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IL78451A0 - Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof - Google Patents

Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

Info

Publication number
IL78451A0
IL78451A0 IL78451A IL7845186A IL78451A0 IL 78451 A0 IL78451 A0 IL 78451A0 IL 78451 A IL78451 A IL 78451A IL 7845186 A IL7845186 A IL 7845186A IL 78451 A0 IL78451 A0 IL 78451A0
Authority
IL
Israel
Prior art keywords
epipodophyllotoxin
intermediates
processes
preparation
production
Prior art date
Application number
IL78451A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IL78451A0 publication Critical patent/IL78451A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/32Unsaturated compounds containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/34Unsaturated compounds containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL78451A 1985-04-12 1986-04-08 Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof IL78451A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/722,932 US4644072A (en) 1985-04-12 1985-04-12 Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (1)

Publication Number Publication Date
IL78451A0 true IL78451A0 (en) 1986-08-31

Family

ID=24904037

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78451A IL78451A0 (en) 1985-04-12 1986-04-08 Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

Country Status (33)

Country Link
US (1) US4644072A (sv)
JP (1) JPS61238758A (sv)
KR (1) KR900005624B1 (sv)
CN (2) CN1021822C (sv)
AT (1) ATA96986A (sv)
AU (6) AU587021B2 (sv)
BE (1) BE904587A (sv)
CA (1) CA1275651C (sv)
CH (2) CH672635A5 (sv)
CY (1) CY1599A (sv)
DE (1) DE3612278A1 (sv)
DK (2) DK167986A (sv)
EG (1) EG18077A (sv)
ES (2) ES8802044A1 (sv)
FI (1) FI861508A (sv)
FR (1) FR2587335B1 (sv)
GB (1) GB2176181B (sv)
GR (1) GR860982B (sv)
HK (1) HK53391A (sv)
HU (4) HU198063B (sv)
IE (1) IE59039B1 (sv)
IL (1) IL78451A0 (sv)
IT (1) IT1208593B (sv)
LU (1) LU86392A1 (sv)
MY (1) MY101618A (sv)
NL (1) NL8600938A (sv)
PT (1) PT82383B (sv)
RU (1) RU1819265C (sv)
SE (2) SE468768B (sv)
SG (1) SG44791G (sv)
SU (1) SU1547707A3 (sv)
YU (2) YU44785B (sv)
ZA (1) ZA862747B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5013851A (en) * 1985-12-05 1991-05-07 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds
US5106996A (en) * 1985-12-05 1992-04-21 Bristol-Myers Company Process for the preparation of podophyllotoxin
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
GB9422947D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Immunosuppressive cyclolignan derivatives
ATE186054T1 (de) * 1995-06-30 1999-11-15 Cerbios Pharma Sa Glykoside, deren zuckerfreie abbauprodukte und derivate derselben
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (sv) * 1965-09-21 1967-03-22
US3716574A (en) * 1967-12-01 1973-02-13 Rayonier Inc Pure crystalline plicatic acid tetrahydrate and the methyl ester thereof
US4122092A (en) * 1977-08-25 1978-10-24 University Of Rochester Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4788216A (en) * 1984-12-28 1988-11-29 Conpharm Ab Medicinal uses for podophyllotoxins
US4771072A (en) * 1985-01-10 1988-09-13 Tanabe Seiyaku Co., Ltd. Alkoxynaphthalene derivatives
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
CN1059520A (zh) 1992-03-18
HUT47071A (en) 1989-01-30
KR900005624B1 (ko) 1990-08-01
AU587021B2 (en) 1989-08-03
JPS61238758A (ja) 1986-10-24
FI861508A (fi) 1986-10-13
FI861508A0 (fi) 1986-04-09
DK167986A (da) 1986-10-13
AU617182B2 (en) 1991-11-21
US4644072A (en) 1987-02-17
YU46212B (sh) 1993-05-28
DE3612278A1 (de) 1986-10-16
SU1547707A3 (ru) 1990-02-28
AU607337B2 (en) 1991-02-28
AU3628789A (en) 1989-10-05
GB2176181A (en) 1986-12-17
MY101618A (en) 1991-12-17
AU617184B2 (en) 1991-11-21
HUT44773A (en) 1988-04-28
SE9202476A0 (sv) 1992-08-28
AU617183B2 (en) 1991-11-21
PT82383A (en) 1986-05-01
YU112487A (en) 1988-02-29
SE8601646L (sv) 1986-11-28
ES8900046A1 (es) 1988-11-16
FR2587335B1 (fr) 1990-09-14
ZA862747B (en) 1986-11-26
SE468768B (sv) 1993-03-15
DK117193A (da) 1993-10-18
DK167986D0 (da) 1986-04-11
AU3628889A (en) 1989-10-05
EG18077A (en) 1991-08-30
GB2176181B (en) 1989-06-28
YU59486A (en) 1988-02-29
AU5599386A (en) 1986-10-16
HU198063B (en) 1989-07-28
DK117193D0 (da) 1993-10-18
SE8601646D0 (sv) 1986-04-11
HU204044B (en) 1991-11-28
BE904587A (fr) 1986-10-13
YU44785B (en) 1991-02-28
IE860955L (en) 1986-10-12
ATA96986A (de) 1994-05-15
HK53391A (en) 1991-07-19
GR860982B (en) 1986-09-01
KR860008198A (ko) 1986-11-12
FR2587335A1 (fr) 1987-03-20
RU1819265C (ru) 1993-05-30
NL8600938A (nl) 1986-11-03
HU199846B (en) 1990-03-28
ES8802044A1 (es) 1988-03-16
AU617185B2 (en) 1991-11-21
ES553868A0 (es) 1988-03-16
CN1021822C (zh) 1993-08-18
HUT47088A (en) 1989-01-30
PT82383B (pt) 1988-10-14
CH669190A5 (de) 1989-02-28
IT8620048A0 (it) 1986-04-11
AU3628689A (en) 1989-10-05
CY1599A (en) 1992-04-03
AU3628489A (en) 1989-10-05
IE59039B1 (en) 1993-12-15
SE9202476D0 (sv) 1992-08-28
SG44791G (en) 1991-07-26
IT1208593B (it) 1989-07-10
CA1275651C (en) 1990-10-30
HU201541B (en) 1990-11-28
CH672635A5 (sv) 1989-12-15
GB8608808D0 (en) 1986-05-14
LU86392A1 (fr) 1986-11-05
ES557772A0 (es) 1988-11-16
AU3628589A (en) 1989-10-05
CN86102404A (zh) 1986-12-03

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