IN2013MU03843A - - Google Patents
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- Publication number
- IN2013MU03843A IN2013MU03843A IN3843MU2013A IN2013MU03843A IN 2013MU03843 A IN2013MU03843 A IN 2013MU03843A IN 3843MU2013 A IN3843MU2013 A IN 3843MU2013A IN 2013MU03843 A IN2013MU03843 A IN 2013MU03843A
- Authority
- IN
- India
- Prior art keywords
- benzyl
- methylpiperidin
- methylamine
- methanol
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI201431805T SI3539965T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| ES14869304T ES2720066T3 (es) | 2013-12-09 | 2014-12-02 | Mejora del proceso de preparación de (3R,4R)-(1-bencil-4-metilpiperidín-3-il)-metilamina |
| PT14869304T PT2994454T (pt) | 2013-12-09 | 2014-12-02 | Um processo melhorado para a preparacao de (3r,4r)-(1-benzil-4- metilpiperidin-3-il)-metilamina |
| EP19150972.8A EP3539965B1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| EP14869304.7A EP2994454B1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| TR2019/04767T TR201904767T4 (tr) | 2013-12-09 | 2014-12-02 | (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanması için geliştirilmiş bir işlem. |
| IN3843MU2013 IN2013MU03843A (pt) | 2013-12-09 | 2014-12-02 | |
| HUE19150972A HUE053975T2 (hu) | 2013-12-09 | 2014-12-02 | Továbbfejlesztett eljárás (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin elõállítására |
| JP2016557204A JP6368794B2 (ja) | 2013-12-09 | 2014-12-02 | （３ｒ，４ｒ）−（１−ベンジル−４−メチルピペリジン−３−イル）−メチルアミンの改良された調製方法 |
| MX2015015432A MX362290B (es) | 2013-12-09 | 2014-12-02 | Un proceso mejorado para la preparacion de (3r,4r)-(1-bencilo-4-me tilpiperidina-3-il)-metilamina. |
| US14/891,028 US9951012B2 (en) | 2013-12-09 | 2014-12-02 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| PT191509728T PT3539965T (pt) | 2013-12-09 | 2014-12-02 | Processo melhorado para a preparação de (3r,4r)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| PL14869304T PL2994454T3 (pl) | 2013-12-09 | 2014-12-02 | Ulepszony sposób wytwarzania (3R,4R)-(1-benzylo-4-metylopiperydyn-3-ylo)metyloaminy |
| HUE14869304A HUE042911T2 (hu) | 2013-12-09 | 2014-12-02 | Javított eljárás a (3R,4R)-(1-benzil-4-metil-piperidin-3-il)-metilamin elõállítására |
| BR112015025543-4A BR112015025543B1 (pt) | 2013-12-09 | 2014-12-02 | processo para a preparação de (3r,4r)-(1-benzil-4- metilpiperidina-3-il)-metilamina e compostos intermediários |
| ES19150972T ES2865058T3 (es) | 2013-12-09 | 2014-12-02 | Un proceso mejorado para la preparación de (3R,4R)-(1-bencil-4-metilpiperidin-3-il)-metilamina |
| PL19150972T PL3539965T3 (pl) | 2013-12-09 | 2014-12-02 | Ulepszony sposób wytwarzania (3r,4r)-(1-benzylo-4-mety-lopiperydyn-3-ylo)metyloaminy |
| SI201431159T SI2994454T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metil piperidin-3-il)-metil amina |
| PCT/IB2014/066510 WO2015087201A1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| ZA2015/06551A ZA201506551B (en) | 2013-12-09 | 2015-09-04 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| US15/590,408 US20170240510A1 (en) | 2013-12-09 | 2017-05-09 | Process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| US15/786,195 US20180037551A1 (en) | 2013-12-09 | 2017-10-17 | Process for the Preparation of (3R,4R)-(1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE |
| US15/868,331 US10829450B2 (en) | 2013-12-09 | 2018-01-11 | Process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (pt) | 2013-12-09 | 2014-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MU03843A true IN2013MU03843A (pt) | 2015-08-14 |
Family
ID=53370688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (pt) | 2013-12-09 | 2014-12-02 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9951012B2 (pt) |
| EP (2) | EP3539965B1 (pt) |
| JP (1) | JP6368794B2 (pt) |
| BR (1) | BR112015025543B1 (pt) |
| ES (2) | ES2865058T3 (pt) |
| HU (2) | HUE042911T2 (pt) |
| IN (1) | IN2013MU03843A (pt) |
| MX (1) | MX362290B (pt) |
| PL (2) | PL2994454T3 (pt) |
| PT (2) | PT3539965T (pt) |
| SI (2) | SI2994454T1 (pt) |
| TR (1) | TR201904767T4 (pt) |
| WO (1) | WO2015087201A1 (pt) |
| ZA (1) | ZA201506551B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2013MU03843A (pt) * | 2013-12-09 | 2015-08-14 | Unichem Lab Ltd | |
| PL3248980T3 (pl) | 2015-01-20 | 2024-03-04 | Wuxi Fortune Pharmaceutical Co., Ltd | Inhibitor jak |
| MX370933B (es) | 2015-04-29 | 2020-01-09 | Wuxi Fortune Pharmaceuticals Co Ltd | Inhibidores jak. |
| AU2016271904B2 (en) | 2015-05-29 | 2018-05-10 | Wuxi Fortune Pharmaceutical Co.,Ltd | Janus kinase inhibitor |
| CN105237463B (zh) * | 2015-10-09 | 2017-10-10 | 刘卫国 | 一种(3r,4r)‑(1‑苄基‑4‑甲基哌啶‑3‑基)甲胺‑l‑二对甲苯甲酰酒石酸盐的制备方法 |
| CN105884781B (zh) * | 2016-04-18 | 2018-04-20 | 山东罗欣药业集团股份有限公司 | 一种枸橼酸托法替布的制备方法 |
| EP3301087A1 (en) * | 2016-09-30 | 2018-04-04 | DPx Fine Chemicals Austria GmbH & Co KG | Process for preparing chiral amines |
| CN107056681B (zh) * | 2017-03-30 | 2019-10-01 | 广州白云山光华制药股份有限公司 | 一种托法替布中间体的制备方法 |
| CN110668995A (zh) * | 2018-07-03 | 2020-01-10 | 江苏海悦康医药科技有限公司 | 一种枸橼酸托法替布中间体及枸橼酸托法替布的制备方法 |
| CN114685515A (zh) * | 2022-03-15 | 2022-07-01 | 上海蓝乐鸟实业有限公司 | 一种托法替尼的制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06145144A (ja) | 1992-11-04 | 1994-05-24 | Ihara Chem Ind Co Ltd | 新規な３−アミノピリジン誘導体第４級アンモニウム塩及びこれを有効成分とする抗癌剤 |
| JP4671079B2 (ja) * | 1999-07-05 | 2011-04-13 | 日本農薬株式会社 | フタラミド誘導体、その中間体及び農園芸用殺虫剤並びにその使用方法 |
| JP3943394B2 (ja) * | 1999-10-20 | 2007-07-11 | 田辺製薬株式会社 | αＬβ２介在細胞接着阻害剤 |
| ES2208433T3 (es) | 1999-12-10 | 2004-06-16 | Pfizer Products Inc. | Compuestos de pirrolo(2,3-d)pirimidina como inhibidores de proteina quinasas. |
| NZ528216A (en) | 2001-02-24 | 2006-12-22 | Boehringer Ingelheim Pharma | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GT200200234A (es) * | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| AU2005317870A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| WO2007012953A2 (en) | 2005-07-29 | 2007-02-01 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis |
| WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| RU2011105768A (ru) * | 2008-08-01 | 2012-09-10 | Биокрист Фармасьютикалз, Инк. (Us) | Производные пиперидина в качестве ингибиторов jakз |
| MX2011010923A (es) | 2009-04-14 | 2011-11-18 | Astellas Pharma Inc | Derivado de pirrolopiridina condensado. |
| BRPI1007737A2 (pt) | 2009-04-20 | 2015-09-01 | Auspex Pharmaceuticals Llc | "composto da fórmula estrutural i, composição farmacêutica, método de tratamento de um distúbio mediano por janus quinase 3, método de preparação de um composto da fórmula estrutural ii, e método de preparação de um composto da fórmula estrutural xii" |
| CA2768373A1 (en) * | 2009-07-21 | 2011-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Heteroaryl benzamides, compositions and methods of use |
| KR20120081609A (ko) * | 2009-09-29 | 2012-07-19 | 글락소 그룹 리미티드 | 신규 화합물 |
| IN2013MU03843A (pt) * | 2013-12-09 | 2015-08-14 | Unichem Lab Ltd |
-
2014
- 2014-12-02 IN IN3843MU2013 patent/IN2013MU03843A/en unknown
- 2014-12-02 ES ES19150972T patent/ES2865058T3/es active Active
- 2014-12-02 SI SI201431159T patent/SI2994454T1/sl unknown
- 2014-12-02 SI SI201431805T patent/SI3539965T1/sl unknown
- 2014-12-02 PT PT191509728T patent/PT3539965T/pt unknown
- 2014-12-02 ES ES14869304T patent/ES2720066T3/es active Active
- 2014-12-02 EP EP19150972.8A patent/EP3539965B1/en active Active
- 2014-12-02 EP EP14869304.7A patent/EP2994454B1/en active Active
- 2014-12-02 BR BR112015025543-4A patent/BR112015025543B1/pt not_active IP Right Cessation
- 2014-12-02 TR TR2019/04767T patent/TR201904767T4/tr unknown
- 2014-12-02 PT PT14869304T patent/PT2994454T/pt unknown
- 2014-12-02 WO PCT/IB2014/066510 patent/WO2015087201A1/en active Application Filing
- 2014-12-02 HU HUE14869304A patent/HUE042911T2/hu unknown
- 2014-12-02 JP JP2016557204A patent/JP6368794B2/ja not_active Expired - Fee Related
- 2014-12-02 PL PL14869304T patent/PL2994454T3/pl unknown
- 2014-12-02 US US14/891,028 patent/US9951012B2/en active Active
- 2014-12-02 PL PL19150972T patent/PL3539965T3/pl unknown
- 2014-12-02 HU HUE19150972A patent/HUE053975T2/hu unknown
- 2014-12-02 MX MX2015015432A patent/MX362290B/es active IP Right Grant
-
2015
- 2015-09-04 ZA ZA2015/06551A patent/ZA201506551B/en unknown
-
2017
- 2017-05-09 US US15/590,408 patent/US20170240510A1/en not_active Abandoned
- 2017-10-17 US US15/786,195 patent/US20180037551A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,331 patent/US10829450B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10829450B2 (en) | 2020-11-10 |
| ZA201506551B (en) | 2017-02-22 |
| MX2015015432A (es) | 2016-03-15 |
| EP3539965B1 (en) | 2021-01-20 |
| ES2865058T3 (es) | 2021-10-14 |
| SI2994454T1 (sl) | 2019-05-31 |
| JP2017503007A (ja) | 2017-01-26 |
| MX362290B (es) | 2019-01-10 |
| US20180037551A1 (en) | 2018-02-08 |
| BR112015025543A2 (pt) | 2017-07-18 |
| PT2994454T (pt) | 2019-04-02 |
| WO2015087201A1 (en) | 2015-06-18 |
| EP2994454A4 (en) | 2016-12-21 |
| US9951012B2 (en) | 2018-04-24 |
| PL3539965T3 (pl) | 2021-07-05 |
| JP6368794B2 (ja) | 2018-08-01 |
| US20170240510A1 (en) | 2017-08-24 |
| EP3539965A1 (en) | 2019-09-18 |
| US20180134661A1 (en) | 2018-05-17 |
| PT3539965T (pt) | 2021-04-07 |
| BR112015025543B1 (pt) | 2020-11-03 |
| SI3539965T1 (sl) | 2021-07-30 |
| TR201904767T4 (tr) | 2019-05-21 |
| HUE042911T2 (hu) | 2019-07-29 |
| PL2994454T3 (pl) | 2019-09-30 |
| US20160102057A1 (en) | 2016-04-14 |
| EP2994454B1 (en) | 2019-03-06 |
| ES2720066T3 (es) | 2019-07-17 |
| EP2994454A1 (en) | 2016-03-16 |
| HUE053975T2 (hu) | 2021-08-30 |
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