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IT1317862B1 - Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso. - Google Patents

Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.

Info

Publication number
IT1317862B1
IT1317862B1 IT2000MI000383A ITMI20000383A IT1317862B1 IT 1317862 B1 IT1317862 B1 IT 1317862B1 IT 2000MI000383 A IT2000MI000383 A IT 2000MI000383A IT MI20000383 A ITMI20000383 A IT MI20000383A IT 1317862 B1 IT1317862 B1 IT 1317862B1
Authority
IT
Italy
Prior art keywords
metal ions
conjugates
biliary acids
complex chelates
chelates
Prior art date
Application number
IT2000MI000383A
Other languages
English (en)
Inventor
Haen Christoph De
Andrea Beltrami
Enrico Cappelletti
Luciano Lattuada
Mario Virtuani
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of ITMI20000383A0 publication Critical patent/ITMI20000383A0/it
Priority to IT2000MI000383A priority Critical patent/IT1317862B1/it
Priority to JP2001564201A priority patent/JP5052726B2/ja
Priority to AT01911677T priority patent/ATE294813T1/de
Priority to DE60110558T priority patent/DE60110558T2/de
Priority to PCT/EP2001/001971 priority patent/WO2001064708A1/en
Priority to US10/220,048 priority patent/US6803030B2/en
Priority to AU40644/01A priority patent/AU4064401A/en
Priority to EP01911677A priority patent/EP1259532B1/en
Publication of ITMI20000383A1 publication Critical patent/ITMI20000383A1/it
Application granted granted Critical
Publication of IT1317862B1 publication Critical patent/IT1317862B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT2000MI000383A 2000-02-29 2000-02-29 Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso. IT1317862B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT2000MI000383A IT1317862B1 (it) 2000-02-29 2000-02-29 Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
PCT/EP2001/001971 WO2001064708A1 (en) 2000-02-29 2001-02-21 Bile acids conjugates with metal ion chelates and the use thereof
AT01911677T ATE294813T1 (de) 2000-02-29 2001-02-21 Konjugate von gallensäure mit metallbindenden chelatverbdingungen und die verwendung davon
DE60110558T DE60110558T2 (de) 2000-02-29 2001-02-21 Konjugate von gallensäure mit metallbindenden chelatverbdingungen und die verwendung davon
JP2001564201A JP5052726B2 (ja) 2000-02-29 2001-02-21 金属イオンキレートとの胆汁酸複合体及びその使用
US10/220,048 US6803030B2 (en) 2000-02-29 2001-02-21 Bile acids conjugates with metal ion chelates and the use thereof
AU40644/01A AU4064401A (en) 2000-02-29 2001-02-21 Bile acids conjugates with metal ion chelates and the use thereof
EP01911677A EP1259532B1 (en) 2000-02-29 2001-02-21 Bile acids conjugates with metal ion chelates and the use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI000383A IT1317862B1 (it) 2000-02-29 2000-02-29 Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.

Publications (3)

Publication Number Publication Date
ITMI20000383A0 ITMI20000383A0 (it) 2000-02-29
ITMI20000383A1 ITMI20000383A1 (it) 2001-08-29
IT1317862B1 true IT1317862B1 (it) 2003-07-15

Family

ID=11444243

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI000383A IT1317862B1 (it) 2000-02-29 2000-02-29 Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.

Country Status (8)

Country Link
US (1) US6803030B2 (it)
EP (1) EP1259532B1 (it)
JP (1) JP5052726B2 (it)
AT (1) ATE294813T1 (it)
AU (1) AU4064401A (it)
DE (1) DE60110558T2 (it)
IT (1) IT1317862B1 (it)
WO (1) WO2001064708A1 (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318485B1 (it) 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
US6919333B2 (en) * 2002-11-12 2005-07-19 Rutgers, The State University Of New Jersey Bis-transition-metal-chelate probes
CA2488819A1 (en) * 2002-03-28 2003-11-06 Rutgers, The State University Of New Jersey Bis-transition-metal-chelate-probes
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2512310C (en) * 2003-01-13 2012-09-25 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE102004038134B4 (de) 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
JP2008508333A (ja) * 2004-08-05 2008-03-21 ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン 標的分子の改変および組織化のための多価キレーター
EP1848465A2 (en) * 2005-02-03 2007-10-31 EPIX Pharmaceuticals, Inc. Steady state perfusion methods
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CN110420211A (zh) 2013-03-15 2019-11-08 布莱阿姆青年大学 治疗炎症、自身免疫性疾病和疼痛的方法
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
US10227376B2 (en) * 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US10975060B2 (en) 2016-11-28 2021-04-13 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
KR20210095168A (ko) 2018-11-23 2021-07-30 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
IT1269839B (it) 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Also Published As

Publication number Publication date
US20030113265A1 (en) 2003-06-19
ITMI20000383A1 (it) 2001-08-29
ATE294813T1 (de) 2005-05-15
DE60110558T2 (de) 2005-09-22
JP5052726B2 (ja) 2012-10-17
US6803030B2 (en) 2004-10-12
ITMI20000383A0 (it) 2000-02-29
EP1259532B1 (en) 2005-05-04
WO2001064708A1 (en) 2001-09-07
EP1259532A1 (en) 2002-11-27
AU4064401A (en) 2001-09-12
DE60110558D1 (de) 2005-06-09
JP2003525306A (ja) 2003-08-26

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