IE34583L - Esters of hydroxyphenylalkanolamines - Google Patents
Esters of hydroxyphenylalkanolaminesInfo
- Publication number
- IE34583L IE34583L IE700394A IE39470A IE34583L IE 34583 L IE34583 L IE 34583L IE 700394 A IE700394 A IE 700394A IE 39470 A IE39470 A IE 39470A IE 34583 L IE34583 L IE 34583L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- cycloalkyl
- alkyl
- hydrogen
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
Abstract
1298771 Sympathomimetic medicines STERLING DRUG Inc 20 March 1970 [1 April 1969] 13690/70 Heading A5B [Also in Division C2] Pharmaceutical compositions having sympathomimetic effects particularly bronchodilator activity being in conventional forms for oral or parenteral administration or in the preferred form as an aerosol inhalant preparation comprise an amino-ester of formulae I or II wherein R is hydrogen (only in formula II), alkyl having 1-4 carbon atoms, or cycloalkyl having 3-6 carbon atoms; R<SP>1</SP> is hydrogen or alkyl having 1-3 carbon atoms; Y is an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, O # cycloalkyl -C n H 2n -C- having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, phenyl -C n H 2n O # -C- wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamine having 1-6 carbon atom groups; and Y<SP>1</SP> and Y<SP>2</SP> are the same or different and are hydrogen or one of the acyl members defined by Y, and wherein in Formula I at least one of Y and Y<SP>1</SP> contains no less than four carbon atoms when R is tert-butyl or cycloalkyl and no less than seven carbon atoms when R is alkyl other than tertbutyl, and in Formula II at least one of Y and Y<SP>1</SP> contains no less than four carbon atoms; or an acid-addition salt thereof and a suitable conventional carrier, and if necessary, a propellant.
[GB1298771A]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE131/73A IE34584B1 (en) | 1969-04-01 | 1970-04-01 | Esters of alpha-aminomethyl-3-(hydroxy or hydroxymethyl)-4-hydroxyphenyl ketones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81237069A | 1969-04-01 | 1969-04-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE34583L true IE34583L (en) | 1970-10-01 |
| IE34583B1 IE34583B1 (en) | 1975-06-25 |
Family
ID=25209368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE394/70A IE34583B1 (en) | 1969-04-01 | 1970-04-01 | Carboxylic esters of hydroxyphenylalkanolamines |
Country Status (17)
| Country | Link |
|---|---|
| JP (2) | JPS5314544B1 (en) |
| AT (1) | AT300762B (en) |
| BE (1) | BE748178A (en) |
| CH (1) | CH522589A (en) |
| DE (1) | DE2015573C3 (en) |
| DK (1) | DK131459B (en) |
| ES (1) | ES378092A1 (en) |
| FI (1) | FI54796C (en) |
| FR (1) | FR2042295B1 (en) |
| GB (1) | GB1298771A (en) |
| IE (1) | IE34583B1 (en) |
| IL (2) | IL34148A (en) |
| NL (1) | NL171155C (en) |
| NO (1) | NO129903B (en) |
| PH (2) | PH9407A (en) |
| SE (2) | SE381039B (en) |
| ZA (1) | ZA702065B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138581A (en) | 1969-04-01 | 1979-02-06 | Sterling Drugs Inc. | 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols |
| US3809714A (en) * | 1972-08-31 | 1974-05-07 | Interx Research Corp | Novel ester of ((methylamino)methyl) benzyl alcohol |
| US3868461A (en) * | 1972-11-22 | 1975-02-25 | Interx Research Corp | Ester of 3,4-dihydroxy-alpha (isopropylamino) methyl benzyl alcohol, composition and anti-asthma use thereof |
| US4046913A (en) | 1973-08-18 | 1977-09-06 | Boehringer Ingelheim Gmbh | 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof |
| LU71637A1 (en) * | 1974-01-15 | 1975-06-17 | ||
| US3957849A (en) * | 1974-09-09 | 1976-05-18 | Zoecon Corporation | Cyclopropane esters |
| US4000315A (en) * | 1974-09-09 | 1976-12-28 | Zoecon Corporation | Cyclopropane esters for the control of mites |
| ATE7689T1 (en) | 1980-07-09 | 1984-06-15 | Aktiebolaget Draco | 1-(DIHYDROXYPHENYL)-2-AMINO-AETHANOL DERIVATIVES, PROCESSES AND MEANS FOR THEIR PREPARATION, AND AGENTS CONTAINING THESE DERIVATIVES. |
| DE3163114D1 (en) * | 1980-07-09 | 1984-05-17 | Draco Ab | Therapeutically active derivatives of phenylethanol amines |
| FR2541999B1 (en) * | 1983-03-04 | 1986-09-19 | Bristol Myers Co | PHENETHANOLAMINES AND THEIR USES |
| US4614830A (en) * | 1985-08-09 | 1986-09-30 | Sterling Drug Inc. | Esterification process |
| IT1229846B (en) * | 1989-04-20 | 1991-09-13 | Simes | ESTERS OF CATECOLAMINS. |
| US5118683A (en) * | 1990-06-13 | 1992-06-02 | Schering Corporation | Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| US5011845A (en) * | 1990-06-13 | 1991-04-30 | Schering Corporation | Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| WO2010121022A1 (en) | 2009-04-15 | 2010-10-21 | Research Triangle Institute | Monoamine reuptake inhibitors |
| ES2546492T3 (en) | 2010-05-21 | 2015-09-24 | Research Triangle Institute | 1-Phenylmorpholine derivatives as hydroxybupropion analogs to treat drug dependence |
| ES2687095T3 (en) | 2010-05-21 | 2018-10-23 | Research Triangle Institute | Phenylimorpholins and analogues thereof |
| WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| CN108997261B (en) * | 2017-06-07 | 2022-01-07 | 东莞市凯法生物医药有限公司 | Compound and preparation method and application thereof |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
| WO2024153813A1 (en) | 2023-01-20 | 2024-07-25 | Atrogi Ab | Beta 2-adrenergic receptor agonists for treatment or prevention of muscle wasting |
| GB202302225D0 (en) | 2023-02-16 | 2023-04-05 | Atrogi Ab | New medical uses |
| GB202303229D0 (en) | 2023-03-06 | 2023-04-19 | Atrogi Ab | New medical uses |
-
1970
- 1970-03-20 NO NO01048/70A patent/NO129903B/no unknown
- 1970-03-20 GB GB03690/70A patent/GB1298771A/en not_active Expired
- 1970-03-24 IL IL34148A patent/IL34148A/en unknown
- 1970-03-24 IL IL42029A patent/IL42029A/en unknown
- 1970-03-25 PH PH11270*UA patent/PH9407A/en unknown
- 1970-03-26 ZA ZA702065A patent/ZA702065B/en unknown
- 1970-03-26 CH CH467070A patent/CH522589A/en not_active IP Right Cessation
- 1970-03-27 BE BE748178D patent/BE748178A/en not_active IP Right Cessation
- 1970-03-31 ES ES378092A patent/ES378092A1/en not_active Expired
- 1970-03-31 SE SE7004367A patent/SE381039B/en unknown
- 1970-03-31 DK DK160470AA patent/DK131459B/en not_active IP Right Cessation
- 1970-04-01 FR FR707011697A patent/FR2042295B1/fr not_active Expired
- 1970-04-01 JP JP2779370A patent/JPS5314544B1/ja active Pending
- 1970-04-01 DE DE2015573A patent/DE2015573C3/en not_active Expired
- 1970-04-01 FI FI908/70A patent/FI54796C/en active
- 1970-04-01 NL NLAANVRAGE7004671,A patent/NL171155C/en not_active IP Right Cessation
- 1970-04-01 AT AT296170A patent/AT300762B/en not_active IP Right Cessation
- 1970-04-01 IE IE394/70A patent/IE34583B1/en unknown
-
1972
- 1972-07-14 PH PH13731A patent/PH14377A/en unknown
-
1973
- 1973-03-23 SE SE7304162A patent/SE413503B/en unknown
- 1973-07-31 JP JP8630073A patent/JPS5414096B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO129903B (en) | 1974-06-10 |
| IL42029A (en) | 1974-01-14 |
| ES378092A1 (en) | 1973-01-01 |
| JPS5314544B1 (en) | 1978-05-18 |
| CH522589A (en) | 1972-06-30 |
| FI54796C (en) | 1979-03-12 |
| FR2042295B1 (en) | 1974-06-14 |
| NL171155C (en) | 1983-02-16 |
| JPS5414096B1 (en) | 1979-06-05 |
| DK131459B (en) | 1975-07-21 |
| IE34583B1 (en) | 1975-06-25 |
| PH9407A (en) | 1975-11-06 |
| FR2042295A1 (en) | 1971-02-12 |
| NL171155B (en) | 1982-09-16 |
| DE2015573B2 (en) | 1978-03-16 |
| DE2015573C3 (en) | 1978-11-02 |
| BE748178A (en) | 1970-09-28 |
| IL34148A (en) | 1974-01-14 |
| DK131459C (en) | 1975-12-08 |
| DE2015573A1 (en) | 1970-10-08 |
| IL34148A0 (en) | 1970-07-19 |
| SE381039B (en) | 1975-11-24 |
| ZA702065B (en) | 1971-01-27 |
| AT300762B (en) | 1972-08-10 |
| FI54796B (en) | 1978-11-30 |
| NL7004671A (en) | 1970-10-05 |
| SE413503B (en) | 1980-06-02 |
| PH14377A (en) | 1981-06-17 |
| GB1298771A (en) | 1972-12-06 |
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