[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ID17358A - Turunan-turunan 1,2-difenilpirol, pembuatan dan penggunaan-penggunaan terapinya - Google Patents

Turunan-turunan 1,2-difenilpirol, pembuatan dan penggunaan-penggunaan terapinya

Info

Publication number
ID17358A
ID17358A IDP971140A ID971140A ID17358A ID 17358 A ID17358 A ID 17358A ID P971140 A IDP971140 A ID P971140A ID 971140 A ID971140 A ID 971140A ID 17358 A ID17358 A ID 17358A
Authority
ID
Indonesia
Prior art keywords
alkyl
hydrogen
optionally substituted
difenilpirol
declinations
Prior art date
Application number
IDP971140A
Other languages
English (en)
Inventor
Tomio Kimura
Yasuo Noguchi
Akira Nakao
Keisuke Suzuki
Shigeru Ushiyama
Akihiro Kawara
Masaaki Miyamoto
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13805966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID17358(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of ID17358A publication Critical patent/ID17358A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IDP971140A 1996-04-05 1997-04-04 Turunan-turunan 1,2-difenilpirol, pembuatan dan penggunaan-penggunaan terapinya ID17358A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8356296 1996-04-05

Publications (1)

Publication Number Publication Date
ID17358A true ID17358A (id) 1997-12-24

Family

ID=13805966

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP971140A ID17358A (id) 1996-04-05 1997-04-04 Turunan-turunan 1,2-difenilpirol, pembuatan dan penggunaan-penggunaan terapinya

Country Status (21)

Country Link
US (2) US5908858A (id)
EP (1) EP0799823B1 (id)
JP (1) JP3034819B2 (id)
KR (1) KR100485426B1 (id)
CN (1) CN1151126C (id)
AT (1) ATE376998T1 (id)
CA (1) CA2201812C (id)
CZ (1) CZ293048B6 (id)
DE (1) DE69738245T2 (id)
DK (1) DK0799823T3 (id)
ES (1) ES2296303T3 (id)
HK (1) HK1003268A1 (id)
HU (1) HU227830B1 (id)
ID (1) ID17358A (id)
IL (1) IL120584A (id)
NO (1) NO308736B1 (id)
NZ (1) NZ314508A (id)
PT (1) PT799823E (id)
RU (1) RU2125044C1 (id)
TW (1) TW409122B (id)
ZA (1) ZA972846B (id)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09212974A (ja) * 1996-01-31 1997-08-15 Mitsubishi Electric Corp ディスク装置
CN1211361C (zh) * 1996-03-18 2005-07-20 卫材株式会社 含有稠环的羧酸衍生物
JP3382624B2 (ja) 1996-04-12 2003-03-04 ジー．ディー．サール アンド カンパニー Ｃｏｘ―２阻害剤のプロドラッグとしての置換ベンゼンスルホンアミド誘導体
AU5377698A (en) * 1996-12-10 1998-07-03 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
EP1369415A1 (en) * 1996-12-10 2003-12-10 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
NZ333399A (en) * 1997-12-24 2000-05-26 Sankyo Co Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
WO1999061016A1 (en) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Cyclooxygenase-2 inhibitors
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds
US6649645B1 (en) 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
CN1414951A (zh) * 1999-10-28 2003-04-30 基本治疗公司 药剂排出泵抑制药
US6376489B1 (en) * 1999-12-23 2002-04-23 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
AP2002002582A0 (en) * 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US6372777B1 (en) * 1999-12-23 2002-04-16 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6440994B1 (en) * 2000-03-29 2002-08-27 Richard J. Sanders, Jr. Method of treating acne
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
GB0212785D0 (en) * 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
CA2492066A1 (en) * 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP4458514B2 (ja) * 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
TWI286130B (en) * 2002-08-20 2007-09-01 Sankyo Co Method for the production of gamma-keto-acetals
JP4601274B2 (ja) * 2002-08-20 2010-12-22 第一三共株式会社 γ−ケトアセタール類の製造方法
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
KR20070091049A (ko) 2002-12-13 2007-09-06 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
EP1745791B1 (en) * 2003-05-07 2013-06-26 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
SI2266584T1 (sl) * 2003-05-07 2012-12-31 Osteologix A/S, Symbion Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti
GB0328024D0 (en) * 2003-12-03 2004-01-07 Glaxo Group Ltd Compounds
KR20080064956A (ko) * 2005-09-27 2008-07-10 미리어드 제네틱스, 인크. 치료학적 화합물로서의 피롤 유도체
US20070167510A1 (en) * 2006-01-13 2007-07-19 Suzanne Lentzsch Methods for inhibiting osteoclastogenesis
MX2008016338A (es) * 2006-06-27 2009-01-16 Abbott Lab Derivados de pirrol y sus metodos de uso.
EP1889617A1 (en) * 2006-07-11 2008-02-20 Freie Universität Berlin Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents
ES2555511T3 (es) * 2006-08-03 2016-01-04 Rottapharm Biotech S.R.L. Inhibidores de COX-2 altamente selectivos y eficaces por vía oral de 1,5-diaril-2-alquil-pirroles 3-sustituidos
TW200812950A (en) * 2006-08-18 2008-03-16 Daiichi Sankyo Co Ltd Process for producing acetophenone bromide
AU2007294553A1 (en) * 2006-09-07 2008-03-13 Myriad Genetics, Inc. Therapeutic compounds for diseases and disorders
AU2007338367B2 (en) 2006-12-22 2010-05-20 Recordati Ireland Limited Combination therapy of lower urinary tract disorders with alpha2delta ligands and NSAIDs
CN101626787A (zh) * 2007-01-19 2010-01-13 马林克罗特公司 诊断的和治疗的环氧合酶-2结合配体
WO2009009778A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
EP2175722A4 (en) * 2007-07-12 2010-08-25 Tragara Pharmaceuticals Inc PATIENT SELECTION AND THERAPEUTIC PROCEDURES WITH PROSTAGLAND INMETABOLISM MARKERS
CA2700673A1 (en) * 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors
EP2284154A1 (en) * 2009-07-29 2011-02-16 Argon Pharma S.L. Antitumor 1,2-diphenylpyrrole compounds and their preparation process
ES2372769B1 (es) * 2010-07-08 2012-12-03 Universitat De Barcelona Fenil metil sulfonas con actividad antiiflamatoria y actividad antitumoral.
CN103443075A (zh) * 2011-03-31 2013-12-11 鲁平有限公司 作为烟碱型乙酰胆碱受体调节剂的吡咯衍生物在治疗神经变性障碍，例如阿耳茨海默氏病和帕金森氏病中的用途
CN110914396A (zh) 2017-07-18 2020-03-24 弗门尼舍有限公司 仙客来气味剂
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356901A (fr) 1958-03-13 1964-04-03 Nouveaux aminoétheroxydes, aminothioéthers et aminoesters dérivés du pyrrole, etleur procédé de préparation
US3168531A (en) 1963-06-12 1965-02-02 Parke Davis & Co 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds
US3168532A (en) 1963-06-12 1965-02-02 Parke Davis & Co 1, 5-diarylpyrrole-2-propionic acid compounds
US3285931A (en) 1964-12-21 1966-11-15 Union Carbide Corp Preparation of substituted pyrrole derivatives
US3427305A (en) * 1966-11-01 1969-02-11 Searle & Co 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids
US3551571A (en) 1967-05-19 1970-12-29 Endo Lab Methods for reducing pain,reducing fever and alleviating inflammatory syndromes with heteroaromatic pyrrol-3-yl ketones
GB1271082A (en) 1968-05-07 1972-04-19 Wyeth John & Brother Ltd Furan, pyrrole and thiophene derivatives
GB1263940A (en) * 1968-08-02 1972-02-16 Innothera Lab Sa 0-phenyl-pyrroles
FR2054474A2 (en) 1969-07-09 1971-04-23 Innothera Lab Sa Analgesic, antiinflammatory 1-phenyl-2, 5-di
US3714232A (en) 1969-06-25 1973-01-30 Merck & Co Inc 5-arylphenyl sulfonic acids
DE2419970C3 (de) 1974-04-25 1980-06-12 Hoechst Ag, 6000 Frankfurt 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung
US4093735A (en) 1974-04-25 1978-06-06 Hoechst Aktiengesellschaft 5-Sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent
CH628622A5 (de) 1976-12-24 1982-03-15 Ciba Geigy Ag Verfahren zur herstellung von neuen in 4-stellung substituierten 3-sulfamoylbenzoesaeuren.
US4335136A (en) 1980-04-18 1982-06-15 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines
DE3309355A1 (de) 1983-03-16 1984-09-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von pyrrolen
US4694018A (en) * 1985-11-29 1987-09-15 G. D. Serale & Co. Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives
US4792568A (en) 1986-04-14 1988-12-20 Rorer Pharmaceutical Corporation Aryl pyrroles as useful antiallergy compounds
NO881411L (no) 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
US5455263A (en) * 1987-07-29 1995-10-03 American Cyanamid Company Methods for the control and the protection of warm-blooded animals against infestation and infection by helminths, acarids and arthropod endo- and ectoparasites
US5010098A (en) * 1987-07-29 1991-04-23 American Cyanamid Company Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof
DE3727114A1 (de) 1987-08-14 1989-02-23 Basf Ag Verfahren zur herstellung von pyrrolen
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
AU641905B2 (en) * 1988-12-09 1993-10-07 Rhone-Poulenc Agrochimie 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production
US5096919A (en) 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
DE3903993A1 (de) * 1989-02-10 1990-08-16 Basf Ag Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus
EP0479951A4 (en) 1989-06-26 1992-12-09 The Research Foundation Of State University Of New York Bis-acyloxymethyl derivatives
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
DD298912A5 (de) 1989-11-17 1992-03-19 �������@������������@��k�� Verfahren zur herstellung von 3-aminopyrrolen
US5157047A (en) * 1990-10-18 1992-10-20 American Cyanamid Company Bis- and tris(trifluoromethyl)arylpyrrole insecticidal and acaricidal agents
DE4036706A1 (de) 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
US5128485A (en) 1990-12-17 1992-07-07 American Cyanamid Company Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents
US5144041A (en) 1990-12-26 1992-09-01 American Cyanamid Company Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
JPH051027A (ja) * 1991-04-09 1993-01-08 Nippon Bayeragrochem Kk 新規２−又は３−クロロピロール類及びその製造方法
US5254713A (en) 1991-04-09 1993-10-19 Nihon Bayer Agrochem K.K. 2- and 3-chloropyrroles and process for preparing the same
YU8592A (sh) 1991-08-28 1994-06-10 Flumroc Ag. Postupak i uređaj za izradu ploča od mineralnih vlakana primenjenih kao nosač zidnog premaza
US5928635A (en) 1994-12-07 1999-07-27 Schmidt; Karlheinz Process for producing active agent complexes
CA2293952A1 (en) * 1993-01-15 1994-07-21 David B. Reitz Preparation of esters and analogs thereof
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5344991A (en) * 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
RU2139281C1 (ru) * 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
US5418254A (en) * 1994-05-04 1995-05-23 G. D. Searle & Co. Substituted cyclopentadienyl compounds for the treatment of inflammation
US5496845A (en) 1994-05-25 1996-03-05 American Cyanamid Co. Suspension concentrate compositions of arylpyrrole insecticidal and acaricidal agents
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
JPH10504542A (ja) * 1994-07-27 1998-05-06 ジー．ディー．サール アンド カンパニー 炎症処置用の置換チアゾール化合物
US5616601A (en) * 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
GB2294879A (en) 1994-10-19 1996-05-15 Merck & Co Inc Cylcooxygenase-2 Inhibitors
JP2636819B2 (ja) * 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
CA2212836C (en) * 1995-02-13 2003-08-12 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5643933A (en) 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
AU6111796A (en) 1995-06-12 1997-01-09 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US5792778A (en) 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
JP2000510816A (ja) 1995-10-17 2000-08-22 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ−２の検出法
WO1997028158A1 (en) 1996-02-01 1997-08-07 Smithkline Beecham Corporation Endothelin receptor antagonists
JP3382624B2 (ja) 1996-04-12 2003-03-04 ジー．ディー．サール アンド カンパニー Ｃｏｘ―２阻害剤のプロドラッグとしての置換ベンゼンスルホンアミド誘導体
AU5377698A (en) 1996-12-10 1998-07-03 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6025353A (en) 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
DE19812059C1 (de) * 1998-03-19 1999-09-23 Wella Ag Diaminobenzol-Derivate sowie diese Diaminobenzol-Derivate enthaltende Haarfärbemittel
US8887786B2 (en) * 2011-03-07 2014-11-18 Hunter Douglas Inc. Control for movable rail

Also Published As

Publication number Publication date
AU710380B2 (en) 1999-09-16
CN1151126C (zh) 2004-05-26
IL120584A0 (en) 1997-08-14
HU227830B1 (hu) 2012-05-02
HUP9700709A3 (en) 2000-04-28
NZ314508A (en) 1999-06-29
AU1665397A (en) 1997-10-09
KR100485426B1 (ko) 2005-10-12
CZ103597A3 (en) 1997-10-15
HUP9700709A2 (hu) 1999-05-28
CN1168372A (zh) 1997-12-24
CA2201812A1 (en) 1997-10-05
CZ293048B6 (cs) 2004-01-14
CA2201812C (en) 2007-09-18
NO308736B1 (no) 2000-10-23
JPH09323971A (ja) 1997-12-16
ZA972846B (en) 1997-11-04
USRE39420E1 (en) 2006-12-05
RU2125044C1 (ru) 1999-01-20
DE69738245T2 (de) 2008-08-14
NO971564L (no) 1997-10-06
KR970069985A (ko) 1997-11-07
DE69738245D1 (de) 2007-12-13
TW409122B (en) 2000-10-21
JP3034819B2 (ja) 2000-04-17
IL120584A (en) 2003-10-31
ES2296303T3 (es) 2008-04-16
EP0799823A1 (en) 1997-10-08
HU9700709D0 (en) 1997-05-28
HK1003268A1 (en) 1998-10-23
US5908858A (en) 1999-06-01
PT799823E (pt) 2008-01-15
DK0799823T3 (da) 2008-03-03
NO971564D0 (no) 1997-04-04
EP0799823B1 (en) 2007-10-31
ATE376998T1 (de) 2007-11-15

Similar Documents

Publication Publication Date Title
ID17358A (id) Turunan-turunan 1,2-difenilpirol, pembuatan dan penggunaan-penggunaan terapinya
SE9604786D0 (sv) New compounds
ATE174592T1 (de) Sulfonamide und derivate zur modulierung der endothelin aktivitat
ATE260255T1 (de) 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate
NO306464B1 (no) Benzimidazolforbindelser, farmasöytiske preparater som omfatter slike forbindelser, samt anvendelse av forbindelsene for fremstilling av medikamenter
ATE248824T1 (de) Substituierte phenylderivate, ihre herstellung und verwendung
DE69432611D1 (de) Herstellung einer substituierten 2,5-Diamino-3-hydroxyhexan
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
DE69326395D1 (de) Spirooxathiolan-quinuclidin-Derivat zur Behandlung des Sjögren-Syndroms
NO161564C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
ATE79257T1 (de) Verwendung von tetrahydrobenz(c,d&gt;indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
IT1295933B1 (it) 2-(2&#39;-idrossifenil)benzotriazoli e procedimento per la loro preparazione
DE69707372D1 (de) Verwendung eines Phosphorsäurediesters zur Herstellung eines Arzneimittels zur Behandlung von Akne
DE60002558D1 (de) Derivate der Phosphonsäure zur Inhibierung von Carboxypeptidase B
NO173991C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
SE9704770D0 (sv) New use
NO951820D0 (no) Cykloheksanderivater, fremgangsmåter for deres fremstilling og anvendelser for behandling av sykdommer
DK0784973T3 (da) Quinoxalinderivater til behandling af tinnitus
DE69827706D1 (de) 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
DE69902142D1 (de) Azetidincarboxamidderivate zur behandlung von zns-erkrankungen
DE69822009D1 (de) Indometacin Calciumsalz Pentahydrat und deren Herstellung
TH26544A (th) อนุพันธ์กรด -4 - อัลคิลไทโอ -ไพรมิดิน -5 - อิล อาซีติก