)
JP (2) JPS58159458A (it)
KR (1) KR890004127B1 (it)
AT (1) AT376204B (it)
BE (1) BE896018A (it)
CA (1) CA1207769A (it)
CH (1) CH658650A5 (it)
DE (1) DE3306006A1 (it)
DK (1) DK155792C (it)
ES (1) ES8403453A1 (it)
FI (1) FI77227C (it)
FR (1) FR2522324B1 (it)
GB (1) GB2115417B (it)
GR (1) GR77920B (it)
IE (1) IE54896B1 (it)
IL (1) IL67929A (it)
IT (1) IT1210673B (it)
LU (1) LU84660A1 (it)
MX (1) MX161088A (it)
NL (1) NL193217C (it)
SE (1) SE453388B (it)
ZA (1) ZA831110B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
US4585784A (en) * 1983-01-26 1986-04-29 Mcneilab, Inc. Pyrrole-2-acetylamino acid derivative compounds
YU251283A (en) * 1983-01-26 1986-04-30 Mcneilab Inc Process for obtaining pyrrol-2-acetylamino acid derivatives
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi
US6180658B1 (en) 1995-07-14 2001-01-30 Medosan Ricerca S.R.L. Method for counteracting blood platelet aggregation in a patient in need thereof
IT1278144B1 (it) * 1995-07-14 1997-11-17 Medosan Ricerca Srl Impiego dell'amtolmetineguacil (med 15) come farmaco antisecretivo sulla secrezione gastrica e quindi gastroprotettivo.
US5889041A (en) * 1995-07-14 1999-03-30 Medosan Ricerca S.R.L. Method for treating an inflammatory pathological condition
WO1999007363A1 (en) * 1997-08-08 1999-02-18 Medosan, Ricerca S.R.L. Use of the compound 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate for the production of an anti-inflammatory drug with prevention of gastric hypersecretion and renal impairment
IT1297140B1 (it) 1997-12-24 1999-08-03 Sigma Tau Ind Farmaceuti Forma cristallina del guaiacil estere dell'acido l-metil-5-p-toluoil- pirrol-2-acetammidoacetico, procedimento per la sua preparazione e
IT1302898B1 (it) 1998-12-03 2000-10-10 Medosan Ricerca Srl Uso di amtolmetine guacil per la produzione di farmaci ad effettoantiinfiammatorio nelle infiammazioni intestinali.
ATE460146T1 (de) 2000-09-15 2010-03-15 Bruder Healthcare Co Wund- und behandlungskompresse und verband
US10105259B2 (en) 2000-09-15 2018-10-23 Bruder Healthcare Company, Llc Wound and therapy compress and dressing
US9925087B2 (en) 2000-09-15 2018-03-27 Bruder Healthcare Company, Llc Wound and therapy compress and dressing
CN100390144C (zh) * 2006-03-29 2008-05-28 安徽省庆云医药化工有限公司 1-甲基-5-对甲苯酰吡咯-2-乙酰氨基乙酸愈创木酚酯的制备方法
WO2014143139A1 (en) 2013-03-15 2014-09-18 Bruder Healthcare Company Wound and therapy compress and dressing
US12029681B2 (en) 2016-03-01 2024-07-09 The Hilsinger Company Parent, Llc Therapeutic eye mask system
US12011388B2 (en) 2016-03-01 2024-06-18 The Hilsinger Company Parent, Llc Therapeutic thermal compress with phase-change material
USD844795S1 (en) 2016-11-30 2019-04-02 Bruder Healthcare Company, Llc Therapeutic eye mask
USD871598S1 (en) 2016-11-30 2019-12-31 Bruder Healthcare Company, Llc Therapeutic eye mask

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1195628A (en) * 1967-07-26 1970-06-17 Mcneilab Inc Aroyl-Substituted Pyrroles
US3952012A (en) * 1970-01-26 1976-04-20 Mcneil Laboratories, Incorporated Aroyl-substituted pyrroles
US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US3950012A (en) * 1975-03-17 1976-04-13 Donovan Robert G Retainer for multi-leafed devices
US4200645A (en) * 1977-05-10 1980-04-29 Beecham Group Limited Pyrrole derivatives
JPS5524141A (en) * 1978-08-11 1980-02-21 Sagami Chem Res Center 1-alkyl-5-(p-toluoyl)-pyrrolyl-2thioacetamide derivative
US4396626A (en) * 1980-10-09 1983-08-02 Beecham Group Limited Cyclic compounds and their use
ES8200092A1 (es) * 1980-11-11 1981-10-16 Calzada & Co Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico
JPS57144256A (en) * 1981-03-03 1982-09-06 Sagami Chem Res Center Preparation of (1-alkyl-5-toluoyl-2-pyrrolyl)acetamide derivative
IT1137229B (it) * 1981-05-26 1986-09-03 Poli Ind Chimica Spa Composto solubile ad attivita' analgesica
US4434175A (en) * 1981-08-10 1984-02-28 Merck & Co., Inc. Nonsteroidal compounds as anti-inflammatory and analgesic agents
IT1210673B (it) * 1982-02-26 1989-09-20 Medosan Ind Biochimi Antinfiammatoria amidi pirrolacetiche ad attivita'
IT1148117B (it) * 1982-03-05 1986-11-26 Medosan Ind Biochimi Attivita'antiflogistica,analgesica,antipiretica,mucolitica e seda tiva della tosse dell'1 metil-5-p-tolilpirrol-2-acetato di 2'metossi-fenile
YU251283A (en) * 1983-01-26 1986-04-30 Mcneilab Inc Process for obtaining pyrrol-2-acetylamino acid derivatives
IT1174773B (it) * 1983-07-29 1987-07-01 Medosan Ind Biochimi Attivita' antiaggregante piastrinica e broncolitica della 7-(1-metil-5-p-metilbenzoilpirrol-2-acetamidoetil)teofillina
IT1197688B (it) * 1983-07-29 1988-12-06 Medosan Ind Biochimi Attivita' antiflogistica,analgesica,antipiretica ed antiaggregante piastrinica di 1-metil-5-metilbenzoilpirrol-2-acetamido acetanilidi

Also Published As

Publication number Publication date
IE830310L (en) 1983-08-26
DK155792C (da) 1989-10-09
ES520112A0 (es) 1984-04-01
DE3306006C2 (it) 1992-02-06
SE8301008D0 (sv) 1983-02-23
IT1210673B (it) 1989-09-20
US4882349A (en) 1989-11-21
SE453388B (sv) 1988-02-01
FI830556L (fi) 1983-08-27
FR2522324B1 (fr) 1985-07-19
MX161088A (es) 1990-07-25
JPH0662562B2 (ja) 1994-08-17
IE54896B1 (en) 1990-03-14
DK70083A (da) 1983-08-27
JPH04210963A (ja) 1992-08-03
NL8300693A (nl) 1983-09-16
CA1207769A (en) 1986-07-15
ES8403453A1 (es) 1984-04-01
GB2115417A (en) 1983-09-07
JPS58159458A (ja) 1983-09-21
KR890004127B1 (ko) 1989-10-21
DK155792B (da) 1989-05-16
US4578481A (en) 1986-03-25
LU84660A1 (fr) 1983-09-08
BE896018A (fr) 1983-06-16
IL67929A0 (en) 1983-06-15
FI77227C (fi) 1989-02-10
CH658650A5 (it) 1986-11-28
NL193217C (nl) 1999-03-03
JPH0350728B2 (it) 1991-08-02
GB2115417B (en) 1985-07-31
AT376204B (de) 1984-10-25
FI77227B (fi) 1988-10-31
ZA831110B (en) 1984-03-28
GB8304996D0 (en) 1983-03-30
ATA67383A (de) 1984-03-15
FI830556A0 (fi) 1983-02-18
NL193217B (nl) 1998-11-02
DE3306006A1 (de) 1983-09-08
SE8301008L (sv) 1983-08-27
DK70083D0 (da) 1983-02-17
IL67929A (en) 1986-10-31
KR840003614A (ko) 1984-09-15
GR77920B (it) 1984-09-25
FR2522324A1 (fr) 1983-09-02

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 477

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 477, 19931006; MEDOSAN INDUSTRIE BIOCHIMICHE RIUNI TE S.R.L.

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970129