IL110820A0 - N-substituted heterocyclic derivatives and their preparation - Google Patents

N-substituted heterocyclic derivatives and their preparation

Info

Publication number: IL110820A0
Authority: IL; Israel
Prior art keywords: alkyl; phenyl; carbonyl; alkoxy; halogen
Prior art date: 1990-03-20

Application number

IL11082094A

Other languages

English (en)

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-20

Filing date

1994-08-30

Publication date

1994-11-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26227935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL110820(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-20 Priority claimed from FR9003563A external-priority patent/FR2659967B1/fr

1990-08-08 Priority claimed from FR9010144A external-priority patent/FR2665702B1/fr

1994-08-30 Application filed by Sanofi Sa filed Critical Sanofi Sa

1994-11-11 Publication of IL110820A0 publication Critical patent/IL110820A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Paints Or Removers (AREA)
Cephalosporin Compounds (AREA)
Organic Insulating Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL11082094A 1990-03-20 1994-08-30 N-substituted heterocyclic derivatives and their preparation IL110820A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9003563A FR2659967B1 (fr)	1990-03-20	1990-03-20	Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
FR9010144A FR2665702B1 (fr)	1990-08-08	1990-08-08	Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.

Publications (1)

Publication Number	Publication Date
IL110820A0 true IL110820A0 (en)	1994-11-11

Family

ID=26227935

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL9761291A IL97612A (en)	1990-03-20	1991-03-20	The history of N-transformed heterocycles, their preparation and the pharmaceutical preparations containing them
IL11082091A IL110820A (en)	1990-03-20	1991-03-20	History of imidazoline - 5 - on and 5, 6 - dihydropyrimidine - 4 - on preparation
IL11082094A IL110820A0 (en)	1990-03-20	1994-08-30	N-substituted heterocyclic derivatives and their preparation

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
IL9761291A IL97612A (en)	1990-03-20	1991-03-20	The history of N-transformed heterocycles, their preparation and the pharmaceutical preparations containing them
IL11082091A IL110820A (en)	1990-03-20	1991-03-20	History of imidazoline - 5 - on and 5, 6 - dihydropyrimidine - 4 - on preparation

Country Status (29)

Country	Link
EP (1)	EP0454511B1 (xx)
JP (2)	JP2868313B2 (xx)
KR (1)	KR0175310B1 (xx)
AT (1)	ATE167475T1 (xx)
AU (1)	AU641005B2 (xx)
CA (1)	CA2057913C (xx)
CZ (2)	CZ287064B6 (xx)
DE (2)	DE19975029I2 (xx)
DK (1)	DK0454511T3 (xx)
ES (1)	ES2119764T3 (xx)
FI (1)	FI103407B1 (xx)
HU (3)	HU223141B1 (xx)
IE (1)	IE910913A1 (xx)
IL (3)	IL97612A (xx)
LU (2)	LU90279I2 (xx)
LV (1)	LV10439B (xx)
MX (1)	MX9203586A (xx)
MY (1)	MY115638A (xx)
NL (2)	NL980039I2 (xx)
NO (3)	NO301977B1 (xx)
NZ (1)	NZ237476A (xx)
PL (3)	PL166581B1 (xx)
PT (1)	PT97078B (xx)
RU (1)	RU2099331C1 (xx)
SG (1)	SG49053A1 (xx)
SK (2)	SK283197B6 (xx)
TW (1)	TW201738B (xx)
UA (1)	UA42669A (xx)
WO (1)	WO1991014679A1 (xx)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
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CA2115989A1 (en) *	1991-08-19	1993-03-04	George Albert Boswell	Angiotensin ii receptor blocking imidazolinone derivatives
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FR2685328B1 (fr) *	1991-12-20	1995-12-01	Rhone Poulenc Agrochimie	Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
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US5326776A (en) *	1992-03-02	1994-07-05	Abbott Laboratories	Angiotensin II receptor antagonists
FR2688781B1 (fr) *	1992-03-23	1994-07-01	Sanofi Elf	Imidazolines n-substituees par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
FR2689887B1 (fr) *	1992-04-13	1995-06-23	Sanofi Elf	Procede de preparation d'un derive de biphenyle.
EP0577025A3 (de) *	1992-07-01	1998-02-04	Hoechst Aktiengesellschaft	Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen
GB9218449D0 (en)	1992-08-29	1992-10-14	Boots Co Plc	Therapeutic agents
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FR2725987B1 (fr) *	1994-10-19	1997-01-10	Sanofi Sa	Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
SE9501881D0 (sv) *	1995-05-19	1995-05-19	Astra Ab	New pharmacological use of AII-receptor antagonists
TW442301B (en) *	1995-06-07	2001-06-23	Sanofi Synthelabo	Pharmaceutical compositions containing irbesartan
US5994348A (en) *	1995-06-07	1999-11-30	Sanofi	Pharmaceutical compositions containing irbesartan
DK0853477T3 (da) *	1995-10-06	2003-02-10	Novartis Ag	AT1-receptor-antagonister til forebyggelse og behandling af postiskæmisk nyresvigt og til beskyttelse af iskæmiske nyrer
CA2196263C (en) *	1996-02-09	2004-10-26	Barry Jackson	Process for the preparation of 4-oxoimidazolinium salts
DE69718146T2 (de)	1996-02-29	2003-10-02	Novartis Ag, Basel	At1 rezeptor antagonist zur anregung von apoptosis
SK283295B6 (sk) *	1996-03-14	2003-05-02	Warner-Lambert Company	Substituovaná cyklická aminokyselina, jej použitie a farmaceutický prostriedok na jej báze
HU218681B (hu)	1997-07-25	2000-10-30	Sanofi-Synthelabo	Eljárás 1,3-diaza-spiro(4,4)non-1-én-4-on-származékok előállitására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
US6162922A (en) *	1998-01-30	2000-12-19	Bristol-Myers Squibb Co.	Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
AU757488B2 (en) *	1998-03-25	2003-02-20	Bristol-Myers Squibb Company	Imidazolone anorectic agents: III. heteroaryl derivatives
KR19990081093A (ko) *	1998-04-25	1999-11-15	조생현	피리미디논 화합물, 이를 함유하는 약제학적 조성물 및 이의제조방법
DE19820064A1 (de) *	1998-05-06	1999-11-11	Hoechst Marion Roussel De Gmbh	Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
FR2780403B3 (fr) *	1998-06-24	2000-07-21	Sanofi Sa	Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
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ES2281978T3 (es)	1998-12-23	2007-10-01	Novartis Ag	Uso de un antagonista del receptor at-1 o de un modulador del receptor at-2 para tratar enfermedades asociadas con un incremento de los receptores at-1 o at-2.
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SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
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FR2831446B1 (fr)	2001-10-26	2004-03-05	Sanofi Synthelabo	Utilisation de l'irbesartan pour la preparation de medicaments utiles pour la prevention ou le traitement de l'hypertension pulmonaire
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DE10335027A1 (de)	2003-07-31	2005-02-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Angiotensin II Rezeptor Antagonisten
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GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
GB0402262D0 (en)	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
KR20070006774A (ko)	2004-03-17	2007-01-11	노파르티스 아게	치료에서 레닌 억제제의 용도
DE602005025755D1 (de)	2004-06-04	2011-02-17	Teva Pharma	Irbesartan enthaltende pharmazeutische zusammensetzung
WO2005122699A2 (en) *	2004-06-16	2005-12-29	Matrix Laboratories Ltd	An improved process for the preparation of n-substituted hetero cyclic derivatives
SI21849A (sl)	2004-07-29	2006-02-28	Krka, Tovarna Zdravil, D.D., Novo Mesto	Priprava hidrokloridnih soli tetrazolskega derivata
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1991
- 1991-03-19 IE IE091391A patent/IE910913A1/en not_active IP Right Cessation
- 1991-03-19 TW TW080102155A patent/TW201738B/zh not_active IP Right Cessation
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- 1991-03-20 SK SK1256-98A patent/SK283197B6/sk not_active IP Right Cessation
- 1991-03-20 RU SU5010343/04A patent/RU2099331C1/ru active
- 1991-03-20 PL PL91304152A patent/PL166581B1/pl unknown
- 1991-03-20 CA CA002057913A patent/CA2057913C/en not_active Expired - Lifetime
- 1991-03-20 AU AU75610/91A patent/AU641005B2/en not_active Expired
- 1991-03-20 IL IL9761291A patent/IL97612A/en active Protection Beyond IP Right Term
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- 1991-03-20 WO PCT/FR1991/000224 patent/WO1991014679A1/fr active IP Right Grant
- 1991-03-20 HU HU9302497A patent/HU223141B1/hu active IP Right Grant
- 1991-03-20 UA UA5010343A patent/UA42669A/uk unknown
- 1991-03-20 ES ES91400745T patent/ES2119764T3/es not_active Expired - Lifetime
- 1991-03-20 KR KR1019910701647A patent/KR0175310B1/ko not_active Expired - Lifetime
- 1991-03-20 DE DE1999175029 patent/DE19975029I2/de active Active
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1992
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1993
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1994
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1996
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1997
- 1997-12-10 JP JP9339895A patent/JPH10279566A/ja active Pending
1998
- 1998-08-21 LU LU90279C patent/LU90279I2/fr unknown
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1999
- 1999-03-05 NL NL990006C patent/NL990006I2/nl unknown
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Also Published As

Publication number	Publication date
NO301977B1 (no)	1998-01-05
SK280096B6 (sk)	1999-08-06
PL166581B1 (pl)	1995-06-30
MX9203586A (es)	1992-07-01
NO914528D0 (no)	1991-11-19
AU7561091A (en)	1991-10-21
DK0454511T3 (da)	1999-04-06
NO1998021I1 (no)	1998-10-05
CA2057913A1 (en)	1991-09-21
SG49053A1 (en)	1998-05-18
KR0175310B1 (ko)	1999-02-18
NO914528L (no)	1992-01-17
LV10439A (lv)	1995-02-20
ES2119764T3 (es)	1998-10-16
CZ287225B6 (cs)	2000-10-11
IL110820A (en)	1995-11-27
HU913603D0 (en)	1992-07-28
HU9302497D0 (en)	1993-11-29
NL980039I1 (nl)	1999-02-01
PL165945B1 (pl)	1995-03-31
RU2099331C1 (ru)	1997-12-20
HUT67648A (en)	1995-04-28
TW201738B (xx)	1993-03-11
NZ237476A (en)	1994-01-26
HK1008918A1 (en)	1999-05-21
NL980039I2 (nl)	1999-09-01
DE69129606T2 (de)	1998-12-17
CZ287064B6 (cs)	2000-08-16
NL990006I1 (nl)	1999-05-03
FI915458A0 (fi)	1991-11-19
JPH04506222A (ja)	1992-10-29
FI103407B (fi)	1999-06-30
FI103407B1 (fi)	1999-06-30
LU90371I2 (fr)	1999-05-12
CA2057913C (en)	1997-07-08
IL97612A0 (en)	1992-06-21
NO1999025I1 (no)	1999-12-09
EP0454511A1 (fr)	1991-10-30
WO1991014679A1 (fr)	1991-10-03
PT97078A (pt)	1991-11-29
NL990006I2 (nl)	1999-10-01
MY115638A (en)	2003-08-30
LU90279I2 (fr)	1998-10-21
DE19975029I2 (de)	2002-05-08
AU641005B2 (en)	1993-09-09
HUT61284A (en)	1992-12-28
EP0454511B1 (fr)	1998-06-17
ATE167475T1 (de)	1998-07-15
PT97078B (pt)	1997-07-31
LV10439B (en)	1995-08-20
UA42669A (uk)	2001-11-15
IE910913A1 (en)	1991-09-25
PL166403B1 (pl)	1995-05-31
HU223141B1 (hu)	2004-03-29
DE69129606D1 (de)	1998-07-23
KR920702349A (ko)	1992-09-03
JP2868313B2 (ja)	1999-03-10
PL293015A1 (xx)	1993-02-08
JPH10279566A (ja)	1998-10-20
CS74591A3 (en)	1991-11-12
HU221188B1 (en)	2002-08-28
SK283197B6 (sk)	2003-03-04
IL97612A (en)	1995-08-31

Publication	Publication Date	Title
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ATE204269T1 (de)	2001-09-15	Substituierte biphenyl- oder phenylpyridinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
CO5261605A1 (es)	2003-03-31	Compustos farmaceuticos
PL324795A1 (en)	1998-06-22	Application of adamantane derivatives in treating internal ear diseases
NO940737D0 (no)	1994-03-03	Antidepressive midler
GR3035277T3 (en)	2001-04-30	Thiazolidines and oxazolidines substituted by a pyridine ring and their use as hypoglycemic agents
TW333532B (en)	1998-06-11	Benzopyrans
ZA90878B (en)	1990-11-28	Arylalkyl-amines and-amides having anticonvulsant and neuroprotective properties
BR9801448B1 (pt)	2009-01-13	compostos heterocÍclicos, processo para sua preparaÇço e composiÇÕes farmacÊuticas contendo os mesmos.
DE69403896D1 (de)	1997-07-24	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten