HUP0203739A2 - A hatos-gyűrűn helyettesített biciklikus imidazo-3-il-amin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
A hatos-gyűrűn helyettesített biciklikus imidazo-3-il-amin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0203739A2 HUP0203739A2 HU0203739A HUP0203739A HUP0203739A2 HU P0203739 A2 HUP0203739 A2 HU P0203739A2 HU 0203739 A HU0203739 A HU 0203739A HU P0203739 A HUP0203739 A HU P0203739A HU P0203739 A2 HUP0203739 A2 HU P0203739A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- branched
- straight
- optionally substituted
- hydrogen atom
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- -1 1,1,3,3-tetramethyl- butyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány (I) általános képletű biciklikus imidazo-3-il-aminokra[mely képletben X jelentése CR4 vagy N és Y jelentése CR5 vagy N,azzal a feltétellel, hogy X és Y egyszerre nem képviselhet N-t; R1jelentése (CH2)nCN (ahol n értéke 4, 5 vagy 6), adott esetbenhelyettesített fenilcsoport, 4-8 szénatomos cikloalkil-csoport,CH2CH2R (ahol R jelentése 4-morfolino-csoport), l,1,3,3-tetrametil-butil-csoport vagy CH2Ra R2 jelentése hidrogénatom, CORb,CH2CH2CO(ORc), CH2-fenil, CH2CH2Rd vagy CONHRe R3 jelentése egyenes- vagy elágazóláncú 1-8 szénatomosalkilcsoport, 3-8 szénatomos cikloalkil-csoport, adott esetbenhelyettesített fenilcsoport, naftilcsoport, pirrolilcsoport,piridilcsoport, furanilcsoport, tiofenil-csoport, antracenil-csoport,fenantrenil-csoport, vagy -kinolinil-csoport; R4, R5, R6 és R7jelentése egymástól függetlenül hidrogénatom, egyenes- vagyelágazóláncú 1-4 szénatomos alkilcsoport, nitrocsoport, aminocsoport,hidroxilcsaport, trifluor-metil-csoport, klór-, fluor- vagy brómatom,cianocsoport, COOR R4 és R5, R5 és R6, vagy R6 és R7 együtt 4-tagú,adott esetben kettőskötéseket tartalmazó szén-hidat képez, amelybenegyes szénatomok helyén heteroatomok lehetnek. a bázis vagygyógyászatilag alkalmas sói formájában, e vegyületek előállítására éshatóanyagként legalább egy fenti vegyületet tartalmazó gyógyászatikészítményekre vonatkozik. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19948434A DE19948434A1 (de) | 1999-10-08 | 1999-10-08 | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| DE1999148437 DE19948437A1 (de) | 1999-10-08 | 1999-10-08 | Am Sechsring substituierte, bicyclische Imidazo-3-aminderivate |
| PCT/EP2000/009095 WO2001027110A2 (de) | 1999-10-08 | 2000-09-18 | Am sechsring substituierte, bicyclische imidazo-3-yl-aminderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0203739A2 true HUP0203739A2 (hu) | 2003-02-28 |
| HUP0203739A3 HUP0203739A3 (en) | 2004-07-28 |
Family
ID=26055217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0203739A HUP0203739A3 (en) | 1999-10-08 | 2000-09-18 | Bicyclic imidazo-3-yl-amine derivatives which are substituted on the sixth ring, process for their preparation and pharmaceutical compositions containing them |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6849642B2 (hu) |
| EP (1) | EP1218380B1 (hu) |
| JP (1) | JP2003517466A (hu) |
| KR (1) | KR20020038804A (hu) |
| CN (1) | CN1222525C (hu) |
| AR (1) | AR025961A1 (hu) |
| AT (1) | ATE256684T1 (hu) |
| AU (1) | AU780823B2 (hu) |
| BR (1) | BR0014826A (hu) |
| CA (1) | CA2386813C (hu) |
| CO (1) | CO5210870A1 (hu) |
| CZ (1) | CZ300315B6 (hu) |
| DE (1) | DE50004817D1 (hu) |
| DK (1) | DK1218380T3 (hu) |
| ES (1) | ES2213044T3 (hu) |
| HK (1) | HK1047748B (hu) |
| HU (1) | HUP0203739A3 (hu) |
| IL (2) | IL148998A0 (hu) |
| MX (1) | MXPA02003547A (hu) |
| NO (1) | NO20021563L (hu) |
| NZ (1) | NZ518637A (hu) |
| PE (1) | PE20010631A1 (hu) |
| PT (1) | PT1218380E (hu) |
| RU (1) | RU2002110282A (hu) |
| SK (1) | SK286450B6 (hu) |
| UY (1) | UY26371A1 (hu) |
| WO (1) | WO2001027110A2 (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043845A1 (de) * | 2000-09-06 | 2002-03-14 | Gruenenthal Gmbh | Verfahren zur Messung der Aktivität der NO-Synthase |
| US20040058938A1 (en) * | 2000-12-13 | 2004-03-25 | Oliver Cullmann | Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds |
| US7157460B2 (en) | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| DE102004021716A1 (de) * | 2004-04-30 | 2005-12-01 | Grünenthal GmbH | Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen |
| DE102004044884A1 (de) | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| DE102005016547A1 (de) * | 2005-04-08 | 2006-10-12 | Grünenthal GmbH | Substituierte 5,6,7,8-Tetrahydro-imidazo(1,2-a)pyridin-2-ylamin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
| CA2653506A1 (en) * | 2006-05-31 | 2007-12-06 | Galapagos Nv. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
| WO2008134553A1 (en) * | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| JP2010533680A (ja) | 2007-07-18 | 2010-10-28 | ノバルティス アーゲー | 二環ヘテロアリール化合物およびそれらのキナーゼ阻害剤としての使用 |
| ES2552733T3 (es) * | 2007-11-16 | 2015-12-01 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| EP2231666B1 (en) | 2007-12-12 | 2015-07-29 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| NZ588376A (en) * | 2008-04-15 | 2011-06-30 | Eisai R&D Man Co Ltd | 3-phenylpyrazolo[5,1-b]thiazole compound having antagonism against corticotropin-releasing factor (CRF) receptor |
| KR101662333B1 (ko) * | 2008-04-23 | 2016-10-04 | 리겔 파마슈티칼스, 인크. | 대사성 장애의 치료를 위한 카르복스아미드 화합물 |
| CN102216298B (zh) | 2008-09-16 | 2014-04-16 | Csir公司 | 作为hiv-1逆转录酶抑制剂的咪唑并吡啶和咪唑并嘧啶 |
| US8481740B2 (en) * | 2009-04-07 | 2013-07-09 | University Of The Witwatersrand, Johannesburg | Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| RU2576662C2 (ru) * | 2010-03-18 | 2016-03-10 | Энститю Пастер Корея | Противоинфекционные соединения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| DE3269604D1 (en) | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| NZ221996A (en) * | 1986-10-07 | 1989-08-29 | Yamanouchi Pharma Co Ltd | Imidazo-pyridine derivatives and pharmaceutical compositions |
| TW274551B (hu) * | 1991-04-16 | 1996-04-21 | Takeda Pharm Industry Co Ltd | |
| AU698867B2 (en) * | 1995-04-21 | 1998-11-12 | Shinnippon Pharmaceutical Inc. | Fused imidazo 1,2-a pyridines |
-
2000
- 2000-09-18 EP EP00964191A patent/EP1218380B1/de not_active Expired - Lifetime
- 2000-09-18 JP JP2001530328A patent/JP2003517466A/ja not_active Withdrawn
- 2000-09-18 NZ NZ518637A patent/NZ518637A/xx unknown
- 2000-09-18 KR KR1020027004504A patent/KR20020038804A/ko not_active Application Discontinuation
- 2000-09-18 HU HU0203739A patent/HUP0203739A3/hu unknown
- 2000-09-18 IL IL14899800A patent/IL148998A0/xx active IP Right Grant
- 2000-09-18 AT AT00964191T patent/ATE256684T1/de active
- 2000-09-18 PT PT00964191T patent/PT1218380E/pt unknown
- 2000-09-18 ES ES00964191T patent/ES2213044T3/es not_active Expired - Lifetime
- 2000-09-18 CA CA002386813A patent/CA2386813C/en not_active Expired - Fee Related
- 2000-09-18 CN CNB008164304A patent/CN1222525C/zh not_active Expired - Fee Related
- 2000-09-18 BR BR0014826-1A patent/BR0014826A/pt not_active IP Right Cessation
- 2000-09-18 WO PCT/EP2000/009095 patent/WO2001027110A2/de active IP Right Grant
- 2000-09-18 DK DK00964191T patent/DK1218380T3/da active
- 2000-09-18 SK SK461-2002A patent/SK286450B6/sk not_active IP Right Cessation
- 2000-09-18 CZ CZ20021243A patent/CZ300315B6/cs not_active IP Right Cessation
- 2000-09-18 AU AU75199/00A patent/AU780823B2/en not_active Ceased
- 2000-09-18 MX MXPA02003547A patent/MXPA02003547A/es active IP Right Grant
- 2000-09-18 RU RU2002110282/04A patent/RU2002110282A/ru not_active Application Discontinuation
- 2000-09-18 DE DE50004817T patent/DE50004817D1/de not_active Expired - Lifetime
- 2000-10-02 CO CO00074643A patent/CO5210870A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105253A patent/AR025961A1/es unknown
- 2000-10-05 UY UY26371A patent/UY26371A1/es not_active Application Discontinuation
- 2000-10-06 PE PE2000001065A patent/PE20010631A1/es not_active Application Discontinuation
-
2002
- 2002-04-03 NO NO20021563A patent/NO20021563L/no not_active Application Discontinuation
- 2002-04-04 IL IL148998A patent/IL148998A/en not_active IP Right Cessation
- 2002-04-08 US US10/117,334 patent/US6849642B2/en not_active Expired - Fee Related
- 2002-12-28 HK HK02109383.4A patent/HK1047748B/zh not_active IP Right Cessation
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| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |