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IL108892A - Azacyclohexapeptide compounds and bactericidal preparations containing them - Google Patents

Azacyclohexapeptide compounds and bactericidal preparations containing them

Info

Publication number
IL108892A
IL108892A IL10889294A IL10889294A IL108892A IL 108892 A IL108892 A IL 108892A IL 10889294 A IL10889294 A IL 10889294A IL 10889294 A IL10889294 A IL 10889294A IL 108892 A IL108892 A IL 108892A
Authority
IL
Israel
Prior art keywords
compound
seq
xaa xaa
ch2ch2nh2
ch2conh2
Prior art date
Application number
IL10889294A
Other languages
English (en)
Hebrew (he)
Other versions
IL108892A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL108892(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL108892A0 publication Critical patent/IL108892A0/xx
Publication of IL108892A publication Critical patent/IL108892A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Chemical Vapour Deposition (AREA)
IL10889294A 1993-03-16 1994-03-08 Azacyclohexapeptide compounds and bactericidal preparations containing them IL108892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
IL108892A0 IL108892A0 (en) 1994-06-24
IL108892A true IL108892A (en) 1998-07-15

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10889294A IL108892A (en) 1993-03-16 1994-03-08 Azacyclohexapeptide compounds and bactericidal preparations containing them

Country Status (33)

Country Link
US (3) US5378804A (no)
EP (1) EP0620232B1 (no)
JP (1) JP2568474B2 (no)
KR (1) KR100329693B1 (no)
CN (1) CN1098274C (no)
AT (1) ATE186736T1 (no)
AU (1) AU668804B2 (no)
BG (1) BG63047B1 (no)
BR (2) BR9406009A (no)
CA (1) CA2118757C (no)
CZ (1) CZ286235B6 (no)
DE (2) DE10299013I2 (no)
DK (1) DK0620232T3 (no)
ES (1) ES2139043T3 (no)
FI (1) FI109542B (no)
GR (1) GR3031872T3 (no)
HK (1) HK1008674A1 (no)
HR (1) HRP940161B1 (no)
HU (2) HU217614B (no)
IL (1) IL108892A (no)
LU (1) LU90875I2 (no)
LV (1) LV12574B (no)
NL (1) NL300076I2 (no)
NO (2) NO318372B1 (no)
NZ (1) NZ263360A (no)
PL (1) PL179261B1 (no)
RO (1) RO113246B1 (no)
RU (1) RU2122548C1 (no)
SI (1) SI9420013B (no)
SK (1) SK282527B6 (no)
UA (1) UA59329C2 (no)
WO (1) WO1994021677A1 (no)
ZA (1) ZA941807B (no)

Families Citing this family (63)

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US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
JP3118466B2 (ja) * 1994-08-23 2000-12-18 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルリポペプチドの側鎖誘導体の改良製造方法
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
EP0781141B1 (en) * 1994-09-16 2002-09-04 Merck & Co. Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
AU691743B2 (en) * 1995-01-26 1998-05-21 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
ATE248625T1 (de) * 1996-09-12 2003-09-15 Merck & Co Inc Fungizide kombinationstherapie
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2380176A1 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
CA2477088A1 (en) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
ES2298821T3 (es) * 2003-07-22 2008-05-16 Theravance, Inc. Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico.
EP1730180A4 (en) * 2004-02-24 2008-06-18 Commw Scient Ind Res Org ANTIFUNGAL PEPTIDES
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
KR101536781B1 (ko) 2006-07-26 2015-07-14 산도즈 아게 카스포펀진 제형
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
WO2009002481A1 (en) 2007-06-26 2008-12-31 Merck & Co., Inc. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
EP2183271A1 (en) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
WO2011014990A1 (zh) * 2009-08-06 2011-02-10 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
MX2013003045A (es) 2010-09-20 2013-06-24 Xellia Pharmaceuticals Aps Composicion de caspofungina.
KR101514903B1 (ko) * 2010-09-29 2015-04-23 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 사이클릭 리포펩타이드 화합물 또는 그의 염의 정제방법
US8877777B2 (en) * 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
US20140005355A1 (en) * 2011-01-03 2014-01-02 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
LT2680873T (lt) 2011-03-03 2017-11-27 Cidara Therapeutics, Inc. Priešgrybeliniai agentai ir jų panaudojimas
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CA2833206A1 (en) 2011-04-28 2012-11-01 Unitris Biopharma Co., Ltd. Intermediate for synthesizing caspofungin and preparation method therefor
CN104507309B (zh) 2012-03-19 2017-05-03 奇达拉治疗公司 用于棘白菌素类化合物的给药方案
DK2922530T3 (en) * 2012-11-20 2017-01-09 Fresenius Kabi Usa Llc Caspofunginacetatformuleringer
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
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CN109154603A (zh) 2016-03-16 2019-01-04 奇达拉治疗公司 用于治疗真菌感染的给药方案
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
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BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
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US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
KR100329693B1 (ko) 2002-08-14
ZA941807B (en) 1994-10-13
DK0620232T3 (da) 2000-03-13
US5514650A (en) 1996-05-07
NL300076I2 (nl) 2002-04-02
UA59329C2 (uk) 2003-09-15
NO2005020I1 (no) 2005-09-13
BG99999A (bg) 1996-04-30
US5792746A (en) 1998-08-11
NL300076I1 (nl) 2002-03-01
RO113246B1 (ro) 1998-05-29
BG63047B1 (bg) 2001-02-28
ES2139043T3 (es) 2000-02-01
DE69421639T2 (de) 2000-06-08
CN1098274C (zh) 2003-01-08
HRP940161B1 (en) 2001-04-30
SK113695A3 (en) 1996-02-07
AU668804B2 (en) 1996-05-16
CA2118757A1 (en) 1994-09-17
SI9420013A (en) 1996-08-31
ATE186736T1 (de) 1999-12-15
LV12574A (en) 2000-11-20
NO318372B1 (no) 2005-03-14
EP0620232B1 (en) 1999-11-17
JP2568474B2 (ja) 1997-01-08
PL179261B1 (pl) 2000-08-31
HU217614B (hu) 2000-03-28
EP0620232A1 (en) 1994-10-19
NO2005020I2 (no) 2008-12-01
FI954327A (fi) 1995-09-14
BR1100273A (pt) 1999-10-13
SI9420013B (sl) 2002-12-31
BR9406009A (pt) 1995-12-26
LV12574B (en) 2001-04-20
HUT73496A (en) 1996-08-28
HK1008674A1 (en) 1999-05-14
JPH06321986A (ja) 1994-11-22
CZ286235B6 (cs) 2000-02-16
RU2122548C1 (ru) 1998-11-27
PL310634A1 (en) 1995-12-27
DE10299013I1 (de) 2003-01-23
CA2118757C (en) 2002-05-14
WO1994021677A1 (en) 1994-09-29
LU90875I2 (en) 2002-03-04
IL108892A0 (en) 1994-06-24
DE10299013I2 (de) 2009-11-19
FI954327A0 (fi) 1995-09-14
KR960701092A (ko) 1996-02-24
HU9502703D0 (en) 1995-11-28
HU211890A9 (en) 1995-12-28
DE69421639D1 (de) 1999-12-23
FI109542B (fi) 2002-08-30
NO953648D0 (no) 1995-09-15
CN1119441A (zh) 1996-03-27
NZ263360A (en) 1997-08-22
US5378804A (en) 1995-01-03
CZ235895A3 (en) 1996-02-14
AU5783294A (en) 1994-09-22
GR3031872T3 (en) 2000-02-29
NO953648L (no) 1995-11-15
HRP940161A2 (en) 1996-08-31
SK282527B6 (sk) 2002-10-08

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