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IN2014DN03167A - - Google Patents

Info

Publication number
IN2014DN03167A
IN2014DN03167A IN3167DEN2014A IN2014DN03167A IN 2014DN03167 A IN2014DN03167 A IN 2014DN03167A IN 3167DEN2014 A IN3167DEN2014 A IN 3167DEN2014A IN 2014DN03167 A IN2014DN03167 A IN 2014DN03167A
Authority
IN
India
Prior art keywords
sample
photo detector
detector means
reference beam
fluorescence
Prior art date
Application number
Inventor
Véronica Lucia Rossi
Giuseppe Ferorelli
Massimo Galdiero
Franco Francini
David Jafrancesco
Original Assignee
Biomerieux Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux Sa filed Critical Biomerieux Sa
Publication of IN2014DN03167A publication Critical patent/IN2014DN03167A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0624—Compensating variation in output of LED source

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention relates to a System (1) for the in vitro detection and/or quantification, by fluorometry, of at least one analyte in a sample (E) of fluid constituting a biological material, in particular for an immunological test, including a radiation source (10), followed by an optical splitter (13) for splitting the main beam (FP) into a sample-energizing beam (FE) and a reference beam, with a first photo detector means (14) for detecting a fluorescence ray (RF) emitted by the sample and a second photo detector means (15) for the reference beam, said System also including a generator (300) outputting a sinusoidal carrier signal (SNM) and at least one digital demodulation signal (SINE, COSINE), and a digital processing means for processing, by demodulation, the signals from the two photo detector means in order to extract a fluorescence value (VALF) that is characteristic of the amplitude of the fluorescence ray and a second reference value (VALR) that is characteristic of the amplitude of the reference beam. The present invention can be used in automated instruments for in vitro diagnosis in the clinical or industrial fields.
IN3167DEN2014 2011-09-26 2012-09-25 IN2014DN03167A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1158532A FR2980577B1 (en) 2011-09-26 2011-09-26 IN VITRO FLUORIMETRIC DETECTION AND / OR QUANTIFICATION SYSTEM
PCT/FR2012/052136 WO2013045807A1 (en) 2011-09-26 2012-09-25 System for in vitro detection and/or quantification by fluorometry

Publications (1)

Publication Number Publication Date
IN2014DN03167A true IN2014DN03167A (en) 2015-06-26

Family

ID=47023007

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3167DEN2014 IN2014DN03167A (en) 2011-09-26 2012-09-25

Country Status (9)

Country Link
US (1) US9632031B2 (en)
EP (1) EP2776812A1 (en)
JP (1) JP6239515B2 (en)
KR (1) KR102099230B1 (en)
CN (1) CN103874915B (en)
BR (1) BR112014007122B1 (en)
FR (1) FR2980577B1 (en)
IN (1) IN2014DN03167A (en)
WO (1) WO2013045807A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104655863B (en) * 2015-02-10 2016-08-24 中国科学院苏州生物医学工程技术研究所 A kind of sample delivery detecting system
FR3035716B1 (en) 2015-04-30 2019-06-21 Biomerieux MACHINE AND METHOD FOR AUTOMATED IN VITRO DETECTION OF ANALYTES USING CHROMATIC SPECTRAL DECOMPOSITION OF AN OPTICAL RESPONSE
JP6861288B2 (en) * 2017-01-30 2021-04-21 メディビーコン，インク． Non-invasive monitoring method of fluorescent tracer agent using diffuse reflection correction
US10945324B2 (en) * 2017-11-30 2021-03-09 Osram Gmbh External assessment device for a lighting system and method of assessing a lighting system
WO2020028766A1 (en) * 2018-08-02 2020-02-06 The Charles Stark Draper Laboratory, Inc. Fluorescence lifetime well array reader and actuator
EP4012610A1 (en) * 2020-12-11 2022-06-15 Biomerieux Detection method for sample presence and device associated
CN113720825B (en) * 2021-11-04 2022-02-08 四川丹诺迪科技有限公司 Optical instant detector and detection method and application
CN114200541B (en) * 2021-12-02 2023-02-24 吉林大学 Three-dimensional gravity-magnetic joint inversion method based on cosine dot product gradient constraint
CN115326762B (en) * 2022-07-08 2024-09-03 常州罗盘星检测科技有限公司 Dissolved oxygen concentration detection system and detection method

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FR2848669B1 (en) 2002-12-12 2005-09-02 Commissariat Energie Atomique METHOD FOR MEASURING A QUANTITY OF PHOTONS PROPORTIONAL TO THE QUANTITY OF PHOTONS RECEIVED BY THE OBJECT AND ASSOCIATED DEVICE
GB2404013B (en) * 2003-07-17 2006-05-31 Isis Innovation Apparatus for and method of measuring fluorescence lifetime
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Also Published As

Publication number Publication date
BR112014007122A2 (en) 2017-04-11
US20140252246A1 (en) 2014-09-11
US9632031B2 (en) 2017-04-25
KR20140067152A (en) 2014-06-03
CN103874915B (en) 2018-08-10
FR2980577A1 (en) 2013-03-29
FR2980577B1 (en) 2013-09-20
JP6239515B2 (en) 2017-11-29
CN103874915A (en) 2014-06-18
EP2776812A1 (en) 2014-09-17
KR102099230B1 (en) 2020-04-10
JP2014531019A (en) 2014-11-20
BR112014007122B1 (en) 2020-11-17
WO2013045807A1 (en) 2013-04-04

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