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IT1405070B1 - Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile - Google Patents

Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile

Info

Publication number
IT1405070B1
IT1405070B1 ITRM2010A000547A ITRM20100547A IT1405070B1 IT 1405070 B1 IT1405070 B1 IT 1405070B1 IT RM2010A000547 A ITRM2010A000547 A IT RM2010A000547A IT RM20100547 A ITRM20100547 A IT RM20100547A IT 1405070 B1 IT1405070 B1 IT 1405070B1
Authority
IT
Italy
Prior art keywords
druged
stokes
multiplicity
modular
energy transfer
Prior art date
Application number
ITRM2010A000547A
Other languages
English (en)
Inventor
Enrico Rampazzo
Damiano Genovese
Riccardo Juris
Sara Bonacchi
Luca Prodi
Marco Montalti
Nelsi Zaccheroni
Original Assignee
Univ Bologna Alma Mater
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bologna Alma Mater filed Critical Univ Bologna Alma Mater
Priority to ITRM2010A000547A priority Critical patent/IT1405070B1/it
Priority to US13/879,408 priority patent/US9616141B2/en
Priority to CN2011800596724A priority patent/CN103260651A/zh
Priority to PCT/IB2011/054546 priority patent/WO2012049657A1/en
Priority to JP2013533319A priority patent/JP6141186B2/ja
Priority to EP11776904.2A priority patent/EP2627360B1/en
Publication of ITRM20100547A1 publication Critical patent/ITRM20100547A1/it
Application granted granted Critical
Publication of IT1405070B1 publication Critical patent/IT1405070B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
ITRM2010A000547A 2010-10-14 2010-10-14 Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile IT1405070B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITRM2010A000547A IT1405070B1 (it) 2010-10-14 2010-10-14 Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile
US13/879,408 US9616141B2 (en) 2010-10-14 2011-10-13 Silica nanoparticles doped with multiple dyes featuring highly efficient energy transfer and tunable Stokes-shift
CN2011800596724A CN103260651A (zh) 2010-10-14 2011-10-13 有高效能量传递和可调斯托克斯位移特征的掺杂有多种染料的二氧化硅纳米颗粒
PCT/IB2011/054546 WO2012049657A1 (en) 2010-10-14 2011-10-13 Silica nanoparticles doped with multiple dyes featuring highly efficient energy transfer and tunable stokes-shift
JP2013533319A JP6141186B2 (ja) 2010-10-14 2011-10-13 非常に効率的なエネルギー移動及び調整可能なストークシフトを特徴とする複数の色素がドープされたシリカナノ粒子
EP11776904.2A EP2627360B1 (en) 2010-10-14 2011-10-13 Silica nanoparticles doped with multiple dyes featuring highly efficient energy transfer and tunable stokes-shift

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2010A000547A IT1405070B1 (it) 2010-10-14 2010-10-14 Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile

Publications (2)

Publication Number Publication Date
ITRM20100547A1 ITRM20100547A1 (it) 2012-04-15
IT1405070B1 true IT1405070B1 (it) 2013-12-16

Family

ID=43629370

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM2010A000547A IT1405070B1 (it) 2010-10-14 2010-10-14 Nanoparticelle di silice drogate con una molteplicita' di coloranti caratterizzate da trasferimento di energia ad elevata efficienza e capaci di stokes-shift modulabile

Country Status (6)

Country Link
US (1) US9616141B2 (it)
EP (1) EP2627360B1 (it)
JP (1) JP6141186B2 (it)
CN (1) CN103260651A (it)
IT (1) IT1405070B1 (it)
WO (1) WO2012049657A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015080668A1 (en) * 2013-11-27 2015-06-04 Agency For Science, Technology And Research A micellar particle
CN104087022B (zh) * 2014-06-30 2016-06-29 肇庆金三江硅材料有限公司 一种核壳型包覆色素的二氧化硅及其制备方法
US10723888B2 (en) 2015-12-31 2020-07-28 3M Innovative Properties Company Anti-fog coating composition including functionalized silica nanoparticles and multifunctional (meth)acrylate monomers
WO2017159750A1 (ja) * 2016-03-15 2017-09-21 信一郎 礒部 アルコキシシリル基含有燐光色素およびその製造方法
CN110540549B (zh) * 2019-10-10 2020-06-30 山东大学 一种香豆素基桥联硅烷及其制备方法
CN112011055B (zh) * 2020-07-29 2021-05-28 山东大学 一种吸附和光控解吸附蛋白质的功能有机硅树脂及其制备方法
US11726000B2 (en) * 2020-12-22 2023-08-15 Whirlpool Corporation Hybrid fluorescent UV dye for refrigerant systems

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7705150B2 (en) * 2004-02-04 2010-04-27 Biosearch Technologies, Inc. Cyanine dyes
US20090162838A1 (en) * 2004-04-23 2009-06-25 Shiv Kumar Fluorescence resonance energy transfer enzyme substrates
US8168447B2 (en) 2005-10-07 2012-05-01 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
US8841134B2 (en) * 2006-04-10 2014-09-23 Bruker Biospin Corporation Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications
WO2008030624A2 (en) * 2006-09-08 2008-03-13 The Research Foundation Of State University Of New York Nanoparticles for two-photon activated photodynamic therapy and imaging
AU2009278007B2 (en) * 2008-07-31 2015-08-27 Alma Mater Studiorum - Universita' Di Bologna Active particles for bio-analytical applications and methods for their preparation
IT1391530B1 (it) * 2008-07-31 2012-01-11 Cyanagen S R L Particelle attive per applicazioni bio-analitiche e metodi per la loro preparazione

Also Published As

Publication number Publication date
JP6141186B2 (ja) 2017-06-07
CN103260651A (zh) 2013-08-21
WO2012049657A1 (en) 2012-04-19
ITRM20100547A1 (it) 2012-04-15
US20130315835A1 (en) 2013-11-28
US9616141B2 (en) 2017-04-11
EP2627360A1 (en) 2013-08-21
EP2627360B1 (en) 2018-03-07
JP2014503471A (ja) 2014-02-13

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