HUE039703T2 - Bispecifikus antigénkötõ molekulák - Google Patents
Bispecifikus antigénkötõ molekulákInfo
- Publication number
- HUE039703T2 HUE039703T2 HUE12755967A HUE12755967A HUE039703T2 HU E039703 T2 HUE039703 T2 HU E039703T2 HU E12755967 A HUE12755967 A HU E12755967A HU E12755967 A HUE12755967 A HU E12755967A HU E039703 T2 HUE039703 T2 HU E039703T2
- Authority
- HU
- Hungary
- Prior art keywords
- antigen binding
- binding molecules
- bispecific antigen
- bispecific
- molecules
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11178371 | 2011-08-23 | ||
| EP12168189 | 2012-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039703T2 true HUE039703T2 (hu) | 2019-01-28 |
Family
ID=46800168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12755967A HUE039703T2 (hu) | 2011-08-23 | 2012-08-21 | Bispecifikus antigénkötõ molekulák |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20130058937A1 (hu) |
| EP (1) | EP2748202B1 (hu) |
| JP (1) | JP5925893B2 (hu) |
| KR (1) | KR101721301B1 (hu) |
| CN (1) | CN103764681B (hu) |
| AR (1) | AR087615A1 (hu) |
| AU (4) | AU2012298535A1 (hu) |
| BR (1) | BR112014003598B1 (hu) |
| CA (1) | CA2844538C (hu) |
| DK (1) | DK2748202T3 (hu) |
| ES (1) | ES2686327T3 (hu) |
| HK (1) | HK1197249A1 (hu) |
| HR (1) | HRP20181355T1 (hu) |
| HU (1) | HUE039703T2 (hu) |
| IL (1) | IL230553B (hu) |
| LT (1) | LT2748202T (hu) |
| MX (1) | MX349095B (hu) |
| MY (1) | MY171038A (hu) |
| PL (1) | PL2748202T3 (hu) |
| PT (1) | PT2748202T (hu) |
| RS (1) | RS57744B1 (hu) |
| RU (1) | RU2650775C2 (hu) |
| SG (1) | SG2014008577A (hu) |
| SI (1) | SI2748202T1 (hu) |
| WO (1) | WO2013026831A1 (hu) |
Families Citing this family (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) * | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| RU2598248C2 (ru) | 2009-04-02 | 2016-09-20 | Роше Гликарт Аг | Полиспецифичные антитела, включающие антитела полной длины и одноцепочечные фрагменты fab |
| SG175077A1 (en) | 2009-04-07 | 2011-11-28 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| EP2478013B1 (en) | 2009-09-16 | 2018-10-24 | F.Hoffmann-La Roche Ag | Coiled coil and/or tether containing protein complexes and uses thereof |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| MX340558B (es) | 2010-08-24 | 2016-07-14 | F Hoffmann-La Roche Ag * | Anticuerpos biespecificos que comprenden fragmento fv estabilizado con disulfuro. |
| EP3434767A1 (en) | 2010-11-30 | 2019-01-30 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| WO2012116927A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
| RU2607038C2 (ru) | 2011-02-28 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Антигенсвязывающие белки |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| JP6159724B2 (ja) | 2011-08-23 | 2017-07-05 | ロシュ グリクアート アーゲー | Ｔ細胞活性化抗原に対して特異的な二重特異性抗体及び腫瘍抗原および使用方法 |
| JP6486686B2 (ja) | 2012-02-10 | 2019-03-20 | ジェネンテック， インコーポレイテッド | 単鎖抗体及び他のヘテロ多量体 |
| US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
| JP6309002B2 (ja) | 2012-06-27 | 2018-04-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的に特異的に結合する少なくとも１つの結合実体を含む抗体Ｆｃ領域結合体を作製するための方法およびその使用 |
| BR112014032193A2 (pt) | 2012-06-27 | 2017-06-27 | Hoffmann La Roche | métodos de produção de anticorpos biespecíficos e de determinação de combinação, anticorpo biespecífico, formulação e uso de anticorpo biespecífico |
| JP6444874B2 (ja) | 2012-10-08 | 2018-12-26 | ロシュ グリクアート アーゲー | ２つのＦａｂフラグメントを含むＦｃ不含抗体および使用方法 |
| JP6571527B2 (ja) | 2012-11-21 | 2019-09-04 | ウーハン ワイゼットワイ バイオファルマ カンパニー リミテッドＷｕｈａｎ Ｙｚｙ Ｂｉｏｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． | 二重特異性抗体 |
| ITTO20130012A1 (it) | 2013-01-09 | 2014-07-10 | Metheresis Translational Res S A | Nuovi frammenti anticorpali, relative composizioni ed usi |
| WO2014122143A1 (en) | 2013-02-05 | 2014-08-14 | Engmab Ag | Method for the selection of antibodies against bcma |
| US20140242080A1 (en) * | 2013-02-26 | 2014-08-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| MY192312A (en) | 2013-02-26 | 2022-08-17 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| MX2015010350A (es) * | 2013-02-26 | 2015-10-29 | Roche Glycart Ag | Moleculas de union a antigeno biespecificas que activan la celula t. |
| AU2014227638A1 (en) * | 2013-03-15 | 2015-09-17 | Merck Patent Gmbh | Tetravalent bispecific antibodies |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| EP3055329B1 (en) | 2013-10-11 | 2018-06-13 | F. Hoffmann-La Roche AG | Multispecific domain exchanged common variable light chain antibodies |
| MX2016008098A (es) | 2013-12-20 | 2017-01-11 | Hoffmann La Roche | Anticuerpos biespecificos del receptor 2 de factor de crecimiento ipidermico himano (her2) y metodo de uso. |
| RU2769133C2 (ru) * | 2013-12-30 | 2022-03-28 | Эпимаб Биотерапьютикс Инк. | Иммуноглобулин с тандемным расположением fab-фрагментов и его применение |
| IL247715B (en) | 2014-04-07 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Antigen binding molecules that activate the immune system |
| CA2947157A1 (en) | 2014-05-13 | 2015-11-19 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| SG11201609707WA (en) | 2014-07-01 | 2017-01-27 | Pfizer | Bispecific heterodimeric diabodies and uses thereof |
| SI3608337T1 (sl) | 2014-08-04 | 2024-07-31 | F. Hoffmann - La Roche Ag | Biospecifične molekule za aktivacijo celic T in antigensko vezavo |
| RS61134B1 (sr) | 2014-11-20 | 2020-12-31 | Hoffmann La Roche | Kombinovana terapija bispecifičnim antigen vezujućim molekulima koji aktiviraju t ćelije za cd3 i folatni receptor 1 (folr1), i antagonistima vezivanja ose pd-1 |
| PT3221357T (pt) * | 2014-11-20 | 2020-07-28 | Hoffmann La Roche | Cadeias leves comuns e métodos de utilização |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| US10472412B2 (en) | 2015-03-25 | 2019-11-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bispecific multivalent fusion proteins |
| NZ775241A (en) | 2015-06-24 | 2024-08-30 | Hoffmann La Roche | Anti-transferrin receptor antibodies with tailored affinity |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| AR106189A1 (es) * | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| MX2018003631A (es) | 2015-10-02 | 2018-08-01 | Hoffmann La Roche | Moleculas biespecificas de union a antigeno activadoras de celulas t. |
| RU2753390C1 (ru) | 2015-10-02 | 2021-08-13 | Ф. Хоффманн-Ля Рош Аг | Биспецифические антитела к человеческому cd20/человеческому рецептору трансферрина и способы их применения |
| US20170247454A1 (en) | 2015-10-02 | 2017-08-31 | Hoffmann-La Roche Inc. | Anti-pd1 antibodies and methods of use |
| US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
| JP6925278B2 (ja) | 2015-11-18 | 2021-08-25 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| CA2997406C (en) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release |
| US10596257B2 (en) | 2016-01-08 | 2020-03-24 | Hoffmann-La Roche Inc. | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
| BR112018014760A2 (pt) | 2016-01-22 | 2018-12-26 | Janssen Biotech Inc | anticorpos anti-ror1, anticorpos biespecíficos para ror1 x cd3 e métodos de uso dos mesmos |
| CU24613B1 (es) | 2016-02-06 | 2022-07-08 | Epimab Biotherapeutics Inc | Proteínas de unión a inmunoglobulinas fabs en tandem (fit-ig) biespecíficas que se unen a cmet y egfr |
| HUE061946T2 (hu) | 2016-03-22 | 2023-09-28 | Hoffmann La Roche | Proteáz-aktivált T-sejt bispecifikus molekulák |
| BR112019002579A2 (pt) * | 2016-08-16 | 2019-05-21 | Epimab Biotherapeutics, Inc. | anticorpos biespecíficos fab monovalentes, assimétricos e tandem |
| US10882918B2 (en) | 2016-09-30 | 2021-01-05 | Hoffmann-La Roche Inc. | Bispecific T cell activating antigen binding molecules |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| JOP20190100A1 (ar) * | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
| CR20190430A (es) | 2017-04-03 | 2019-11-01 | Hoffmann La Roche | Anticuerpos que se unen a steap-1 |
| SI3606954T1 (sl) | 2017-04-05 | 2022-10-28 | F. Hoffmann - La Roche Ag | Protitelesa proti LAG3 |
| EP3606955B1 (en) | 2017-04-05 | 2024-11-06 | F. Hoffmann-La Roche AG | Bispecific antibodies specifically binding to pd1 and lag3 |
| WO2019077092A1 (en) | 2017-10-20 | 2019-04-25 | F. Hoffmann-La Roche Ag | METHOD FOR GENERATING MULTISPECIFIC ANTIBODIES FROM MONOSPECIFIC ANTIBODIES |
| CN111372947A (zh) | 2017-10-30 | 2020-07-03 | 豪夫迈·罗氏有限公司 | 在体内从单特异性抗体产生多特异性抗体的方法 |
| KR102575787B1 (ko) | 2017-12-21 | 2023-09-08 | 에프. 호프만-라 로슈 아게 | Hla-a2/wt1에 결합하는 항체 |
| US11945839B2 (en) | 2017-12-22 | 2024-04-02 | Hoffmann-La Roche Inc. | Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography |
| CN111479588A (zh) | 2017-12-29 | 2020-07-31 | 豪夫迈·罗氏有限公司 | 用于改善抗vegf抗体的vegf受体阻断选择性的方法 |
| CN111655730A (zh) | 2018-01-31 | 2020-09-11 | 豪夫迈·罗氏有限公司 | 包含与lag3结合的抗原结合位点的双特异性抗体 |
| WO2019149715A1 (en) | 2018-01-31 | 2019-08-08 | F. Hoffmann-La Roche Ag | Stabilized immunoglobulin domains |
| WO2019157308A1 (en) | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
| CN111936625A (zh) | 2018-03-29 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 调节哺乳动物细胞中的生乳活性 |
| AR114789A1 (es) | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
| AR115052A1 (es) | 2018-04-18 | 2020-11-25 | Hoffmann La Roche | Anticuerpos multiespecíficos y utilización de los mismos |
| EP3788079A4 (en) | 2018-05-03 | 2022-12-21 | Shanghai Epimab Biotherapeutics Co., Ltd. | HIGH AFFINITY ANTIBODIES AGAINST PD-1 AND LAG-3 AND B-SPECIFIC BINDING PROTEINS PRODUCED FROM THEM |
| CA3113548A1 (en) * | 2018-10-01 | 2020-04-09 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules comprising anti-fap clone 212 |
| TW202428614A (zh) | 2018-12-21 | 2024-07-16 | 瑞士商赫孚孟拉羅股份公司 | 結合cd3之抗體 |
| US11965030B2 (en) | 2018-12-24 | 2024-04-23 | Sanofi | Multispecific binding proteins with mutant fab domains |
| JP2022515473A (ja) | 2018-12-28 | 2022-02-18 | エフ．ホフマン－ラ ロシュ アーゲー | 免疫応答が増幅された患者における治療的使用のためのペプチド－ｍｈｃ－ｉ－抗体融合タンパク質 |
| WO2020135804A1 (zh) * | 2018-12-29 | 2020-07-02 | 上海一宸医药科技有限公司 | 异源二聚体融合蛋白 |
| CA3142886A1 (en) * | 2019-06-06 | 2020-12-10 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| AU2020296247A1 (en) | 2019-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Method for the generation of a trivalent antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| BR112021025436A2 (pt) | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Métodos para produzir um anticorpo biespecífico trivalente, biespecífico bivalente, biespecífico multivalente, para produzir uma célula de mamífero recombinante e para produzir um anticorpo trivalente, ácidos desoxirribonucleicos, usos de um ácido desoxirribonucleico, células de mamífero recombinante, composições e uso de mrna de recombinase cre |
| EP3990646A1 (en) | 2019-06-26 | 2022-05-04 | F. Hoffmann-La Roche AG | Mammalian cell lines with sirt-1 gene knockout |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| JP2022543551A (ja) | 2019-07-31 | 2022-10-13 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｇｐｒｃ５ｄに結合する抗体 |
| KR20220028035A (ko) | 2019-07-31 | 2022-03-08 | 에프. 호프만-라 로슈 아게 | Gprc5d에 결합하는 항체 |
| CA3150999A1 (en) | 2019-09-18 | 2021-03-25 | James Thomas Koerber | Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use |
| CN110669137B (zh) | 2019-10-24 | 2021-07-16 | 高新 | 一种多特异性抗体及其制备方法和用途 |
| WO2021094508A1 (en) | 2019-11-15 | 2021-05-20 | F. Hoffmann-La Roche Ag | Prevention of visible particle formation in aqueous protein solutions |
| WO2021122733A1 (en) | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
| WO2021122875A1 (en) | 2019-12-18 | 2021-06-24 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a2/mage-a4 |
| CR20220334A (es) | 2019-12-23 | 2022-08-26 | Genentech Inc | Anticuerpos específicos de apolipoproteína l1 y métodos de uso |
| MX2022008442A (es) | 2020-01-15 | 2022-08-02 | Hoffmann La Roche | Metodos para disminuir impurezas de procesos de manufacturacion de proteinas recombinantes. |
| TW202202620A (zh) | 2020-03-26 | 2022-01-16 | 美商建南德克公司 | 經修飾之哺乳動物細胞 |
| EP4133269A1 (en) | 2020-04-08 | 2023-02-15 | F. Hoffmann-La Roche AG | Large molecule unspecific clearance assay |
| WO2021228917A1 (en) | 2020-05-15 | 2021-11-18 | F. Hoffmann-La Roche Ag | Prevention of visible particle formation in parenteral protein solutions |
| CN115605185A (zh) | 2020-05-19 | 2023-01-13 | 豪夫迈·罗氏有限公司（Ch） | 螯合剂用于防止胃肠外蛋白质溶液中形成可见颗粒的用途 |
| CR20220659A (es) | 2020-06-08 | 2023-08-21 | Hoffmann La Roche | Anticuerpos anti-hbv y metodos de uso |
| CN115916825A (zh) | 2020-06-19 | 2023-04-04 | 豪夫迈·罗氏有限公司 | 与cd3和cd19结合的抗体 |
| PE20230835A1 (es) | 2020-06-19 | 2023-05-19 | Hoffmann La Roche | Anticuerpos que se unen a cd3 |
| CA3185513A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and folr1 |
| WO2021255146A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea |
| US20220041672A1 (en) | 2020-06-24 | 2022-02-10 | Genentech, Inc. | Apoptosis resistant cell lines |
| EP4178529A1 (en) | 2020-07-07 | 2023-05-17 | F. Hoffmann-La Roche AG | Alternative surfactants as stabilizers for therapeutic protein formulations |
| WO2022016037A1 (en) | 2020-07-17 | 2022-01-20 | Genentech, Inc. | Anti-notch2 antibodies and methods of use |
| JP2023539201A (ja) | 2020-08-28 | 2023-09-13 | ジェネンテック， インコーポレイテッド | 宿主細胞タンパク質のＣＲＩＳＰＲ／Ｃａｓ９マルチプレックスノックアウト |
| CN114195900B (zh) * | 2020-09-17 | 2024-02-23 | 普米斯生物技术(珠海)有限公司 | 一种抗4-1bb/pd-l1双特异性抗体及其用途 |
| AU2021342566A1 (en) | 2020-09-21 | 2023-03-02 | Genentech, Inc. | Purification of multispecific antibodies |
| JP2023542228A (ja) | 2020-09-24 | 2023-10-05 | エフ． ホフマン－ラ ロシュ アーゲー | 遺伝子ノックアウトを有する哺乳動物細胞株 |
| TW202233671A (zh) | 2020-10-20 | 2022-09-01 | 美商建南德克公司 | Ｐｅｇ結合抗ｍｅｒｔｋ抗體及其使用方法 |
| US20240016949A1 (en) * | 2020-12-04 | 2024-01-18 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof |
| IL303656A (en) | 2020-12-17 | 2023-08-01 | Hoffmann La Roche | ANTI-HLA-G antibodies and their use |
| WO2022136140A1 (en) | 2020-12-22 | 2022-06-30 | F. Hoffmann-La Roche Ag | Oligonucleotides targeting xbp1 |
| JP2024509695A (ja) | 2021-02-03 | 2024-03-05 | ジェネンテック， インコーポレイテッド | 多重特異性結合タンパク質分解プラットフォームおよび使用方法 |
| JP2024512377A (ja) | 2021-03-12 | 2024-03-19 | ジェネンテック， インコーポレイテッド | 抗ｋｌｋ７抗体、抗ｋｌｋ５抗体、多重特異性抗ｋｌｋ５／ｋｌｋ７抗体、及び使用方法 |
| JP2024513474A (ja) | 2021-04-09 | 2024-03-25 | エフ． ホフマン－ラ ロシュ アーゲー | 異種ポリペプチドを発現する細胞クローンを選択するための方法 |
| JP2024514222A (ja) | 2021-04-19 | 2024-03-28 | ジェネンテック， インコーポレイテッド | 改変された哺乳動物細胞 |
| JP2024521107A (ja) | 2021-05-21 | 2024-05-28 | ジェネンテック， インコーポレイテッド | 目的の組換え産物を産生するための修飾細胞 |
| CN113278071B (zh) | 2021-05-27 | 2021-12-21 | 江苏荃信生物医药股份有限公司 | 抗人干扰素α受体1单克隆抗体及其应用 |
| KR20240021859A (ko) | 2021-06-18 | 2024-02-19 | 에프. 호프만-라 로슈 아게 | 이중특이적 항-ccl2 항체 |
| EP4371125A1 (en) | 2021-07-13 | 2024-05-22 | Genentech, Inc. | Multi-variate model for predicting cytokine release syndrome |
| KR20240036570A (ko) | 2021-07-22 | 2024-03-20 | 에프. 호프만-라 로슈 아게 | 이종이량체 Fc 도메인 항체 |
| JP2024528217A (ja) | 2021-08-03 | 2024-07-26 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗体および使用方法 |
| CN113683694B (zh) | 2021-09-03 | 2022-05-13 | 江苏荃信生物医药股份有限公司 | 一种抗人tslp单克隆抗体及其应用 |
| CN113603775B (zh) | 2021-09-03 | 2022-05-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素-33单克隆抗体及其应用 |
| WO2023094282A1 (en) | 2021-11-25 | 2023-06-01 | F. Hoffmann-La Roche Ag | Quantification of low amounts of antibody sideproducts |
| AR127887A1 (es) | 2021-12-10 | 2024-03-06 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y plap |
| EP4416301A1 (en) | 2021-12-21 | 2024-08-21 | F. Hoffmann-La Roche AG | Method for the determination of hydrolytic activity |
| US20230322958A1 (en) | 2022-01-19 | 2023-10-12 | Genentech, Inc. | Anti-Notch2 Antibodies and Conjugates and Methods of Use |
| WO2023202967A1 (en) | 2022-04-19 | 2023-10-26 | F. Hoffmann-La Roche Ag | Improved production cells |
| WO2023232961A1 (en) | 2022-06-03 | 2023-12-07 | F. Hoffmann-La Roche Ag | Improved production cells |
| TW202417504A (zh) | 2022-07-22 | 2024-05-01 | 美商建南德克公司 | 抗ｓｔｅａｐ１抗原結合分子及其用途 |
| TW202430211A (zh) | 2022-10-10 | 2024-08-01 | 瑞士商赫孚孟拉羅股份公司 | Ｇｐｒｃ５ｄ ｔｃｂ及ｉｍｉｄ之組合療法 |
| TW202423970A (zh) | 2022-10-10 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | Ｇｐｒｃ５ｄ ｔｃｂ及ｃｄ３８抗體之組合療法 |
| TW202423969A (zh) | 2022-10-10 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | Ｇｐｒｃ５ｄ ｔｃｂ及蛋白酶體抑制劑之組合療法 |
| WO2024079069A1 (en) | 2022-10-12 | 2024-04-18 | F. Hoffmann-La Roche Ag | Method for classifying cells |
| WO2024110426A1 (en) | 2022-11-23 | 2024-05-30 | F. Hoffmann-La Roche Ag | Method for increasing recombinant protein expression |
| WO2024129594A1 (en) | 2022-12-12 | 2024-06-20 | Genentech, Inc. | Optimizing polypeptide sialic acid content |
| WO2024156672A1 (en) | 2023-01-25 | 2024-08-02 | F. Hoffmann-La Roche Ag | Antibodies binding to csf1r and cd3 |
| WO2024184287A1 (en) | 2023-03-06 | 2024-09-12 | F. Hoffmann-La Roche Ag | Combination therapy of an anti-egfrviii/anti-cd3 antibody and an tumor-targeted 4-1bb agonist |
| WO2024191785A1 (en) | 2023-03-10 | 2024-09-19 | Genentech, Inc. | Fusions with proteases and uses thereof |
| WO2024206788A1 (en) | 2023-03-31 | 2024-10-03 | Genentech, Inc. | Anti-alpha v beta 8 integrin antibodies and methods of use |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2388385B1 (fr) | 1977-04-18 | 1982-01-08 | Hitachi Metals Ltd | Piece d'ornement fixee par des aimants permanents |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
| ATE503496T1 (de) | 1992-02-06 | 2011-04-15 | Novartis Vaccines & Diagnostic | Biosynthetisches bindeprotein für tumormarker |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| EP1034298B1 (en) | 1997-12-05 | 2011-11-02 | The Scripps Research Institute | Humanization of murine antibody |
| AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PT1914244E (pt) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| ATE303445T1 (de) | 1999-10-04 | 2005-09-15 | Medicago Inc | Verfahren zur regulation der transkription von fremden genen in gegenwart von stickstoff |
| NZ521540A (en) * | 2000-04-11 | 2004-09-24 | Genentech Inc | Multivalent antibodies and uses therefor |
| WO2003056914A1 (en) | 2001-12-27 | 2003-07-17 | Glycofi, Inc. | Methods to engineer mammalian-type carbohydrate structures |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US20050118164A1 (en) * | 2001-03-09 | 2005-06-02 | William Herman | Targeted ligands |
| CA2455365C (en) | 2001-08-03 | 2014-07-29 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| US20030157108A1 (en) | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
| EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | AN ANTIBODY COMPOSITION CONTAINING MEDICAMENT FOR PATIENTS WITH Fc gamma RIIIa POLYMORPHISM |
| AU2003236020B2 (en) | 2002-04-09 | 2009-03-19 | Kyowa Hakko Kirin Co., Ltd. | Cell with depression or deletion of the activity of protein participating in GDP-fucose transport |
| AU2003236022A1 (en) | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells with modified genome |
| WO2003085118A1 (fr) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production de composition anticorps |
| JPWO2003085119A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物のＦｃγ受容体ＩＩＩａに対する結合活性を高める方法 |
| PT1539966E (pt) | 2002-09-12 | 2010-09-14 | Greenovation Biotech Gmbh | Método de produção de proteínas |
| US20060235208A1 (en) * | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| RU2326127C2 (ru) | 2002-12-16 | 2008-06-10 | Джинентех, Инк. | Варианты иммуноглобулинов и их применение |
| AU2003294912B2 (en) | 2002-12-20 | 2009-06-04 | Greenovation Biotech Gmbh | Production of heterologous glycosylated proteins in bryophyte cells |
| US8367374B2 (en) | 2003-01-22 | 2013-02-05 | Roche Glycart Ag | Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function |
| EP2395016A3 (en) * | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| EP1740615B1 (en) | 2004-03-31 | 2014-11-05 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| DK1737891T3 (da) | 2004-04-13 | 2013-03-25 | Hoffmann La Roche | Anti-p-selectin-antistoffer |
| NZ552485A (en) | 2004-08-05 | 2009-11-27 | Genentech Inc | Humanized anti-cmet antagonists |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| EP1871805B1 (en) | 2005-02-07 | 2019-09-25 | Roche Glycart AG | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
| US20060206947A1 (en) * | 2005-02-28 | 2006-09-14 | Scallon Bernard J | Heterodimeric protein binding compositions |
| CN101374546B (zh) * | 2005-12-16 | 2016-03-23 | Ibc医药公司 | 基于免疫球蛋白的多价生物活性装配体 |
| WO2007073499A2 (en) * | 2005-12-21 | 2007-06-28 | Medimmune, Inc. | Epha2 bite molecules and uses thereof |
| RS58217B1 (sr) | 2007-04-03 | 2019-03-29 | Amgen Res Munich Gmbh | Interspecijski specifičan vezujući domen |
| US20090023189A1 (en) * | 2007-05-18 | 2009-01-22 | Applera Corporation | Apparatus and methods for preparation of subtantially uniform emulsions containing a particle |
| EP2626371A1 (en) * | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| US8227577B2 (en) * | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| US8242247B2 (en) * | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US9266967B2 (en) * | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) * | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| ES2563027T3 (es) | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| EP2342231A1 (en) * | 2008-09-26 | 2011-07-13 | Roche Glycart AG | Bispecific anti-egfr/anti-igf-1r antibodies |
| PE20120550A1 (es) * | 2009-04-07 | 2012-05-21 | Roche Glycart Ag | ANTICUERPOS BIESPECIFICOS ANTI-ErbB-3/ANTI-C-MET |
| AU2010233993A1 (en) * | 2009-04-07 | 2011-09-08 | Roche Glycart Ag | Bispecific anti-ErbB-1/anti-c-Met antibodies |
| SG175077A1 (en) * | 2009-04-07 | 2011-11-28 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| WO2010117456A2 (en) * | 2009-04-08 | 2010-10-14 | Applied Biosystems, Llc | Column enrichment of pcr beads comprising tethered amplicons |
| PE20120540A1 (es) * | 2009-05-27 | 2012-05-09 | Hoffmann La Roche | Anticuerpos triespecificos o tetraespecificos |
| US9676845B2 (en) * | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| PE20121552A1 (es) | 2009-08-31 | 2012-11-26 | Roche Glycart Ag | Anticuerpos monoclonales anti cea humanizados de afinidad madura |
| JP5680671B2 (ja) | 2009-12-22 | 2015-03-04 | ロシュ グリクアート アーゲー | 抗ｈｅｒ３抗体及びその使用 |
| MX358859B (es) | 2010-08-13 | 2018-09-05 | Roche Glycart Ag | Anticuerpos anti-fap y métodos de utilización. |
| EP3434767A1 (en) * | 2010-11-30 | 2019-01-30 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| WO2015096063A1 (en) * | 2013-12-25 | 2015-07-02 | Coyote Bioscience Co., Ltd. | Methods and systems for nucleic acid amplification |
| US10443086B2 (en) * | 2013-12-31 | 2019-10-15 | University Of Maryland, College Park | Methods, devices and systems for emulsion/droplet PCR |
| TW201641687A (zh) * | 2014-12-31 | 2016-12-01 | 卡尤迪生物科技（北京）有限公司 | 用于進行化學反應的設備和方法 |
| CN104846100B (zh) * | 2015-05-24 | 2017-10-10 | 北京工业大学 | 一种可用于微滴数字pcr的微滴制备方法 |
| CN104928368A (zh) * | 2015-05-24 | 2015-09-23 | 北京工业大学 | 一种利用硅油的适用于微滴数字pcr的微滴制备方法 |
| CN105256013B (zh) * | 2015-09-29 | 2018-08-31 | 上海市农业科学院 | 一种同步检测猪羊牛动物源性成分的微滴pcr引物体系及检测方法 |
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2014
- 2014-01-20 IL IL230553A patent/IL230553B/en active IP Right Grant
- 2014-10-28 HK HK14110799A patent/HK1197249A1/xx unknown
-
2016
- 2016-10-20 US US15/298,675 patent/US20170198043A1/en not_active Abandoned
-
2017
- 2017-08-07 AU AU2017210666A patent/AU2017210666A1/en not_active Abandoned
-
2018
- 2018-08-24 HR HRP20181355TT patent/HRP20181355T1/hr unknown
-
2019
- 2019-07-22 AU AU2019206138A patent/AU2019206138A1/en not_active Abandoned
-
2021
- 2021-08-23 AU AU2021221376A patent/AU2021221376A1/en active Pending
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