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IT1201474B - Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono - Google Patents

Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Info

Publication number
IT1201474B
IT1201474B IT22327/85A IT2232785A IT1201474B IT 1201474 B IT1201474 B IT 1201474B IT 22327/85 A IT22327/85 A IT 22327/85A IT 2232785 A IT2232785 A IT 2232785A IT 1201474 B IT1201474 B IT 1201474B
Authority
IT
Italy
Prior art keywords
cdp
derivatives
macromolecularized
colina
procedure
Prior art date
Application number
IT22327/85A
Other languages
English (en)
Other versions
IT8522327A0 (it
Inventor
Vincenzo Zappia
Rosa Mario De
Original Assignee
Vincenzo Zappia
Rosa Mario De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vincenzo Zappia, Rosa Mario De filed Critical Vincenzo Zappia
Priority to IT22327/85A priority Critical patent/IT1201474B/it
Publication of IT8522327A0 publication Critical patent/IT8522327A0/it
Priority to JP61231069A priority patent/JPS62129296A/ja
Priority to US06/913,841 priority patent/US4772463A/en
Priority to AT86113539T priority patent/ATE48231T1/de
Priority to ES86113539T priority patent/ES2011767B3/es
Priority to EP86113539A priority patent/EP0218190B1/en
Priority to DE8686113539T priority patent/DE3667139D1/de
Application granted granted Critical
Publication of IT1201474B publication Critical patent/IT1201474B/it
Priority to GR89400263T priority patent/GR3000235T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
IT22327/85A 1985-10-01 1985-10-01 Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono IT1201474B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT22327/85A IT1201474B (it) 1985-10-01 1985-10-01 Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
JP61231069A JPS62129296A (ja) 1985-10-01 1986-09-29 巨大分子cdp−コリン誘導体、その製造方法及びこれを含有する薬剤組成物
US06/913,841 US4772463A (en) 1985-10-01 1986-09-30 Macromolecular CDP-choline derivatives, process for their preparation and pharmaceutical compositions containing them
AT86113539T ATE48231T1 (de) 1985-10-01 1986-10-01 Makromolekulare cdp-cholinderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel.
ES86113539T ES2011767B3 (es) 1985-10-01 1986-10-01 Derivados macromoleculares de cdp-colina, procedimiento para su preparacion, y composiciones farmaceuticas que los contienen.
EP86113539A EP0218190B1 (en) 1985-10-01 1986-10-01 Macromolecular cdp-choline derivatives, process for their preparation and pharmaceutical compositions containing them
DE8686113539T DE3667139D1 (de) 1985-10-01 1986-10-01 Makromolekulare cdp-cholinderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel.
GR89400263T GR3000235T3 (en) 1985-10-01 1989-11-30 Macromolecular cdp-choline derivatives, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22327/85A IT1201474B (it) 1985-10-01 1985-10-01 Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Publications (2)

Publication Number Publication Date
IT8522327A0 IT8522327A0 (it) 1985-10-01
IT1201474B true IT1201474B (it) 1989-02-02

Family

ID=11194722

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22327/85A IT1201474B (it) 1985-10-01 1985-10-01 Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Country Status (8)

Country Link
US (1) US4772463A (it)
EP (1) EP0218190B1 (it)
JP (1) JPS62129296A (it)
AT (1) ATE48231T1 (it)
DE (1) DE3667139D1 (it)
ES (1) ES2011767B3 (it)
GR (1) GR3000235T3 (it)
IT (1) IT1201474B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408668B1 (en) * 1988-10-27 1994-05-11 Massachusetts Institute Of Technology Process for increasing phosphatidylcholine in vivo
EP0506979B1 (en) * 1990-10-24 2001-07-11 Masayuki Kuzuya Organic polymer compound and production thereof
CN1208064C (zh) * 1997-12-24 2005-06-29 英特纳龙制药公司 高水合化胞磷胆碱、方法和应用
ES2425114T3 (es) 2000-03-16 2013-10-11 The Mclean Hospital Corporation CDP-colina y uridina para el tratamiento del abuso del acohol
CN100430066C (zh) 2002-11-08 2008-11-05 麦克莱恩医院 用于烟草依赖性和戒断治疗的化合物
US7737128B2 (en) 2004-06-10 2010-06-15 The Mclean Hospital Corporation Pyrimidines, such as uridine, in treatments for patients with bipolar disorder
WO2006020703A1 (en) 2004-08-11 2006-02-23 The Mclean Hospital Corporation Compounds for the treatment of marihuana dependence, withdrawal, and usage
CN103509073B (zh) * 2013-08-29 2016-01-06 洪军 一种胞磷胆碱钠化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2402664A1 (fr) * 1977-09-07 1979-04-06 Agronomique Inst Nat Rech Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications
IT1207106B (it) * 1980-04-18 1989-05-17 Made Italiana Srl Ora Searle I Preparazione farmaceutica contenente citidin disfofocolina assorbibile per via orale
JPS5821426A (ja) * 1981-07-30 1983-02-08 Teijin Ltd 細胞毒性物質を結合した重合体を活性成分とする抗腫瘍剤およびその製造法

Also Published As

Publication number Publication date
JPS62129296A (ja) 1987-06-11
DE3667139D1 (de) 1990-01-04
GR3000235T3 (en) 1991-03-15
ES2011767B3 (es) 1990-02-16
EP0218190B1 (en) 1989-11-29
EP0218190A3 (en) 1987-09-30
EP0218190A2 (en) 1987-04-15
IT8522327A0 (it) 1985-10-01
ATE48231T1 (de) 1989-12-15
US4772463A (en) 1988-09-20

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