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HUE036378T2 - Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére - Google Patents

Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére

Info

Publication number
HUE036378T2
HUE036378T2 HUE07755255A HUE07755255A HUE036378T2 HU E036378 T2 HUE036378 T2 HU E036378T2 HU E07755255 A HUE07755255 A HU E07755255A HU E07755255 A HUE07755255 A HU E07755255A HU E036378 T2 HUE036378 T2 HU E036378T2
Authority
HU
Hungary
Prior art keywords
chemicals
methods
stem cells
embryonic stem
human embryonic
Prior art date
Application number
HUE07755255A
Other languages
English (en)
Inventor
Gabriela Cezar
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of HUE036378T2 publication Critical patent/HUE036378T2/hu

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
HUE07755255A 2006-04-10 2007-04-10 Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére HUE036378T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79064706P 2006-04-10 2006-04-10
US82216306P 2006-08-11 2006-08-11

Publications (1)

Publication Number Publication Date
HUE036378T2 true HUE036378T2 (hu) 2018-07-30

Family

ID=38515874

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE07755255A HUE036378T2 (hu) 2006-04-10 2007-04-10 Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére

Country Status (11)

Country Link
US (2) US8703483B2 (hu)
EP (1) EP2013619B1 (hu)
JP (2) JP5421767B2 (hu)
BR (1) BRPI0710054B8 (hu)
CA (1) CA2648218C (hu)
DK (1) DK2013619T3 (hu)
GB (1) GB2451042A (hu)
HU (1) HUE036378T2 (hu)
MX (1) MX2008013002A (hu)
SE (2) SE1050445A1 (hu)
WO (1) WO2007120699A2 (hu)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153359B2 (en) 2006-10-02 2012-04-10 Cellartis Ab Toxicity assay based on human blastocyst-derived stem cells and progenitor cells
MX2009008247A (es) * 2007-02-05 2009-08-12 Wisconsin Alumni Res Found Biomarcadores de respuesta a la radiacion ionizante.
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US20100285446A1 (en) * 2007-07-20 2010-11-11 Akos Vertes Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry
US8901487B2 (en) * 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
WO2010030293A1 (en) * 2008-09-15 2010-03-18 Gentron, Inc. Methods, systems, and compositions for cancer diagnosis
US20120088679A1 (en) * 2009-03-10 2012-04-12 Bayer Healthcare Llc Method for Monitoring Cell Culture
GB0911060D0 (en) 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
WO2011044253A1 (en) * 2009-10-06 2011-04-14 Wisconsin Alumni Research Foundation Metabolic biomarkers of drug-induced cardiotoxicity
EP2491508A2 (de) * 2009-10-21 2012-08-29 BASF Plant Science Company GmbH Verfahren zur erzeugung von biomarker-referenzpattern
EP2550365B1 (en) * 2010-03-22 2018-07-04 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
WO2011139914A1 (en) * 2010-04-29 2011-11-10 Wisconsin Alumni Research Foundation Metabolic biomarkers of autism
US8945847B2 (en) 2010-05-24 2015-02-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and kits for ascertaining biosafety of an agent
WO2012068170A2 (en) 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
WO2013085572A2 (en) 2011-07-14 2013-06-13 The George Washington University Plume collimation for laser ablation electrospray ionization mass spectrometry
US9164106B2 (en) * 2012-03-15 2015-10-20 Greenwood Genetic Center, Inc. Determination of decreased metabolism of tryptophan in diagnosis of autism spectrum disorders
EP2914748B1 (en) 2012-11-02 2019-03-13 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomic ratios
US9457053B2 (en) 2012-11-30 2016-10-04 Accelerated Biosciences Corp. Methods of differentiating stem cells by modulating MIR-124
US20160146789A1 (en) * 2013-07-03 2016-05-26 Coyne Scientific, Llc Methods for Predicting Responses to Chemical or Biological Substances
WO2016086132A1 (en) 2014-11-26 2016-06-02 Accelerated Biosciences Corp. Induced hepatocytes and uses thereof
GB201519186D0 (en) * 2015-10-30 2015-12-16 Electrophoretics Ltd Isotopic methods for measurement of tryptophan and metabolites thereof
WO2018157004A1 (en) * 2017-02-24 2018-08-30 Coyne Scientific, Llc Methods for determining the incidence and/or intensity of effects of a chemical or biological agent on members of a target population using stem cells
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
KR102083408B1 (ko) * 2017-04-28 2020-03-02 가천대학교 산학협력단 줄기세포 기반의 독성 물질 스크리닝 방법
US12076437B2 (en) 2021-07-12 2024-09-03 Brown University Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue
AU2022451480A1 (en) 2022-03-30 2024-10-17 Infinite D.O.O. A method for predictive testing of agents to assess triggering and suppressing adverse outcomes and/or diseases

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
JPH11225795A (ja) * 1998-02-13 1999-08-24 Oriental Yeast Co Ltd 細胞障害マーカー
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
WO2001094616A1 (en) 2000-06-02 2001-12-13 Large Scale Proteomics Corp. Protein markers for pharmaceuticals and related toxicity
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
EP1176189A1 (en) 2000-07-21 2002-01-30 Fornix Biosciences N.V. Stem cell-like cells
JP4027803B2 (ja) 2001-02-23 2007-12-26 三菱化学株式会社 薬物代謝酵素遺伝子を有するトランスジェニック動物およびその利用
EP1417629B1 (en) 2001-07-06 2008-02-20 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
CA2458575C (en) * 2001-08-24 2014-07-08 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
US6982152B2 (en) * 2002-04-17 2006-01-03 Promega Corporation Cytotoxicity assay
US20040121305A1 (en) 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
WO2004065616A2 (en) * 2003-01-16 2004-08-05 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
JP2005022096A (ja) 2003-06-30 2005-01-27 Three M Innovative Properties Co 遮光性装飾シート
DK1644485T3 (da) * 2003-07-08 2011-08-15 Axiogenesis Ag Udskilte proteiner som markører for celledifferentiering
CA2558946C (en) 2003-07-08 2013-05-21 Axiogenesis Ag Novel method for the preparation of embryoid bodies (ebs) and uses thereof
US20070298453A1 (en) 2004-02-12 2007-12-27 University Of Newcastle Upon Tyne Stem Cells
EP1740945B1 (en) 2004-04-07 2018-09-19 Ncardia AG Non-invasive, in vitro functional tissue assay systems

Also Published As

Publication number Publication date
US8703483B2 (en) 2014-04-22
DK2013619T3 (en) 2017-12-04
JP2009533056A (ja) 2009-09-17
GB2451042A (en) 2009-01-14
EP2013619B1 (en) 2017-10-11
BRPI0710054A2 (pt) 2011-08-02
WO2007120699A3 (en) 2008-01-24
US20140255969A1 (en) 2014-09-11
GB0820454D0 (en) 2008-12-17
CA2648218A1 (en) 2007-10-25
SE0850071L (sv) 2008-12-19
JP5421767B2 (ja) 2014-02-19
US20070248947A1 (en) 2007-10-25
BRPI0710054B8 (pt) 2021-07-27
CA2648218C (en) 2015-06-02
WO2007120699A2 (en) 2007-10-25
JP2013078342A (ja) 2013-05-02
MX2008013002A (es) 2008-10-17
EP2013619A2 (en) 2009-01-14
BRPI0710054B1 (pt) 2020-11-17
SE1050445A1 (sv) 2010-05-04

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