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HUP0202776A2 - (+)-Tramadol, O-demetil-tramadol, (+)-O-demetil-tramadol, O-demetil-N-mono-demetil-tramadol, illetve (+)-O-demetil-N-mono-demetil-tramadol felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására - Google Patents

(+)-Tramadol, O-demetil-tramadol, (+)-O-demetil-tramadol, O-demetil-N-mono-demetil-tramadol, illetve (+)-O-demetil-N-mono-demetil-tramadol felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására

Info

Publication number
HUP0202776A2
HUP0202776A2 HU0202776A HUP0202776A HUP0202776A2 HU P0202776 A2 HUP0202776 A2 HU P0202776A2 HU 0202776 A HU0202776 A HU 0202776A HU P0202776 A HUP0202776 A HU P0202776A HU P0202776 A2 HUP0202776 A2 HU P0202776A2
Authority
HU
Hungary
Prior art keywords
desmethyl
tramadol
demethyltramadol
mono
urinary incontinence
Prior art date
Application number
HU0202776A
Other languages
English (en)
Inventor
Thomas Christoph
Elmar Friderichs
Original Assignee
Grünenthal GmbH.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19947747A external-priority patent/DE19947747A1/de
Priority claimed from DE20002943U external-priority patent/DE20002943U1/de
Application filed by Grünenthal GmbH. filed Critical Grünenthal GmbH.
Publication of HUP0202776A2 publication Critical patent/HUP0202776A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya (+)-tramadol, illetve 0-demetil-tramadol, különösen(+)-0-demetil-tramadol, 0-demetil-N-mono-demetiltramadol, különösen(+)-0-demetil-N-mono-demetil-tramadol felhasználása a szabad bázisés/vagy gyógyászatilag alkalmas sók formájában megnövekedett vizelésiinger, illetve vizeletinkontinencia kezelésére alkalmas gyógyászatikészítmények előállítására. A találmány továbbá a megfelelőgyógyászati készítményekre, valamint megnövekedett vizelési inger,illetve vizeletinkontinencia kezelési eljárására vonatkozik. Ó
HU0202776A 1999-10-05 2000-09-27 (+)-Tramadol, O-demetil-tramadol, (+)-O-demetil-tramadol, O-demetil-N-mono-demetil-tramadol, illetve (+)-O-demetil-N-mono-demetil-tramadol felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására HUP0202776A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19947747A DE19947747A1 (de) 1999-10-05 1999-10-05 Verwendung von (+)-Tramadol, O-Demethyltramadol bzw. (+)-O-Demethyltramadol zur Therapie der Harninkontinenz
DE20002943U DE20002943U1 (de) 2000-02-21 2000-02-21 Arzneimittel enthaltend O-desmethyl-N-mono-desmethyl-tramadol
PCT/EP2000/009420 WO2001024783A2 (de) 1999-10-05 2000-09-27 Verwendung von (+)-tramadol, o-demethyltramadol bzw. (+)-o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol bzw. (+)-o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz

Publications (1)

Publication Number Publication Date
HUP0202776A2 true HUP0202776A2 (hu) 2003-02-28

Family

ID=26055167

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202776A HUP0202776A2 (hu) 1999-10-05 2000-09-27 (+)-Tramadol, O-demetil-tramadol, (+)-O-demetil-tramadol, O-demetil-N-mono-demetil-tramadol, illetve (+)-O-demetil-N-mono-demetil-tramadol felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására

Country Status (13)

Country Link
US (1) US6660774B2 (hu)
EP (1) EP1217998B1 (hu)
JP (1) JP5477881B2 (hu)
AT (1) ATE368455T1 (hu)
AU (1) AU7907600A (hu)
CA (1) CA2386381A1 (hu)
DE (1) DE50014532D1 (hu)
ES (1) ES2291223T3 (hu)
HK (1) HK1047707A1 (hu)
HU (1) HUP0202776A2 (hu)
MX (1) MXPA02003491A (hu)
PE (1) PE20010623A1 (hu)
WO (1) WO2001024783A2 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
FR2815691B1 (fr) * 2000-10-20 2003-08-15 Valois Sa Bille de clapet
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
DE10224107A1 (de) * 2002-05-29 2003-12-11 Gruenenthal Gmbh Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
DE10224624A1 (de) * 2002-05-30 2003-12-11 Gruenenthal Gmbh Metabolite und Prodrugs von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol
DE10224556A1 (de) * 2002-05-31 2004-01-08 Grünenthal GmbH 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
US20050182131A1 (en) * 2002-07-19 2005-08-18 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
JP4059259B2 (ja) 2005-06-30 2008-03-12 ヤマハ株式会社 スピーカシステムおよびスピーカエンクロージャー
JPWO2007018234A1 (ja) * 2005-08-10 2009-02-19 日本新薬株式会社 尿道内圧上昇作用剤
ZA200801162B (en) * 2005-09-09 2009-04-29 Labopharm Inc Trazodone composition for once a day administration
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
EP2281558A1 (en) * 2009-08-06 2011-02-09 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compounds of O-Desmethyl-Tramadol and COX-inhibitors
US10702485B2 (en) * 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG80535A1 (en) 1991-09-06 2001-05-22 Mcneilab Inc Composition comprising a tramadol material and acetaminophen and its use
ES2096726T3 (es) 1991-09-06 1997-03-16 Mcneilab Inc Composiciones que contienen tramadol y cualquier codeina, oxicodona o hidrocodona, y su utilizacion.
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE19601744C2 (de) 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
ES2227814T3 (es) * 1997-03-11 2005-04-01 Arakis Ltd. Formas de dosificacion que comprenden porciones separadas de enantiomeros r y s.
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
WO1998046216A1 (fr) * 1997-04-11 1998-10-22 Nippon Shinyaku Co., Ltd. Traitements des mictions frequentes et de l'incontinence urinaire
GB9709972D0 (en) * 1997-05-19 1997-07-09 Pfizer Ltd Tetrazoles

Also Published As

Publication number Publication date
WO2001024783A3 (de) 2002-02-28
JP5477881B2 (ja) 2014-04-23
US6660774B2 (en) 2003-12-09
JP2003510350A (ja) 2003-03-18
MXPA02003491A (es) 2002-08-20
EP1217998B1 (de) 2007-08-01
ATE368455T1 (de) 2007-08-15
DE50014532D1 (de) 2007-09-13
WO2001024783A2 (de) 2001-04-12
HK1047707A1 (zh) 2003-03-07
AU7907600A (en) 2001-05-10
PE20010623A1 (es) 2001-07-07
ES2291223T3 (es) 2008-03-01
CA2386381A1 (en) 2001-04-12
EP1217998A2 (de) 2002-07-03
US20030069314A1 (en) 2003-04-10

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