IT1393337B1 - Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina - Google Patents
Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridinaInfo
- Publication number
- IT1393337B1 IT1393337B1 ITMI2009A000332A ITMI20090332A IT1393337B1 IT 1393337 B1 IT1393337 B1 IT 1393337B1 IT MI2009A000332 A ITMI2009A000332 A IT MI2009A000332A IT MI20090332 A ITMI20090332 A IT MI20090332A IT 1393337 B1 IT1393337 B1 IT 1393337B1
- Authority
- IT
- Italy
- Prior art keywords
- ottaidro
- pirrolo
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000332A IT1393337B1 (it) | 2009-03-06 | 2009-03-06 | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
| PCT/EP2010/052734 WO2010100215A1 (en) | 2009-03-06 | 2010-03-04 | SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLO[3,4-b]PYRIDINE |
| EP20100708517 EP2403831B1 (en) | 2009-03-06 | 2010-03-04 | SYNTHESIS OF (4aS,7aS)-OCTAHYDRO-1H-PYRROLOÝ3,4-b¨PYRIDINE |
| US13/056,458 US8680276B2 (en) | 2009-03-06 | 2010-03-04 | Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine |
| CA2751548A CA2751548C (en) | 2009-03-06 | 2010-03-04 | Synthesis of (4as,7as)-octahydro-1h-pyrrolo[3,4-b]pyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000332A IT1393337B1 (it) | 2009-03-06 | 2009-03-06 | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20090332A1 ITMI20090332A1 (it) | 2010-09-07 |
| IT1393337B1 true IT1393337B1 (it) | 2012-04-20 |
Family
ID=41137093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI2009A000332A IT1393337B1 (it) | 2009-03-06 | 2009-03-06 | Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8680276B2 (it) |
| EP (1) | EP2403831B1 (it) |
| CA (1) | CA2751548C (it) |
| IT (1) | IT1393337B1 (it) |
| WO (1) | WO2010100215A1 (it) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20110705A1 (it) | 2011-07-29 | 2013-01-30 | Italiana Sint Spa | Procedimento di preparazione della moxifloxacina cloridrato e relativi intermedi |
| CN102952130B (zh) * | 2011-08-24 | 2016-03-23 | 重庆华邦胜凯制药有限公司 | 手性合成(s,s)-2,8-二氮杂双环壬烷的方法 |
| US9073881B2 (en) | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
| CN103497187A (zh) * | 2013-09-25 | 2014-01-08 | 苏州维桢生物医药科技有限公司 | 一种用于工业上提高莫西沙星侧链化学纯度的方法 |
| CN104016981B (zh) * | 2014-06-23 | 2016-03-23 | 南京正大天晴制药有限公司 | 一种盐酸莫西沙星结构类似物及其制备方法 |
| CN105566319B (zh) * | 2014-10-09 | 2018-06-01 | 和鼎（南京）医药技术有限公司 | 一种(s,s)-2,8-二氮杂二环[4,3,0]壬烷的制备方法 |
| CN104370907A (zh) * | 2014-11-17 | 2015-02-25 | 安徽美诺华药物化学有限公司 | 喹诺酮衍生物的制备方法 |
| CN110183445B (zh) * | 2019-06-28 | 2021-08-24 | 昆明学院 | 莫西沙星及其衍生物的合成方法 |
| CN112939849B (zh) * | 2019-12-11 | 2022-05-03 | 浙江新和成股份有限公司 | 一种(s,s)-2,8-二氮杂双环[4.3.0]壬烷中间体及其制备方法和应用 |
| CN111100125A (zh) * | 2019-12-31 | 2020-05-05 | 厦门本素药业有限公司 | 莫西沙星中间体的制备方法 |
| CN112759590B (zh) * | 2020-11-19 | 2021-12-31 | 内蒙古源宏精细化工有限公司 | 一种莫西沙星的制备方法 |
| CN112920184B (zh) * | 2021-02-06 | 2022-03-01 | 台州市生物医化产业研究院有限公司 | 一种制备莫西沙星中间体(s,s)-2,8-二氮杂二环[4,3,0]壬烷的方法 |
| CN112939847B (zh) * | 2021-02-06 | 2022-05-13 | 台州市生物医化产业研究院有限公司 | 一种制备莫西沙星中间体(s,s)-2,8-二氮杂二环[4,3,0]壬烷的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| TW209865B (it) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| DE4234078A1 (de) | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| DE19735198A1 (de) | 1997-08-14 | 1999-02-18 | Bayer Ag | Verfahren zur Racematspaltung von cis- und trans-Pyrrolopiperidin |
| DE19751948A1 (de) | 1997-11-24 | 1999-05-27 | Bayer Ag | Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren |
| DE19821039A1 (de) | 1998-05-11 | 1999-11-18 | Bayer Ag | Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan |
| DE19927412A1 (de) | 1999-06-16 | 2000-12-21 | Bayer Ag | Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0]nonan |
| DE19931115A1 (de) | 1999-07-06 | 2001-01-11 | Bayer Ag | Racemisierung von R, S-Dioxo-Benzylpyrrolopiperidin |
| CA2434044A1 (en) | 2001-01-11 | 2002-07-18 | Bristol-Myers Squibb Pharma Company | 1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha |
| DE10226923A1 (de) | 2002-06-17 | 2003-12-24 | Bayer Ag | Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonan |
| WO2005012285A1 (en) | 2003-08-05 | 2005-02-10 | Matrix Laboratories Ltd | An improved process for the preparation of moxifloxacin hydrochloride |
| WO2005054239A1 (en) | 2003-12-05 | 2005-06-16 | Bayer Healthcare Ag | 2-aminopyrimidine derivatives |
| US20060111369A1 (en) | 2004-11-10 | 2006-05-25 | Somberg John C | Synthesis, characterization and biological action of optically active isomers of floxacins |
| WO2006134491A2 (en) | 2005-06-14 | 2006-12-21 | Aurobindo Pharma Limited | New crystalline form of moxifloxacin hydrochloride and process for its preparation |
| NL2000323C2 (nl) | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
| ES2284380B1 (es) | 2006-03-10 | 2008-11-01 | Quimica Sintetica S.A. | Procedimiento para la preparacion de moxifloxacino y moxifloxacino clorhidrato. |
| CN101511190A (zh) | 2006-07-11 | 2009-08-19 | 詹森药业有限公司 | 组胺h4受体的苯并呋喃并-和苯并噻吩并嘧啶调节剂 |
| DE102006050516A1 (de) | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
| US7692655B2 (en) | 2007-02-16 | 2010-04-06 | Mitac International Corporation | Apparatus and method of generating curved baseline for map labeling |
-
2009
- 2009-03-06 IT ITMI2009A000332A patent/IT1393337B1/it active
-
2010
- 2010-03-04 US US13/056,458 patent/US8680276B2/en not_active Expired - Fee Related
- 2010-03-04 EP EP20100708517 patent/EP2403831B1/en not_active Not-in-force
- 2010-03-04 WO PCT/EP2010/052734 patent/WO2010100215A1/en active Application Filing
- 2010-03-04 CA CA2751548A patent/CA2751548C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2751548A1 (en) | 2010-09-10 |
| EP2403831B1 (en) | 2015-05-20 |
| EP2403831A1 (en) | 2012-01-11 |
| ITMI20090332A1 (it) | 2010-09-07 |
| US8680276B2 (en) | 2014-03-25 |
| CA2751548C (en) | 2017-04-11 |
| WO2010100215A1 (en) | 2010-09-10 |
| US20110137036A1 (en) | 2011-06-09 |
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