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HUP0600726A2 - N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same - Google Patents

N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same

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Publication number
HUP0600726A2
HUP0600726A2 HU0600726A HUP0600726A HUP0600726A2 HU P0600726 A2 HUP0600726 A2 HU P0600726A2 HU 0600726 A HU0600726 A HU 0600726A HU P0600726 A HUP0600726 A HU P0600726A HU P0600726 A2 HUP0600726 A2 HU P0600726A2
Authority
HU
Hungary
Prior art keywords
alkyl
straight
atom
branched
optionally substituted
Prior art date
Application number
HU0600726A
Other languages
Hungarian (hu)
Inventor
Behr Agnes Pappne
Zoltan Kapui
Peter Aranyi
Sandor Batori
Bodor Veronika Bartane
Nagy Lajos T
Marton Varga
Gyoergy Ferenczy
Endre Mikus
Katalin Urban-Szabo
Szeredi Judit Vargane
Erzsebet Walcz
Edit Susan
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Priority to HU0600726A priority Critical patent/HUP0600726A3/en
Priority to AU2006293635A priority patent/AU2006293635A1/en
Priority to EP06795036A priority patent/EP1931620A1/en
Priority to RU2008115499/04A priority patent/RU2008115499A/en
Priority to CA002623317A priority patent/CA2623317A1/en
Priority to BRPI0616150-2A priority patent/BRPI0616150A2/en
Priority to JP2008531798A priority patent/JP2009508929A/en
Priority to KR1020087007021A priority patent/KR20080046209A/en
Priority to PCT/HU2006/000078 priority patent/WO2007034252A1/en
Publication of HU0600726D0 publication Critical patent/HU0600726D0/en
Priority to IL190094A priority patent/IL190094A0/en
Priority to US12/050,969 priority patent/US20080287434A1/en
Publication of HUP0600726A2 publication Critical patent/HUP0600726A2/en
Publication of HUP0600726A3 publication Critical patent/HUP0600726A3/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Amino alkyl amide derivatives and their salts, solvates and their isomers are new. Amino alkyl amide derivatives of formula Ar 1-X-N(R 1)-Y-N(R 2)-C(=O)-Z'-Ar 2 and their salts, solvates and their isomers are new. Ar 1phenyl (optionally substituted by halogen); X,Y : straight 1-4C alkylene (optionally substituted by straight or branched 1-4C alkyl); Z' : straight 2-4C alkylene or alkenylene (both optionally substituted by straight or branched 1-4C alkyl) or valence bond; R 1,R 2hydrogen atom or straight or branched 1-4C alkyl; Ar 2phenyl-, thienyl- or furyl (all optionally substituted by straight or branched 1-4C alkyl or alkoxy, hydroxyl, amino (optionally mono- or di-substituted by straight or branched 1-4C alkyl), trifluoromethyl, cyano, 1-2C alkylenedioxy or halogen atom), 5- or 6-membered heterocyclic ring (containing 1 - 3 nitrogen atoms, or 2 nitrogen atoms and 1 oxygen atom, or 1 nitrogen atom and 1 oxygen atom, or 1 nitrogen atom and 1 sulfur atom and optionally substituted by straight or branched 1-4C alkyl or alkoxy, halogen atom, nitro, cyano, carboxyl, phenyl (optionally substituted by straight or branched 1-4C alkyl, halogen atom or benzyloxy), oxo, NR 1 0R 1 1, CONR 1 0R 1 1 or SO 2NR 1 0R 1 1), the benzologs of these 5- or 6-membered heterocycle (in which the benzene ring is optionally substituted by T 1, trifluoromethyl, nitro, 1-2C alkylenedioxy or sulfonyl) or 5- or 6-membered heterocyclic ring (containing 1 - 3 nitrogen atoms, or 1 nitrogen atom and 1 oxygen atom, or 1 nitrogen atom and 1 sulfur atom and condensed with 6-membered heteroaromatic rings (containing 1 or 2 nitrogen atoms) and optionally substituted by T 1); T 1halogen atom, straight or branched 1-4C alkyl or alkoxy, cyano, carboxyl, hydroxyl, NR 1 0R 1 1, CONR 1 0R 1 1 or SO 2NR 1 0R 1 1; R 1 0,R 1 1,R 1 4hydrogen atom, straight or branched 1-4C alkyl, 3-6C cycloalkyl or benzyl; NR 1 0+R 1 1a group of formula (i); R 1 2,R 1 3hydrogen atom or straight or branched 1-4C alkyl; A : methylene group, oxygen atom, sulfur atom or NR 1 4; q : 0 - 3; r : 1 or 2; o,s : 0 or 1. Independent claims are included for the following: (1) preparation of the amino-alkyl-amide derivatives (I); and (2) a pyridine compound of formula Ar' 2-Z 1-C(=O)-W' forming a narrower group of a ketone compound of formula Ar 2-Z'-C(=O)-W' (II). Ar' 21,2,4-triazolo[1,5-a]pyridine- or triazolo[5,4-b]pyridine group (both optionally substituted by straight or branched 1-4C alkyl or alkoxy, hydroxyl, NR 1 0R 1 1, CONR 1 0R 1 1 or SO 2NR 1 0R 1 1); Z 11,3-propylene group; W' : halogen atom, hydroxyl, O(1-4C alkyl) or OCO-Z'-Ar 2. ACTIVITY : Antiasthmatic; Dermatological; Antiinflammatory; Gastrointestinal-Gen.; Antiulcer; Antiallergic; Ophthalmological; Neuroprotective; Virucide; Anti-HIV. MECHANISM OF ACTION : CC chemokine receptor 3 (CCR3) receptor antagonist. The CCR3 receptor antagonist effect of the amino-alkyl-amide derivatives (I) was examined on eotaxin binding test on human CCR3 (hCCR3) receptor expressing recombinant K562 and RBL2H3 cells and using Eotaxin labeled with radioactive iodine ( 1> 2> 3>I). The compound (I) showed IC 5 0 value of 0.5 - 500 (preferably 0.5 - 15) nM. No results for specific compounds are given.
HU0600726A 2005-09-22 2006-09-15 N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same HUP0600726A3 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU0600726A HUP0600726A3 (en) 2006-09-15 2006-09-15 N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same
BRPI0616150-2A BRPI0616150A2 (en) 2005-09-22 2006-09-19 amino alkyl amide derivatives as ccr3 receptor liquids
EP06795036A EP1931620A1 (en) 2005-09-22 2006-09-19 Amino-alkyl-amide derivatives as ccr3 receptor liquids
RU2008115499/04A RU2008115499A (en) 2005-09-22 2006-09-19 NEW AMINOKILAMIDE DERIVATIVES AS CCR3 RECEPTOR LIGAND ANTAGONISTS
CA002623317A CA2623317A1 (en) 2005-09-22 2006-09-19 Amino-alkyl-amide derivatives as ccr3 receptor liquids
AU2006293635A AU2006293635A1 (en) 2005-09-22 2006-09-19 Amino-alkyl-amide derivatives as CCR3 receptor liquids
JP2008531798A JP2009508929A (en) 2005-09-22 2006-09-19 Amino-alkyl-amide derivatives as CCR3 receptor ligands
KR1020087007021A KR20080046209A (en) 2005-09-22 2006-09-19 Novel amino-alkyl-amide derivatives as Cr3 receptor ligands
PCT/HU2006/000078 WO2007034252A1 (en) 2005-09-22 2006-09-19 Amino-alkyl-amide derivatives as ccr3 receptor liquids
IL190094A IL190094A0 (en) 2005-09-22 2008-03-11 Amino-alkyl-amide derivatives as ccr3 receptor liquids
US12/050,969 US20080287434A1 (en) 2005-09-22 2008-03-19 New amino-alkyl-amide derivatives as CCR3 receptor ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0600726A HUP0600726A3 (en) 2006-09-15 2006-09-15 N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same

Publications (3)

Publication Number Publication Date
HU0600726D0 HU0600726D0 (en) 2006-11-28
HUP0600726A2 true HUP0600726A2 (en) 2008-06-30
HUP0600726A3 HUP0600726A3 (en) 2008-07-28

Family

ID=89987032

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0600726A HUP0600726A3 (en) 2005-09-22 2006-09-15 N-(phenalkylamino-alkyl)-carboxylic acid amides, process for their preparation, their use and pharmaceutical compositions containing the same

Country Status (1)

Country Link
HU (1) HUP0600726A3 (en)

Also Published As

Publication number Publication date
HU0600726D0 (en) 2006-11-28
HUP0600726A3 (en) 2008-07-28

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Legal Events

Date Code Title Description
FC4A Lapse of provisional application due to refusal