IL106748A0 - 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase - Google Patents

2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Info

Publication number: IL106748A0
Authority: IL; Israel
Prior art keywords: inhibitors; enkephalinase; derivatives useful; tricyclic derivatives; substituted indane
Prior art date: 1992-08-24

Application number

IL106748A

Other languages

English (en)

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-24

Filing date

1993-08-20

Publication date

1993-12-08

1993-06-17 Priority claimed from US08/078,787 external-priority patent/US5420271A/en

1993-08-20 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1993-12-08 Publication of IL106748A0 publication Critical patent/IL106748A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IL106748A 1992-08-24 1993-08-20 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase IL106748A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US93483392A	1992-08-24	1992-08-24
US08/078,787 US5420271A (en)	1992-08-24	1993-06-17	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Publications (1)

Publication Number	Publication Date
IL106748A0 true IL106748A0 (en)	1993-12-08

Family

ID=26760940

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL106748A IL106748A0 (en)	1992-08-24	1993-08-20	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Country Status (18)

Country	Link
US (2)	US5491141A (da)
EP (1)	EP0656001B1 (da)
JP (1)	JP3427937B2 (da)
AT (1)	ATE184604T1 (da)
AU (1)	AU679452B2 (da)
CA (1)	CA2141563C (da)
DE (1)	DE69326474T2 (da)
DK (1)	DK0656001T3 (da)
ES (1)	ES2139669T3 (da)
FI (1)	FI950842A (da)
GR (1)	GR3031602T3 (da)
HU (1)	HUT71246A (da)
IL (1)	IL106748A0 (da)
MX (1)	MX9305093A (da)
NO (1)	NO303635B1 (da)
NZ (1)	NZ254656A (da)
TW (1)	TW404949B (da)
WO (1)	WO1994004531A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5508272A (en) *	1993-06-15	1996-04-16	Bristol-Myers Squibb Company	Compounds containing a fused bicycle ring and processes therefor
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en)	1996-12-23	2004-01-27	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6509331B1 (en)	1998-06-22	2003-01-21	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en)	1998-06-22	2004-08-10	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en)	1998-06-22	2005-10-25	Elan Pharmaceuticals, Inc.	Polycyclic α-amino-ε-caprolactams and related compounds
US6528505B1 (en)	1998-06-22	2003-03-04	Elan Pharmaceuticals, Inc.	Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en)	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
MX2011012479A (es)	2009-05-22	2012-03-06	Abbott Lab	Moduladores de los receptores 5-ht y metodos de uso de los mismos.
RU2015140748A (ru)	2010-05-21	2018-12-26	Эббви Инк.	Модуляторы 5-нт рецепторов и способы их применения
EP3414239A2 (en)	2016-02-05	2018-12-19	Denali Therapeutics Inc.	Inhibitors of receptor-interacting protein kinase 1
PL3552017T3 (pl)	2016-12-09	2022-08-08	Denali Therapeutics Inc.	Związki użyteczne jako inhibitory RIPK1
MX2024008648A (es)	2022-01-12	2024-09-23	Denali Therapeutics Inc	Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
FR2611712B1 (fr) *	1987-02-26	1989-06-23	Roussel Uclaf	Nouveaux derives n-substitues de l'alpha-mercaptomethyl benzene propanamide, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
US4879309A (en) *	1988-09-27	1989-11-07	Schering Corporation	Mercapto-acylamino acids as antihypertensives
ZA902661B (en) *	1989-04-10	1991-01-30	Schering Corp	Mercapto-acyl amino acids
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU657793B2 (en) *	1991-09-27	1995-03-23	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (en) *	1991-09-27	2003-12-09	Alan M. Warshawsky	2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

1993
- 1993-07-23 CA CA002141563A patent/CA2141563C/en not_active Expired - Fee Related
- 1993-07-23 NZ NZ254656A patent/NZ254656A/en unknown
- 1993-07-23 JP JP50627294A patent/JP3427937B2/ja not_active Expired - Fee Related
- 1993-07-23 ES ES93917323T patent/ES2139669T3/es not_active Expired - Lifetime
- 1993-07-23 AT AT93917323T patent/ATE184604T1/de not_active IP Right Cessation
- 1993-07-23 DE DE69326474T patent/DE69326474T2/de not_active Expired - Fee Related
- 1993-07-23 AU AU46872/93A patent/AU679452B2/en not_active Ceased
- 1993-07-23 HU HU9500559A patent/HUT71246A/hu active IP Right Revival
- 1993-07-23 WO PCT/US1993/006920 patent/WO1994004531A1/en active IP Right Grant
- 1993-07-23 EP EP93917323A patent/EP0656001B1/en not_active Expired - Lifetime
- 1993-07-23 DK DK93917323T patent/DK0656001T3/da active
- 1993-08-19 TW TW082106677A patent/TW404949B/zh not_active IP Right Cessation
- 1993-08-20 IL IL106748A patent/IL106748A0/xx unknown
- 1993-08-23 MX MX9305093A patent/MX9305093A/es not_active IP Right Cessation
1995
- 1995-02-23 NO NO950683A patent/NO303635B1/no not_active IP Right Cessation
- 1995-02-23 FI FI950842A patent/FI950842A/fi unknown
- 1995-03-01 US US08/396,833 patent/US5491141A/en not_active Expired - Fee Related
- 1995-03-01 US US08/396,945 patent/US5491142A/en not_active Expired - Fee Related
1999
- 1999-10-21 GR GR990402698T patent/GR3031602T3/el unknown

Also Published As

Publication number	Publication date
GR3031602T3 (en)	2000-01-31
US5491142A (en)	1996-02-13
AU679452B2 (en)	1997-07-03
FI950842A0 (fi)	1995-02-23
NO950683L (no)	1995-03-23
WO1994004531A1 (en)	1994-03-03
DE69326474T2 (de)	2000-02-17
DK0656001T3 (da)	2000-04-03
EP0656001B1 (en)	1999-09-15
NO950683D0 (no)	1995-02-23
FI950842A (fi)	1995-02-23
DE69326474D1 (de)	1999-10-21
AU4687293A (en)	1994-03-15
MX9305093A (es)	1994-04-29
NZ254656A (en)	1995-12-21
US5491141A (en)	1996-02-13
ES2139669T3 (es)	2000-02-16
JPH08500591A (ja)	1996-01-23
JP3427937B2 (ja)	2003-07-22
TW404949B (en)	2000-09-11
ATE184604T1 (de)	1999-10-15
CA2141563A1 (en)	1994-03-03
EP0656001A1 (en)	1995-06-07
HU9500559D0 (en)	1995-04-28
NO303635B1 (no)	1998-08-10
HUT71246A (en)	1995-11-28
CA2141563C (en)	1998-07-28

Publication	Publication Date	Title
TW269682B (da)	1996-02-01
AU657166B2 (en)	1995-03-02	Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
TW225534B (da)	1994-06-21
EP0534396A3 (en)	1993-06-09	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
IL99769A0 (en)	1992-08-18	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
TW327172B (en)	1998-02-21	Novel mercaptoacetylamide bicyclic lactam derivatives
GR3031602T3 (en)	2000-01-31	Novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase.
ZA936059B (en)	1994-03-14	Novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
MX9603348A (es)	1997-12-31	Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa.
HU9201474D0 (en)	1992-07-28	2-mercaptomethylene-tetrahydro-naphtalyn- and indene-2-carboxamide derivatives with enkephalynase inhibitor effect