IT1401109B1 - Nuovo processo per la preparazione di tapentadol e suoi intermedi. - Google Patents

Nuovo processo per la preparazione di tapentadol e suoi intermedi.

Info

Publication number: IT1401109B1
Authority: IT; Italy
Prior art keywords: tapentadol; intermediates; preparation; new process; new
Prior art date: 2010-07-02

Application number

ITMI2010A001224A

Other languages

English (en)

Inventor

Giuseppe Motta

Giorgio Bertolini

Nicola Landoni

Domenico Vergani

Original Assignee

Archimica Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-07-02

Filing date

2010-07-02

Publication date

2013-07-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43432160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1401109(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-07-02 Application filed by Archimica Srl filed Critical Archimica Srl

2010-07-02 Priority to ITMI2010A001224A priority Critical patent/IT1401109B1/it

2011-06-20 Priority to BR112012029882A priority patent/BR112012029882A2/pt

2011-06-20 Priority to JP2013517610A priority patent/JP5857044B2/ja

2011-06-20 Priority to PCT/IB2011/052685 priority patent/WO2012001571A1/en

2011-06-20 Priority to CA2797757A priority patent/CA2797757C/en

2011-06-20 Priority to ES11735552.9T priority patent/ES2572637T3/es

2011-06-20 Priority to AU2011273044A priority patent/AU2011273044B2/en

2011-06-20 Priority to US13/807,356 priority patent/US8791287B2/en

2011-06-20 Priority to MX2012015161A priority patent/MX340833B/es

2011-06-20 Priority to EP11735552.9A priority patent/EP2588429B1/en

2011-06-20 Priority to CN201180022910.4A priority patent/CN102958868B/zh

2012-01-03 Publication of ITMI20101224A1 publication Critical patent/ITMI20101224A1/it

2012-11-15 Priority to IL223066A priority patent/IL223066A/en

2012-12-31 Priority to CL2012003760A priority patent/CL2012003760A1/es

2013-07-12 Publication of IT1401109B1 publication Critical patent/IT1401109B1/it

2013-07-12 Application granted granted Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ITMI2010A001224A 2010-07-02 2010-07-02 Nuovo processo per la preparazione di tapentadol e suoi intermedi. IT1401109B1 (it)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
ITMI2010A001224A IT1401109B1 (it)	2010-07-02	2010-07-02	Nuovo processo per la preparazione di tapentadol e suoi intermedi.
AU2011273044A AU2011273044B2 (en)	2010-07-02	2011-06-20	New process for the synthesis of tapentadol and intermediates thereof
MX2012015161A MX340833B (es)	2010-07-02	2011-06-20	Nuevo proceso para la sintesis de tapentadol e intermediarios del mismo.
PCT/IB2011/052685 WO2012001571A1 (en)	2010-07-02	2011-06-20	New process for the synthesis of tapentadol and intermediates thereof
CA2797757A CA2797757C (en)	2010-07-02	2011-06-20	New process for the synthesis of tapentadol and intermediates thereof
ES11735552.9T ES2572637T3 (es)	2010-07-02	2011-06-20	Nuevo proceso para la síntesis de tapentadol y productos intermedios del mismo
BR112012029882A BR112012029882A2 (pt)	2010-07-02	2011-06-20	novo processo para a síntese de tapentadol e intermediários do mesmo
US13/807,356 US8791287B2 (en)	2010-07-02	2011-06-20	Process for the synthesis of tapentadol and intermediates thereof
JP2013517610A JP5857044B2 (ja)	2010-07-02	2011-06-20	タペンタドールおよびその中間体を合成する新規のプロセス
EP11735552.9A EP2588429B1 (en)	2010-07-02	2011-06-20	New process for the synthesis of tapentadol and intermediates thereof
CN201180022910.4A CN102958868B (zh)	2010-07-02	2011-06-20	用于合成他喷他多及其中间体的新方法
IL223066A IL223066A (en)	2010-07-02	2012-11-15	A process for taptadol synthesis and its intermediates
CL2012003760A CL2012003760A1 (es)	2010-07-02	2012-12-31	Proceso para la sintesis del tapentadol que comprende una alquilacion de la cetona con un haluro metálico; formas cristalinas i y ii de la base libre del tapentadol y compuestos intermediarios.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI2010A001224A IT1401109B1 (it)	2010-07-02	2010-07-02	Nuovo processo per la preparazione di tapentadol e suoi intermedi.

Publications (2)

Publication Number	Publication Date
ITMI20101224A1 ITMI20101224A1 (it)	2012-01-03
IT1401109B1 true IT1401109B1 (it)	2013-07-12

Family

ID=43432160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI2010A001224A IT1401109B1 (it)	2010-07-02	2010-07-02	Nuovo processo per la preparazione di tapentadol e suoi intermedi.

Country Status (13)

Country	Link
US (1)	US8791287B2 (it)
EP (1)	EP2588429B1 (it)
JP (1)	JP5857044B2 (it)
CN (1)	CN102958868B (it)
AU (1)	AU2011273044B2 (it)
BR (1)	BR112012029882A2 (it)
CA (1)	CA2797757C (it)
CL (1)	CL2012003760A1 (it)
ES (1)	ES2572637T3 (it)
IL (1)	IL223066A (it)
IT (1)	IT1401109B1 (it)
MX (1)	MX340833B (it)
WO (1)	WO2012001571A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013111161A2 (en) *	2012-01-10	2013-08-01	Msn Laboratories Limited	Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
EP2674414A1 (en)	2012-06-15	2013-12-18	Siegfried AG	Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
US9090539B2 (en)	2013-05-24	2015-07-28	Ampac Fine Chemicals Llc	Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
CZ307492B6 (cs)	2014-02-04	2018-10-17	Zentiva, K.S.	Pevná forma maleátu tapentadolu a způsob její přípravy
EP4116288A1 (en)	2021-07-08	2023-01-11	KRKA, d.d., Novo mesto	Racemization of (s) and/or (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one and its mixtures
CN113861155A (zh) *	2021-10-21	2021-12-31	华南师范大学	一种二氢异香豆素类衍生物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US429833A (en)		1890-06-10		Means for creating artificial currents
US3888901A (en)	1972-07-20	1975-06-10	American Cyanamid Co	Process of preparing 3-alkyl-3-(benzoyl)propionitriles
DE2901180A1 (de) *	1979-01-13	1980-07-24	Basf Ag	Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE4426245A1 (de)	1994-07-23	1996-02-22	Gruenenthal Gmbh	1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE10326097A1 (de)	2003-06-06	2005-01-05	Grünenthal GmbH	Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
ES2339403T3 (es) *	2006-07-24	2010-05-19	Janssen Pharmaceutica Nv	Preparacion de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina.
TWI448447B (zh) *	2006-07-24	2014-08-11	Gruenenthal Chemie	製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
TWI401237B (zh) *	2006-07-24	2013-07-11		３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備

2010
- 2010-07-02 IT ITMI2010A001224A patent/IT1401109B1/it active
2011
- 2011-06-20 ES ES11735552.9T patent/ES2572637T3/es active Active
- 2011-06-20 CA CA2797757A patent/CA2797757C/en active Active
- 2011-06-20 CN CN201180022910.4A patent/CN102958868B/zh not_active Expired - Fee Related
- 2011-06-20 MX MX2012015161A patent/MX340833B/es active IP Right Grant
- 2011-06-20 US US13/807,356 patent/US8791287B2/en active Active
- 2011-06-20 JP JP2013517610A patent/JP5857044B2/ja not_active Expired - Fee Related
- 2011-06-20 BR BR112012029882A patent/BR112012029882A2/pt not_active IP Right Cessation
- 2011-06-20 WO PCT/IB2011/052685 patent/WO2012001571A1/en active Application Filing
- 2011-06-20 EP EP11735552.9A patent/EP2588429B1/en active Active
- 2011-06-20 AU AU2011273044A patent/AU2011273044B2/en not_active Ceased
2012
- 2012-11-15 IL IL223066A patent/IL223066A/en active IP Right Grant
- 2012-12-31 CL CL2012003760A patent/CL2012003760A1/es unknown

Also Published As

Publication number	Publication date
MX2012015161A (es)	2013-06-28
ITMI20101224A1 (it)	2012-01-03
US8791287B2 (en)	2014-07-29
CA2797757C (en)	2018-09-25
JP5857044B2 (ja)	2016-02-10
BR112012029882A2 (pt)	2018-05-15
IL223066A (en)	2015-09-24
EP2588429A1 (en)	2013-05-08
CL2012003760A1 (es)	2013-12-13
JP2013529676A (ja)	2013-07-22
IL223066A0 (en)	2013-02-03
MX340833B (es)	2016-07-27
WO2012001571A1 (en)	2012-01-05
CN102958868A (zh)	2013-03-06
AU2011273044B2 (en)	2015-02-12
CA2797757A1 (en)	2012-01-05
CN102958868B (zh)	2014-11-05
EP2588429B1 (en)	2016-02-24
US20130178644A1 (en)	2013-07-11
AU2011273044A1 (en)	2012-11-15
ES2572637T3 (es)	2016-06-01

Publication	Publication Date	Title
IT1405680B1 (it)	2014-01-24	Processo per la produzione di l-fucosio.
IT1395594B1 (it)	2012-10-16	Processo per la preparazione di fenolo e cicloesanone
BR112013009486A2 (pt)	2019-09-24	processo para preparação de formas de dosagem gastrirretentivas multiparticuladas
BRPI1009466A2 (pt)	2016-03-01	processo para a preparação de c10-aldeídos alfa, beta-insaturados
IT1397189B1 (it)	2013-01-04	Nuovo processo per la preparazione di tapentadol e suoi intermedi.
IT1398044B1 (it)	2013-02-07	Processo per la preparazione della lacosamide
IT1403890B1 (it)	2013-11-08	Processo per la produzione di nicorandil
IT1400714B1 (it)	2013-06-28	Processo ed intermedi per la preparazione di un principio attivo.
IT1401109B1 (it)	2013-07-12	Nuovo processo per la preparazione di tapentadol e suoi intermedi.
BR112013007778A2 (pt)	2016-06-07	composição, processo para sua fabricação e composição cosmética
BR112012025490A2 (pt)	2015-10-06	''método para produção de 1,5 oebtanodiamina''
ITMI20110464A1 (it)	2012-04-15	Nuovo procedimento per la preparazione di erlotinib
IT1400395B1 (it)	2013-05-31	Processo one-pot per la sintesi di dalfampridine.
IT1397503B1 (it)	2013-01-16	Processo per la preparazione di olopatadina
IT1399912B1 (it)	2013-05-09	Processo di preparazione di ritodrina cloridrato.
IT1391108B1 (it)	2011-11-18	Processo per la preparazione di etilidennorbornene.
IT1405996B1 (it)	2014-02-06	Procedimento per la preparazione di 2,5-diaminotoluolo
FI20096106A0 (fi)	2009-10-28	Menetelmä komposiittituotteen valmistamiseksi, komposiittituote ja sen käyttö
ITTO20110857A1 (it)	2012-03-28	Procedimento per la produzione di cicloesanonossina.
IT1396623B1 (it)	2012-12-14	Procedimento per la preparazione di cinacalcet e suoi intermedi
IT1403988B1 (it)	2013-11-08	Processo per la preparazione di agenti di contrasto.
BR112014015518A2 (pt)	2017-06-13	processo para a produção das ariloxiacetamidas, ariloxiacetamidas e utilização
IT1396373B1 (it)	2012-11-19	Procedimento per la preparazione di fesoterodina.
IT1400485B1 (it)	2013-06-11	Nuovo processo per la preparazione dell'aminaftone
SM201000062B (it)	2012-10-31	Processo per la preparazione di gabapentin