IE881949L - Process for preparing benzothiazepine derivatives - Google Patents
Process for preparing benzothiazepine derivativesInfo
- Publication number
- IE881949L IE881949L IE881949A IE194988A IE881949L IE 881949 L IE881949 L IE 881949L IE 881949 A IE881949 A IE 881949A IE 194988 A IE194988 A IE 194988A IE 881949 L IE881949 L IE 881949L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- expressed
- formula
- cerebral
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To readily obtain the titled compound useful as a medicinal compound having excellent hypotensive, cerebral coronary vasodilator and/or blood platelet agglutination inhibitory action, by reacting a specific compound with amines as raw materials. CONSTITUTION:An compound expressed by formula I (R<1> is lower alkyl or lower alkoxy; R<2> is H or lower alkanoyl; either of R<3> and R<4> is lower alkyl or halogen and the other is H; X' is reactive residue) is reacted with an amine expressed by formula II (R<5> and R<6> are lower alkyl) or salt thereof in a suitable solvent in the presence or absence of a deacidifying agent, preferably at ambient temperature - while being heated to afford the aimed compound, expressed by formula III and useful for treating.preventing cerebropathy, such as cerebral vasospasm, cerebral ischemia or cerebral infraction, and cardiopathy, such as angina pectoris. The above-mentioned compound is treated with an acid to provide an acid addition salt. Furthermore, since the aforementioned reaction proceeds without accompanying racemization, the aimed compound can also be obtained as an optically active substance by using the optically active compound expressed by formula I.
[JP1045376A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62202027A JPS6445376A (en) | 1987-08-12 | 1987-08-12 | Production of 1,5-benzothiazepine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE881949L true IE881949L (en) | 1989-02-12 |
| IE61168B1 IE61168B1 (en) | 1994-10-05 |
Family
ID=16450708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE194988A IE61168B1 (en) | 1987-08-12 | 1988-06-27 | Process for preparing 1.5-benzothiazepine derivatives |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS6445376A (en) |
| KR (1) | KR890003722A (en) |
| CN (1) | CN1030570C (en) |
| AT (1) | AT395010B (en) |
| BG (1) | BG50501A3 (en) |
| CA (1) | CA1337346C (en) |
| ES (1) | ES2007990A6 (en) |
| FI (1) | FI883115A (en) |
| GR (1) | GR1000385B (en) |
| IE (1) | IE61168B1 (en) |
| IL (1) | IL86978A0 (en) |
| NO (1) | NO170017C (en) |
| PT (1) | PT88250B (en) |
| SU (1) | SU1709908A3 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| US3895006A (en) * | 1974-04-19 | 1975-07-15 | Squibb & Sons Inc | 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones |
| SE449611B (en) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES |
| US4567175A (en) * | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
| GB8315364D0 (en) * | 1983-06-03 | 1983-07-06 | Tanabe Seiyaku Co | 8-chloro-1 5-benzothiazepine derivatives |
| GB8406318D0 (en) * | 1984-03-10 | 1984-04-11 | Tanabe Seiyaku Co | 1 5-benzothiazepine derivatives |
| JPS60204776A (en) * | 1984-03-30 | 1985-10-16 | Roller Japan Kk | 1,5-benzothiazepine derivative |
| JPS61103877A (en) * | 1984-10-24 | 1986-05-22 | Tanabe Seiyaku Co Ltd | Benzothiazepine derivative and its preparation |
-
1987
- 1987-08-12 JP JP62202027A patent/JPS6445376A/en active Pending
-
1988
- 1988-06-27 IE IE194988A patent/IE61168B1/en not_active IP Right Cessation
- 1988-06-29 FI FI883115A patent/FI883115A/en not_active Application Discontinuation
- 1988-07-04 IL IL86978A patent/IL86978A0/en not_active IP Right Cessation
- 1988-07-07 CA CA000571438A patent/CA1337346C/en not_active Expired - Fee Related
- 1988-07-11 CN CN88104387A patent/CN1030570C/en not_active Expired - Fee Related
- 1988-08-02 BG BG085116A patent/BG50501A3/en unknown
- 1988-08-04 GR GR880100515A patent/GR1000385B/en unknown
- 1988-08-09 NO NO883525A patent/NO170017C/en unknown
- 1988-08-10 KR KR1019880010209A patent/KR890003722A/en not_active Application Discontinuation
- 1988-08-11 ES ES8802522A patent/ES2007990A6/en not_active Expired
- 1988-08-11 SU SU884356317A patent/SU1709908A3/en active
- 1988-08-11 PT PT88250A patent/PT88250B/en not_active IP Right Cessation
- 1988-08-11 AT AT0202388A patent/AT395010B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2007990A6 (en) | 1989-07-01 |
| JPS6445376A (en) | 1989-02-17 |
| IE61168B1 (en) | 1994-10-05 |
| CA1337346C (en) | 1995-10-17 |
| GR880100515A (en) | 1989-05-25 |
| ATA202388A (en) | 1992-01-15 |
| PT88250B (en) | 1995-03-01 |
| GR1000385B (en) | 1992-06-30 |
| KR890003722A (en) | 1989-04-17 |
| PT88250A (en) | 1989-06-30 |
| SU1709908A3 (en) | 1992-01-30 |
| FI883115A0 (en) | 1988-06-29 |
| NO170017B (en) | 1992-05-25 |
| CN1031229A (en) | 1989-02-22 |
| IL86978A0 (en) | 1988-12-30 |
| CN1030570C (en) | 1995-12-27 |
| NO883525D0 (en) | 1988-08-09 |
| NO883525L (en) | 1989-02-13 |
| AT395010B (en) | 1992-08-25 |
| NO170017C (en) | 1992-09-02 |
| FI883115A (en) | 1989-02-13 |
| BG50501A3 (en) | 1992-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |