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HUP0302957A2 - Hepatitis C vírus alkil- és aril-alanin P2 csoportokat tartalmazó makrociklusos NS-3 szerin proteáz inhibitorai - Google Patents

Hepatitis C vírus alkil- és aril-alanin P2 csoportokat tartalmazó makrociklusos NS-3 szerin proteáz inhibitorai

Info

Publication number
HUP0302957A2
HUP0302957A2 HU0302957A HUP0302957A HUP0302957A2 HU P0302957 A2 HUP0302957 A2 HU P0302957A2 HU 0302957 A HU0302957 A HU 0302957A HU P0302957 A HUP0302957 A HU P0302957A HU P0302957 A2 HUP0302957 A2 HU P0302957A2
Authority
HU
Hungary
Prior art keywords
hepatitis
virus
protease inhibitors
serine protease
macrocyclic
Prior art date
Application number
HU0302957A
Other languages
English (en)
Inventor
Ashok Arasappan
Tin-Yau Chan
Kevin X. Chen
Viyyoor M. Girijavallabhan
Vincent Stewart Madison
Brian A. Mckittrick
F. George Njoroge
Andrew J. Prongay
Srikanth Venkatraman
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HUP0302957A2 publication Critical patent/HUP0302957A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát új hepatitis C vírus (<HCV<) proteáz inhibitorok,egy vagy több ilyen inhibitort tartalmazó gyógyszerkészítmények, ilyeninhibitorok előállítására szolgáló eljárások, valamint eljárásokképezik inhibitorok alkalmazására hepatitis C és hasonló betegségekkezelésére. A találmány konkrétan HCV NS3/NS4a szerin proteázinhibitorokként szolgáló új makrociklusos vegyületeket ismertet. Ó
HU0302957A 2000-04-19 2001-04-17 Hepatitis C vírus alkil- és aril-alanin P2 csoportokat tartalmazó makrociklusos NS-3 szerin proteáz inhibitorai HUP0302957A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19820400P 2000-04-19 2000-04-19
PCT/US2001/012530 WO2001081325A2 (en) 2000-04-19 2001-04-17 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising alkyl and aryl alanine p2 moieties

Publications (1)

Publication Number Publication Date
HUP0302957A2 true HUP0302957A2 (hu) 2003-12-29

Family

ID=22732422

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302957A HUP0302957A2 (hu) 2000-04-19 2001-04-17 Hepatitis C vírus alkil- és aril-alanin P2 csoportokat tartalmazó makrociklusos NS-3 szerin proteáz inhibitorai

Country Status (22)

Country Link
US (1) US6914122B2 (hu)
EP (1) EP1274724A2 (hu)
JP (1) JP4748912B2 (hu)
KR (1) KR20020097220A (hu)
CN (3) CN1935833A (hu)
AR (1) AR030558A1 (hu)
AU (1) AU2001253621A1 (hu)
BR (1) BR0110104A (hu)
CA (1) CA2406532A1 (hu)
CZ (1) CZ20023473A3 (hu)
HK (1) HK1048479A1 (hu)
HU (1) HUP0302957A2 (hu)
IL (1) IL151935A0 (hu)
MX (1) MXPA02010375A (hu)
NO (1) NO20025030L (hu)
NZ (1) NZ521456A (hu)
PE (1) PE20011288A1 (hu)
PL (1) PL358591A1 (hu)
RU (1) RU2002131163A (hu)
SK (1) SK14952002A3 (hu)
WO (1) WO2001081325A2 (hu)
ZA (1) ZA200208014B (hu)

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