[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

IN2012DN01972A - - Google Patents

Download PDF

Info

Publication number
IN2012DN01972A
IN2012DN01972A IN1972DEN2012A IN2012DN01972A IN 2012DN01972 A IN2012DN01972 A IN 2012DN01972A IN 1972DEN2012 A IN1972DEN2012 A IN 1972DEN2012A IN 2012DN01972 A IN2012DN01972 A IN 2012DN01972A
Authority
IN
India
Prior art keywords
hydrophilic
hydrophobic
emulsions
common intersection
channels
Prior art date
Application number
Inventor
David A Weitz
Mark Romanowsky
Christian Holtze
Original Assignee
Harvard College
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Basf Se filed Critical Harvard College
Publication of IN2012DN01972A publication Critical patent/IN2012DN01972A/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/3035Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/414Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80Forming a predetermined ratio of the substances to be mixed
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/0318Processes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/87571Multiple inlet with single outlet

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Colloid Chemistry (AREA)

Abstract

The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
IN1972DEN2012 2009-09-02 2010-09-01 IN2012DN01972A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23940209P 2009-09-02 2009-09-02
PCT/US2010/047458 WO2011028760A2 (en) 2009-09-02 2010-09-01 Multiple emulsions created using junctions

Publications (1)

Publication Number Publication Date
IN2012DN01972A true IN2012DN01972A (en) 2015-08-21

Family

ID=43649932

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1972DEN2012 IN2012DN01972A (en) 2009-09-02 2010-09-01

Country Status (8)

Country Link
US (1) US20120199226A1 (en)
EP (1) EP2473262A4 (en)
JP (1) JP2013503742A (en)
KR (1) KR20120089662A (en)
CN (1) CN102481529A (en)
BR (1) BR112012004715A2 (en)
IN (1) IN2012DN01972A (en)
WO (1) WO2011028760A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535644A (en) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Method and apparatus for the formation of multiple emulsions
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US20140024023A1 (en) * 2012-07-23 2014-01-23 Bio- Rad Laboratories, Inc Droplet generation system with features for sample positioning
GB2471522B (en) * 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
CN102574078B (en) 2009-09-02 2016-05-18 哈佛学院院长等 Use and spray the multiple emulsion producing with other technology
KR101243147B1 (en) 2011-03-15 2013-03-13 충남대학교산학협력단 Method for selective surface modification of microfluidic chip channel and preparation of microfluidic chip for multiple emulsion
JP6122843B2 (en) 2011-05-23 2017-04-26 プレジデント アンド フェローズ オブ ハーバード カレッジ Emulsion control including multiple emulsions
EP3120923A3 (en) 2011-07-06 2017-03-01 President and Fellows of Harvard College Article comprising a particle having a shell and a fluid
US20130064862A1 (en) 2011-08-30 2013-03-14 Basf Se Systems and methods for shell encapsulation
CN102553504B (en) * 2012-01-18 2014-12-17 朗盛(常州)有限公司 Preparation method of emulsion, leather care emulsion, and use leather care emulsion
WO2013155531A2 (en) * 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
EP2986385B1 (en) * 2013-04-17 2018-02-14 Bio-rad Laboratories, Inc. Method of making a droplet-generating device
US20160279068A1 (en) 2013-11-08 2016-09-29 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
WO2015160919A1 (en) 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
CA2966915A1 (en) 2014-11-24 2016-06-02 The Procter & Gamble Company Methods for encapsulation of actives within droplets and other compartments
CA3001679A1 (en) 2015-10-13 2017-04-20 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
CN106492716B (en) * 2016-12-20 2024-01-30 中国工程物理研究院激光聚变研究中心 Integrated double-emulsion particle generating device and processing method thereof
EP3625353B1 (en) 2017-05-18 2022-11-30 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. Microfluidic channel networks for partitioning
US20190321791A1 (en) * 2018-04-19 2019-10-24 President And Fellows Of Harvard College Apparatus and method for forming emulsions
EP3917654A1 (en) * 2019-01-31 2021-12-08 Samplix ApS A microfluidic device and a method for provision of double emulsion droplets
JPWO2022107898A1 (en) * 2020-11-20 2022-05-27

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59131355A (en) * 1983-01-17 1984-07-28 森下仁丹株式会社 Multiple soft capsule
US6623788B1 (en) * 2000-07-25 2003-09-23 Seagate Technology Llc Defect-free patterning of sol-gel-coated substrates for magnetic recording media
WO2002068104A1 (en) * 2001-02-23 2002-09-06 Japan Science And Technology Corporation Process for producing emulsion and microcapsules and apparatus therefor
JP3860186B2 (en) * 2001-02-23 2006-12-20 独立行政法人科学技術振興機構 Emulsion production equipment
JP4186637B2 (en) * 2002-11-06 2008-11-26 東ソー株式会社 Particle manufacturing method and microchannel structure therefor
US7595195B2 (en) * 2003-02-11 2009-09-29 The Regents Of The University Of California Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles
JP2006522303A (en) * 2003-03-31 2006-09-28 ベール ゲーエムベーハー ウント コー カーゲー Heat exchanger and surface treatment method thereof
JP4341372B2 (en) * 2003-10-30 2009-10-07 コニカミノルタホールディングス株式会社 Liquid mixing method, mixing apparatus and mixing system
JP4042683B2 (en) * 2003-11-17 2008-02-06 東ソー株式会社 Microchannel structure and microparticle manufacturing method using the same
JP3777427B2 (en) * 2003-11-25 2006-05-24 独立行政法人食品総合研究所 Emulsion production method and production apparatus
JP4305145B2 (en) * 2003-11-25 2009-07-29 東ソー株式会社 Particle production method using micro flow channel
JP4777238B2 (en) * 2004-03-23 2011-09-21 独立行政法人科学技術振興機構 Method and apparatus for generating microdroplets
JP4461900B2 (en) * 2004-05-10 2010-05-12 富士ゼロックス株式会社 Method for feeding fine particle dispersion and liquid feeding device for fine particle dispersion
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US7776927B2 (en) * 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2009048532A2 (en) * 2007-10-05 2009-04-16 President And Fellows Of Harvard College Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation
US9011777B2 (en) * 2008-03-21 2015-04-21 Lawrence Livermore National Security, Llc Monodisperse microdroplet generation and stopping without coalescence
US8802027B2 (en) * 2008-03-28 2014-08-12 President And Fellows Of Harvard College Surfaces, including microfluidic channels, with controlled wetting properties
KR101132732B1 (en) * 2008-11-26 2012-04-06 한국과학기술연구원 Intelligent porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof
US9446360B2 (en) * 2009-05-07 2016-09-20 Universite De Strasbourg Microfluidic system and methods for highly selective droplet fusion
GB2471522B (en) * 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices

Also Published As

Publication number Publication date
JP2013503742A (en) 2013-02-04
US20120199226A1 (en) 2012-08-09
EP2473262A4 (en) 2015-12-02
KR20120089662A (en) 2012-08-13
WO2011028760A2 (en) 2011-03-10
WO2011028760A3 (en) 2011-07-14
BR112012004715A2 (en) 2017-05-23
CN102481529A (en) 2012-05-30
EP2473262A2 (en) 2012-07-11

Similar Documents

Publication Publication Date Title
IN2012DN01972A (en)
TW200626225A (en) Mixer and mixing method
DE502006000086D1 (en) FLOW CONTROL
MX339887B (en) Systems for the control and use of fluids and particles.
WO2007127322A3 (en) Flow distribution channels to control flow in process channels
MX2013011876A (en) Selectively variable flow restrictor for use in a subterranean well.
SG149889A1 (en) Multilayer hydrodynamic sheath flow structure
ATE491636T1 (en) AERODYNAMIC FLOW SYSTEM AND ASSOCIATED METHOD
ATE313378T1 (en) MICROFLUIDIC DEVICES WITH DISTRIBUTION INLETS
MY178064A (en) Flow conditioner and method of designing same
DE502006007046D1 (en) FORMATION OF AN EMULSION IN A FLUIDIC MICROSYSTEM
MX2012001982A (en) Flow path control based on fluid characteristics to thereby variably resist flow in a subterranean well.
ATE445115T1 (en) FOUR WAY VALVE ARRANGEMENT WITH TWO OUTLETS
WO2007024410A3 (en) Fluidic mixing structure, method for fabricating same, and mixing method
DE602006015435D1 (en) NOISE-REDUCING LIQUID FLOWS FOR FLOW REGULATORS
MA32348B1 (en) Differential pressure gauge
WO2007120402A3 (en) Device and method for creating hydrodynamic cavitation in fluids
EP4218993A3 (en) Fluidic device
WO2009025136A1 (en) Resin pipe fitting and method for producing the same
DK3004527T3 (en) Choker
CA2900708C (en) Mixing of fluids in fluidic systems
WO2008018036A3 (en) Micro-fluidic system
WO2015071675A3 (en) Servo valves
MX367368B (en) Shower head with rotatable control disk.
BR112017026602A2 (en) microfluidic device