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IN2014MN02559A - - Google Patents

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Publication number
IN2014MN02559A
IN2014MN02559A IN2559MUN2014A IN2014MN02559A IN 2014MN02559 A IN2014MN02559 A IN 2014MN02559A IN 2559MUN2014 A IN2559MUN2014 A IN 2559MUN2014A IN 2014MN02559 A IN2014MN02559 A IN 2014MN02559A
Authority
IN
India
Prior art keywords
suspension array
array
multiplex
multiplexing capacity
suspension
Prior art date
Application number
Inventor
Dayong Jin
Yiqing Lu
Jiangbo Zhao
Original Assignee
Univ Macquarie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2012902652A external-priority patent/AU2012902652A0/en
Application filed by Univ Macquarie filed Critical Univ Macquarie
Publication of IN2014MN02559A publication Critical patent/IN2014MN02559A/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B42—BOOKBINDING; ALBUMS; FILES; SPECIAL PRINTED MATTER
    • B42D—BOOKS; BOOK COVERS; LOOSE LEAVES; PRINTED MATTER CHARACTERISED BY IDENTIFICATION OR SECURITY FEATURES; PRINTED MATTER OF SPECIAL FORMAT OR STYLE NOT OTHERWISE PROVIDED FOR; DEVICES FOR USE THEREWITH AND NOT OTHERWISE PROVIDED FOR; MOVABLE-STRIP WRITING OR READING APPARATUS
    • B42D25/00—Information-bearing cards or sheet-like structures characterised by identification or security features; Manufacture thereof
    • B42D25/30—Identification or security features, e.g. for preventing forgery
    • B42D25/36—Identification or security features, e.g. for preventing forgery comprising special materials
    • B42D25/378—Special inks
    • B42D25/382—Special inks absorbing or reflecting infrared light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B42—BOOKBINDING; ALBUMS; FILES; SPECIAL PRINTED MATTER
    • B42D—BOOKS; BOOK COVERS; LOOSE LEAVES; PRINTED MATTER CHARACTERISED BY IDENTIFICATION OR SECURITY FEATURES; PRINTED MATTER OF SPECIAL FORMAT OR STYLE NOT OTHERWISE PROVIDED FOR; DEVICES FOR USE THEREWITH AND NOT OTHERWISE PROVIDED FOR; MOVABLE-STRIP WRITING OR READING APPARATUS
    • B42D25/00—Information-bearing cards or sheet-like structures characterised by identification or security features; Manufacture thereof
    • B42D25/30—Identification or security features, e.g. for preventing forgery
    • B42D25/36—Identification or security features, e.g. for preventing forgery comprising special materials
    • B42D25/378—Special inks
    • B42D25/387—Special inks absorbing or reflecting ultraviolet light
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/50—Sympathetic, colour changing or similar inks
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7766—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing two or more rare earth metals
    • C09K11/7772—Halogenides
    • C09K11/7773—Halogenides with alkali or alkaline earth metal
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/18—Metal complexes
    • C09K2211/182—Metal complexes of the rare earth metals, i.e. Sc, Y or lanthanide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A system device and/or method for multiplex assays. In a particular but non limiting example there is provided a multiplex array such as a suspension array. Luminescence decay lifetimes are utilised for probes in a suspension array and coding/decoding the codes from time resolved spectra. Lifetime populations can be generated at distinct colour bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations thereby expanding the multiplexing capacity of a suspension array. In one example form the multiplexing capacity of a suspension array can be expanded to the order of about 5. This provides a reliable high throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences data storage and security.
IN2559MUN2014 2012-06-22 2013-06-21 IN2014MN02559A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2012902652A AU2012902652A0 (en) 2012-06-22 Multiplex suspension assay/array using lifetime coding
PCT/AU2013/000672 WO2013188927A1 (en) 2012-06-22 2013-06-21 Multiplex suspension assay/array using lifetime coding

Publications (1)

Publication Number Publication Date
IN2014MN02559A true IN2014MN02559A (en) 2015-07-24

Family

ID=49767949

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2559MUN2014 IN2014MN02559A (en) 2012-06-22 2013-06-21

Country Status (6)

Country Link
US (1) US9816926B2 (en)
EP (1) EP2864783A4 (en)
CN (1) CN104641233B (en)
AU (1) AU2013277946B2 (en)
IN (1) IN2014MN02559A (en)
WO (1) WO2013188927A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106574182A (en) * 2014-07-15 2017-04-19 耶路撒冷希伯来大学伊森姆研究发展有限公司 Patterns of fluorescent seeded nanorods
RU2584922C1 (en) * 2014-12-15 2016-05-20 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Multichannel fibre-optic neural interface for multimodal microscopy of animal brain
US10081736B2 (en) * 2015-05-18 2018-09-25 Troy Group, Inc. Composition and method of making NIR-to-visible upconversion inkjet inks
US20170038299A1 (en) * 2015-08-07 2017-02-09 Sentinel Monitoring Systems, Inc. Online process monitoring
WO2017112025A2 (en) 2015-10-05 2017-06-29 The University Of North Carolina At Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
WO2017139797A1 (en) * 2016-02-13 2017-08-17 BacTrac Technologies LLC Lanthanide-doped nanoparticle compositions for detecting microorganisms
EP3494384A4 (en) * 2016-08-03 2020-03-11 Royal Melbourne Institute Of Technology A method for distinguishing between more than one fluorescent species present in a sample
JP2019531206A (en) 2016-09-12 2019-10-31 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． Printing subassembly
CN106404642B (en) * 2016-11-01 2019-01-04 北京信息科技大学 A kind of fluidic cell system fluorescence lifetime Gauss curve fitting measurement method
CN107907684A (en) * 2017-09-29 2018-04-13 何皓 A kind of prostatic cancer early diagnosis system based on multi-fluorescence service life resolved detection technology
CN108410266B (en) * 2018-03-09 2021-03-02 南开大学 Novel invisible anti-counterfeiting two-dimensional code based on nano metal organic framework material
CN108277004A (en) * 2018-03-30 2018-07-13 哈尔滨工业大学 The adjusting method of near-infrared nano-crystal with core-shell structure fluorescence lifetime
SG11202102505RA (en) * 2018-09-25 2021-04-29 Univ Sydney Technology Analyte quantitation
KR102008934B1 (en) * 2018-11-26 2019-08-08 한국조폐공사 Plastic product comprising photoluminescent material and method for determining authenticity of the same
US11275026B2 (en) * 2019-05-14 2022-03-15 Becton, Dickinson And Company Phase-calibration for imaging flow cytometry
CN111308075A (en) * 2020-03-18 2020-06-19 杭州广科安德生物科技有限公司 Multi-tumor combined detection kit and use method thereof
CA3187594A1 (en) * 2020-06-23 2021-12-30 The Brigham And Women's Hospital, Inc. Single molecule assays for ultrasensitive detection of biomolecules
DE102020131382A1 (en) 2020-11-26 2022-06-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Method for marking products with an optical security feature with a time dimension
CN112724977B (en) * 2021-01-19 2022-05-27 吉林大学 Size-adjustable beta-Na (LuY) F4Preparation method of intersoluble body nanocrystal
WO2022256867A1 (en) * 2021-06-08 2022-12-15 University Of South Australia Improvements in optical data storage
CN113916865B (en) * 2021-10-09 2024-03-29 中国工程物理研究院激光聚变研究中心 Online Raman measurement method for air retention performance of hollow microspheres

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665255A1 (en) 1990-07-24 1992-01-31 Inrets DEVICE FOR EVALUATING THE DEGREE OF WEAR OF TIRES OF VEHICLES.
US5515864A (en) 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5622821A (en) 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
FI963989A (en) 1996-10-04 1998-04-05 Wallac Oy Homogeneous methods of determination based on the transmission of luminescence energy
DE19705047A1 (en) 1997-02-03 1998-08-06 Buerger Joachim Detailed tyre tread depth measurement and recording using laser beam illumination
US20010046673A1 (en) * 1999-03-16 2001-11-29 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
JP4744778B2 (en) 2000-06-21 2011-08-10 バイオアレイ ソルーションズ リミテッド Method for analyzing multiple analyte molecules using a specific random particle array
WO2003035671A2 (en) 2001-10-24 2003-05-01 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US20090314946A1 (en) 2002-08-27 2009-12-24 Kimberly-Clark Worldwide, Inc. Membrane-Based Assay Devices that Utilize Time-Resolved Fluorescence
DE10239765C5 (en) 2002-08-29 2010-02-18 Maha Maschinenbau Haldenwang Gmbh & Co. Kg Profiltiefenmeßvorrichtung
CN1893976A (en) * 2003-12-17 2007-01-10 皇家飞利浦电子股份有限公司 Radiation therapy and medical imaging using uv emitting nanoparticles
WO2006098923A2 (en) * 2005-03-11 2006-09-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Semiconductor nanocrystals as novel antennae for lanthanide cations and associated methods
DE502006003568D1 (en) 2005-11-22 2009-06-04 Frank H Schaefer DEVICE FOR TESTING TIRE PROFILE DEPTH AND TYPE, SPEED AND BODY FREQUENCY ON VEHICLES DURING THE RIDE
DE102006062447B4 (en) 2006-12-28 2009-08-20 Chronos Vision Gmbh Method and device for detecting the three-dimensional surface of an object, in particular a vehicle tire
US7998414B2 (en) * 2007-02-28 2011-08-16 Corning Incorporated System for high throughput GPCR functional assay
FI20070171A0 (en) 2007-02-28 2007-02-28 Hidex Oy Bioassay and bioassay equipment
EP2664916B1 (en) * 2007-04-02 2017-02-08 Acoustic Cytometry Systems, Inc. Method for manipulating a fluid medium within a flow cell using acoustic focusing
US7578180B2 (en) 2007-06-29 2009-08-25 The Goodyear Tire & Rubber Company Tread depth sensing device and method for measuring same
CN102002365B (en) * 2009-08-31 2013-08-21 南京希光光电科技有限公司 Transparent nano florescent material composition and application thereof in invisible anti-counterfeiting products
CN101735216B (en) 2009-11-26 2012-01-04 上海大学 Europium complex silicon dioxide fluorescent nano particles and preparation method thereof
US20120288852A1 (en) 2010-01-15 2012-11-15 Richard Willson Force Mediated Assays
CN101806802B (en) * 2010-04-29 2013-06-26 华中科技大学 Fluorescence resonance energy transfer-based homogeneous immunoassay method for multi-component simultaneous detection
KR101519379B1 (en) 2010-04-29 2015-05-12 삼성전자 주식회사 Centrifugal Micro-fluidic Device and Method for immunoassay
CN102353790B (en) * 2011-06-25 2014-03-05 南方医科大学 Homogeneous time-resolved fluorescence analysis method of alpha-fetalprotein

Also Published As

Publication number Publication date
EP2864783A1 (en) 2015-04-29
US20150185149A1 (en) 2015-07-02
WO2013188927A1 (en) 2013-12-27
CN104641233B (en) 2018-01-09
AU2013277946A1 (en) 2015-01-22
EP2864783A4 (en) 2016-02-10
AU2013277946B2 (en) 2018-07-12
US9816926B2 (en) 2017-11-14
CN104641233A (en) 2015-05-20

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