IE33205B1 - 6,7-methylene-20-spiroxanes - Google Patents
6,7-methylene-20-spiroxanesInfo
- Publication number
- IE33205B1 IE33205B1 IE317/69A IE31769A IE33205B1 IE 33205 B1 IE33205 B1 IE 33205B1 IE 317/69 A IE317/69 A IE 317/69A IE 31769 A IE31769 A IE 31769A IE 33205 B1 IE33205 B1 IE 33205B1
- Authority
- IE
- Ireland
- Prior art keywords
- oxo
- novel
- methylene
- ols
- dienes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- E—FIXED CONSTRUCTIONS
- E05—LOCKS; KEYS; WINDOW OR DOOR FITTINGS; SAFES
- E05G—SAFES OR STRONG-ROOMS FOR VALUABLES; BANK PROTECTION DEVICES; SAFETY TRANSACTION PARTITIONS
- E05G1/00—Safes or strong-rooms for valuables
- E05G1/02—Details
- E05G1/024—Wall or panel structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
1,235,768. 6,7 - Methylene - 20 - spiroxanes. MERCK & CO. Inc. 17 March, 1969 [22 March, 1968], No. 13874/69. Heading C2U. Novel 3 - oxo - (6α,7α and 6#,7#) - methylene- 20-spirox-4-enes and -1,4-dienes that optionally contain 11#-hydroxy, 11-oxo, 21-oxo and 9α- fluoro substituents, and their novel 19-nor analogues, and corresponding 11α-ols, are prepared by reacting the corresponding 4,6-dienes not containing a #'-double bond or an 11-oxo group with dimethyl-oxo-sulphonium methylide and when the #<SP>1</SP>-compounds are required, dehydrogenating the products with dichlorodicyanobenzoquinane, and when the 11-ones are required, oxidizing the 11-ols. The product mixtures of 6α,7α- and 6α,7α-isomers may be separated by chromatography if required. The novel spiroxane compounds, which block the salt-retaining effects of aldosterene and other salt-retaining steroids, may be made up into pharmaceutical compositions with suitable carriers. Specification 1,041,534 is referred to.
[GB1235768A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71516068A | 1968-03-22 | 1968-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33205L IE33205L (en) | 1969-09-22 |
| IE33205B1 true IE33205B1 (en) | 1974-04-17 |
Family
ID=24872890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE317/69A IE33205B1 (en) | 1968-03-22 | 1969-03-11 | 6,7-methylene-20-spiroxanes |
Country Status (14)
| Country | Link |
|---|---|
| AT (1) | AT297948B (en) |
| BE (1) | BE730163A (en) |
| BR (1) | BR6907426D0 (en) |
| CH (1) | CH525876A (en) |
| DK (1) | DK123353B (en) |
| FI (1) | FI47354C (en) |
| FR (1) | FR2004562A1 (en) |
| GB (1) | GB1235768A (en) |
| IE (1) | IE33205B1 (en) |
| IL (1) | IL31769A (en) |
| NL (1) | NL166267C (en) |
| NO (1) | NO131175C (en) |
| SE (1) | SE351636B (en) |
| YU (1) | YU34303B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792624A (en) * | 1972-05-22 | 1973-06-12 | Merck & Co Inc | ALDOSTERONE INHIBITORS AND THEIR OBTAINING |
| DE2652761C2 (en) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-methylene-spirolactones, processes for their preparation and pharmaceuticals containing them |
| AT351191B (en) * | 1976-12-20 | 1979-07-10 | Hoffmann La Roche | METHOD FOR PRODUCING NEW D-HOMOSTEROIDS |
| DE3222265A1 (en) * | 1982-06-09 | 1983-12-15 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6SS.7SS-METHYLENE-17 (ALPHA) -PREGN-4-EN-21.17-CARBOLACTONE, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT |
| JPS59139400A (en) * | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | Steroid derivative with antialdosteronic activity |
-
1969
- 1969-03-04 NL NL6903322.A patent/NL166267C/en not_active IP Right Cessation
- 1969-03-10 IL IL31769A patent/IL31769A/en unknown
- 1969-03-10 YU YU581/69A patent/YU34303B/en unknown
- 1969-03-11 IE IE317/69A patent/IE33205B1/en unknown
- 1969-03-11 FI FI690718A patent/FI47354C/en active
- 1969-03-13 SE SE03497/69A patent/SE351636B/xx unknown
- 1969-03-17 GB GB03874/69A patent/GB1235768A/en not_active Expired
- 1969-03-20 AT AT277969A patent/AT297948B/en not_active IP Right Cessation
- 1969-03-20 BE BE730163D patent/BE730163A/xx unknown
- 1969-03-20 CH CH421969A patent/CH525876A/en not_active IP Right Cessation
- 1969-03-21 NO NO1181/69A patent/NO131175C/no unknown
- 1969-03-21 BR BR207426/69A patent/BR6907426D0/en unknown
- 1969-03-21 FR FR6908468A patent/FR2004562A1/fr not_active Withdrawn
- 1969-03-21 DK DK157269AA patent/DK123353B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL31769A0 (en) | 1969-05-28 |
| CH525876A (en) | 1972-07-31 |
| YU34303B (en) | 1979-04-30 |
| NO131175C (en) | 1975-04-16 |
| NL166267B (en) | 1981-02-16 |
| YU58169A (en) | 1978-10-31 |
| NL6903322A (en) | 1969-09-24 |
| FI47354C (en) | 1973-11-12 |
| BE730163A (en) | 1969-09-22 |
| FR2004562A1 (en) | 1969-11-28 |
| IE33205L (en) | 1969-09-22 |
| DE1914507A1 (en) | 1969-10-09 |
| GB1235768A (en) | 1971-06-16 |
| NL166267C (en) | 1981-07-15 |
| AT297948B (en) | 1972-04-10 |
| FI47354B (en) | 1973-07-31 |
| NO131175B (en) | 1975-01-06 |
| BR6907426D0 (en) | 1973-05-31 |
| SE351636B (en) | 1972-12-04 |
| DK123353B (en) | 1972-06-12 |
| IL31769A (en) | 1973-08-29 |
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