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HUT65763A - Process for producing carboxylic acid esters of rapamycin and pharmaceutical preparations containing them - Google Patents

Process for producing carboxylic acid esters of rapamycin and pharmaceutical preparations containing them

Info

Publication number
HUT65763A
HUT65763A HU9300776A HU77693A HUT65763A HU T65763 A HUT65763 A HU T65763A HU 9300776 A HU9300776 A HU 9300776A HU 77693 A HU77693 A HU 77693A HU T65763 A HUT65763 A HU T65763A
Authority
HU
Hungary
Prior art keywords
rapamycin
carboxylic acid
acid esters
pharmaceutical preparations
preparations containing
Prior art date
Application number
HU9300776A
Other languages
Hungarian (hu)
Other versions
HU9300776D0 (en
Inventor
Craig Eugene Caufield
Robert John Steffan
Amedeo Arturo Failli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/657,294 external-priority patent/US5130307A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of HU9300776D0 publication Critical patent/HU9300776D0/en
Publication of HUT65763A publication Critical patent/HUT65763A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU9300776A 1990-09-19 1991-09-19 Process for producing carboxylic acid esters of rapamycin and pharmaceutical preparations containing them HUT65763A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58483390A 1990-09-19 1990-09-19
US58987890A 1990-09-28 1990-09-28
US07/657,294 US5130307A (en) 1990-09-28 1991-02-19 Aminoesters of rapamycin

Publications (2)

Publication Number Publication Date
HU9300776D0 HU9300776D0 (en) 1993-06-28
HUT65763A true HUT65763A (en) 1994-07-28

Family

ID=27416444

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9300776A HUT65763A (en) 1990-09-19 1991-09-19 Process for producing carboxylic acid esters of rapamycin and pharmaceutical preparations containing them

Country Status (9)

Country Link
EP (1) EP0549727A1 (en)
JP (1) JPH06501012A (en)
AU (1) AU653175B2 (en)
FI (1) FI931203A (en)
HU (1) HUT65763A (en)
IE (1) IE913302A1 (en)
MX (1) MX9101139A (en)
PT (1) PT98990A (en)
WO (1) WO1992005179A1 (en)

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EP0549727A1 (en) 1993-07-07
AU653175B2 (en) 1994-09-22
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JPH06501012A (en) 1994-01-27
HU9300776D0 (en) 1993-06-28
IE913302A1 (en) 1992-02-25

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