[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ID19406A - Keaktifan anti bakterial yang memiliki ketolida 6-0-tersubstitusi - Google Patents

Keaktifan anti bakterial yang memiliki ketolida 6-0-tersubstitusi

Info

Publication number
ID19406A
ID19406A IDP973095A ID973095A ID19406A ID 19406 A ID19406 A ID 19406A ID P973095 A IDP973095 A ID P973095A ID 973095 A ID973095 A ID 973095A ID 19406 A ID19406 A ID 19406A
Authority
ID
Indonesia
Prior art keywords
alkyl
substituted
heteroaryl
aryl
optionally substituted
Prior art date
Application number
IDP973095A
Other languages
English (en)
Inventor
Yat Sun Or
Daniel T Chu
Zhenkun Ma
Jacob J Plattner
Richard F Clark
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID19406(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ID19406A publication Critical patent/ID19406A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IDP973095A 1996-09-04 1997-09-04 Keaktifan anti bakterial yang memiliki ketolida 6-0-tersubstitusi ID19406A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity

Publications (1)

Publication Number Publication Date
ID19406A true ID19406A (id) 1998-07-09

Family

ID=27107953

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP973095A ID19406A (id) 1996-09-04 1997-09-04 Keaktifan anti bakterial yang memiliki ketolida 6-0-tersubstitusi

Country Status (28)

Country Link
US (4) US6028181A (id)
EP (5) EP0929563B1 (id)
JP (1) JP4597274B2 (id)
KR (5) KR20050044816A (id)
CN (4) CN1680419A (id)
AT (5) ATE296308T1 (id)
BG (1) BG63547B1 (id)
BR (1) BR9711661A (id)
CA (1) CA2263972C (id)
CZ (1) CZ300106B6 (id)
DE (5) DE69733370T2 (id)
DK (5) DK1291353T3 (id)
ES (5) ES2242811T3 (id)
HK (1) HK1021537A1 (id)
HR (5) HRP970473B1 (id)
HU (1) HU230166B1 (id)
ID (1) ID19406A (id)
IL (1) IL128681A0 (id)
NO (1) NO314230B1 (id)
NZ (1) NZ334274A (id)
PL (1) PL188173B1 (id)
PT (5) PT1291353E (id)
RO (1) RO121473B1 (id)
RU (1) RU2192427C2 (id)
SI (1) SI20023B (id)
SK (5) SK285536B6 (id)
TR (1) TR199901127T2 (id)
WO (1) WO1998009978A1 (id)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ATE243219T1 (de) 1998-04-24 2003-07-15 Pfizer Prod Inc 9a, 11b-dehydro derivative von 9-oxime-3-keto-6-0-methylerythromycin
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AP2001002131A0 (en) 1998-11-03 2001-06-30 Pfizer Prod Inc Novel macrolide antibiotics.
PL350650A1 (en) * 1999-03-15 2003-01-27 Abbott Lab 6-o-substituted macrolides having antibacterial activity
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
ES2208334T3 (es) * 1999-06-07 2004-06-16 Abbott Laboratories Derivados cetolida de 6-0 carbamato.
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
EP1404693A2 (en) * 2001-07-03 2004-04-07 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
CA2460947A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
CA2469304A1 (en) 2001-12-05 2003-06-19 Ortho-Mcneil Pharmaceutical, Inc. 6-o acyl ketolide antibacterials
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
EP1474431A2 (en) * 2002-02-13 2004-11-10 Abbott Laboratories Macrolide antibacterial compounds
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
CA2477088A1 (en) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
CN1671726A (zh) * 2002-05-31 2005-09-21 詹森药业有限公司 3－脱克拉定糖基－6－o－氨基甲酰基和6－o－烷氧基羰基大环内酯抗菌药
WO2004078771A1 (ja) * 2003-03-07 2004-09-16 Taisho Pharmaceutical Co., Ltd. ２－フルオロ－６－ｏ－置換ケトライド誘導体
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
JP2006524706A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション 新規なケトライド誘導体
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
AU2005279050A1 (en) * 2004-07-30 2006-03-09 Centre National De La Recherche Scientifique (Cnrs) Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, and the synthesis and uses thereof as antibacterial agents
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
US7312201B2 (en) * 2004-12-13 2007-12-25 Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides
EP1836211B1 (en) 2004-12-21 2010-03-03 Pfizer Products Inc. Macrolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
CN101541331A (zh) 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
KR101223158B1 (ko) * 2007-09-17 2013-01-17 이난타 파마슈티칼스, 인코포레이티드 6,11-다리걸친 바이아릴 매크로라이드
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
JPWO2009139181A1 (ja) 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
WO2010048600A1 (en) * 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
WO2010136971A1 (en) 2009-05-27 2010-12-02 Wockhardt Research Centre Ketolide compounds having antimicrobial activity
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
WO2012127351A1 (en) 2011-03-22 2012-09-27 Wockhardt Limited Process for preparation of ketolide compounds
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
SG11201405895UA (en) * 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
CN110234323A (zh) * 2016-10-04 2019-09-13 Ti生物制药有限公司 具有抗菌活性的酮内酯
EP3589327A4 (en) * 2017-03-03 2022-04-06 Synovo GmbH NOVEL ANTI-INFECTION AND ANTI-INFLAMMATORY COMPOUNDS
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
IL293115A (en) * 2019-12-02 2022-07-01 Aliquantumrx Inc Salts and polymorphs of cethromycin for the treatment of disease Salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
EP0553353A1 (en) * 1990-10-15 1993-08-04 Taisho Pharmaceutical Co. Ltd 2'-modified erythromycin or derivative thereof
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
DE69127457T2 (de) * 1990-11-28 1998-01-22 Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo 6-0-methylerythromycin a-derivat
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
WO1993021199A1 (en) * 1992-04-22 1993-10-28 Taisho Pharmaceutical Co., Ltd. 5-o-desosaminylerythronolide a derivative
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
ES2218604T3 (es) * 1995-11-08 2004-11-16 Abbott Laboratories Derivados triciclicos de eritromicina.
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
KR100576988B1 (ko) 2006-05-10
SI20023B (en) 2001-02-28
BG103292A (en) 1999-12-30
HRP20060277A2 (en) 2007-10-31
ATE296831T1 (de) 2005-06-15
KR20050043994A (ko) 2005-05-11
SK28699A3 (en) 2000-03-13
KR100523679B1 (ko) 2005-10-26
DE69733439T2 (de) 2006-05-04
EP1291351B1 (en) 2005-07-13
PT1291353E (pt) 2005-10-31
DE69733723T2 (de) 2006-04-20
CN1273475C (zh) 2006-09-06
ES2242813T3 (es) 2005-11-16
DE69733439D1 (de) 2005-07-07
KR100610043B1 (ko) 2006-08-08
KR20050044815A (ko) 2005-05-12
DE69733422D1 (de) 2005-07-07
DE69733369D1 (de) 2005-06-30
WO1998009978A1 (en) 1998-03-12
KR20050044816A (ko) 2005-05-12
CN1680419A (zh) 2005-10-12
SK285534B6 (sk) 2007-03-01
JP4597274B2 (ja) 2010-12-15
EP1291353B1 (en) 2005-06-01
SI20023A (sl) 2000-02-29
EP0929563B1 (en) 2005-06-01
NO991022L (no) 1999-05-03
EP1291350A1 (en) 2003-03-12
DE69733370T2 (de) 2006-02-02
ES2242812T3 (es) 2005-11-16
ATE296308T1 (de) 2005-06-15
PT1291351E (pt) 2005-11-30
US6075133A (en) 2000-06-13
RU2192427C2 (ru) 2002-11-10
SK285536B6 (sk) 2007-03-01
CN100460415C (zh) 2009-02-11
US6147197A (en) 2000-11-14
ATE296307T1 (de) 2005-06-15
EP1291353A1 (en) 2003-03-12
ATE299508T1 (de) 2005-07-15
HRP20060275A2 (en) 2007-10-31
HRP20060277B1 (hr) 2014-04-11
EP1291351A1 (en) 2003-03-12
HRP20060278A2 (en) 2007-10-31
DK1291350T3 (da) 2005-09-26
EP1291350B1 (en) 2005-05-25
KR100568455B1 (ko) 2006-04-07
BR9711661A (pt) 1999-08-24
NZ334274A (en) 2001-02-23
ATE296832T1 (de) 2005-06-15
PT1291350E (pt) 2005-09-30
CN1237183A (zh) 1999-12-01
HRP20060278B1 (hr) 2014-04-11
EP0929563A1 (en) 1999-07-21
US6028181A (en) 2000-02-22
CA2263972A1 (en) 1998-03-12
JP2001500855A (ja) 2001-01-23
CA2263972C (en) 2008-01-29
CZ68599A3 (cs) 1999-08-11
RO121473B1 (ro) 2007-06-29
DK1291353T3 (da) 2005-10-03
IL128681A0 (en) 2000-01-31
PT1291352E (pt) 2005-09-30
HRP970473A2 (en) 1998-08-31
DK0929563T3 (da) 2005-10-03
HRP20060276A2 (en) 2007-10-31
HU230166B1 (hu) 2015-09-28
PT929563E (pt) 2005-10-31
DE69733723D1 (de) 2005-08-18
EP1291352B1 (en) 2005-05-25
DK1291352T3 (da) 2005-09-19
NO991022D0 (no) 1999-03-02
DE69733370D1 (de) 2005-06-30
CN100441591C (zh) 2008-12-10
DE69733369T2 (de) 2006-01-26
HRP20060276B1 (hr) 2014-04-25
DE69733422T2 (de) 2006-05-04
DK1291351T3 (da) 2005-10-24
SK285533B6 (sk) 2007-03-01
PL332009A1 (en) 1999-08-16
EP1291352A1 (en) 2003-03-12
ES2242983T3 (es) 2005-11-16
BG63547B1 (bg) 2002-04-30
HRP970473B1 (en) 2007-02-28
KR20050043993A (ko) 2005-05-11
KR20000068435A (ko) 2000-11-25
CN1680418A (zh) 2005-10-12
SK285535B6 (sk) 2007-03-01
HK1021537A1 (en) 2000-06-16
NO314230B1 (no) 2003-02-17
CZ300106B6 (cs) 2009-02-11
ES2242811T3 (es) 2005-11-16
AU4178097A (en) 1998-03-26
HRP20060275B1 (hr) 2014-04-11
TR199901127T2 (xx) 1999-07-21
SK286181B6 (sk) 2008-04-07
HUP9902869A3 (en) 2001-04-28
CN1680420A (zh) 2005-10-12
HUP9902869A2 (hu) 2000-02-28
AU729348B2 (en) 2001-02-01
PL188173B1 (pl) 2004-12-31
USRE39591E1 (en) 2007-04-24
ES2244716T3 (es) 2005-12-16

Similar Documents

Publication Publication Date Title
ID19406A (id) Keaktifan anti bakterial yang memiliki ketolida 6-0-tersubstitusi
EP0107201A3 (en) Phenyl-substituted tricyclic antibacterial agents
HK1008898A1 (en) Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
CA2096969A1 (en) 6-0-methylerythromycin a derivatives
KR890005124A (ko) 세펨 화합물 및 이의 제조방법
IL103252A (en) CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES8505691A1 (es) Un procedimiento para preparar derivados de cefem
EP0677522A4 (en) 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE.
TW354780B (en) 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
CA2231812A1 (en) Cyclic nitrones and pharmaceutical compositions containing them
NZ334317A (en) beta-lactam compounds as antibacterial agents effective against methicillin-resistant and coagulase-negative Staphylococci and process for preparing the same
HUP9902893A2 (hu) 6-O-Szubsztituált eritromicinszármazékok és eljárás előállításukra
TW349950B (en) Substituted tetracyclic azepine derivatives
CA2194399A1 (en) Novel carbapenem derivative
ES2021556A6 (es) Un procedimiento para producir un derivado de penam y sus sales.
HUP9903423A3 (en) 3-descladinose-2,3-anhydroerythromycin derivatives
EP0926139A4 (en) CHINOLINE SULFIDE DERIVATIVES
GR3023189T3 (en) Spiro[cycloalkylbenzene-1,1'-(1',2',3',4'-tetrahydroisoquinolines)] having neuroprotective properties
IT1274017B (it) Derivati iodurati del bifenile e loro impiego diagnostico