IL154254A0 - Prodrugs to nmda receptor ligands - Google Patents

Prodrugs to nmda receptor ligands

Info

Publication number: IL154254A0
Authority: IL; Israel
Prior art keywords: prodrugs; nmda receptor; receptor ligands; ligands; nmda
Prior art date: 2000-08-21

Application number

IL15425401A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-21

Filing date

2001-08-20

Publication date

2003-09-17

2001-08-20 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-09-17 Publication of IL154254A0 publication Critical patent/IL154254A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

IL15425401A 2000-08-21 2001-08-20 Prodrugs to nmda receptor ligands IL154254A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00117918		2000-08-21
PCT/EP2001/009561 WO2002016321A1 (en)	2000-08-21	2001-08-20	Prodrugs to nmda receptor ligands

Publications (1)

Publication Number	Publication Date
IL154254A0 true IL154254A0 (en)	2003-09-17

Family

ID=8169594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15425401A IL154254A0 (en)	2000-08-21	2001-08-20	Prodrugs to nmda receptor ligands

Country Status (35)

Country	Link
US (1)	US6407235B1 (pt)
EP (1)	EP1313703B1 (pt)
JP (1)	JP4162991B2 (pt)
KR (1)	KR100589991B1 (pt)
CN (1)	CN1227230C (pt)
AR (1)	AR030373A1 (pt)
AT (1)	ATE386022T1 (pt)
AU (2)	AU2001285894B2 (pt)
BR (1)	BR0113348A (pt)
CA (1)	CA2419279C (pt)
CY (1)	CY1107937T1 (pt)
CZ (1)	CZ303319B6 (pt)
DE (1)	DE60132782T2 (pt)
DK (1)	DK1313703T3 (pt)
EC (1)	ECSP034489A (pt)
EG (1)	EG24293A (pt)
ES (1)	ES2299508T3 (pt)
HR (1)	HRP20030125B1 (pt)
HU (1)	HU229802B1 (pt)
IL (1)	IL154254A0 (pt)
JO (1)	JO2289B1 (pt)
MA (1)	MA26947A1 (pt)
MX (1)	MXPA03001311A (pt)
MY (1)	MY136065A (pt)
NO (1)	NO324941B1 (pt)
NZ (1)	NZ523990A (pt)
PA (1)	PA8525601A1 (pt)
PE (1)	PE20020291A1 (pt)
PL (1)	PL204215B1 (pt)
PT (1)	PT1313703E (pt)
RS (1)	RS51467B (pt)
RU (1)	RU2272027C2 (pt)
SI (1)	SI1313703T1 (pt)
WO (1)	WO2002016321A1 (pt)
ZA (1)	ZA200300894B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001245891A1 (en) *	2000-03-21	2001-10-03	The Procter & Gamble Company	Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
US6713490B2 (en)	2002-04-26	2004-03-30	Pfizer, Inc.	3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
CA2633010A1 (en) *	2005-12-19	2007-06-28	Methylgene Inc.	Histone deacetylase inhibitors for enhancing activity of antifungal agents
AU2007335216C1 (en)	2006-12-19	2014-07-10	Methylgene Inc.	Inhibitors of histone deacetylase and prodrugs thereof
US8796330B2 (en) *	2006-12-19	2014-08-05	Methylgene Inc.	Inhibitors of histone deacetylase and prodrugs thereof
CN105683180B (zh)	2013-11-05	2020-01-21	阿斯利康(瑞典)有限公司	Nmda拮抗剂前药

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2134361T3 (es) *	1994-01-31	1999-10-01	Pfizer	Compuestos de cromano neuroprotectores.
DE4410822A1 (de)	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
TW340842B (en) *	1995-08-24	1998-09-21	Pfizer	Substituted benzylaminopiperidine compounds
TW498067B (en)	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives
TWI254043B (en)	1999-06-08	2006-05-01	Hoffmann La Roche	Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor

2001
- 2001-08-16 PE PE2001000820A patent/PE20020291A1/es not_active Application Discontinuation
- 2001-08-16 PA PA20018525601A patent/PA8525601A1/es unknown
- 2001-08-16 US US09/931,431 patent/US6407235B1/en not_active Expired - Lifetime
- 2001-08-17 AR ARP010103939A patent/AR030373A1/es active IP Right Grant
- 2001-08-17 MY MYPI20013876A patent/MY136065A/en unknown
- 2001-08-19 JO JO2001136A patent/JO2289B1/en active
- 2001-08-20 BR BR0113348-9A patent/BR0113348A/pt not_active Application Discontinuation
- 2001-08-20 HR HR20030125A patent/HRP20030125B1/xx not_active IP Right Cessation
- 2001-08-20 SI SI200130812T patent/SI1313703T1/sl unknown
- 2001-08-20 CA CA002419279A patent/CA2419279C/en not_active Expired - Fee Related
- 2001-08-20 IL IL15425401A patent/IL154254A0/xx not_active IP Right Cessation
- 2001-08-20 HU HU0301548A patent/HU229802B1/hu not_active IP Right Cessation
- 2001-08-20 CN CNB01814361XA patent/CN1227230C/zh not_active Expired - Fee Related
- 2001-08-20 PT PT01965201T patent/PT1313703E/pt unknown
- 2001-08-20 CZ CZ20030492A patent/CZ303319B6/cs not_active IP Right Cessation
- 2001-08-20 DK DK01965201T patent/DK1313703T3/da active
- 2001-08-20 JP JP2002521197A patent/JP4162991B2/ja not_active Expired - Fee Related
- 2001-08-20 PL PL361387A patent/PL204215B1/pl unknown
- 2001-08-20 EG EG20010906A patent/EG24293A/xx active
- 2001-08-20 RS YUP-130/03A patent/RS51467B/sr unknown
- 2001-08-20 DE DE60132782T patent/DE60132782T2/de not_active Expired - Lifetime
- 2001-08-20 AU AU2001285894A patent/AU2001285894B2/en not_active Ceased
- 2001-08-20 EP EP01965201A patent/EP1313703B1/en not_active Expired - Lifetime
- 2001-08-20 NZ NZ523990A patent/NZ523990A/en not_active IP Right Cessation
- 2001-08-20 AT AT01965201T patent/ATE386022T1/de active
- 2001-08-20 KR KR1020037002485A patent/KR100589991B1/ko not_active Expired - Fee Related
- 2001-08-20 RU RU2003107572/04A patent/RU2272027C2/ru not_active IP Right Cessation
- 2001-08-20 ES ES01965201T patent/ES2299508T3/es not_active Expired - Lifetime
- 2001-08-20 MX MXPA03001311A patent/MXPA03001311A/es active IP Right Grant
- 2001-08-20 AU AU8589401A patent/AU8589401A/xx active Pending
- 2001-08-20 WO PCT/EP2001/009561 patent/WO2002016321A1/en active IP Right Grant
2003
- 2003-01-31 ZA ZA200300894A patent/ZA200300894B/en unknown
- 2003-02-19 NO NO20030781A patent/NO324941B1/no not_active IP Right Cessation
- 2003-02-20 EC EC2003004489A patent/ECSP034489A/es unknown
- 2003-02-21 MA MA27052A patent/MA26947A1/fr unknown
2008
- 2008-05-08 CY CY20081100485T patent/CY1107937T1/el unknown

Also Published As

Publication number	Publication date
CN1447793A (zh)	2003-10-08
RU2272027C2 (ru)	2006-03-20
CA2419279C (en)	2008-10-14
DE60132782D1 (de)	2008-03-27
AU2001285894B2 (en)	2006-06-15
ATE386022T1 (de)	2008-03-15
JP4162991B2 (ja)	2008-10-08
RS51467B (sr)	2011-04-30
JO2289B1 (en)	2005-09-12
ZA200300894B (en)	2004-04-30
AU8589401A (en)	2002-03-04
BR0113348A (pt)	2003-07-08
ES2299508T3 (es)	2008-06-01
NO324941B1 (no)	2008-01-07
HUP0301548A3 (en)	2010-03-29
WO2002016321A1 (en)	2002-02-28
DE60132782T2 (de)	2009-02-05
PE20020291A1 (es)	2002-04-17
US6407235B1 (en)	2002-06-18
PL361387A1 (en)	2004-10-04
EG24293A (en)	2009-01-08
NZ523990A (en)	2004-09-24
EP1313703B1 (en)	2008-02-13
HU229802B1 (hu)	2014-07-28
HRP20030125A2 (en)	2005-02-28
KR100589991B1 (ko)	2006-06-15
AR030373A1 (es)	2003-08-20
PL204215B1 (pl)	2009-12-31
CZ303319B6 (cs)	2012-08-01
HRP20030125B1 (en)	2011-07-31
JP2004506715A (ja)	2004-03-04
US20020040037A1 (en)	2002-04-04
PT1313703E (pt)	2008-03-25
EP1313703A1 (en)	2003-05-28
YU13003A (sh)	2006-05-25
CN1227230C (zh)	2005-11-16
KR20030022417A (ko)	2003-03-15
CA2419279A1 (en)	2002-02-28
HK1059083A1 (en)	2004-06-18
ECSP034489A (es)	2003-03-31
MXPA03001311A (es)	2003-06-30
SI1313703T1 (sl)	2008-06-30
CY1107937T1 (el)	2013-09-04
PA8525601A1 (es)	2002-04-25
NO20030781D0 (no)	2003-02-19
CZ2003492A3 (cs)	2004-01-14
NO20030781L (no)	2003-02-19
HUP0301548A2 (hu)	2003-08-28
MY136065A (en)	2008-08-29
DK1313703T3 (da)	2008-05-19
MA26947A1 (fr)	2004-12-20

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Legal Events

Date	Code	Title
2008-08-10	FF	Patent granted
2008-11-03	KB	Patent renewed
2011-08-31	KB	Patent renewed
2016-04-21	MM9K	Patent not in force due to non-payment of renewal fees