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IN2012DN02081A - - Google Patents

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Publication number
IN2012DN02081A
IN2012DN02081A IN2081DEN2012A IN2012DN02081A IN 2012DN02081 A IN2012DN02081 A IN 2012DN02081A IN 2081DEN2012 A IN2081DEN2012 A IN 2081DEN2012A IN 2012DN02081 A IN2012DN02081 A IN 2012DN02081A
Authority
IN
India
Prior art keywords
prophylaxis
disorders
preparation
treatment
heteroarylmethyl
Prior art date
Application number
Inventor
Lucking Ulrich
Cleve Arwed
Haendler Bernard
Faus Gimenez Hortensia
Kohr Silke
Irlbacher Horst
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of IN2012DN02081A publication Critical patent/IN2012DN02081A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to substituted (heteroarylmethyl)thiohydantoin compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, and their use for the preparation of medicaments for the treatment and/or prophylaxis of disorders, in particular of prostate cancer.
IN2081DEN2012 2009-09-11 2010-08-28 IN2012DN02081A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09075421 2009-09-11
EP10075069 2010-02-17
PCT/EP2010/005297 WO2011029537A1 (en) 2009-09-11 2010-08-28 Sustituted ( heteroarylmethyl ) thiohydantoins as anticancer drugs

Publications (1)

Publication Number Publication Date
IN2012DN02081A true IN2012DN02081A (en) 2015-08-21

Family

ID=42782041

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2081DEN2012 IN2012DN02081A (en) 2009-09-11 2010-08-28

Country Status (28)

Country Link
US (1) US20120251551A1 (en)
EP (1) EP2475653A1 (en)
JP (1) JP2013504523A (en)
KR (1) KR20120065396A (en)
CN (1) CN102639523A (en)
AR (1) AR078166A1 (en)
AU (1) AU2010294588A1 (en)
BR (1) BR112012005526A2 (en)
CA (1) CA2773591A1 (en)
CL (1) CL2012000623A1 (en)
CO (1) CO6511228A2 (en)
CR (1) CR20120113A (en)
CU (1) CU20120042A7 (en)
DO (1) DOP2012000063A (en)
EA (1) EA201200473A1 (en)
EC (1) ECSP12011716A (en)
IL (1) IL218390A0 (en)
IN (1) IN2012DN02081A (en)
MA (1) MA33566B1 (en)
MX (1) MX2012002977A (en)
NZ (1) NZ598643A (en)
PE (1) PE20121180A1 (en)
PH (1) PH12012500497A1 (en)
SG (1) SG178919A1 (en)
TN (1) TN2012000108A1 (en)
TW (1) TW201111378A (en)
UY (1) UY32882A (en)
WO (1) WO2011029537A1 (en)

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SG183304A1 (en) 2010-02-17 2012-09-27 Takeda Pharmaceutical Heterocyclic compound
WO2011150457A2 (en) * 2010-06-01 2011-12-08 The University Of Queensland Haematopoietic-prostaglandin d2 synthase inhibitors
LT2794627T (en) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AP3545A (en) 2012-05-25 2016-01-14 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
TW201418243A (en) 2012-11-15 2014-05-16 Bayer Pharma AG N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group
EP2935303B1 (en) 2012-12-21 2021-02-17 Janssen BioPharma, Inc. 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv
WO2014153280A1 (en) * 2013-03-22 2014-09-25 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
CN104341351B (en) * 2013-07-30 2018-02-06 北京海美源医药科技有限公司 A kind of Diarylthiohydantoin derivative and its application
CA2933480C (en) * 2013-12-11 2022-08-23 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
CN105829296A (en) 2013-12-18 2016-08-03 巴斯夫欧洲公司 Azole compounds carrying an imine-derived substituent
US9682960B2 (en) * 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103896847B (en) * 2014-04-09 2016-01-20 沈江 A kind of nonsteroidal Anti-androgenic compounds and its preparation method and application
CA2944103A1 (en) 2014-05-07 2015-11-12 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
TWI656121B (en) 2014-08-04 2019-04-11 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridine
CN106187905B (en) * 2015-05-05 2020-02-21 北京海步医药科技股份有限公司 Crystalline forms of bufutamide and methods of making the same
WO2017060167A1 (en) 2015-10-08 2017-04-13 Bayer Pharma Aktiengesellschaft Novel modified macrocyclic compounds
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
TWI726969B (en) 2016-01-11 2021-05-11 比利時商健生藥品公司 Substituted thiohydantoin derivatives as androgen receptor antagonists
CA3057891A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
US11254690B2 (en) 2017-03-28 2022-02-22 Bayer Pharma Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
CN110770210A (en) 2017-05-18 2020-02-07 Pi工业有限公司 Novel amidine compounds
IL276437B2 (en) 2018-02-13 2024-03-01 Bayer Ag Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for the treatment of diffuse large B-cell lymphoma
US20220194932A1 (en) * 2019-04-11 2022-06-23 University Of Miami Improved inhibitors of the notch transcriptional activation complex and methods for use of the same
CA3165120A1 (en) * 2020-01-21 2021-07-29 Berkley E. GRYDER Aryl hydantoin heterocycles and methods of use
WO2022206742A1 (en) * 2021-03-30 2022-10-06 苏州开拓药业股份有限公司 Method for synthesizing thiohydantoin derivative by means of one-step method

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FR2693461B1 (en) * 1992-07-08 1994-09-02 Roussel Uclaf New substituted phenylimidazolidines, process for their preparation, their use as medicaments and the pharmaceutical compositions containing them.
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Also Published As

Publication number Publication date
NZ598643A (en) 2013-10-25
CU20120042A7 (en) 2012-06-21
IL218390A0 (en) 2012-04-30
CL2012000623A1 (en) 2012-09-14
WO2011029537A1 (en) 2011-03-17
ECSP12011716A (en) 2012-04-30
CO6511228A2 (en) 2012-08-31
AU2010294588A1 (en) 2012-04-05
PH12012500497A1 (en) 2012-10-22
AR078166A1 (en) 2011-10-19
PE20121180A1 (en) 2012-08-24
US20120251551A1 (en) 2012-10-04
BR112012005526A2 (en) 2016-04-26
CR20120113A (en) 2012-05-02
JP2013504523A (en) 2013-02-07
EP2475653A1 (en) 2012-07-18
EA201200473A1 (en) 2012-10-30
DOP2012000063A (en) 2012-05-15
MX2012002977A (en) 2012-04-30
TW201111378A (en) 2011-04-01
CA2773591A1 (en) 2011-03-17
CN102639523A (en) 2012-08-15
SG178919A1 (en) 2012-04-27
UY32882A (en) 2011-04-29
MA33566B1 (en) 2012-09-01
TN2012000108A1 (en) 2013-09-19
KR20120065396A (en) 2012-06-20

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