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IN2014DN09053A - - Google Patents

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Publication number
IN2014DN09053A
IN2014DN09053A IN9053DEN2014A IN2014DN09053A IN 2014DN09053 A IN2014DN09053 A IN 2014DN09053A IN 9053DEN2014 A IN9053DEN2014 A IN 9053DEN2014A IN 2014DN09053 A IN2014DN09053 A IN 2014DN09053A
Authority
IN
India
Prior art keywords
tetrahydrolactoylpterin
lactoylpterin
sepiapterin
reaction formula
good yield
Prior art date
Application number
Inventor
Hiroshi Yoshino
Taichi Komoda
Yuichi Shiro
Shunichi Murata
Shizuaki Murata
Yasuhiro Kuroda
Original Assignee
Shiratori Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiratori Pharm filed Critical Shiratori Pharm
Publication of IN2014DN09053A publication Critical patent/IN2014DN09053A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided is a method for producing sepiapterin lactoylpterin and tetrahydrolactoylpterin. Sepiapterin lactoylpterin and tetrahydrolactoylpterin are obtained at a good yield by the reaction formula.
IN9053DEN2014 2012-05-07 2013-05-07 IN2014DN09053A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012105758 2012-05-07
JP2012247255 2012-11-09
PCT/JP2013/062817 WO2013168693A1 (en) 2012-05-07 2013-05-07 Method for producing sepiapterin and tetrahydrolactoylpterin

Publications (1)

Publication Number Publication Date
IN2014DN09053A true IN2014DN09053A (en) 2015-05-22

Family

ID=49550728

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9053DEN2014 IN2014DN09053A (en) 2012-05-07 2013-05-07

Country Status (7)

Country Link
US (1) US9181254B2 (en)
EP (1) EP2848619B1 (en)
JP (1) JP6084967B2 (en)
CN (1) CN104736539B (en)
ES (1) ES2681345T3 (en)
IN (1) IN2014DN09053A (en)
WO (1) WO2013168693A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5066756B2 (en) 2010-04-22 2012-11-07 学校法人日本大学 Drugs and foods for prevention and improvement of brain dysfunction
JP6809781B2 (en) * 2015-11-18 2021-01-06 白鳥製薬株式会社 Pterin derivative or salt thereof
WO2018102314A1 (en) 2016-11-29 2018-06-07 Censa Pharmaceuticals Inc. Polymorphic form of sepiapterin
CN116903624A (en) * 2016-11-29 2023-10-20 Ptc医疗Mp公司 Polymorphs of aminopterin and salts thereof
EP3675863A4 (en) 2017-09-01 2021-01-27 PTC Therapeutics MP, Inc. Pharmaceutical compositions comprising sepiapterin and uses thereof
CA3102106A1 (en) 2018-05-30 2019-12-05 Ptc Therapeutics Mp, Inc. Methods for increasing sepiapterin plasma exposure
BR112020024332A2 (en) * 2018-05-30 2021-02-23 Ptc Therapeutics Mp, Inc. pharmaceutically acceptable salts of sepiapterin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172877A (en) 1985-01-28 1986-08-04 Shiratori Seiyaku Kk Production of (6r)-tetrahydro-l-biopterin
US4713454A (en) 1985-01-28 1987-12-15 Shiratori Pharmaceutical Co., Ltd. Preparation process of (6R)-tetrahydro-L-biopterin
AU2004290692A1 (en) 2003-11-17 2005-06-02 Biomarin Pharmaceutical Inc. Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin
JP2011011976A (en) 2007-10-10 2011-01-20 Shiratori Pharmaceutical Co Ltd Method for producing pteridine compound and l-biopterin
JP5066756B2 (en) 2010-04-22 2012-11-07 学校法人日本大学 Drugs and foods for prevention and improvement of brain dysfunction

Also Published As

Publication number Publication date
CN104736539B (en) 2017-09-01
CN104736539A (en) 2015-06-24
EP2848619A1 (en) 2015-03-18
EP2848619B1 (en) 2018-07-11
US9181254B2 (en) 2015-11-10
ES2681345T3 (en) 2018-09-12
JP6084967B2 (en) 2017-02-22
EP2848619A4 (en) 2015-11-04
JPWO2013168693A1 (en) 2016-01-07
US20150119574A1 (en) 2015-04-30
WO2013168693A1 (en) 2013-11-14

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