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IT1264712B1 - Metodo di sintesi biologica di peptidi - Google Patents

Metodo di sintesi biologica di peptidi

Info

Publication number
IT1264712B1
IT1264712B1 IT93MI001534A ITMI931534A IT1264712B1 IT 1264712 B1 IT1264712 B1 IT 1264712B1 IT 93MI001534 A IT93MI001534 A IT 93MI001534A IT MI931534 A ITMI931534 A IT MI931534A IT 1264712 B1 IT1264712 B1 IT 1264712B1
Authority
IT
Italy
Prior art keywords
peptides
synthesis method
biological synthesis
peptide synthetases
modified
Prior art date
Application number
IT93MI001534A
Other languages
English (en)
Inventor
Guido Grandi
Ferra Francesca De
Giuliano Galli
Paola Cosmina
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT93MI001534A priority Critical patent/IT1264712B1/it
Publication of ITMI931534A0 publication Critical patent/ITMI931534A0/it
Priority to EP94201952A priority patent/EP0637630A3/en
Priority to US08/268,542 priority patent/US5652116A/en
Priority to JP6183066A priority patent/JPH07147978A/ja
Publication of ITMI931534A1 publication Critical patent/ITMI931534A1/it
Application granted granted Critical
Publication of IT1264712B1 publication Critical patent/IT1264712B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Si descrive un nuovo metodo per la sintesi in vivo o in vitro di peptidi modificati mediante l'impiego di microrganismi ingegnerizzati capaci di esprimere sintetasi peptidiche con una specificità di substrato modificata o delle sintetasi peptidiche estratte dai suddetti microrganismi.
IT93MI001534A 1993-07-13 1993-07-13 Metodo di sintesi biologica di peptidi IT1264712B1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT93MI001534A IT1264712B1 (it) 1993-07-13 1993-07-13 Metodo di sintesi biologica di peptidi
EP94201952A EP0637630A3 (en) 1993-07-13 1994-07-06 Method for the biological synthesis of peptides
US08/268,542 US5652116A (en) 1993-07-13 1994-07-06 Method for genetically manipulating peptide synthetases
JP6183066A JPH07147978A (ja) 1993-07-13 1994-07-13 変性ペプチドの生物学的製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001534A IT1264712B1 (it) 1993-07-13 1993-07-13 Metodo di sintesi biologica di peptidi

Publications (3)

Publication Number Publication Date
ITMI931534A0 ITMI931534A0 (it) 1993-07-13
ITMI931534A1 ITMI931534A1 (it) 1995-01-13
IT1264712B1 true IT1264712B1 (it) 1996-10-04

Family

ID=11366592

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001534A IT1264712B1 (it) 1993-07-13 1993-07-13 Metodo di sintesi biologica di peptidi

Country Status (4)

Country Link
US (1) US5652116A (it)
EP (1) EP0637630A3 (it)
JP (1) JPH07147978A (it)
IT (1) IT1264712B1 (it)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
IT1277466B1 (it) * 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
FR2739628B1 (fr) * 1995-10-05 1997-12-26 Pasteur Institut Procede de synthese de molecules hybrides consistant en la condensation d'au moins deux segments appartenant a des especes chimiques differentes sequences et proteines pour sa mise en oeuvre
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
EP2270234B1 (en) 1997-12-08 2013-03-06 California Institute of Technology Method for creating polynucleotide and polypeptide sequences
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
AU774306B2 (en) * 1999-01-05 2004-06-24 Trustees Of Boston University Improved nucleic acid cloning
DE19909146A1 (de) * 1999-03-03 2000-09-28 Mohamed A Marahiel Verfahren zur gezielten biologischen Synthese von Peptiden
EP1041150A1 (en) * 1999-03-19 2000-10-04 Gesellschaft für Biotechnologische Forschung mbH (GBF) Hybrid synthetase, fungus/bacterium strain, hybrid peptide and compositions containing same
DE19928313A1 (de) * 1999-06-16 2000-12-21 Ullrich Keller Verfahren zur Veränderung von Peptidsynthefasen in der Weise, daß sie ihre Substrataminosäuren N-methylieren können
DE19951196A1 (de) * 1999-10-22 2001-05-10 Mohamed A Marahiel Massgeschneiderte Peptidsynthetasen und ihre Verwendung
AU1279901A (en) * 1999-11-05 2001-05-14 Biomade B.V. Methods for the preparation of (lipo)peptide synthetases and (lipo)peptides produced therewith
KR20100039443A (ko) * 2001-08-06 2010-04-15 큐비스트 파마슈티컬즈 인코포레이티드 답토마이신 생합성 유전자 클러스터에 관련된 조성물 및 방법
KR101043562B1 (ko) 2002-12-26 2011-06-22 교와 핫꼬 바이오 가부시키가이샤 디펩티드의 제조법
US20080051326A1 (en) * 2004-11-12 2008-02-28 Alexander Dylan C Antiinfective Lipopeptides
JP4881854B2 (ja) * 2005-03-18 2012-02-22 協和発酵バイオ株式会社 ジペプチドの製造法
WO2007025181A2 (en) * 2005-08-26 2007-03-01 Aureogen Biosciences Aureobasidin a synthetase
US20090197303A1 (en) * 2005-12-27 2009-08-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
US7981685B2 (en) * 2007-04-16 2011-07-19 Modular Genetics, Inc. Generation of acyl amino acids
WO2009028253A1 (ja) * 2007-08-31 2009-03-05 Kyowa Hakko Bio Co., Ltd. ペプチドの製造法
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
WO2014144649A1 (en) 2013-03-15 2014-09-18 Modular Genetics, Inc. Generation of acyl amino acids
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US12123004B2 (en) 2018-07-18 2024-10-22 Modular Genetics, Inc. Generation of acyl amino acids

Also Published As

Publication number Publication date
US5652116A (en) 1997-07-29
JPH07147978A (ja) 1995-06-13
EP0637630A2 (en) 1995-02-08
ITMI931534A0 (it) 1993-07-13
EP0637630A3 (en) 1997-11-05
ITMI931534A1 (it) 1995-01-13

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970710