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IT1255449B - Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. - Google Patents

Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.

Info

Publication number
IT1255449B
IT1255449B ITMI921601A ITMI921601A IT1255449B IT 1255449 B IT1255449 B IT 1255449B IT MI921601 A ITMI921601 A IT MI921601A IT MI921601 A ITMI921601 A IT MI921601A IT 1255449 B IT1255449 B IT 1255449B
Authority
IT
Italy
Prior art keywords
derivatives
homo
bile acids
absorption promoters
drugs
Prior art date
Application number
ITMI921601A
Other languages
English (en)
Inventor
Fabio Berlati
Giancarlo Ceschel
Celestino Ronchi
Original Assignee
Fabio Berlati
Giancarlo Ceschel
Celestino Ronchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabio Berlati, Giancarlo Ceschel, Celestino Ronchi filed Critical Fabio Berlati
Publication of ITMI921601A0 publication Critical patent/ITMI921601A0/it
Priority to ITMI921601A priority Critical patent/IT1255449B/it
Priority to US08/360,833 priority patent/US5656277A/en
Priority to PCT/EP1993/001508 priority patent/WO1994000155A1/en
Priority to DK93912975T priority patent/DK0652773T3/da
Priority to JP6501998A priority patent/JPH07508013A/ja
Priority to ES93912975T priority patent/ES2114056T3/es
Priority to DE69316217T priority patent/DE69316217T2/de
Priority to AT93912975T priority patent/ATE161731T1/de
Priority to EP93912975A priority patent/EP0652773B1/en
Publication of ITMI921601A1 publication Critical patent/ITMI921601A1/it
Application granted granted Critical
Publication of IT1255449B publication Critical patent/IT1255449B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

E' descritto l'uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.Tali derivati presentano il vantaggio di migliorare l'assorbimento di farmaci attraverso le mucose e di non essere metabolizzati dalla flora intestinale, potendo così essere rapidamente escreti. Inoltre, i derivati dell'invenzione presentano tossicità assolutamente trascurabile.
ITMI921601A 1992-06-30 1992-06-30 Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci. IT1255449B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI921601A IT1255449B (it) 1992-06-30 1992-06-30 Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
JP6501998A JPH07508013A (ja) 1992-06-30 1993-06-15 医薬物用吸収促進剤としてのノルおよびホモ胆汁酸誘導体の使用
PCT/EP1993/001508 WO1994000155A1 (en) 1992-06-30 1993-06-15 The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments
DK93912975T DK0652773T3 (da) 1992-06-30 1993-06-15 Anvendelse af nor- og homo-galdesyrederivater somabsorptionsfremmende bestanddele i lægemidler
US08/360,833 US5656277A (en) 1992-06-30 1993-06-15 Nor- and homo- bile acids derivatives as absorption enhancers for medicaments
ES93912975T ES2114056T3 (es) 1992-06-30 1993-06-15 Uso de derivados nor y homo de acidos biliares como potenciadores de absorcion para medicamentos.
DE69316217T DE69316217T2 (de) 1992-06-30 1993-06-15 Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel
AT93912975T ATE161731T1 (de) 1992-06-30 1993-06-15 Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel
EP93912975A EP0652773B1 (en) 1992-06-30 1993-06-15 The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921601A IT1255449B (it) 1992-06-30 1992-06-30 Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.

Publications (3)

Publication Number Publication Date
ITMI921601A0 ITMI921601A0 (it) 1992-06-30
ITMI921601A1 ITMI921601A1 (it) 1993-12-30
IT1255449B true IT1255449B (it) 1995-10-31

Family

ID=11363597

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921601A IT1255449B (it) 1992-06-30 1992-06-30 Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.

Country Status (9)

Country Link
US (1) US5656277A (it)
EP (1) EP0652773B1 (it)
JP (1) JPH07508013A (it)
AT (1) ATE161731T1 (it)
DE (1) DE69316217T2 (it)
DK (1) DK0652773T3 (it)
ES (1) ES2114056T3 (it)
IT (1) IT1255449B (it)
WO (1) WO1994000155A1 (it)

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EP0821970A1 (en) * 1996-08-02 1998-02-04 Edward Henri Charles Verhaeren Carrier composition for influencing the tight junction permeability
ATE321882T1 (de) * 1997-07-01 2006-04-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
WO2000019978A2 (en) 1998-10-05 2000-04-13 The Penn State Research Foundation Compositions and methods for enhancing receptor-mediated cellular internalization
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US20030118547A1 (en) * 2000-01-27 2003-06-26 Vandenberg Grant William Composition for intestinal delivery
JP4452970B2 (ja) * 2002-03-27 2010-04-21 日本臓器製薬株式会社 ジクロフェナクナトリウム経口製剤
JP4584987B2 (ja) 2004-04-30 2010-11-24 アルニラム ファーマスーティカルズ インコーポレイテッド Ｃ５修飾ピリミジンを含むオリゴヌクレオチド
SI2392337T1 (sl) 2005-05-12 2015-10-30 Medizinische Universitaet Graz Uporaba 24-norUDCA
WO2009013334A1 (en) * 2007-07-25 2009-01-29 Medizinische Universität Graz Use of nor-bile acids in the treatment of arteriosclerosis
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
SG11201703717SA (en) 2014-11-06 2017-06-29 Enanta Pharm Inc Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
US11578097B2 (en) 2014-11-26 2023-02-14 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof
JP2017535570A (ja) 2014-11-26 2017-11-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2016130809A1 (en) 2015-02-11 2016-08-18 Enanta Pharmaceuticals, Inc. Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
SI3277286T1 (sl) 2015-03-31 2021-09-30 Enanta Pharmaceuticals, Inc. Derivati žolčne kisline kot antagonisti FXR/TGR5 in metode za njihovo uporabo
US10323061B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
EP3548038B1 (en) 2016-11-29 2022-04-13 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonylurea bile acid derivatives
US10472386B2 (en) 2017-02-14 2019-11-12 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR agonists and methods of use thereof
AU2018249950B2 (en) 2017-04-07 2023-09-21 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonyl carbamate bile acid derivatives
GB201911821D0 (en) 2019-08-16 2019-10-02 Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid Compounds for use in the treatment of liver disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746508A (en) * 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Also Published As

Publication number Publication date
ITMI921601A0 (it) 1992-06-30
DK0652773T3 (da) 1998-09-07
ATE161731T1 (de) 1998-01-15
EP0652773B1 (en) 1998-01-07
DE69316217D1 (de) 1998-02-12
ITMI921601A1 (it) 1993-12-30
US5656277A (en) 1997-08-12
WO1994000155A1 (en) 1994-01-06
EP0652773A1 (en) 1995-05-17
ES2114056T3 (es) 1998-05-16
JPH07508013A (ja) 1995-09-07
DE69316217T2 (de) 1998-08-20

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960627