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IT1247034B - Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono - Google Patents

Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono

Info

Publication number
IT1247034B
IT1247034B ITFI910160A ITFI910160A IT1247034B IT 1247034 B IT1247034 B IT 1247034B IT FI910160 A ITFI910160 A IT FI910160A IT FI910160 A ITFI910160 A IT FI910160A IT 1247034 B IT1247034 B IT 1247034B
Authority
IT
Italy
Prior art keywords
production process
diphosphonics
dimethylamine
salts
pharmaceutical compositions
Prior art date
Application number
ITFI910160A
Other languages
English (en)
Inventor
Sergio Rosini
Giuseppe Guainai-Ricci
Maurizio Mian
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ITFI910160A0 publication Critical patent/ITFI910160A0/it
Priority to ITFI910160A priority Critical patent/IT1247034B/it
Priority to AU21507/92A priority patent/AU2150792A/en
Priority to PCT/IT1992/000058 priority patent/WO1993000348A1/en
Priority to EP92913148A priority patent/EP0592488A1/en
Priority to JP5501416A priority patent/JPH06508833A/ja
Priority to CA002112250A priority patent/CA2112250A1/en
Priority to MX9203205A priority patent/MX9203205A/es
Priority to PT100624A priority patent/PT100624B/pt
Publication of ITFI910160A1 publication Critical patent/ITFI910160A1/it
Application granted granted Critical
Publication of IT1247034B publication Critical patent/IT1247034B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Acidi dimetilamino 1-idrossi-alcan-1,1-difosfonici di formula: (FORMULA) in cui n= 4, 5, e loro procedimento produttivo.
ITFI910160A 1991-06-26 1991-06-26 Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono IT1247034B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITFI910160A IT1247034B (it) 1991-06-26 1991-06-26 Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono
JP5501416A JPH06508833A (ja) 1991-06-26 1992-05-27 ジメチルアミノ−ヒドロキシ−アルカンジホスホン酸類およびこれらを含有する医薬組成物
PCT/IT1992/000058 WO1993000348A1 (en) 1991-06-26 1992-05-27 Dimethylamino-hydroxy-alkan diphosphonic acids and pharmaceutical compositions containing them
EP92913148A EP0592488A1 (en) 1991-06-26 1992-05-27 Dimethylamino-hydroxy-alkan diphosphonic acids and pharmaceutical compositions containing them
AU21507/92A AU2150792A (en) 1991-06-26 1992-05-27 Dimethylamino-hydroxy-alkan diphosphonic acids and pharmaceutical compositions containing them
CA002112250A CA2112250A1 (en) 1991-06-26 1992-05-27 Dimethylamino-hydroxy-alkan diphosphonic acids and pharmaceutical compositions containing them
MX9203205A MX9203205A (es) 1991-06-26 1992-06-24 Novedosos acidos dimetilamino-hidroxi-alcan-difosfonicos y sales de los mismos, en procedimiento de produccion y composiciones farmaceuticas relacionadas.
PT100624A PT100624B (pt) 1991-06-26 1992-06-25 Novos acidos dimetilamino-hidroxi-alcano-difosfonicos e seus sais, processo para a sua preparacao e composicoes farmaceuticas que os contem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI910160A IT1247034B (it) 1991-06-26 1991-06-26 Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono

Publications (3)

Publication Number Publication Date
ITFI910160A0 ITFI910160A0 (it) 1991-06-26
ITFI910160A1 ITFI910160A1 (it) 1992-12-26
IT1247034B true IT1247034B (it) 1994-12-12

Family

ID=11349724

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI910160A IT1247034B (it) 1991-06-26 1991-06-26 Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono

Country Status (8)

Country Link
EP (1) EP0592488A1 (it)
JP (1) JPH06508833A (it)
AU (1) AU2150792A (it)
CA (1) CA2112250A1 (it)
IT (1) IT1247034B (it)
MX (1) MX9203205A (it)
PT (1) PT100624B (it)
WO (1) WO1993000348A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1303672B1 (it) 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
ES2336312T3 (es) * 2001-07-16 2010-04-12 Universite Paris 13 Procedimiento de preparacion de derivados de bisfosfonatos.
DE102014115154A1 (de) * 2014-10-17 2016-04-21 SCV-SpezialChemikalien-Vertrieb GmbH Konjugierte Bisphosphonate für die Diagnostik und Therapie von Knochenerkrankungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194748B (it) * 1981-02-12 1988-09-28 Gentili Ist Spa Composizioni farmaceutiche per il trattamento di osteopatie
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
ITFI910160A0 (it) 1991-06-26
MX9203205A (es) 1994-06-30
JPH06508833A (ja) 1994-10-06
AU2150792A (en) 1993-01-25
PT100624A (pt) 1993-10-29
CA2112250A1 (en) 1993-01-07
PT100624B (pt) 1999-07-30
ITFI910160A1 (it) 1992-12-26
EP0592488A1 (en) 1994-04-20
WO1993000348A1 (en) 1993-01-07

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950622