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IT1270994B - Macromolecole ramificate a struttura poliossialchilica e loro usi - Google Patents

Macromolecole ramificate a struttura poliossialchilica e loro usi

Info

Publication number
IT1270994B
IT1270994B ITMI940512A ITMI940512A IT1270994B IT 1270994 B IT1270994 B IT 1270994B IT MI940512 A ITMI940512 A IT MI940512A IT MI940512 A ITMI940512 A IT MI940512A IT 1270994 B IT1270994 B IT 1270994B
Authority
IT
Italy
Prior art keywords
polyoxykylic
macromolecules
nucleus
structure macromolecules
transporters
Prior art date
Application number
ITMI940512A
Other languages
English (en)
Inventor
Luigia Gozzini
Monica Muttoni
Haen Christoph De
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of ITMI940512A0 publication Critical patent/ITMI940512A0/it
Priority to ITMI940512A priority Critical patent/IT1270994B/it
Priority to AU20703/95A priority patent/AU689244B2/en
Priority to PCT/EP1995/000943 priority patent/WO1995025763A1/en
Priority to AT95913106T priority patent/ATE211155T1/de
Priority to DE69524738T priority patent/DE69524738T2/de
Priority to EP95913106A priority patent/EP0750649B1/en
Priority to JP7524352A priority patent/JPH09510489A/ja
Priority to CA002185647A priority patent/CA2185647A1/en
Priority to US08/404,259 priority patent/US5780644A/en
Priority to IL11300495A priority patent/IL113004A/xx
Priority to ZA952165A priority patent/ZA952165B/xx
Publication of ITMI940512A1 publication Critical patent/ITMI940512A1/it
Priority to NO19963872A priority patent/NO312901B1/no
Priority to FI963646A priority patent/FI963646A0/fi
Priority to KR1019960705119A priority patent/KR970701748A/ko
Application granted granted Critical
Publication of IT1270994B publication Critical patent/IT1270994B/it
Priority to US09/069,958 priority patent/US5886110A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Macromolecole ramificate di tipo dendrimerico, costituite da un nucleo centrale (preferibilmente neopentilico) e da una serie di catene poliossialchileniche propagantisi da detto nucleo con ramificazioni a cascata, si prestano come trasportatori di farmaci o agenti di contrasto, veicolanti di specie metalliche radioattive, eccetera.
ITMI940512A 1994-03-18 1994-03-18 Macromolecole ramificate a struttura poliossialchilica e loro usi IT1270994B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ITMI940512A IT1270994B (it) 1994-03-18 1994-03-18 Macromolecole ramificate a struttura poliossialchilica e loro usi
AU20703/95A AU689244B2 (en) 1994-03-18 1995-03-14 Branched polyoxaalkyl macromolecules, process for making them and their uses
PCT/EP1995/000943 WO1995025763A1 (en) 1994-03-18 1995-03-14 Branched polyoxaalkyl macromolecules, process for making them and their uses
AT95913106T ATE211155T1 (de) 1994-03-18 1995-03-14 Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung
DE69524738T DE69524738T2 (de) 1994-03-18 1995-03-14 Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung
EP95913106A EP0750649B1 (en) 1994-03-18 1995-03-14 Branched polyoxaalkyl macromolecules, process for making them and their uses
JP7524352A JPH09510489A (ja) 1994-03-18 1995-03-14 枝分かれポリオキサアルキル高分子、その製造方法並びに使用方法
CA002185647A CA2185647A1 (en) 1994-03-18 1995-03-14 Branched polyoxaalkyl macromolecules, process for making them and their uses
US08/404,259 US5780644A (en) 1994-03-18 1995-03-15 Branced polyoxaalkyl macromolecules
IL11300495A IL113004A (en) 1994-03-18 1995-03-16 Branched polyoxaalkyl macromolecules
ZA952165A ZA952165B (en) 1994-03-18 1995-03-16 Branched polyoxaalkyl macromolecules process for making them and their uses
NO19963872A NO312901B1 (no) 1994-03-18 1996-09-16 Dendrimert makromolekyl, fremgangsmåte ved dets fremstilling og dets anvendelser
FI963646A FI963646A0 (fi) 1994-03-18 1996-09-16 Haarautuneet polyoksa-alkyylimakromolekyylit, menetelmä niiden valmistamiseksi sekä niiden käytöt
KR1019960705119A KR970701748A (ko) 1994-03-18 1996-09-16 분지된 폴리옥사알킬 거대 분자, 그의 제조 방법 및 용도(Branched Polyoxaalkyl Macromolecules. Process for Making Them and Their Uses)
US09/069,958 US5886110A (en) 1994-03-18 1998-04-30 Binary-branched polyoxaalkylene macromolecules process for making them and their uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940512A IT1270994B (it) 1994-03-18 1994-03-18 Macromolecole ramificate a struttura poliossialchilica e loro usi

Publications (3)

Publication Number Publication Date
ITMI940512A0 ITMI940512A0 (it) 1994-03-18
ITMI940512A1 ITMI940512A1 (it) 1995-09-18
IT1270994B true IT1270994B (it) 1997-05-26

Family

ID=11368259

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI940512A IT1270994B (it) 1994-03-18 1994-03-18 Macromolecole ramificate a struttura poliossialchilica e loro usi

Country Status (14)

Country Link
US (1) US5780644A (it)
EP (1) EP0750649B1 (it)
JP (1) JPH09510489A (it)
KR (1) KR970701748A (it)
AT (1) ATE211155T1 (it)
AU (1) AU689244B2 (it)
CA (1) CA2185647A1 (it)
DE (1) DE69524738T2 (it)
FI (1) FI963646A0 (it)
IL (1) IL113004A (it)
IT (1) IT1270994B (it)
NO (1) NO312901B1 (it)
WO (1) WO1995025763A1 (it)
ZA (1) ZA952165B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019240A1 (en) * 1994-12-21 1996-06-27 Novartis Ag Oligonucleotide-dendrimer conjugates
IT1277414B1 (it) * 1995-08-02 1997-11-10 Bracco Spa Uso di macromolecole di tipo dendrimerico come catalizzatori o coadiuvanti delle reazioni in condizioni di trasferimento di fase
IT1277596B1 (it) * 1995-09-15 1997-11-11 Bracco Spa Composti macromolecolari di tipo dendrimerico
WO1997014740A1 (en) * 1995-10-19 1997-04-24 Receptagen Corporation Discrete-length polyethylene glycols
DE19624705A1 (de) * 1996-06-20 1998-01-08 Deutsches Krebsforsch Dendrimere auf Saccharid-Basis
US6214988B1 (en) 1999-01-03 2001-04-10 Schlumberger Technology Corporation Process for making an HMX product
US6201117B1 (en) 1999-05-26 2001-03-13 Schlumberger Technology Corporation Process for making a 1,3,5,7-tetraalkanoyl-1,3,5,7-tetraazacyclooctane
US6265573B1 (en) 1999-05-26 2001-07-24 Schlumberger Technology Corporation Purification process
US6428724B1 (en) 1999-05-26 2002-08-06 Schlumberger Technology Corporation Granulation process
US6194571B1 (en) 1999-05-26 2001-02-27 Schlumberger Technology Corporation HMX compositions and processes for their preparation
YU6502A (sh) 1999-07-29 2005-06-10 Epix Medical Inc. Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja
US7560520B1 (en) 2004-11-08 2009-07-14 The United States Of America As Represented By The Secretary Of The Army Interface-directed branched polymer transports and methods for producing same
US7645854B2 (en) * 2005-03-04 2010-01-12 Central Michigan University Board Of Trustees Conjugate addition products of primary amines and activated acceptors
EP1955712A1 (en) 2007-02-09 2008-08-13 Scil proteins GmbH Multimeric conjugate
US8178726B2 (en) 2007-03-15 2012-05-15 Huntsman Petrochemical Llc High functionality amine compounds and uses therefor
CN102834435B (zh) * 2010-03-30 2015-04-22 斯帕果图像有限公司 支化的紧凑型聚乙二醇衍生物
US8816099B2 (en) * 2010-03-31 2014-08-26 Nof Corporation Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
US9133114B2 (en) * 2012-01-31 2015-09-15 University Of Maryland, Baltimore Dendrimers and methods of preparing same through proportionate branching

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US5099042A (en) * 1989-03-14 1992-03-24 Thiokol Corporation Synthesis of tetrafunctional polyethers and compositions formed therefrom
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5294365A (en) * 1991-12-12 1994-03-15 Basf Corporation Hydroxypolyethers as low-foam surfactants

Also Published As

Publication number Publication date
IL113004A0 (en) 1995-06-29
ITMI940512A1 (it) 1995-09-18
ZA952165B (en) 1995-12-14
ATE211155T1 (de) 2002-01-15
US5780644A (en) 1998-07-14
AU689244B2 (en) 1998-03-26
JPH09510489A (ja) 1997-10-21
FI963646A (fi) 1996-09-16
CA2185647A1 (en) 1995-09-28
IL113004A (en) 2000-08-31
FI963646A0 (fi) 1996-09-16
NO963872L (no) 1996-09-16
WO1995025763A1 (en) 1995-09-28
NO963872D0 (no) 1996-09-16
AU2070395A (en) 1995-10-09
DE69524738D1 (de) 2002-01-31
NO312901B1 (no) 2002-07-15
KR970701748A (ko) 1997-04-12
DE69524738T2 (de) 2002-06-13
EP0750649A1 (en) 1997-01-02
ITMI940512A0 (it) 1994-03-18
EP0750649B1 (en) 2001-12-19

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