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IT201900004729A1 - Processo per la preparazione di midostaurina ad elevato grado di purezza - Google Patents

Processo per la preparazione di midostaurina ad elevato grado di purezza

Info

Publication number
IT201900004729A1
IT201900004729A1 IT102019000004729A IT201900004729A IT201900004729A1 IT 201900004729 A1 IT201900004729 A1 IT 201900004729A1 IT 102019000004729 A IT102019000004729 A IT 102019000004729A IT 201900004729 A IT201900004729 A IT 201900004729A IT 201900004729 A1 IT201900004729 A1 IT 201900004729A1
Authority
IT
Italy
Prior art keywords
midostaurin
preparation
high purity
purity
purity midostaurin
Prior art date
Application number
IT102019000004729A
Other languages
English (en)
Inventor
Alberto Lena
Antonio Toppino
Katia Miele
Jacopo Roletto
Paolo Paissoni
Original Assignee
Procos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procos Spa filed Critical Procos Spa
Priority to IT102019000004729A priority Critical patent/IT201900004729A1/it
Priority to EP20712975.0A priority patent/EP3947393B1/en
Priority to HUE20712975A priority patent/HUE064707T2/hu
Priority to PT207129750T priority patent/PT3947393T/pt
Priority to ES20712975T priority patent/ES2964997T3/es
Priority to PCT/EP2020/058273 priority patent/WO2020200945A1/en
Priority to US17/426,356 priority patent/US11939342B2/en
Publication of IT201900004729A1 publication Critical patent/IT201900004729A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT102019000004729A 2019-03-29 2019-03-29 Processo per la preparazione di midostaurina ad elevato grado di purezza IT201900004729A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT102019000004729A IT201900004729A1 (it) 2019-03-29 2019-03-29 Processo per la preparazione di midostaurina ad elevato grado di purezza
EP20712975.0A EP3947393B1 (en) 2019-03-29 2020-03-25 Process for the preparation of midostaurin with high purity
HUE20712975A HUE064707T2 (hu) 2019-03-29 2020-03-25 Eljárás nagy tisztaságú midosztaurin elõállítására
PT207129750T PT3947393T (pt) 2019-03-29 2020-03-25 Processo para a preparação de midostaurina com elevada pureza
ES20712975T ES2964997T3 (es) 2019-03-29 2020-03-25 Proceso para la preparación de midostaurina con alta pureza
PCT/EP2020/058273 WO2020200945A1 (en) 2019-03-29 2020-03-25 Process for the preparation of midostaurin with high purity
US17/426,356 US11939342B2 (en) 2019-03-29 2020-03-25 Process for the preparation of midostaurin with high purity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000004729A IT201900004729A1 (it) 2019-03-29 2019-03-29 Processo per la preparazione di midostaurina ad elevato grado di purezza

Publications (1)

Publication Number Publication Date
IT201900004729A1 true IT201900004729A1 (it) 2020-09-29

Family

ID=67002276

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000004729A IT201900004729A1 (it) 2019-03-29 2019-03-29 Processo per la preparazione di midostaurina ad elevato grado di purezza

Country Status (7)

Country Link
US (1) US11939342B2 (it)
EP (1) EP3947393B1 (it)
ES (1) ES2964997T3 (it)
HU (1) HUE064707T2 (it)
IT (1) IT201900004729A1 (it)
PT (1) PT3947393T (it)
WO (1) WO2020200945A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112812129A (zh) * 2020-12-31 2021-05-18 浙江海正药业股份有限公司 米哚妥林的新晶型及其制备方法和用途
CN115124551B (zh) * 2021-03-24 2024-04-30 奥锐特药业(天津)有限公司 一种高纯度米哚妥林的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5247055B2 (it) 1973-12-04 1977-11-30
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
EP0575955A1 (en) 1992-06-22 1993-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
WO2006048296A1 (en) 2004-11-05 2006-05-11 Novartis Ag Organic compounds
WO2011064355A1 (en) 2009-11-30 2011-06-03 Novartis Ag Polymorphous forms iii and iv of n-benzoyl staurosporine
WO2018165071A1 (en) 2017-03-06 2018-09-13 Teva Pharmaceutical Works Ltd. Solid state forms of midostaurin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5247055B2 (ja) 2007-03-30 2013-07-24 株式会社パイロットコーポレーション 筆記具用レフィル

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5247055B2 (it) 1973-12-04 1977-11-30
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
EP0575955A1 (en) 1992-06-22 1993-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
WO2006048296A1 (en) 2004-11-05 2006-05-11 Novartis Ag Organic compounds
WO2011064355A1 (en) 2009-11-30 2011-06-03 Novartis Ag Polymorphous forms iii and iv of n-benzoyl staurosporine
WO2018165071A1 (en) 2017-03-06 2018-09-13 Teva Pharmaceutical Works Ltd. Solid state forms of midostaurin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol. 57, no. 38, 2018, pages 5576 - 5590
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 3, 1994, pages 399 - 404
CLINICAL PHARMACOKINETICS, vol. 47, no. 12, 2008, pages 807 - 816

Also Published As

Publication number Publication date
US11939342B2 (en) 2024-03-26
EP3947393A1 (en) 2022-02-09
US20220098216A1 (en) 2022-03-31
EP3947393B1 (en) 2023-10-25
HUE064707T2 (hu) 2024-04-28
PT3947393T (pt) 2023-11-30
WO2020200945A1 (en) 2020-10-08
ES2964997T3 (es) 2024-04-10

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