IT201900006884A1 - TOPICAL PRODUCT PREFERABLY OF NATURAL DERIVATION - Google Patents
TOPICAL PRODUCT PREFERABLY OF NATURAL DERIVATION Download PDFInfo
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- IT201900006884A1 IT201900006884A1 IT102019000006884A IT201900006884A IT201900006884A1 IT 201900006884 A1 IT201900006884 A1 IT 201900006884A1 IT 102019000006884 A IT102019000006884 A IT 102019000006884A IT 201900006884 A IT201900006884 A IT 201900006884A IT 201900006884 A1 IT201900006884 A1 IT 201900006884A1
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- polyalcohols
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- 229940025703 topical product Drugs 0.000 title claims description 47
- 238000009795 derivation Methods 0.000 title description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 10
- 229920001273 Polyhydroxy acid Polymers 0.000 claims description 9
- 150000002009 diols Chemical class 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 239000002738 chelating agent Substances 0.000 claims description 7
- 150000004072 triols Chemical class 0.000 claims description 7
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 3
- 125000000422 delta-lactone group Chemical group 0.000 claims description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- 230000003113 alkalizing effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 125000000686 lactone group Chemical group 0.000 claims 3
- 230000000699 topical effect Effects 0.000 description 12
- 239000002537 cosmetic Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000012209 glucono delta-lactone Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002596 lactones Chemical group 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 229940083982 sodium phytate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000000182 glucono-delta-lactone Substances 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- LBUSGXDHOHEPQQ-UHFFFAOYSA-N propane-1,1,1-triol Chemical compound CCC(O)(O)O LBUSGXDHOHEPQQ-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
DESCRIZIONE DESCRIPTION
PRODOTTO TOPICO PREFERIBILMENTE DI DERIVAZIONE NATURALE TOPICAL PRODUCT PREFERABLY OF NATURAL DERIVATION
La presente invenzione ha per oggetto un prodotto topico preferibilmente di derivazione naturale del tipo precisato nel preambolo della prima rivendicazione. Come noto un prodotto topico, ad esempio un cosmetico, un medicamento o un qualsiasi altro prodotto destinato a essere applicato su pelle o mucosa, presenta una complessa matrice formulativa ad alto contenuto di principi attivi (medici e/o cosmetici). The present invention relates to a topical product preferably of natural derivation of the type specified in the preamble of the first claim. As known, a topical product, for example a cosmetic, a medicament or any other product intended to be applied to the skin or mucosa, has a complex formulation matrix with a high content of active ingredients (medical and / or cosmetic).
In particolare, i prodotti topici presentano una formulazione specifica per ogni specifica applicazione. Pertanto è a oggi in commercio un’elevata varietà di prodotti topici ciascuno dei quali aventi spiccate dote rivolte a uno specifico problema. La tecnica nota descritta comprende alcuni importanti inconvenienti. In particular, topical products have a specific formulation for each specific application. Therefore, a high variety of topical products are currently on the market, each of which has a strong talent aimed at a specific problem. The known art described includes some important drawbacks.
Infatti, i prodotti topici a oggi in commercio sono inabili a lavorare in maniera ottimale su più problemi costringendo l’utilizzatore ad acquistare e quindi usare contemporaneamente più prodotti topici con notevole incremento di costi, praticità e complessità d’uso. In fact, the topical products currently on the market are unable to work optimally on multiple problems, forcing the user to purchase and then use multiple topical products at the same time with a significant increase in costs, convenience and complexity of use.
Un altro inconveniente è rappresentato dal fatto che, nonostante quanto sopra esposto, i prodotti topici a oggi noti non presentano un’efficacia particolarmente elevata e una rapida decadenza dei loro effetti. Another drawback is represented by the fact that, despite the above, the topical products known to date do not have a particularly high efficacy and a rapid decline of their effects.
Tale inconveniente risulta evidente sia nei prodotti topici cosmetici dove si ha la necessità di una loro ripetuta applicazione sia nei prodotti topici medici dove è frequentemente richiesta l’applicazione d’ingenti quantitativi di prodotto. This drawback is evident both in topical cosmetic products where there is a need for their repeated application and in topical medical products where the application of large quantities of product is frequently required.
Si evidenzia infine come i suddetti inconvenienti, imponendo un alto utilizzo di prodotti topici, possono portare all’insorgere di effetti collaterali come sensibilizzazioni e allergie. Finally, it should be noted that the aforementioned drawbacks, imposing a high use of topical products, can lead to the onset of side effects such as sensitization and allergies.
In questa situazione il compito tecnico alla base della presente invenzione è ideare un prodotto topico in grado di ovviare sostanzialmente ad almeno parte degli inconvenienti citati. In this situation, the technical task underlying the present invention is to devise a topical product capable of substantially obviating at least part of the aforementioned drawbacks.
Nell'ambito di detto compito tecnico è un importante scopo dell'invenzione ottenere un prodotto topico totalmente di derivazione naturale e caratterizzato da un pratico utilizzo e ad alta compliance per il consumatore. Within the scope of said technical task, it is an important object of the invention to obtain a topical product totally of natural origin and characterized by a practical use and with high compliance for the consumer.
Un altro scopo dell'invenzione è realizzare un prodotto topico privo degli effetti collaterali che normalmente affliggono i prodotti topici a oggi in commercio come sensibilizzazioni e allergie. Another object of the invention is to produce a topical product devoid of the side effects that normally afflict topical products currently on the market such as sensitizations and allergies.
Il compito tecnico e gli scopi specificati sono raggiunti da un prodotto topico come rivendicato nell’annessa rivendicazione 1. Esempi di realizzazione preferita sono descritti nelle rivendicazioni dipendenti. The technical task and the specified purposes are achieved by a topical product as claimed in the attached claim 1. Examples of preferred embodiment are described in the dependent claims.
Nel presente documento, le misure, i valori, le forme e i riferimenti geometrici (come perpendicolarità e parallelismo), quando associati a parole come "circa" o altri simili termini quali "pressoché" o "sostanzialmente", sono da intendersi come a meno di errori di misura o imprecisioni dovute a errori di produzione e/o fabbricazione e, soprattutto, a meno di una lieve divergenza dal valore, dalla misura, dalla forma o riferimento geometrico cui è associato. Ad esempio, tali termini, se associati a un valore, indicano preferibilmente una divergenza non superiore al 10% del valore stesso. In this document, measurements, values, shapes and geometric references (such as perpendicularity and parallelism), when associated with words such as "about" or other similar terms such as "almost" or "substantially", are to be understood as less than measurement errors or inaccuracies due to production and / or manufacturing errors and, above all, unless there is a slight divergence from the value, measurement, shape or geometric reference to which it is associated. For example, these terms, if associated with a value, preferably indicate a divergence of no more than 10% of the value itself.
Le misurazioni e i dati riportati nel presente testo sono da considerarsi, salvo diversamente indicato, come effettuati in Atmosfera Standard Internazionale ICAO (ISO 2533). The measurements and data reported in this text are to be considered, unless otherwise indicated, as carried out in the ICAO International Standard Atmosphere (ISO 2533).
Il prodotto topico secondo l'invenzione è identificabile in un qualsiasi prodotto da applicare, preferibilmente per scopi medici e\o estetici, su superfici esterne di un paziente, preferibilmente umano, (epidermide, sistema pilifero e capelli, unghie, labbra, organi genitali esterni) e in alcuni casi sui denti e sulle mucose della bocca. Esso può essere identificato in un prodotto topico a uso cosmetico abile a migliorare la piacevolezza e/o modificare l’aspetto, l'apparenza e l'estetica. Esso può trovare applicazione in diversi ambiti come la cosmetica per la cura del corpo, viso e/o capelli, la cosmesi decorativa o il trucco, la detergenza e l’igiene personale. The topical product according to the invention can be identified in any product to be applied, preferably for medical and / or aesthetic purposes, on external surfaces of a patient, preferably human, (epidermis, hair system and hair, nails, lips, external genital organs ) and in some cases on the teeth and mucous membranes of the mouth. It can be identified in a topical cosmetic product capable of improving the pleasantness and / or modifying the appearance, appearance and aesthetics. It can be used in various areas such as cosmetics for body, face and / or hair care, decorative cosmetics or make-up, cleansing and personal hygiene.
In alcuni casi il prodotto topico può essere identificato in un prodotto topico a uso medico ossia un fitoterapico o una sostanza farmacologicamente attiva per via locale così che l’azione farmacologica si esplichi direttamente sulla cute o la mucosa dove è applicata. In some cases, the topical product can be identified in a topical product for medical use, that is, a phytotherapic or a locally pharmacologically active substance so that the pharmacological action takes place directly on the skin or mucosa where it is applied.
Il prodotto topico secondo l'invenzione può essere sotto forma di crema, emulsione, pomata, liquido o gel. The topical product according to the invention can be in the form of a cream, emulsion, ointment, liquid or gel.
Il prodotto topico comprende un preparato attivo definente almeno un principio attivo del prodotto topico; un composto funzionale riducente il valore di acqua libera del prodotto topico, ossia l'acqua contenuta nel prodotto topico contenuta in forma biodisponibile. The topical product comprises an active preparation defining at least one active principle of the topical product; a functional compound that reduces the free water value of the topical product, i.e. the water contained in the topical product contained in a bioavailable form.
Il composto definisce un valore di acqua libera del prodotto topico pressoché inferiore a 0,95 in particolare a 0,9 e più in particolare a 0,85. Opportunamente il valore di acqua libera del prodotto topico è sostanzialmente compreso tra 0,85 e 0,79. The compound defines a free water value of the topical product practically lower than 0.95 in particular at 0.9 and more particularly at 0.85. Conveniently, the free water value of the topical product is substantially between 0.85 and 0.79.
Si precisa che il valore di acqua libera è definito come attività dell'acqua (water activity) notoriamente indicata con il simbolo Aw. Esso è determinabile come rapporto tra pressione di vapore dell'acqua nel prodotto topico e pressione di vapore dell'acqua pura a una medesima temperatura. It should be noted that the free water value is defined as water activity, known as the symbol Aw. It can be determined as the ratio between the vapor pressure of the water in the topical product and the vapor pressure of pure water at the same temperature.
Il composto funzionale può comprendere esclusivamente componenti di derivazione naturale. The functional compound may only comprise naturally derived components.
Esso comprende polialcoli. It includes sugar alcohols.
Il contenuto di polialcoli è sostanzialmente compreso tra il 20% e il 35 % e in dettaglio tra il 25% e il 30%. The sugar alcohol content is substantially between 20% and 35% and in detail between 25% and 30%.
Il contenuto dei polialcoli, così come quello degli altri componenti, è presentato sotto forma di percentuale in funzione del rapporto tra il peso del componente e il peso dell’intero prodotto topico. The content of the sugar alcohols, as well as that of the other components, is presented in the form of a percentage depending on the ratio between the weight of the component and the weight of the entire topical product.
I polialcoli sono preferibilmente di derivazione naturale. The sugar alcohols are preferably naturally derived.
I polialcoli possono comprendere polialcoli in forma di dioli (preferibilmente propandiolo e più preferibilmente 1,3-propandiolo) opportunamente derivanti da fermentazione di zucchero di mais. The polyalcohols can comprise polyalcohols in the form of diols (preferably propanediol and more preferably 1,3-propanediol) suitably deriving from the fermentation of corn sugar.
Il contenuto di polialcoli in forma di dioli è sostanzialmente compreso tra il 5% e il 20% e in dettaglio tra il 10% e il 15%. The content of polyalcohols in the form of diols is substantially between 5% and 20% and in detail between 10% and 15%.
I polialcoli possono comprendere polialcoli in forma di trioli (preferibilmente propantriolo e più preferibilmente 1,2,3-propantriolo, noto come glicerolo o glicerina) opportunamente derivanti da trigliceridi vegetali quali ad esempio olio esausto. Il contenuto di polialcoli in forma di trioli è sostanzialmente compreso tra il 5% e il 25% e in dettaglio tra il 10% e il 20%. The polyalcohols can comprise polyalcohols in the form of triols (preferably propantriol and more preferably 1,2,3-propantriol, known as glycerol or glycerin) suitably deriving from vegetable triglycerides such as for example exhausted oil. The content of polyalcohols in the form of triols is substantially between 5% and 25% and in detail between 10% and 20%.
Il composto funzionale comprende un polidrossiacido (preferibilmente in forma lattonica e più preferibilmente glucone delta lattone (noto anche come GDL, gluconolattone o E575) opportunamente derivante da fermentazione di saccaromiceti. The functional compound comprises a polyhydroxyacid (preferably in the lactone form and more preferably glucone delta lactone (also known as GDL, gluconolactone or E575) suitably deriving from the fermentation of saccharomycetes.
Il contenuto di polidrossiacido è sostanzialmente compreso tra il 2% e il 20% e in dettaglio tra il 5% e il 15%. Esso è preferibilmente pari al 10%. The polyhydroxy acid content is substantially between 2% and 20% and in detail between 5% and 15%. It is preferably equal to 10%.
Il polidrossiacido è preferibilmente di derivazione naturale. The polyhydroxy acid is preferably naturally derived.
In alcuni casi il composto funzionale può comprendere un chelante. In some cases the functional compound may comprise a chelator.
Il chelante può comprendere acido fitico. In alternativa esso comprende fitato di sodio e in particolare una composizione di fitato di sodio, acqua e Alcohol come ad esempio quella commercialmente nota come Dermofeel<® >PA-3. The chelator may comprise phytic acid. Alternatively it comprises sodium phytate and in particular a composition of sodium phytate, water and Alcohol such as for example that commercially known as Dermofeel <®> PA-3.
Il contenuto di chelante è pressoché inferiore all’1% e in particolare sostanzialmente compresa tra lo 0,5% e lo 0,1%. Esso è sostanzialmente pari a 0,2%. The chelator content is almost less than 1% and in particular substantially between 0.5% and 0.1%. It is substantially equal to 0.2%.
Riassumendo il composto funzionale comprende, preferibilmente in esclusiva, polialcoli in forma di dioli e di trioli, polidrossiacido e opportunamente un chelante. In alcuni casi il prodotto topico può comprendere un pH-regolatore. In summary, the functional compound comprises, preferably exclusively, polyalcohols in the form of diols and triols, polyhydroxyacid and suitably a chelator. In some cases the topical product may include a pH-regulator.
Il pH-regolatore definisce per il prodotto topico un pH sostanzialmente compreso tra 4 e 7 in dettaglio sostanzialmente tra 5 e 6 e più in dettaglio sostanzialmente pari a 5,5. The pH-regulator defines for the topical product a pH substantially comprised between 4 and 7 in detail substantially between 5 and 6 and more in detail substantially equal to 5.5.
Il pH-regolatore identifica un alcalinizzante, opportunamente NaOH, atto a contrapporsi all’azione acidificante del composto funzionale e in particolare del polidrossiacido e più in particolare del glucone delta lattone. The pH-regulator identifies an alkalizing agent, suitably NaOH, capable of counteracting the acidifying action of the functional compound and in particular of the polyhydroxyacid and more particularly of the glucone delta lactone.
Il contenuto del pH-regolatore è sostanzialmente inferiore al 5% in particolare al 3% e più in particolare pressoché compreso tra lo 0,1% e il 2%. The content of the pH-regulator is substantially lower than 5%, in particular 3% and more particularly almost comprised between 0.1% and 2%.
Il preparato attivo definisce almeno un principio attivo del prodotto topico; The active preparation defines at least one active principle of the topical product;
In particolare, nel caso di prodotto topico a uso cosmetico l’almeno un principio attivo abile a migliorare la piacevolezza e/o modificare l’aspetto, l'apparenza e l'estetica. Il preparato attivo può quindi comprendere uno o più ingredienti (anche di tipo noto) utilizzabili, ad esempio, per la cura di corpo, viso o capelli, la cosmesi decorativa, il trucco, la detergenza e\o l’igiene personale. In particular, in the case of a topical product for cosmetic use, at least one active ingredient capable of improving the pleasantness and / or modifying the appearance, appearance and aesthetics. The active preparation can therefore comprise one or more ingredients (including known types) that can be used, for example, for body, face or hair care, decorative cosmetics, make-up, cleansing and / or personal hygiene.
Nel caso di prodotto topico a uso medico l’almeno un principio definisce un’azione farmacologica. Il preparato attivo può così comprendere uno o più ingredienti (anche di tipo noto) capaci di provocare modificazioni funzionali mediante un'azione chimica o fisica allo scopo di ripristinare, correggere, modificare funzioni fisiologiche, esercitando un'azione farmacologica, immunologica o metabolica. Il preparato attivo è preferibilmente di derivazione naturale. In the case of a topical product for medical use, at least one principle defines a pharmacological action. The active preparation can thus comprise one or more ingredients (also of a known type) capable of causing functional modifications by means of a chemical or physical action in order to restore, correct, modify physiological functions, exerting a pharmacological, immunological or metabolic action. The active preparation is preferably naturally derived.
Il contenuto del preparato attivo è sostanzialmente complementare a quello del composto funzionale e se presente del pH regolatore. The content of the active preparation is substantially complementary to that of the functional compound and, if present, of the pH regulator.
Il prodotto topico secondo l’invenzione consegue importanti vantaggi. The topical product according to the invention achieves important advantages.
Un primo fondamentale vantaggio è rappresentato dal fatto che il prodotto topico prevede preferibilmente l’uso di componenti totalmente di derivazione naturale. Tale aspetto è stato innovativamente ottenuto grazie all’uso di un composto funzionale con un limitato apporto e in alcuni casi in totale assenza di componenti chimici. A first fundamental advantage is represented by the fact that the topical product preferably involves the use of totally naturally derived components. This aspect was innovatively obtained thanks to the use of a functional compound with a limited contribution and in some cases in the total absence of chemical components.
Un fondamentale vantaggio è dato dal fatto che il prodotto topico secondo l’invenzione presenta, rispetto ai noti prodotti topici, una maggiore efficacia e durata degli effetti a parità di preparato attivo. A fundamental advantage is given by the fact that the topical product according to the invention has, compared to the known topical products, greater efficacy and duration of effects for the same active preparation.
Tale vantaggio è stato raggiunto, in maniera particolarmente evidente, grazie all’introduzione del descritto composto funzionale che conferisce una straordinaria e inattesa assorbibilità al prodotto topico che risulta così capace di un’azione estremamente più rapida, profonda e intensa rispetto ai prodotti topici attualmente in commercio. This advantage has been achieved, in a particularly evident way, thanks to the introduction of the described functional compound which confers an extraordinary and unexpected absorbability to the topical product which is thus capable of an extremely faster, deeper and more intense action than the topical products currently in business.
Infatti, l’uso del composto funzionale e quindi il particolarmente ridotto contento di acqua libera Aw, ha conferito all’innovativo prodotto topico una straordinaria capacità di aumentare l’idratazione nella zona di applicazione del prodotto topico che determina un vantaggioso microclima\condizione climatica caratterizzato da un tasso di umidità elevato, che crea una situazione locale favorevole all’assorbimento del prodotto topico. In fact, the use of the functional compound and therefore the particularly reduced content of free water Aw, has given the innovative topical product an extraordinary ability to increase hydration in the area of application of the topical product which determines an advantageous microclimate \ climatic condition characterized by a high humidity rate, which creates a local situation favorable to the absorption of the topical product.
Tale abbassamento dei valori di acqua libera Aw è reso possibile dalla scoperta di sinergie dei componenti del composto funzionale che permettono di abbassare notevolmente il valore di acqua libera pur con una limitata integrazione di detti componenti. Infatti, studi apportati dall’inventore hanno evidenziato come i suddetti valori di acqua libera siano raggiungibili con elevate concentrazioni dei componenti del composto funzionale se usati singolarmente (in dettaglio valori di acqua libera inferiori a 0,9 sono ottenibili con un contenuto del 50% di polialcoli in forma di trioli, o del 30% di polialcoli in forma di dioli, mentre i poliidrossiacidi in forma lattonica sono praticamente privi di effetti se usati da soli). This lowering of the values of free water Aw is made possible by the discovery of synergies of the components of the functional compound which allow to considerably lower the value of free water even with a limited integration of said components. In fact, studies carried out by the inventor have shown how the aforementioned free water values can be reached with high concentrations of the components of the functional compound if used individually (in detail free water values lower than 0.9 are obtainable with a content of 50% of polyalcohols in the form of triols, or 30% of polyalcohols in the form of diols, while the polyhydroxyacids in the lactone form are practically ineffective when used alone).
Si sottolinea come gli effetti sinergici sopra descritti siano potenziati dalla presenza del chelante che presenta a sua volta effetti sinergici con gli altri componenti del composto funzionale. Esso infatti sottrae ioni (in particolare cationi quali il calcio) dall’acqua contenuta nel prodotto topico. It is emphasized that the synergistic effects described above are enhanced by the presence of the chelator which in turn has synergistic effects with the other components of the functional compound. In fact, it subtracts ions (in particular cations such as calcium) from the water contained in the topical product.
Si sottolinea come l’aver massimizzato gli effetti del composto funzionale ha inoltre permesso di minimizzare il contenuto dello stesso composto funzionale e conseguentemente elevare a valori eccelsi il contenuto di preparato attivo e quindi l’efficacia del prodotto topico. It is emphasized that maximizing the effects of the functional compound has also made it possible to minimize the content of the functional compound itself and consequently raise the content of the active preparation to excellent values and therefore the effectiveness of the topical product.
L’invenzione è suscettibile di varianti rientranti nell'ambito del concetto inventivo definito dalle rivendicazioni. Ad esempio, i polialcoli in forma di dioli (preferibilmente propandiolo e più preferibilmente 1,3-propandiolo) possono essere rimpiazzati da glicole dietilenico (nome IUPAC 2,2'-ossodietanolo). Il contenuto di glicole dietilenico è sostanzialmente compreso tra il 20% e il 35 % e in dettaglio tra il 25% e il 30%. In tale ambito tutti i dettagli sono sostituibili da elementi equivalenti e i materiali, le forme e le dimensioni possono essere qualsiasi. The invention is susceptible of variants falling within the scope of the inventive concept defined by the claims. For example, the polyalcohols in the form of diols (preferably propandiol and more preferably 1,3-propandiol) can be replaced by diethylene glycol (IUPAC name 2,2'-oxodiethanol). The content of diethylene glycol is substantially between 20% and 35% and in detail between 25% and 30%. In this context, all the details can be replaced by equivalent elements and the materials, shapes and dimensions can be any.
Claims (10)
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