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HUP0301868A3 - Pharmaceutical composition comprising a factor viia and a factor xiii - Google Patents

Pharmaceutical composition comprising a factor viia and a factor xiii

Info

Publication number
HUP0301868A3
HUP0301868A3 HU0301868A HUP0301868A HUP0301868A3 HU P0301868 A3 HUP0301868 A3 HU P0301868A3 HU 0301868 A HU0301868 A HU 0301868A HU P0301868 A HUP0301868 A HU P0301868A HU P0301868 A3 HUP0301868 A3 HU P0301868A3
Authority
HU
Hungary
Prior art keywords
factor
pharmaceutical composition
xiii
viia
factor viia
Prior art date
Application number
HU0301868A
Other languages
English (en)
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of HUP0301868A2 publication Critical patent/HUP0301868A2/hu
Publication of HUP0301868A3 publication Critical patent/HUP0301868A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
HU0301868A 2000-05-10 2001-05-10 Pharmaceutical composition comprising a factor viia and a factor xiii HUP0301868A3 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200000771 2000-05-10
DKPA200000778 2000-05-10
US20621200P 2000-05-22 2000-05-22
US20619400P 2000-05-22 2000-05-22
DKPA200000871 2000-06-06
US21285700P 2000-06-20 2000-06-20
PCT/DK2001/000322 WO2001085198A1 (en) 2000-05-10 2001-05-10 tHARMACEUTICAL COMPOSITION COMPRISING A FACTOR VIIA AND A FACTOR XIII

Publications (2)

Publication Number Publication Date
HUP0301868A2 HUP0301868A2 (hu) 2003-08-28
HUP0301868A3 true HUP0301868A3 (en) 2006-11-28

Family

ID=27222387

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301868A HUP0301868A3 (en) 2000-05-10 2001-05-10 Pharmaceutical composition comprising a factor viia and a factor xiii

Country Status (17)

Country Link
US (3) US20030092627A1 (hu)
EP (3) EP1282438B1 (hu)
JP (2) JP2003532684A (hu)
CN (1) CN1304049C (hu)
AT (2) ATE311198T1 (hu)
AU (3) AU5822801A (hu)
BR (1) BR0110659A (hu)
CA (1) CA2406583A1 (hu)
CZ (1) CZ20023667A3 (hu)
DE (2) DE60115422T2 (hu)
DK (1) DK1282438T3 (hu)
ES (2) ES2247106T3 (hu)
HU (1) HUP0301868A3 (hu)
IL (1) IL152554A0 (hu)
NO (1) NO20025355L (hu)
PL (1) PL365042A1 (hu)
WO (2) WO2001085199A1 (hu)

Families Citing this family (50)

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EP1491208B1 (en) * 1999-10-04 2010-04-14 Novartis Vaccines and Diagnostics, Inc. Stabilized liquid pharmaceutical compositions containing TFPI
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US7015194B2 (en) 2000-05-10 2006-03-21 Novo Nordisk A/S Pharmaceutical composition comprising factor VIIa and anti-TFPI
AU2001287550B2 (en) * 2000-09-13 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor VII variants
MXPA03001984A (es) 2000-09-13 2003-08-29 Novo Nordisk Healthcare Ag Variantes de factor vii de coagulacion humano.
ATE360437T1 (de) * 2000-11-03 2007-05-15 Zymogenetics Inc Verwendung des blutgerinnungsfaktors xiii für die behandlung der hämophilie a
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
AU2002226004A1 (en) * 2000-11-10 2002-05-21 Zymogenetics Inc. Use of factor xiii for treating hemophilia b
JP2004517950A (ja) * 2001-02-05 2004-06-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチド及び第ｖｉｉｉ因子ポリペプチドの組合された使用
EP1379271A1 (en) * 2001-02-21 2004-01-14 ZymoGenetics, Inc. Method for treating von willebrand's disease
EP1425034A4 (en) * 2001-09-10 2005-09-21 Zymogenetics Inc METHOD FOR THE TREATMENT OF CUMARIN-INDUCED BLEEDING
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
EP1446147A1 (en) * 2001-11-09 2004-08-18 Novo Nordisk Health Care AG Pharmaceutical composition comprising factor vii polypeptides and tranexamic acid
US20030119723A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides
US7291587B2 (en) 2001-11-09 2007-11-06 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides
JP2006510568A (ja) * 2001-11-09 2006-03-30 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドおよびイプシロン―アミノカプロン酸を含む薬学的組成物
CA2470511C (en) 2001-12-21 2014-05-27 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
CN101675991A (zh) * 2001-12-21 2010-03-24 诺和诺德医疗保健公司 因子ⅶ多肽的液体组合物
WO2004000347A1 (en) 2002-06-21 2003-12-31 Novo Nordisk A/S Stabilised solid compositions of factor vii polypeptides
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
SI1599222T1 (sl) * 2003-01-08 2009-08-31 Novartis Vaccines & Diagnostic Stabilizirani vodni sestavki, ki obsegajo inhibitor poti tkivnega faktorja (TFPI) ali varianto inhibitorja poti tkivnega faktorja
EP1641487B1 (en) 2003-06-25 2012-02-29 Novo Nordisk Health Care AG Liquid composition of factor vii polypeptides
ES2574581T3 (es) 2003-08-14 2016-06-20 Novo Nordisk Health Care Ag Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII
JP4824559B2 (ja) 2003-09-09 2011-11-30 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 凝固因子ｖｉｉポリペプチド
EP1750758A1 (en) * 2004-05-11 2007-02-14 Novo Nordisk Health Care AG Use of factor viia for the treatment of burn traumas
WO2005115442A1 (en) * 2004-05-25 2005-12-08 Novo Nordisk Health Care Ag Use of coagulation factor xiii for treatment of post surgical bleedings
CN101010333B (zh) * 2004-08-27 2013-08-14 诺和诺德医疗保健公司 从生物材料中纯化凝血因子xⅲ多肽
AU2005282065B2 (en) * 2004-09-10 2013-02-07 Pharmaorigin Aps Methods for treating local tracheal, bronchial or alveolar bleeding or hemoptysis
US8461302B2 (en) 2004-11-23 2013-06-11 Zymogenetics, Inc. Purification of recombinant human factor XIII
EP1855712A2 (en) * 2005-02-28 2007-11-21 Novo Nordisk Health Care AG Fxiii variants with improved properties
US20080161425A1 (en) * 2005-07-29 2008-07-03 Universiteit Van Maastricht Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor
US8461115B2 (en) 2006-03-16 2013-06-11 Stellaris Pharmaceuticals Aps Methods for local treatment with factor VII
WO2008009635A2 (en) * 2006-07-17 2008-01-24 Novo Nordisk Health Care Ag Factor viia analogues with increased activity for treating thrombocytopenia
ES2537328T3 (es) * 2007-04-13 2015-06-05 Catalyst Biosciences, Inc. Polipéptidos de factor VII modificados y usos de los mismos
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
EP2268267B1 (en) 2008-04-21 2017-06-14 Novo Nordisk Health Care AG Dry transglutaminase composition
EP2149603A1 (en) 2008-07-28 2010-02-03 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
DK2379096T3 (da) * 2008-12-19 2019-11-25 Baxalta GmbH TFPI-inhibitorer og fremgangsmåder til anvendelse
KR101948463B1 (ko) 2010-03-19 2019-02-14 박스알타 인코퍼레이티드 Tfpi 저해제 및 사용 방법
CN103179982A (zh) * 2010-08-05 2013-06-26 科学与工业研究委员会 具有溶血栓和抗凝血性质的蛋白融合构建体
NZ629130A (en) 2012-03-21 2016-10-28 Baxalta Inc Tfpi inhibitors and methods of use
EP2881463A1 (en) 2013-12-09 2015-06-10 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders
JP6559188B2 (ja) * 2017-07-06 2019-08-14 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 組織因子経路インヒビター（ｔｆｐｉ）に対するモノクローナル抗体
JP2018038398A (ja) * 2017-09-04 2018-03-15 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 組織因子経路インヒビター（ｔｆｐｉ）に対するモノクローナル抗体
JP2018108089A (ja) * 2018-02-19 2018-07-12 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 組織因子経路インヒビター（ｔｆｐｉ）に対するモノクローナル抗体
WO2020021890A1 (ja) * 2018-07-25 2020-01-30 ソニー株式会社 血液凝固系解析装置
JP6848016B2 (ja) * 2019-07-16 2021-03-24 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 組織因子経路インヒビター（ｔｆｐｉ）に対するモノクローナル抗体
EP3833381B1 (en) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration

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EP0651655A4 (en) * 1992-07-24 1996-05-29 Oklahoma Med Res Found REDUCTION OF MICROVASCULAR BLEEDING DURING SURGERY BY BLOCKING PROTEIN C ACTIVATION
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WO1999032143A1 (en) * 1997-12-23 1999-07-01 Nuvas Llc Thrombogenic polypeptide chimeras and conjugates having activity dependent upon association with tumor vascular endothelium
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JP2004517950A (ja) * 2001-02-05 2004-06-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチド及び第ｖｉｉｉ因子ポリペプチドの組合された使用
US20030203845A1 (en) * 2001-02-05 2003-10-30 Knudsen Jens Bjerre Combined use of factor VII polypeptides and factor IX polypeptides
US20060025336A1 (en) * 2001-07-16 2006-02-02 Novo Nordisk A/S Pharmaceutical compositions comprising combinations of factor VII polypeptides and aprotinin polypeptides
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US20030119741A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and aprotinin polypeptides
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
WO2003039585A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors
JP2005526004A (ja) * 2001-11-09 2005-09-02 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドおよびトラネキサム酸を含む薬学的組成物
JP2006510568A (ja) * 2001-11-09 2006-03-30 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドおよびイプシロン―アミノカプロン酸を含む薬学的組成物
US7125846B2 (en) * 2001-11-09 2006-10-24 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
US20030119743A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and tissue plasminogen inhibitors
US20030119723A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides
US7078479B2 (en) * 2001-11-09 2006-07-18 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides
US7291587B2 (en) * 2001-11-09 2007-11-06 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides
US20030124118A1 (en) * 2001-11-27 2003-07-03 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors

Also Published As

Publication number Publication date
AU2001258230A1 (en) 2001-11-20
PL365042A1 (en) 2004-12-27
US20070280920A1 (en) 2007-12-06
JP2004505016A (ja) 2004-02-19
ES2247106T3 (es) 2006-03-01
JP2003532684A (ja) 2003-11-05
US20060199766A1 (en) 2006-09-07
EP1593389A1 (en) 2005-11-09
WO2001085199A1 (en) 2001-11-15
ATE311198T1 (de) 2005-12-15
NO20025355L (no) 2003-01-09
ATE300953T1 (de) 2005-08-15
DE60115422D1 (de) 2006-01-05
US20030092627A1 (en) 2003-05-15
WO2001085198A1 (en) 2001-11-15
AU2001258228B2 (en) 2006-01-12
DE60112429D1 (de) 2005-09-08
CN1304049C (zh) 2007-03-14
HUP0301868A2 (hu) 2003-08-28
NO20025355D0 (no) 2002-11-08
EP1282438A1 (en) 2003-02-12
EP1282439A1 (en) 2003-02-12
IL152554A0 (en) 2003-05-29
DE60115422T2 (de) 2006-08-17
DK1282438T3 (da) 2005-11-14
CN1429117A (zh) 2003-07-09
BR0110659A (pt) 2003-02-11
AU5822801A (en) 2001-11-20
DE60112429T2 (de) 2006-06-01
CZ20023667A3 (cs) 2003-04-16
EP1282439B1 (en) 2005-11-30
CA2406583A1 (en) 2001-11-15
EP1282438B1 (en) 2005-08-03
ES2254414T3 (es) 2006-06-16

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees