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HUP0003203A2 - Eljárás bisz-indolil-maleimidek előállítására - Google Patents

Eljárás bisz-indolil-maleimidek előállítására

Info

Publication number
HUP0003203A2
HUP0003203A2 HU0003203A HUP0003203A HUP0003203A2 HU P0003203 A2 HUP0003203 A2 HU P0003203A2 HU 0003203 A HU0003203 A HU 0003203A HU P0003203 A HUP0003203 A HU P0003203A HU P0003203 A2 HUP0003203 A2 HU P0003203A2
Authority
HU
Hungary
Prior art keywords
bisindolymalimides
producing
reaction
optionally substituted
acetamides
Prior art date
Application number
HU0003203A
Other languages
English (en)
Inventor
Margaret Mary Faul
Leonard L. Winneroski
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0003203A2 publication Critical patent/HUP0003203A2/hu
Publication of HUP0003203A3 publication Critical patent/HUP0003203A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A jelen találmány eljárást szolgáltat (I) általános képletű - aképletben R1 és R2 jelentése a tetszőlegesen helyettesített 3-indolil-csoport és R11 jelentése metilcsoport vagy hidrogénatom - potenciálisPKC inhbitorok előállítására, tetszőlegesen helyettesített indol-3-acetamidok és tetszőlegesen helyettesített metil indol-3-glioxilátreagens reakciójával. A reakció nagymértékben hatékony és nagyteljesítményű makrociklus képzési módszer. Ó
HU0003203A 1996-08-23 1997-08-22 Process for producing bisindolymalimides HUP0003203A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2412096P 1996-08-23 1996-08-23
PCT/US1997/014771 WO1998007693A1 (en) 1996-08-23 1997-08-22 Synthesis of bisindolylmalimides

Publications (2)

Publication Number Publication Date
HUP0003203A2 true HUP0003203A2 (hu) 2001-06-28
HUP0003203A3 HUP0003203A3 (en) 2002-01-28

Family

ID=21818966

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003203A HUP0003203A3 (en) 1996-08-23 1997-08-22 Process for producing bisindolymalimides

Country Status (16)

Country Link
US (2) US5990319A (hu)
EP (1) EP0825190A1 (hu)
JP (1) JP2000516632A (hu)
KR (1) KR20000068323A (hu)
CN (1) CN1228082A (hu)
AU (1) AU716840B2 (hu)
BR (1) BR9711363A (hu)
CA (1) CA2263862A1 (hu)
EA (1) EA001392B1 (hu)
HU (1) HUP0003203A3 (hu)
IL (1) IL128376A0 (hu)
NO (1) NO990832L (hu)
NZ (1) NZ334030A (hu)
PL (1) PL331899A1 (hu)
WO (1) WO1998007693A1 (hu)
YU (1) YU9499A (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
NZ560225A (en) 2005-02-09 2010-10-29 Arqule Inc Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
WO2009002807A2 (en) 2007-06-22 2008-12-31 Arqule, Inc. Indolyl pyrrolidines for the treatment of cancer
US8304425B2 (en) 2007-06-22 2012-11-06 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
US8232285B2 (en) 2007-06-22 2012-07-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
TW201350483A (zh) * 2012-04-23 2013-12-16 Arqule Inc 高純度吡咯並喹啉基－吡咯－２，５－二酮及吡咯並喹啉基－吡咯啶－２，５－二酮以及彼等之製備方法
CN104496970B (zh) * 2014-12-17 2017-01-11 河南师范大学 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用
CN104710412B (zh) * 2015-03-27 2017-03-22 河南师范大学 具有抗癌活性的3,4‑二（3‑吲哚）‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5339712A (en) * 1993-10-25 1994-08-23 Daryoush Keyvani Hand tool having offset work elements
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
BR9711363A (pt) 1999-08-17
PL331899A1 (en) 1999-08-16
YU9499A (sh) 2000-03-21
EP0825190A1 (en) 1998-02-25
HUP0003203A3 (en) 2002-01-28
KR20000068323A (ko) 2000-11-25
US5948907A (en) 1999-09-07
CN1228082A (zh) 1999-09-08
NO990832L (no) 1999-04-13
EA199900221A1 (ru) 1999-08-26
AU716840B2 (en) 2000-03-09
US5990319A (en) 1999-11-23
NZ334030A (en) 2000-08-25
NO990832D0 (no) 1999-02-22
IL128376A0 (en) 2000-01-31
CA2263862A1 (en) 1998-02-26
WO1998007693A1 (en) 1998-02-26
AU4157097A (en) 1998-03-06
JP2000516632A (ja) 2000-12-12
EA001392B1 (ru) 2001-02-26

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