IT1256320B - Derivati eterociclici - Google Patents
Derivati eterocicliciInfo
- Publication number
- IT1256320B IT1256320B ITMI922661A ITMI922661A IT1256320B IT 1256320 B IT1256320 B IT 1256320B IT MI922661 A ITMI922661 A IT MI922661A IT MI922661 A ITMI922661 A IT MI922661A IT 1256320 B IT1256320 B IT 1256320B
- Authority
- IT
- Italy
- Prior art keywords
- compounds
- relates
- heterocyclic derivatives
- new compounds
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invenzione riguarda composti farmaceuticamente utili di formula I, in cui R1, R2, R3, R4 e A1 hanno i diversi significati qui definiti, e loro sali non tossici e composizioni farmaceutiche che li contengono. I nuovi composti sono importanti nel trattamento di condizioni come ipertensione ed insufficienza cardiaca congestiva. L'invenzione riguarda inoltre procedimenti per la fabbricazione dei nuovi composti e l'impiego dei composti nel trattamento medico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919125842A GB9125842D0 (en) | 1991-12-04 | 1991-12-04 | Heterocyclic derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI922661A0 ITMI922661A0 (it) | 1992-11-20 |
| ITMI922661A1 ITMI922661A1 (it) | 1993-06-05 |
| IT1256320B true IT1256320B (it) | 1995-11-30 |
Family
ID=10705730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI922661A IT1256320B (it) | 1991-12-04 | 1992-11-20 | Derivati eterociclici |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPH05255327A (it) |
| BE (1) | BE1005473A3 (it) |
| CA (1) | CA2082668A1 (it) |
| DE (1) | DE4239440A1 (it) |
| FR (1) | FR2684672A1 (it) |
| GB (2) | GB9125842D0 (it) |
| IE (1) | IE922785A1 (it) |
| IT (1) | IT1256320B (it) |
| NL (1) | NL9202091A (it) |
| ZA (1) | ZA928742B (it) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5439911A (en) * | 1992-12-28 | 1995-08-08 | Shionogi & Co., Ltd. | Aminopyrimidine derivatives and their production and use |
| EP0618207B1 (en) * | 1993-03-24 | 1999-01-07 | American Home Products Corporation | Substituted pyridopyrimidines as antihypertensives |
| KR100300566B1 (ko) * | 1994-09-17 | 2001-11-22 | 조생현 | 피리미디논유도체와그의제조방법및용도 |
| US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
| US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
| EP1303495B1 (en) | 2000-07-24 | 2010-05-26 | Krenitsky Pharmaceuticals, Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| ES2257616T3 (es) * | 2003-04-25 | 2006-08-01 | Actimis Pharmaceuticals, Inc. | Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2. |
| WO2005073234A2 (en) | 2004-01-31 | 2005-08-11 | Actimis Pharmaceuticals, Inc. | Imidazo[1,2-c]pyrimidinylacetic acid derivatives |
| AU2008305633B2 (en) | 2007-09-25 | 2013-09-12 | Actimis Pharmaceuticals, Inc. | 2-S-benzyl substituted pyrimidines as CRTH2 antagonists |
| KR20100061747A (ko) | 2007-09-25 | 2010-06-08 | 액티미스 파마수티컬스 인코포레이티드 | Ｃｒｔｈ２ 길항제로서의 알킬티오 피리미딘 |
| KR102481705B1 (ko) * | 2020-08-04 | 2022-12-27 | 연세대학교 산학협력단 | 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물 |
| KR20230170658A (ko) * | 2021-04-09 | 2023-12-19 | 심시어 자이밍 파마슈티컬 컴퍼니 리미티드 | 유비퀴틴 특이적 프로테아제 1(usp1) 억제제 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0424317A3 (en) * | 1989-10-19 | 1991-09-25 | Ciba-Geigy Ag | Pyrimidines |
| IE912956A1 (en) * | 1990-09-10 | 1992-03-11 | Abbott Lab | Angiotensin ii receptor antagonists |
| US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
-
1991
- 1991-12-04 GB GB919125842A patent/GB9125842D0/en active Pending
-
1992
- 1992-11-03 IE IE278592A patent/IE922785A1/en not_active IP Right Cessation
- 1992-11-12 ZA ZA928742A patent/ZA928742B/xx unknown
- 1992-11-12 CA CA002082668A patent/CA2082668A1/en not_active Abandoned
- 1992-11-20 IT ITMI922661A patent/IT1256320B/it active IP Right Grant
- 1992-11-24 DE DE4239440A patent/DE4239440A1/de not_active Withdrawn
- 1992-11-30 FR FR9214376A patent/FR2684672A1/fr active Pending
- 1992-12-02 NL NL9202091A patent/NL9202091A/nl not_active Application Discontinuation
- 1992-12-03 BE BE9201065A patent/BE1005473A3/fr not_active IP Right Cessation
- 1992-12-03 GB GB9225283A patent/GB2262096A/en not_active Withdrawn
- 1992-12-04 JP JP4325478A patent/JPH05255327A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE922785A1 (en) | 1993-06-16 |
| JPH05255327A (ja) | 1993-10-05 |
| ITMI922661A0 (it) | 1992-11-20 |
| DE4239440A1 (it) | 1993-06-09 |
| GB9225283D0 (en) | 1993-01-27 |
| GB9125842D0 (en) | 1992-02-05 |
| NL9202091A (nl) | 1993-07-01 |
| CA2082668A1 (en) | 1993-06-05 |
| ITMI922661A1 (it) | 1993-06-05 |
| ZA928742B (en) | 1993-06-09 |
| FR2684672A1 (fr) | 1993-06-11 |
| BE1005473A3 (fr) | 1993-08-03 |
| GB2262096A (en) | 1993-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |