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IL184943A0 - Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability - Google Patents

Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability

Info

Publication number
IL184943A0
IL184943A0 IL184943A IL18494307A IL184943A0 IL 184943 A0 IL184943 A0 IL 184943A0 IL 184943 A IL184943 A IL 184943A IL 18494307 A IL18494307 A IL 18494307A IL 184943 A0 IL184943 A0 IL 184943A0
Authority
IL
Israel
Prior art keywords
stability
preparation
analytical control
atomoxetine hydrochloride
stable atomoxetine
Prior art date
Application number
IL184943A
Original Assignee
Teva Pharm Fine Chemicals Srl
Castelli Eugenio
Riva Paolo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharm Fine Chemicals Srl, Castelli Eugenio, Riva Paolo filed Critical Teva Pharm Fine Chemicals Srl
Publication of IL184943A0 publication Critical patent/IL184943A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
IL184943A 2005-04-05 2007-07-31 Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability IL184943A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66874105P 2005-04-05 2005-04-05
US68638605P 2005-05-31 2005-05-31
US68840605P 2005-06-07 2005-06-07
PCT/US2006/012959 WO2006108120A1 (en) 2005-04-05 2006-04-05 Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability

Publications (1)

Publication Number Publication Date
IL184943A0 true IL184943A0 (en) 2007-12-03

Family

ID=36649080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL184943A IL184943A0 (en) 2005-04-05 2007-07-31 Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability

Country Status (8)

Country Link
US (1) US7569729B2 (en)
EP (1) EP1751085A1 (en)
JP (1) JP2008501721A (en)
CA (1) CA2600609A1 (en)
IL (1) IL184943A0 (en)
MX (1) MX2007010268A (en)
TW (1) TW200727891A (en)
WO (1) WO2006108120A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2838510B1 (en) * 2013-11-08 2016-09-21 Eli Lilly and Company Atomoxetine solution
JP7090847B2 (en) * 2020-12-01 2022-06-27 高田製薬株式会社 Atomoxetine Tablets and Atomoxetine Tablets Manufacturing Method

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
GR75395B (en) * 1980-11-14 1984-07-13 Lilly Co Eli
US4777291A (en) * 1985-02-27 1988-10-11 Eli Lilly And Company Racemization process
US4868344A (en) * 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
DE4123253A1 (en) * 1991-07-15 1993-01-21 Schneider Manfred Prof Dr Racemic ester(s) of halogenated aryl-alkanol(s) - can be enzymically hydrolysed to give pure (R)-alcohol and pure (S)-ester which can then be further reacted to tomoxetine, fluoxetine, nisoxetine etc.
HU9202128D0 (en) * 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine
US5658590A (en) * 1995-01-11 1997-08-19 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
GB9812413D0 (en) * 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
WO2000058262A1 (en) * 1999-03-29 2000-10-05 Eli Lilly And Company Stereospecific method for preparing tomoxetine and intermediates thereof
AU3877500A (en) * 1999-04-09 2000-11-14 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
AU4010000A (en) * 1999-04-26 2000-11-10 Eli Lilly And Company Epimerization reaction for the production of r-fluoxetine
EP1761478B1 (en) * 2004-06-28 2008-09-03 Teva Pharmaceutical Fine Chemicals S.R.L. An isolated atomoxetine impurity, processes for the preparation of atomoxetine impurities and their use as reference standards
CA2568629A1 (en) * 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of atomoxetine hydrochloride
WO2006037055A1 (en) 2004-09-27 2006-04-06 Dr. Reddy's Laboratories Ltd. Synthesis of atomoxetine hydrochloride
EP1798215A1 (en) 2005-12-14 2007-06-20 SOLMAG S.p.A. Polymorph of atomoxetine hydrochloride in crystalline form

Also Published As

Publication number Publication date
TW200727891A (en) 2007-08-01
CA2600609A1 (en) 2006-10-12
JP2008501721A (en) 2008-01-24
US7569729B2 (en) 2009-08-04
US20060252836A1 (en) 2006-11-09
WO2006108120A1 (en) 2006-10-12
MX2007010268A (en) 2008-02-19
EP1751085A1 (en) 2007-02-14

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