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IL64584A - 2-acylaminomethyl-5-phenyl-1,4-benzodiazepines and salts thereof,their manufacture and pharmaceutical compositions containing them - Google Patents

2-acylaminomethyl-5-phenyl-1,4-benzodiazepines and salts thereof,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL64584A
IL64584A IL64584A IL6458481A IL64584A IL 64584 A IL64584 A IL 64584A IL 64584 A IL64584 A IL 64584A IL 6458481 A IL6458481 A IL 6458481A IL 64584 A IL64584 A IL 64584A
Authority
IL
Israel
Prior art keywords
amino
substituent
phenyl
lower alkyl
alkyl
Prior art date
Application number
IL64584A
Other languages
English (en)
Other versions
IL64584A0 (en
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of IL64584A0 publication Critical patent/IL64584A0/xx
Publication of IL64584A publication Critical patent/IL64584A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL64584A 1980-12-20 1981-12-18 2-acylaminomethyl-5-phenyl-1,4-benzodiazepines and salts thereof,their manufacture and pharmaceutical compositions containing them IL64584A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803048264 DE3048264A1 (de) 1980-12-20 1980-12-20 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
IL64584A0 IL64584A0 (en) 1982-03-31
IL64584A true IL64584A (en) 1985-05-31

Family

ID=6119800

Family Applications (1)

Application Number Title Priority Date Filing Date
IL64584A IL64584A (en) 1980-12-20 1981-12-18 2-acylaminomethyl-5-phenyl-1,4-benzodiazepines and salts thereof,their manufacture and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4533662A (ja)
EP (1) EP0054839B1 (ja)
JP (1) JPS57123171A (ja)
AT (1) ATE13883T1 (ja)
AU (1) AU543172B2 (ja)
CA (1) CA1173440A (ja)
DD (1) DD201789A5 (ja)
DE (2) DE3048264A1 (ja)
DK (1) DK563681A (ja)
ES (1) ES508113A0 (ja)
FI (1) FI68046C (ja)
GR (1) GR82268B (ja)
HU (1) HU187397B (ja)
IE (1) IE51799B1 (ja)
IL (1) IL64584A (ja)
NO (1) NO157376C (ja)
NZ (1) NZ199318A (ja)
PH (1) PH21646A (ja)
PT (1) PT74115B (ja)
ZA (1) ZA818775B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684646A (en) * 1984-06-26 1987-08-04 Merck & Co., Inc. 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists
US4724237A (en) * 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
EP0170024A3 (en) * 1984-06-26 1990-01-31 Merck & Co. Inc. Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
BRPI0409241A (pt) * 2003-04-10 2006-03-28 Pfizer compostos bicìclicos como antagonistas do receptor de nr2b, composições farmacêuticas compreendendo os mesmos e seu uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2265371C3 (de) * 1972-05-03 1980-12-11 Kali-Chemie Ag, 3000 Hannover N-(3-Benzoylaminopropyl)-aniline
DE2353187A1 (de) * 1973-05-02 1974-11-14 Kali Chemie Ag Neue benzodiazepinderivate
US3925358A (en) * 1973-07-27 1975-12-09 Hoffmann La Roche 1-Lower alkyl-2-substituted-1,4-benzodiazepines
BE839365R (fr) * 1976-03-09 1976-09-09 Derives de diazepine
JPS6045875B2 (ja) * 1979-12-07 1985-10-12 エフ・ホフマン・ラ・ロツシユ・ウント・カンパニ−・アクチエンゲゼルシヤフト イミダゾ−ル誘導体
DE2952279A1 (de) * 1979-12-24 1981-06-25 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
ATE13883T1 (de) 1985-07-15
ES8300721A1 (es) 1982-11-01
ZA818775B (en) 1982-11-24
US4533662A (en) 1985-08-06
DD201789A5 (de) 1983-08-10
NO814356L (no) 1982-06-21
PT74115B (en) 1983-05-11
PT74115A (en) 1982-01-01
HU187397B (en) 1985-12-28
AU7865481A (en) 1982-07-01
PH21646A (en) 1988-01-13
IE51799B1 (en) 1987-04-01
GR82268B (ja) 1984-12-13
ES508113A0 (es) 1982-11-01
FI814032L (fi) 1982-06-21
CA1173440A (en) 1984-08-28
EP0054839B1 (de) 1985-06-19
DE3048264A1 (de) 1982-09-09
FI68046B (fi) 1985-03-29
NO157376B (no) 1987-11-30
NO157376C (no) 1988-03-09
AU543172B2 (en) 1985-04-04
IE812989L (en) 1982-06-20
JPS57123171A (en) 1982-07-31
EP0054839A2 (de) 1982-06-30
DE3171071D1 (en) 1985-07-25
NZ199318A (en) 1983-06-17
FI68046C (fi) 1985-07-10
EP0054839A3 (en) 1983-01-05
JPH0155271B2 (ja) 1989-11-22
DK563681A (da) 1982-06-21
IL64584A0 (en) 1982-03-31

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