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IL110724A - Retroviral protease inhibitors and pharmaceutical compositions containing them - Google Patents

Retroviral protease inhibitors and pharmaceutical compositions containing them

Info

Publication number
IL110724A
IL110724A IL11072494A IL11072494A IL110724A IL 110724 A IL110724 A IL 110724A IL 11072494 A IL11072494 A IL 11072494A IL 11072494 A IL11072494 A IL 11072494A IL 110724 A IL110724 A IL 110724A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
protease inhibitors
retroviral protease
retroviral
Prior art date
Application number
IL11072494A
Other versions
IL110724A0 (en
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/253,531 external-priority patent/US5750648A/en
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Publication of IL110724A0 publication Critical patent/IL110724A0/en
Publication of IL110724A publication Critical patent/IL110724A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11072494A 1993-08-20 1994-08-19 Retroviral protease inhibitors and pharmaceutical compositions containing them IL110724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10978793A 1993-08-20 1993-08-20
US08/253,531 US5750648A (en) 1993-08-20 1994-06-03 Retroviral protease inhibitors and combinations thereof

Publications (2)

Publication Number Publication Date
IL110724A0 IL110724A0 (en) 1994-11-11
IL110724A true IL110724A (en) 1999-08-17

Family

ID=26807360

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11072494A IL110724A (en) 1993-08-20 1994-08-19 Retroviral protease inhibitors and pharmaceutical compositions containing them

Country Status (3)

Country Link
AU (1) AU7518694A (en)
IL (1) IL110724A (en)
WO (1) WO1995006061A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
DE69830241T2 (en) * 1997-02-14 2006-01-26 G.D. Searle Llc, Chicago USE OF N-SUBSTITUTED 1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY OF INFECTIONS CAUSED BY HEPATITISVIRUS
CA2309321A1 (en) 1997-11-10 1999-05-20 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
MY122185A (en) 1998-02-12 2006-03-31 Searle & Co Use of n-substituted-1, 5-dideoxy-1, 5-imino-d-glucitol compounds for treating hepatitis virus infections
DE60039729D1 (en) 1999-02-12 2008-09-11 United Therapeutics Corp N- (8,8,8-trifluoro-octyl) -1,5-dideoxy-1,5-imino-D-glucitol for the treatment of hepatitis virus infections
CA2362785A1 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
DK1248600T3 (en) 2000-01-19 2008-09-08 Abbott Lab Improved pharmaceutical formulations
CN102816111B (en) 2007-03-12 2014-08-06 尼克塔治疗公司 Oligomer-protease inhibitor conjugates
WO2009114151A1 (en) 2008-03-12 2009-09-17 Nektar Therapeutics Oligomer-amino acid and olgomer-atazanavir conjugates
JP2012530069A (en) 2009-06-12 2012-11-29 ネクター セラピューティックス Covalent conjugate comprising a protease inhibitor, a water-soluble non-peptide oligomer and a lipophilic moiety

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2096525C (en) * 1990-11-19 2005-02-08 Deborah Elizabeth Bertenshaw Retroviral protease inhibitors
CA2131182C (en) * 1992-05-20 2005-04-26 John S. Ng Method for making intermediates useful in synthesis of retroviral protease inhibitors

Also Published As

Publication number Publication date
AU7518694A (en) 1995-03-21
IL110724A0 (en) 1994-11-11
WO1995006061A1 (en) 1995-03-02

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees