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IL242408B - Continuous multistep process for purifying antibodies - Google Patents

Continuous multistep process for purifying antibodies

Info

Publication number
IL242408B
IL242408B IL242408A IL24240815A IL242408B IL 242408 B IL242408 B IL 242408B IL 242408 A IL242408 A IL 242408A IL 24240815 A IL24240815 A IL 24240815A IL 242408 B IL242408 B IL 242408B
Authority
IL
Israel
Prior art keywords
multistep process
purifying antibodies
continuous multistep
continuous
antibodies
Prior art date
Application number
IL242408A
Other languages
Hebrew (he)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL242408B publication Critical patent/IL242408B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Water Supply & Treatment (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
IL242408A 2013-05-06 2015-11-02 Continuous multistep process for purifying antibodies IL242408B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13305593 2013-05-06
PCT/EP2014/059246 WO2014180852A1 (en) 2013-05-06 2014-05-06 Continuous multistep process for purifying antibodies

Publications (1)

Publication Number Publication Date
IL242408B true IL242408B (en) 2020-04-30

Family

ID=48430636

Family Applications (1)

Application Number Title Priority Date Filing Date
IL242408A IL242408B (en) 2013-05-06 2015-11-02 Continuous multistep process for purifying antibodies

Country Status (19)

Country Link
US (1) US10793622B2 (en)
EP (2) EP3301115B1 (en)
JP (2) JP6463734B2 (en)
KR (1) KR102272851B1 (en)
CN (2) CN116003579A (en)
AU (1) AU2014264697B2 (en)
BR (1) BR112015027812B1 (en)
CA (1) CA2911462C (en)
CY (1) CY1125281T1 (en)
DK (2) DK3301115T3 (en)
ES (2) ES2665645T3 (en)
HU (2) HUE057119T2 (en)
IL (1) IL242408B (en)
MX (1) MX368177B (en)
NO (1) NO2994485T3 (en)
RU (1) RU2662668C2 (en)
SG (1) SG11201508968XA (en)
TW (2) TWI631132B (en)
WO (1) WO2014180852A1 (en)

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US20170101437A1 (en) * 2015-10-09 2017-04-13 Hetero Drugs Ltd. Process for purification of darbepoetin alfa
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US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
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KR102774707B1 (en) * 2017-03-24 2025-02-27 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 A process for the purification of recombinant antibody fragments
GB201711481D0 (en) * 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
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EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
KR102337683B1 (en) 2018-09-21 2021-12-13 주식회사 녹십자 Highly efficient anti-TFPI antibody composition
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WO2020084503A1 (en) * 2018-10-26 2020-04-30 Cadila Healthcare Limited A composition comprising antibody with reduced level of basic variants thereof
WO2020183332A1 (en) * 2019-03-11 2020-09-17 Intas Pharmaceuticals Ltd. Purification of adalimumab using tandem chromatography
EP3947705A1 (en) * 2019-04-03 2022-02-09 Genzyme Corporation Continuous production of recombinant proteins
WO2020258704A1 (en) * 2019-06-28 2020-12-30 信达生物制药(苏州)有限公司 Seamless continuous flow chromatographic method
KR102154952B1 (en) * 2020-02-21 2020-09-10 프레스티지바이오로직스 주식회사 Non-Protein A Purification of Adalimumab
CN112574321B (en) * 2020-12-30 2023-10-20 上海赛金生物医药有限公司 Affinity purification method for capturing monoclonal antibody-tumor necrosis factor fusion protein
WO2022234412A1 (en) 2021-05-03 2022-11-10 Lupin Limited A process for purification of fc-fusion proteins

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Also Published As

Publication number Publication date
AU2014264697B2 (en) 2019-08-22
DK2994485T3 (en) 2018-04-23
EP3301115B1 (en) 2021-11-10
AU2014264697A1 (en) 2015-11-26
DK3301115T3 (en) 2022-01-31
EP2994485A1 (en) 2016-03-16
BR112015027812A2 (en) 2017-07-25
CN116003579A (en) 2023-04-25
WO2014180852A1 (en) 2014-11-13
EP3301115A1 (en) 2018-04-04
CA2911462A1 (en) 2014-11-13
TWI631132B (en) 2018-08-01
JP2019104735A (en) 2019-06-27
MX368177B (en) 2019-09-23
US10793622B2 (en) 2020-10-06
MX2015015482A (en) 2016-03-21
JP6463734B2 (en) 2019-02-06
NO2994485T3 (en) 2018-06-09
BR112015027812B1 (en) 2021-03-30
CN105358572A (en) 2016-02-24
US20160083454A1 (en) 2016-03-24
RU2015151869A (en) 2017-06-13
EP2994485B1 (en) 2018-01-10
TW201908331A (en) 2019-03-01
KR20160005047A (en) 2016-01-13
CA2911462C (en) 2021-04-06
RU2662668C2 (en) 2018-07-26
ES2905675T3 (en) 2022-04-11
HUE038741T2 (en) 2018-11-28
ES2665645T3 (en) 2018-04-26
CY1125281T1 (en) 2023-06-09
TW201522363A (en) 2015-06-16
JP2016519137A (en) 2016-06-30
KR102272851B1 (en) 2021-07-02
SG11201508968XA (en) 2015-11-27
TWI675041B (en) 2019-10-21
HUE057119T2 (en) 2022-04-28

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