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IT1397061B1 - Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale. - Google Patents

Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.

Info

Publication number
IT1397061B1
IT1397061B1 ITFI2009A000273A ITFI20090273A IT1397061B1 IT 1397061 B1 IT1397061 B1 IT 1397061B1 IT FI2009A000273 A ITFI2009A000273 A IT FI2009A000273A IT FI20090273 A ITFI20090273 A IT FI20090273A IT 1397061 B1 IT1397061 B1 IT 1397061B1
Authority
IT
Italy
Prior art keywords
gammaglobuline
purification
industrial
human plasma
new process
Prior art date
Application number
ITFI2009A000273A
Other languages
English (en)
Inventor
Arianna Petrucci
Alessandra Lazzarotti
Andrea Morelli
Sabrina Esposito
Claudia Nardini
Filippo Mori
Original Assignee
Kedrion Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kedrion Spa filed Critical Kedrion Spa
Priority to ITFI2009A000273A priority Critical patent/IT1397061B1/it
Priority to ES10813137.6T priority patent/ES2640215T3/es
Priority to US13/519,368 priority patent/US8933204B2/en
Priority to AU2010337871A priority patent/AU2010337871B2/en
Priority to CA2785825A priority patent/CA2785825C/en
Priority to PCT/IB2010/056093 priority patent/WO2011080698A1/en
Priority to EP10813137.6A priority patent/EP2519540B1/en
Publication of ITFI20090273A1 publication Critical patent/ITFI20090273A1/it
Application granted granted Critical
Publication of IT1397061B1 publication Critical patent/IT1397061B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ITFI2009A000273A 2009-12-28 2009-12-28 Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale. IT1397061B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITFI2009A000273A IT1397061B1 (it) 2009-12-28 2009-12-28 Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.
ES10813137.6T ES2640215T3 (es) 2009-12-28 2010-12-28 Procedimiento para la purificación a escala industrial de gammaglobulinas a partir de plasma humano para aplicaciones industriales
US13/519,368 US8933204B2 (en) 2009-12-28 2010-12-28 Process for the industrial-scale purification of gamma globulins from human plasma for industrial applications
AU2010337871A AU2010337871B2 (en) 2009-12-28 2010-12-28 Process for the industrial - scale purification of gamma globulins from human plasma for industrial applications
CA2785825A CA2785825C (en) 2009-12-28 2010-12-28 Process for the industrial-scale purification of gamma globulins from human plasma for industrial applications
PCT/IB2010/056093 WO2011080698A1 (en) 2009-12-28 2010-12-28 Process for the industrial - scale purification of gamma globulins from human plasma for industrial applications
EP10813137.6A EP2519540B1 (en) 2009-12-28 2010-12-28 Process for the industrial-scale purification of gamma globulins from human plasma for industrial applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI2009A000273A IT1397061B1 (it) 2009-12-28 2009-12-28 Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.

Publications (2)

Publication Number Publication Date
ITFI20090273A1 ITFI20090273A1 (it) 2011-06-29
IT1397061B1 true IT1397061B1 (it) 2012-12-28

Family

ID=42289019

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI2009A000273A IT1397061B1 (it) 2009-12-28 2009-12-28 Nuovo processo di purificazione su scala industriale di gammaglobuline da plasma umano per uso industriale.

Country Status (7)

Country Link
US (1) US8933204B2 (it)
EP (1) EP2519540B1 (it)
AU (1) AU2010337871B2 (it)
CA (1) CA2785825C (it)
ES (1) ES2640215T3 (it)
IT (1) IT1397061B1 (it)
WO (1) WO2011080698A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2855504B1 (en) * 2012-05-31 2018-10-24 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
CN106132517B (zh) 2014-06-25 2019-12-13 Emd 密理博公司 过滤器元件、切向流过滤系统、液体过滤工艺
KR102188947B1 (ko) 2014-08-29 2020-12-09 이엠디 밀리포어 코포레이션 잔류물의 재순환을 이용한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템
WO2016033553A1 (en) 2014-08-29 2016-03-03 Emd Millipore Corporation Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
US9556253B2 (en) 2014-12-02 2017-01-31 Hemarus Therapeutics Limited Process for increased yield of immunoglobulin from human plasma
EP3275897A1 (en) 2016-07-27 2018-01-31 Biotest AG Process for preparing immunoglobulin compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE348942B (it) * 1970-06-02 1972-09-18 Statens Bakteriologiska Labor
US5118796A (en) * 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
FR2706466B1 (fr) 1993-06-14 1995-08-25 Aetsrn Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré.
DE59309332D1 (de) * 1993-12-27 1999-03-04 Rotkreuzstiftung Zentratrallab Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
TW491855B (en) 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DK2272870T3 (da) 1998-06-09 2013-08-05 Csl Behring Ag Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter.
FR2824568B1 (fr) 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
EP1736538A1 (en) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Process for the preparative purification of virus-like-particles (VLPs)
US20070049732A1 (en) 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
NZ571479A (en) * 2006-04-05 2012-10-26 Abbott Biotech Ltd Antibody purification

Also Published As

Publication number Publication date
AU2010337871B2 (en) 2013-05-09
CA2785825C (en) 2018-05-29
WO2011080698A1 (en) 2011-07-07
ITFI20090273A1 (it) 2011-06-29
US8933204B2 (en) 2015-01-13
EP2519540A1 (en) 2012-11-07
EP2519540B1 (en) 2017-06-14
AU2010337871A1 (en) 2012-08-09
US20120316323A1 (en) 2012-12-13
ES2640215T3 (es) 2017-11-02
CA2785825A1 (en) 2011-07-07

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