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IN2014DN10764A - - Google Patents

Info

Publication number
IN2014DN10764A
IN2014DN10764A IN10764DEN2014A IN2014DN10764A IN 2014DN10764 A IN2014DN10764 A IN 2014DN10764A IN 10764DEN2014 A IN10764DEN2014 A IN 10764DEN2014A IN 2014DN10764 A IN2014DN10764 A IN 2014DN10764A
Authority
IN
India
Prior art keywords
sulforaphane
cyclodextrin
synthesising
aqueous solvent
reacting
Prior art date
Application number
Inventor
Sahadeva Reddy Damireddi
Kpakpo Ambroise Akue
Jared K Nelson
Albert Roger Frisbee
Peter Wyatt Newsome
Original Assignee
Pharmagra Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagra Labs Inc filed Critical Pharmagra Labs Inc
Publication of IN2014DN10764A publication Critical patent/IN2014DN10764A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
    • C07C331/20—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.
IN10764DEN2014 2012-06-01 2013-05-31 IN2014DN10764A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654277P 2012-06-01 2012-06-01
PCT/GB2013/051458 WO2013179057A1 (en) 2012-06-01 2013-05-31 Method of synthesising sulforaphane

Publications (1)

Publication Number Publication Date
IN2014DN10764A true IN2014DN10764A (en) 2015-09-04

Family

ID=48576452

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10764DEN2014 IN2014DN10764A (en) 2012-06-01 2013-05-31

Country Status (14)

Country Link
US (4) US9567405B2 (en)
EP (1) EP2854861B1 (en)
JP (2) JP6130910B2 (en)
CN (1) CN104703628B (en)
AU (1) AU2013269340B9 (en)
BR (1) BR112014029841B1 (en)
CA (1) CA2875063C (en)
DK (1) DK2854861T3 (en)
ES (1) ES2653248T3 (en)
HU (1) HUE038055T2 (en)
IN (1) IN2014DN10764A (en)
NO (1) NO2882932T3 (en)
PL (1) PL2854861T3 (en)
WO (1) WO2013179057A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105001135B (en) * 2015-07-10 2017-04-12 北京化工大学 Chemical synthetic method for raphanin
CN108503568A (en) * 2017-02-27 2018-09-07 无锡杰西医药股份有限公司 A kind of high-purity isosulfocyanate compound preparation method suitable for industrialized production
CN107468666B (en) * 2017-08-18 2021-01-01 赣州华汉生物科技有限公司 Sulforaphane capsule capable of being stably stored and preparation method thereof
EP4241878A3 (en) 2018-09-24 2023-11-15 Chevron Phillips Chemical Company LP Methods for making supported chromium catalysts with increased polymerization activity
GB202005238D0 (en) 2020-04-08 2020-05-20 Evgen Pharma Plc Crystalline complexes
US11801273B2 (en) 2020-12-23 2023-10-31 Church & Dwight Co., Inc. Compositions and methods to increase production of isothiocyanates

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US135618A (en) 1873-02-11 Improvement in printing-presses
JP3604172B2 (en) 1994-03-22 2004-12-22 株式会社白元 Disinfection composition and disinfection method
FR2776666B1 (en) 1998-03-31 2002-09-06 Commissariat Energie Atomique COMPLEXES OF INCLUSION IN CYCLODEXTRINS OF ORGANIC ISOTHIOCYANATES, IN PARTICULAR BACTERIOSTATICS, BACTERICIDES AND / OR FUNGICIDES OR THEIR NATURAL PRECURSORS, AND THEIR PREPARATION
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
KR20020063914A (en) 1999-12-20 2002-08-05 코니스 프랑스, 에스.에이. Cosmetic and/or pharmaceutical preparations
JP5132865B2 (en) 2000-08-21 2013-01-30 ジェド ダブリュ． ファーヒー Treatment of Helicobacter with isothiocyanate
JP2002187842A (en) 2000-12-19 2002-07-05 Toyo Shinyaku:Kk Processed product of kale and method for processing the same
JP2003146803A (en) 2001-11-13 2003-05-21 Carex Inc Antimicrobial powder composition and method for producing the same
FR2845599B1 (en) 2002-10-11 2005-01-07 Lmd MEDICAMENT COMPRISING A THIOUREE FOR ITS USE AS A DEPIGMENTING
CA2603235A1 (en) 2005-03-28 2006-10-05 Bioresponse, Llc Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health
FR2888235B1 (en) 2005-07-07 2007-09-14 Nutrinov Sa PROCESS FOR EXTRACTING SULFORAPHANE FROM CRUCIFEROUS BROYA CONTAINING GLUCORAPHANINE
WO2008008954A2 (en) 2006-07-14 2008-01-17 Wisconsin Alumni Research Foundation Isothiocyanates and glucosinolate compounds and anti-tumor compositios containing same
WO2008015315A1 (en) 2006-08-03 2008-02-07 Lmd Thiourea-containing medicinal compounds for treating cancer in association with chemotheraputic agents or ionizing or non-ionizing radiation
CN101120948A (en) 2006-08-08 2008-02-13 普文英 Compound composition with chemical protecting, cancer preventing and treating use
WO2008091608A1 (en) * 2007-01-23 2008-07-31 Pharmagra Labs, Inc. Stabilized sulforaphane
CN102249968B (en) 2011-06-17 2013-07-17 常州大学 Synthetic method for sulforaphane
CN102423492A (en) 2011-12-31 2012-04-25 肖广惠 Sulforaphane inclusion compound and preparation method thereof
CN102688219A (en) 2012-02-03 2012-09-26 马建华 Sulforaphane microencapsulation method

Also Published As

Publication number Publication date
WO2013179057A1 (en) 2013-12-05
JP2015518041A (en) 2015-06-25
JP6130910B2 (en) 2017-05-17
NO2882932T3 (en) 2018-08-04
US20190282534A1 (en) 2019-09-19
US9567405B2 (en) 2017-02-14
JP2017141288A (en) 2017-08-17
CA2875063A1 (en) 2013-12-05
AU2013269340A1 (en) 2015-01-22
AU2013269340A8 (en) 2015-03-12
US10864186B2 (en) 2020-12-15
BR112014029841B1 (en) 2021-01-19
HUE038055T2 (en) 2018-10-29
BR112014029841A2 (en) 2017-06-27
DK2854861T3 (en) 2018-01-02
CA2875063C (en) 2021-01-12
AU2013269340B9 (en) 2017-08-17
JP6385511B2 (en) 2018-09-05
ES2653248T3 (en) 2018-02-06
PL2854861T3 (en) 2018-02-28
CN104703628B (en) 2017-09-08
US20210212978A1 (en) 2021-07-15
EP2854861B1 (en) 2017-10-04
CN104703628A (en) 2015-06-10
US10307390B2 (en) 2019-06-04
EP2854861A1 (en) 2015-04-08
US20150191551A1 (en) 2015-07-09
US20170112796A1 (en) 2017-04-27
US11571406B2 (en) 2023-02-07
AU2013269340B2 (en) 2017-02-16

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