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IN2014DN07983A - - Google Patents

Info

Publication number
IN2014DN07983A
IN2014DN07983A IN7983DEN2014A IN2014DN07983A IN 2014DN07983 A IN2014DN07983 A IN 2014DN07983A IN 7983DEN2014 A IN7983DEN2014 A IN 7983DEN2014A IN 2014DN07983 A IN2014DN07983 A IN 2014DN07983A
Authority
IN
India
Prior art keywords
aceton
dimethylbenzene
bromo
preparation
discloses
Prior art date
Application number
Inventor
Doerwald Florencio Zaragoza
Anna Kulesza
Stephan Elzner
Robert Bujok
Zbigniew Wrobel
Krzysztof Wojciechowski
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN07983(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070870 external-priority patent/WO2012172119A2/en
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IN2014DN07983A publication Critical patent/IN2014DN07983A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton.
IN7983DEN2014 2012-05-08 2012-11-15 IN2014DN07983A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261644284P 2012-05-08 2012-05-08
EP12167134 2012-05-08
PCT/EP2012/070870 WO2012172119A2 (en) 2012-05-08 2012-10-22 Method for the preparation of medetomidine
EP12192612 2012-11-14
PCT/EP2012/072796 WO2013011155A2 (en) 2012-05-08 2012-11-15 Method for preparation of medetomidine

Publications (1)

Publication Number Publication Date
IN2014DN07983A true IN2014DN07983A (en) 2015-05-01

Family

ID=47558543

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7983DEN2014 IN2014DN07983A (en) 2012-05-08 2012-11-15

Country Status (21)

Country Link
US (1) US9045433B2 (en)
EP (1) EP2847173B1 (en)
JP (1) JP5779297B2 (en)
KR (1) KR101530506B1 (en)
CN (1) CN104245679B (en)
AU (1) AU2012285675B2 (en)
CA (1) CA2866424A1 (en)
CL (1) CL2014002905A1 (en)
CY (1) CY1117490T1 (en)
DK (1) DK2847173T3 (en)
EA (1) EA025950B1 (en)
ES (1) ES2563816T3 (en)
HK (1) HK1201532A1 (en)
HR (1) HRP20160215T1 (en)
HU (1) HUE027384T2 (en)
IN (1) IN2014DN07983A (en)
MY (1) MY166058A (en)
PL (1) PL2847173T3 (en)
SG (1) SG11201405606RA (en)
TW (1) TWI529164B (en)
WO (1) WO2013011155A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012285675B2 (en) * 2012-05-08 2016-03-03 Lonza Ltd Method for preparation of medetomidine
MY165212A (en) * 2012-05-08 2018-03-05 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1- propanal
EP2867211B1 (en) * 2012-06-28 2015-12-30 Lonza Ltd Method for preparation of medetomidine with chloroacetone
JP5779298B2 (en) 2012-06-28 2015-09-16 ロンザ・リミテッド Method for preparing 2- (2,3-dimethylphenyl) -1-propanal using chloroacetone
CN106518812A (en) * 2016-10-25 2017-03-22 湖南大学 Preparation method of medetomidine and intermediate thereof
CN111548308A (en) * 2020-03-18 2020-08-18 遂成药业股份有限公司 Synthesis process of dexmedetomidine hydrochloride
KR102341174B1 (en) * 2021-09-13 2021-12-20 주식회사 세라수 a method for acidifying terephthalylidene dicamphor sulfonate using cation exchange fiber
CN114671811A (en) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 Racemization recovery method of dexmedetomidine resolution byproduct

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790604A (en) 1971-10-28 1973-04-26 Sandoz Sa NEW AMINOALCANOLS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
DE3586403T2 (en) 1984-02-24 1993-02-04 Sagami Chem Res METHOD FOR ISOMERIZING A GLYCIDATE.
JPS62103037A (en) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk Production of 2-(4-isobutylphenyl)-propionaldehyde
DE19714042A1 (en) 1997-04-05 1998-10-08 Henkel Kgaa Process for the preparation of aromatic aldehydes
SE513474C2 (en) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Method for preventing crustaceans, especially sea turtles, establishment on solid surfaces by a substance that disturbs nerve signals, the substance being medetomidine, ie (+) - 4- / 1- (2,3-dimethylphenyl) -ethyl / -IH- imidazole
EP1918282A1 (en) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) * 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
WO2011070069A1 (en) 2009-12-09 2011-06-16 I-Tech Ab Process for preparation of medetomidine
AU2012285675B2 (en) * 2012-05-08 2016-03-03 Lonza Ltd Method for preparation of medetomidine
WO2012172120A2 (en) 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
MY165212A (en) 2012-05-08 2018-03-05 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1- propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
EP2867211B1 (en) 2012-06-28 2015-12-30 Lonza Ltd Method for preparation of medetomidine with chloroacetone
JP5779298B2 (en) 2012-06-28 2015-09-16 ロンザ・リミテッド Method for preparing 2- (2,3-dimethylphenyl) -1-propanal using chloroacetone
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone

Also Published As

Publication number Publication date
WO2013011155A3 (en) 2013-04-04
AU2012285675A1 (en) 2014-10-16
JP5779297B2 (en) 2015-09-16
DK2847173T3 (en) 2016-04-04
EP2847173B1 (en) 2015-12-30
CN104245679B (en) 2016-03-02
SG11201405606RA (en) 2014-11-27
US20150057453A1 (en) 2015-02-26
MY166058A (en) 2018-05-22
KR101530506B1 (en) 2015-06-19
ES2563816T3 (en) 2016-03-16
CL2014002905A1 (en) 2014-12-12
JP2015517472A (en) 2015-06-22
CA2866424A1 (en) 2013-01-24
HRP20160215T1 (en) 2016-03-25
WO2013011155A2 (en) 2013-01-24
AU2012285675B2 (en) 2016-03-03
PL2847173T3 (en) 2016-06-30
EA025950B1 (en) 2017-02-28
KR20140136523A (en) 2014-11-28
EP2847173A2 (en) 2015-03-18
EA201400940A1 (en) 2015-01-30
HK1201532A1 (en) 2015-09-04
TWI529164B (en) 2016-04-11
NZ700640A (en) 2016-03-31
TW201408648A (en) 2014-03-01
CN104245679A (en) 2014-12-24
US9045433B2 (en) 2015-06-02
CY1117490T1 (en) 2017-04-26
HUE027384T2 (en) 2016-10-28

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